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Panama

$179+ Cheap flights from Louisville (SDF) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Louisville to Panama

Cheapest flights from Louisville to Panama
Explore the most affordable flight options available from Louisville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:10 amSDF - PTY
1 stop12h 28mUnited Airlines
Thu 12/48:55 amPTY - SDF
1 stop10h 59mUnited Airlines
Deal found 10/30$424
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:00 amSDF - PTY
2 stops12h 38mUnited Airlines
Sat 12/610:00 amPTY - SDF
1 stop9h 27mUnited Airlines
Deal found 10/27$437
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/149:31 amSDF - PTY
1 stop29h 14mUnited Airlines
Sun 12/218:55 amPTY - SDF
1 stop12h 59mUnited Airlines
Deal found 10/30$439
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:00 amSDF - PTY
1 stop13h 59mDelta
Fri 12/53:46 pmPTY - SDF
1 stop8h 13mDelta
Deal found 10/29$442
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:25 amSDF - PTY
2 stops31h 18mAmerican Airlines
Thu 12/44:43 pmPTY - SDF
2 stops18h 34mAmerican Airlines
Deal found 10/30$443
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:10 amSDF - PTY
1 stop12h 28mUnited Airlines
Tue 11/48:55 amPTY - SDF
1 stop10h 59mUnited Airlines
Deal found 10/29$444
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/279:00 amSDF - PTY
2 stops29h 45mUnited Airlines
Tue 12/24:41 pmPTY - SDF
2 stops18h 51mUnited Airlines
Deal found 10/27$452
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:10 amSDF - PTY
1 stop12h 28mUnited Airlines
Sun 11/164:41 pmPTY - SDF
1 stop29h 16mUnited Airlines
Deal found 10/28$453

Cheap flight deals from Louisville to Panama

Keep the following information in mind while searching for Louisville to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$424
(United Airlines)

One-way from

$179
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$499
Provider with most accurate pricing for Louisville Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Panama City Tocumen Intl flights.
Search Deals
From Louisville Intl to Panama
Search Deals
One-way flight from Louisville Intl to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($99 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Louisville to Panama that are best for you.

Fly from

Louisville

Fly to

Panama

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 1/7

9:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Thu 1/29

8:55 am-9:59 pm

1 stop13h 04m

$424

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Fri 3/20

6:31 am-12:10 pm

1 stop6h 39m

Panama City Tocumen Intl

Thu 4/2

3:50 pm-12:14 am

1 stop7h 24m

$424

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 1/8

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Thu 1/29

10:00 am-7:31 pm

1 stop9h 31m

$424

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 1/7

5:35 am-8:02 pm

2 stops14h 27m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-1:28 pm

2 stops20h 47m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 1/8

5:35 am-5:07 pm

2 stops11h 32m

Panama City Tocumen Intl

Wed 1/28

10:00 am-7:31 pm

1 stop9h 31m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 1/6

6:00 am-2:45 pm

1 stop8h 45m

Panama City Tocumen Intl

Wed 1/21

4:41 pm-5:37 pm

2 stops24h 56m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 11/27

7:10 am-7:38 pm

1 stop12h 28m

Panama City Tocumen Intl

Thu 12/4

4:41 pm-11:32 am

2 stops18h 51m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 1/5

9:05 am-7:38 pm

1 stop10h 33m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-1:28 pm

2 stops20h 47m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 1/6

6:00 am-7:38 pm

1 stop13h 38m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-1:28 pm

2 stops20h 47m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 1/7

9:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Wed 1/28

4:41 pm-1:28 pm

2 stops20h 47m

$428

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 11 results
1
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Best time to book a flight from Louisville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama

What is the cheapest month to book a flight from Louisville to Panama?

Currently, June is the cheapest month in which you can book a flight from Louisville to Panama (average of $337). Flying from Louisville to Panama in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to PA?

Find hourly flight availability from Louisville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s optimal to fly from Louisville to Panama in the afternoon. By choosing this option you can save up to 67% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Louisville to Panama, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Food

7.3

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to Panama?

    Louisville Intl (SDF) is the airport you will fly out of if you book a flight from Louisville to Panama. It is only a 5.3 mi journey to Louisville Intl (SDF) from Louisville’s city center.

  • How long is the flight from Louisville to Panama?

    Airlines like United Airlines and American Airlines fly from Louisville to Panama in about 6h 39m. The time it takes to get you to your destination can typically vary by up to 1h 13m. The distance between Louisville and Panama is about 2048 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Louisville to Panama that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama.

  • Can I find deals for business class flights from Louisville to Panama?

    Yes. Cheapflights offers flight deals from Louisville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama?

    Currently, June is the cheapest month in which you can book a flight from Louisville to Panama (average of $337). Flying from Louisville to Panama in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisville to Panama

Discover the top 3 airlines that operate flights from Louisville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$351Average$534FlexibilityNo cancel feeOn-time69%
DeltaCheapest$392Average$499FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$562FlexibilityNo cancel feeOn-time71%

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