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$424+ Cheap flights from Louisville (SDF) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Louisville to Panama

Cheapest flights from Louisville to Panama
Explore the most affordable flight options available from Louisville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:24 pmSDF - PTY
2 stops18h 29mAmerican Airlines
Sat 12/272:53 pmPTY - SDF
2 stops17h 57mAmerican Airlines
Deal found 12/16$568
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:14 amSDF - PTY
1 stop9h 46mDelta
Sat 12/278:00 amPTY - SDF
1 stop12h 51mDelta
Deal found 12/17$572
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:11 pmSDF - PTY
2 stops20h 34mUnited Airlines
Sat 12/278:55 amPTY - SDF
1 stop12h 59mUnited Airlines
Deal found 12/16$596
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amSDF - PTY
1 stop11h 07mUnited Airlines
Wed 12/318:55 amPTY - SDF
1 stop12h 59mUnited Airlines
Deal found 12/16$674
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:24 pmSDF - PTY
2 stops18h 29mAmerican Airlines
Wed 12/314:55 pmPTY - SDF
2 stops17h 59mAmerican Airlines
Deal found 12/16$688
This Mytrip deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:05 amSDF - PTY
2 stops19h 35mMultiple Airlines
Tue 12/302:55 amPTY - SDF
3 stops21h 04mMultiple Airlines
Deal found 12/16$983
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:30 amSDF - PTY
1 stop11h 30mDelta
Sun 1/48:00 amPTY - SDF
1 stop12h 49mDelta
Deal found 12/16$1,021

Find flight deals from Louisville to Panama

Keep the following information in mind while searching for Louisville to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$424
(United Airlines)

Popular in

November

Cheapest in

September

Average price

$588
Provider with most accurate pricing for Louisville Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Panama City Tocumen Intl flights.
Search Deals
From Louisville Intl to Panama
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Louisville to Panama that are best for you.

Fly from

Louisville

Fly to

Panama

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 2/23

10:45 am-8:02 pm

1 stop9h 17m

Panama City Tocumen Intl

Wed 3/4

11:35 am-7:51 pm

1 stop8h 16m

$424

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 2/2

6:00 am-2:45 pm

1 stop8h 45m

Panama City Tocumen Intl

Thu 2/5

10:00 am-7:31 pm

1 stop9h 31m

$424

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 2/23

7:47 pm-1:50 pm

2 stops18h 03m

Panama City Tocumen Intl

Wed 3/4

2:50 pm-11:59 pm

1 stop9h 09m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 5/18

6:31 pm-12:15 pm

2 stops18h 44m

Panama City Tocumen Intl

Tue 6/2

1:50 pm-10:22 am

2 stops19h 32m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 3/16

1:58 pm-1:45 pm

2 stops24h 47m

Panama City Tocumen Intl

Mon 3/23

3:41 pm-1:17 pm

2 stops20h 36m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 3/5

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Thu 3/12

3:41 pm-1:17 pm

2 stops20h 36m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 3/17

6:00 am-6:38 pm

1 stop13h 38m

Panama City Tocumen Intl

Thu 3/19

3:41 pm-1:17 pm

2 stops20h 36m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 2/17

5:35 am-7:38 pm

2 stops14h 03m

Panama City Tocumen Intl

Mon 3/30

10:55 pm-4:51 pm

2 stops16h 56m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 3/16

1:58 pm-1:45 pm

2 stops24h 47m

Panama City Tocumen Intl

Thu 3/19

3:41 pm-1:17 pm

2 stops20h 36m

$428

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Best time to book a flight from Louisville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama

What is the cheapest month to book a flight from Louisville to Panama?

Currently, June is the cheapest month in which you can book a flight from Louisville to Panama (average of $337). Flying from Louisville to Panama in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to PA?

Find hourly flight availability from Louisville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s optimal to fly from Louisville to Panama in the afternoon. By choosing this option you can save up to 67% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Louisville to Panama, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,091 reviews
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to Panama?

    Louisville Intl (SDF) is the airport you will fly out of if you book a flight from Louisville to Panama. It is only a 5.3 mi journey to Louisville Intl (SDF) from Louisville’s city center.

  • How long is the flight from Louisville to Panama?

    Airlines like United Airlines and American Airlines fly from Louisville to Panama in about 9h 17m. The time it takes to get you to your destination can typically vary by up to 8h 46m. The distance between Louisville and Panama is about 2048 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Louisville to Panama that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama.

  • Can I find deals for business class flights from Louisville to Panama?

    Yes. Cheapflights offers flight deals from Louisville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama?

    Currently, June is the cheapest month in which you can book a flight from Louisville to Panama (average of $337). Flying from Louisville to Panama in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisville to Panama

Discover the top 3 airlines that operate flights from Louisville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$381Average$506FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$410Average$562FlexibilityNo cancel feeOn-time71%
DeltaCheapest$423Average$477FlexibilityNo cancel feeOn-timeN/A

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