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$190+ Cheap flights from Louisville (SDF) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Louisville to Panama

Cheapest flights from Louisville to Panama
Explore the most affordable flight options available from Louisville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/219:15 am
SDF
-
PTY
1 stop7h 57m
United Airlines
Sat 4/2510:00 am
PTY
-
SDF
1 stop10h 59m
United Airlines
Deal found 1/27$443
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:15 am
SDF
-
PTY
1 stop10h 23m
United Airlines
Wed 3/48:55 am
PTY
-
SDF
1 stop12h 51m
United Airlines
Deal found 1/28$445
This KAYAK deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:15 am
SDF
-
PTY
1 stop13h 47m
Copa Airlines
Thu 3/511:35 am
PTY
-
SDF
1 stop10h 37m
Copa Airlines
Deal found 1/27$450
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:15 am
SDF
-
PTY
1 stop7h 52m
United Airlines
Sat 3/78:55 am
PTY
-
SDF
1 stop13h 04m
United Airlines
Deal found 1/27$454
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:45 pm
SDF
-
PTY
2 stops11h 25m
United Airlines
Wed 4/110:00 am
PTY
-
SDF
1 stop10h 59m
United Airlines
Deal found 1/27$456
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
SDF
-
PTY
1 stop13h 38m
United Airlines
Fri 2/274:41 pm
PTY
-
SDF
2 stops20h 42m
United Airlines
Deal found 1/28$458
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:00 am
SDF
-
PTY
1 stop8h 45m
United Airlines
Thu 3/58:55 am
PTY
-
SDF
1 stop13h 17m
United Airlines
Deal found 1/27$465
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:05 am
SDF
-
PTY
2 stops22h 05m
United Airlines
Fri 3/137:55 am
PTY
-
SDF
1 stop13h 04m
United Airlines
Deal found 1/27$467
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:15 am
SDF
-
PTY
1 stop7h 52m
United Airlines
Sat 3/78:55 am
PTY
-
SDF
1 stop13h 04m
United Airlines
Deal found 1/27$474
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:15 am
SDF
-
PTY
1 stop7h 52m
United Airlines
Fri 3/64:41 pm
PTY
-
SDF
2 stops20h 36m
United Airlines
Deal found 1/27$478

Find flight deals from Louisville to Panama

Keep the following information in mind while searching for Louisville to Panama flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$443
(United Airlines)

One-way from

$190
(Delta)

Popular in

December

Cheapest in

September

Average price

$458
Provider with most accurate pricing for Louisville Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Panama City Tocumen Intl flights.
Search Deals
From Louisville Intl to Panama
Search Deals
One-way flight from Louisville Intl to Panama
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Louisville to Panama that are best for you.

Fly from

Louisville

Fly to

Panama

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 4/21

7:20 am-6:37 pm

2 stops12h 17m

Panama City Tocumen Intl

Sat 4/25

7:55 am-8:16 pm

2 stops11h 21m

$443

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 2/24

9:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Tue 3/3

8:55 am-9:46 pm

1 stop12h 51m

$445

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 2/17

6:00 am-7:38 pm

1 stop13h 38m

Panama City Tocumen Intl

Tue 3/3

8:55 am-9:46 pm

1 stop12h 51m

$445

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 2/23

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Wed 3/4

10:00 am-7:55 pm

1 stop9h 55m

$445

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 2/25

9:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Thu 3/5

11:35 am-10:12 pm

1 stop10h 37m

$449

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 2/26

5:35 am-8:02 pm

2 stops14h 27m

Panama City Tocumen Intl

Thu 3/5

4:41 pm-4:46 pm

2 stops24h 05m

$449

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sun 3/1

7:51 pm-1:50 pm

1 stop17h 59m

$190

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 3/2

5:54 pm-2:45 pm

2 stops20h 51m

$190

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 3/2

5:33 am-1:50 pm

1 stop8h 17m

$190

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 2/25

10:45 am-8:02 pm

1 stop9h 17m

$190

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 14 results
1
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Best time to book a flight from Louisville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama

What is the cheapest month to book a flight from Louisville to Panama?

Currently, May is the cheapest month in which you can book a flight from Louisville to Panama (average of $229). Flying from Louisville to Panama in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Louisville to Panama, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to Panama?

    Louisville Intl (SDF) is the airport you will fly out of if you book a flight from Louisville to Panama. It is only a 5.3 mi journey to Louisville Intl (SDF) from Louisville’s city center.

  • How long is the flight from Louisville to Panama?

    Airlines like United Airlines fly from Louisville to Panama in about 12h 17m. The time it takes to get you to your destination can typically vary by up to . The distance between Louisville and Panama is about 2048 mi.

  • Can I find deals for flights from Louisville to Panama that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama.

  • Can I find deals for business class flights from Louisville to Panama?

    Yes. Cheapflights offers flight deals from Louisville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama?

    Currently, May is the cheapest month in which you can book a flight from Louisville to Panama (average of $229). Flying from Louisville to Panama in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisville to Panama

Discover the top 3 airlines that operate flights from Louisville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$381Average$481FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$410Average$586FlexibilityNo cancel feeOn-time71%
DeltaCheapest$423Average$542FlexibilityNo cancel feeOn-timeN/A

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