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$275+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2211:58 amTYS - PTY
1 stop7h 40mUnited Airlines
Mon 12/298:55 amPTY - TYS
1 stop9h 15mUnited Airlines
Deal found 10/28$436
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amTYS - PTY
1 stop9h 42mAmerican Airlines
Fri 12/192:53 pmPTY - TYS
1 stop9h 45mAmerican Airlines
Deal found 10/28$526
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amTYS - PTY
1 stop7h 47mAmerican Airlines
Sat 12/204:55 pmPTY - TYS
1 stop7h 43mAmerican Airlines
Deal found 10/29$586
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:10 amTYS - PTY
1 stop10h 28mUnited Airlines
Fri 12/1911:35 amPTY - TYS
1 stop12h 07mUnited Airlines
Deal found 10/27$616
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:08 pmTYS - PTY
2 stops20h 45mAmerican Airlines
Mon 12/294:55 pmPTY - TYS
2 stops21h 33mAmerican Airlines
Deal found 10/28$650
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:23 amTYS - PTY
3 stops23h 27mMultiple Airlines
Thu 12/182:55 amPTY - TYS
3 stops18h 58mMultiple Airlines
Deal found 10/28$775

Cheap flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$440
(American Airlines)

One-way from

$275
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$582
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
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From Knoxville McGhee Tyson to Panama
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($160 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Knoxville

Fly to

Panama

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 4/6

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Tue 4/7

2:20 pm-11:44 pm

1 stop8h 24m

$476

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-11:34 am

2 stops18h 44m

$485

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 12/12

6:00 am-3:42 pm

1 stop9h 42m

Panama City Tocumen Intl

Fri 12/19

2:53 pm-8:56 am

2 stops18h 03m

$530

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 4/6

7:04 am-12:10 pm

1 stop6h 06m

Panama City Tocumen Intl

Tue 4/7

1:55 pm-11:18 am

2 stops20h 23m

$535

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 12/13

6:00 am-1:47 pm

1 stop7h 47m

Panama City Tocumen Intl

Sat 12/20

4:55 pm-12:38 am

1 stop7h 43m

$586

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 12/12

9:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Fri 12/19

11:35 am-11:42 pm

1 stop12h 07m

$616

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

7:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Sun 1/18

4:41 pm-7:50 pm

1 stop27h 09m

$635

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 12/12

11:42 am-7:38 pm

1 stop7h 56m

$275

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 12/25

9:05 am-7:38 pm

1 stop10h 33m

$331

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 12/23

7:00 am-2:45 pm

1 stop7h 45m

$401

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 13 results
1
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Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $359). Flying from Knoxville to Panama in July is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA?

Find hourly flight availability from Knoxville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Knoxville to Panama, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 69% versus a flight in the morning.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,998 reviews

Overall

7.4

Boarding

7.7

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,998 reviews
United Airlines
7.4
Good
8,998 reviews

Overall

7.4

Boarding

7.7

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
American Airlines
7.2
Good
11,035 reviews
United Airlines
7.4
Good
8,998 reviews

Overall

7.4

Boarding

7.7

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama?

    For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Panama?

    Airlines like Delta and American Airlines fly from Knoxville to Panama in about 8h 25m. The time it takes to get you to your destination can typically vary by up to 11h 03m. Airlines will cover a distance of 1869 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Panama that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

  • Can I find deals for business class flights from Knoxville to Panama?

    Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $359). Flying from Knoxville to Panama in July is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Chattanooga to Philip S.W.Goldson flights
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Memphis to Guatemala City flights
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Top 2 airlines flying from Knoxville to Panama

Discover the top 2 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$655FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$440Average$617FlexibilityNo cancel feeOn-time71%

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