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Panama

$183+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated September 16, 2025.

Round-trip from

$466
(Kiwi.com)

One-way from

$183
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$471
From Knoxville McGhee Tyson to Panama
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One-way flight from Knoxville McGhee Tyson to Panama
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Highest demand for flights based on searches. 20% potential increase in price ($164 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($46 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:58 amTYS - PTY
1 stop11h 21mMultiple Airlines
Thu 11/612:03 pmPTY - TYS
1 stop10h 30mMultiple Airlines
Deal found 9/15$466
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:37 pmTYS - PTY
2 stops21h 26mAmerican Airlines
Thu 11/62:49 pmPTY - TYS
2 stops19h 01mAmerican Airlines
Deal found 9/15$492
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/244:18 pmTYS - PTY
2 stops21h 25mAmerican Airlines
Fri 11/282:43 pmPTY - TYS
2 stops20h 09mAmerican Airlines
Deal found 9/15$522
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:37 pmTYS - PTY
2 stops18h 26mAmerican Airlines
Sat 10/183:15 pmPTY - TYS
2 stops20h 38mAmerican Airlines
Deal found 9/14$552
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:37 pmTYS - PTY
2 stops18h 26mAmerican Airlines
Sun 10/193:15 pmPTY - TYS
2 stops20h 16mAmerican Airlines
Deal found 9/14$557
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:59 amTYS - PTY
1 stop6h 56mDelta
Wed 10/12:10 pmPTY - TYS
1 stop8h 34mDelta
Deal found 9/14$597
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:24 pmTYS - PTY
2 stops21h 07mAmerican Airlines
Wed 10/11:45 pmPTY - TYS
1 stop9h 05mAmerican Airlines
Deal found 9/14$602
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:07 pmTYS - PTY
1 stop20h 42mAmerican Airlines
Fri 11/212:43 pmPTY - TYS
1 stop9h 13mAmerican Airlines
Deal found 9/15$611

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Knoxville

Fly to

Panama

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 11/14

4:38 pm-1:49 pm

2 stops21h 11m

Panama City Tocumen Intl

Fri 11/21

2:43 pm-11:56 pm

1 stop9h 13m

$492

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 10/30

5:37 pm-2:03 pm

2 stops21h 26m

Panama City Tocumen Intl

Thu 11/6

2:49 pm-9:50 am

2 stops19h 01m

$492

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 11/24

4:18 pm-1:43 pm

2 stops21h 25m

Panama City Tocumen Intl

Fri 11/28

2:43 pm-10:52 am

2 stops20h 09m

$522

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

8:25 am-8:00 pm

1 stop11h 35m

Panama City Tocumen Intl

Sun 1/18

8:05 am-3:06 pm

1 stop7h 01m

$527

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 10/9

8:37 pm-2:03 pm

2 stops18h 26m

Panama City Tocumen Intl

Sat 10/18

3:15 pm-12:53 pm

2 stops20h 38m

$552

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 10/12

8:37 pm-2:03 pm

2 stops18h 26m

Panama City Tocumen Intl

Sun 10/19

3:15 pm-12:31 pm

2 stops20h 16m

$557

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

4:28 pm-1:53 pm

2 stops21h 25m

Panama City Tocumen Intl

Sun 1/18

2:45 pm-10:30 am

2 stops19h 45m

$592

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 9/27

6:59 am-12:55 pm

1 stop6h 56m

Panama City Tocumen Intl

Wed 10/1

2:10 pm-11:44 pm

1 stop8h 34m

$597

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 10/30

9:58 am-1:00 am

2 stops16h 02m

Panama City Tocumen Intl

Thu 11/6

1:45 pm-10:26 pm

3 stops32h 41m

$598

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 10/23

4:23 pm-9:10 pm

2 stops29h 47m

$183

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama (average of $478). Flying from Knoxville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA?

Find hourly flight availability from Knoxville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 16, 2025.
Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,924 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,924 reviews
United Airlines
7.4
Good
8,924 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,924 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama?

    For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Panama?

    Airlines like American Airlines and Delta fly from Knoxville to Panama in about 11h 35m. The time it takes to get you to your destination can typically vary by up to 9h 36m. Airlines will cover a distance of 1869 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Panama that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

  • Can I find deals for business class flights from Knoxville to Panama?

    Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama (average of $478). Flying from Knoxville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Panama

Discover the top 2 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$665FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$440Average$602FlexibilityNo cancel feeOn-time71%

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