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$251+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
May 1 — May 81
Fri 5/1
Fri 5/8
1 adult, Economy
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Cheap flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.

This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/235:57 pm
TYS
-
PTY
2 stops21h 17m
United Airlines
Wed 8/2610:00 am
PTY
-
TYS
1 stop10h 30m
United Airlines
Deal found 3/29$527
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:00 am
TYS
-
PTY
2 stops13h 31m
United Airlines
Tue 5/197:55 am
PTY
-
TYS
1 stop9h 16m
United Airlines
Deal found 3/28$547
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:11 pm
TYS
-
PTY
2 stops20h 35m
American Airlines
Thu 5/211:14 pm
PTY
-
TYS
1 stop9h 45m
American Airlines
Deal found 3/30$551
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:59 pm
TYS
-
PTY
2 stops17h 15m
American Airlines
Sun 5/311:14 pm
PTY
-
TYS
2 stops22h 56m
American Airlines
Deal found 3/26$566
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:57 pm
TYS
-
PTY
2 stops21h 17m
United Airlines
Sat 8/2210:00 am
PTY
-
TYS
1 stop10h 30m
United Airlines
Deal found 3/31$587
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 am
TYS
-
PTY
1 stop7h 45m
United Airlines
Sat 11/2110:00 am
PTY
-
TYS
2 stops13h 37m
United Airlines
Deal found 3/30$591
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:10 pm
TYS
-
PTY
1 stop27h 04m
United Airlines
Fri 6/1210:55 pm
PTY
-
TYS
2 stops16h 56m
United Airlines
Deal found 3/29$602

Find flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated April 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$527
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$496
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
Search Deals
From Knoxville McGhee Tyson to Panama
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 5/12

7:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

Tue 5/19

7:55 am-6:11 pm

1 stop9h 16m

$547

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 5/14

11:40 am-6:37 pm

1 stop7h 57m

Panama City Tocumen Intl

Thu 5/21

7:55 am-11:12 pm

1 stop14h 17m

$547

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 5/28

7:34 pm-12:14 pm

1 stop17h 40m

Panama City Tocumen Intl

Sun 5/31

1:14 pm-11:59 pm

1 stop9h 45m

$573

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 6/5

5:45 am-7:31 pm

2 stops14h 46m

Panama City Tocumen Intl

Fri 6/12

10:55 pm-8:56 pm

2 stops21h 01m

$591
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 6/5

6:00 am-12:14 pm

1 stop7h 14m

Panama City Tocumen Intl

Fri 6/12

1:14 pm-11:59 pm

1 stop9h 45m

$627

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 4/7

9:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Thu 4/9

7:55 am-7:56 pm

1 stop11h 01m

$667

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 6/29

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Sun 7/5

10:00 am-11:12 pm

1 stop12h 12m

$714
Cheapest one-way
Quickest one-way

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/11

5:40 am-2:10 pm

1 stop9h 30m

$251

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/1

6:07 pm-12:14 pm

2 stops19h 07m

$407

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/11

6:30 am-6:37 pm

3 stops13h 07m

$1,938

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Sorted by cheapest first

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $385). Flying from Knoxville to Panama in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 1, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,529 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,529 reviews
United Airlines
7.4
Good
9,529 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,544 reviews
United Airlines
7.4
Good
9,529 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama?

    For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Panama?

    Airlines like United Airlines and American Airlines fly from Knoxville to Panama in about 13h 31m. The time it takes to get you to your destination can typically vary by up to 4h 09m. Airlines will cover a distance of 1869 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Panama that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

  • Can I find deals for business class flights from Knoxville to Panama?

    Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $385). Flying from Knoxville to Panama in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Panama

Discover the top 2 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$261Average$507FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$475Average$617FlexibilityNo cancel feeOn-time71%

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