How long is the flight from Knoxville to Panama?

Airlines like United Airlines and American Airlines fly from Knoxville to Panama in about 9h 18m. The time it takes to get you to your destination can typically vary by up to 3h 19m. Airlines will cover a distance of 1869 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What airport do you fly from for flights from Knoxville to Panama?

For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

Can I find deals for flights from Knoxville to Panama that include hotel bookings?

Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Panama?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

Can I find deals for business class flights from Knoxville to Panama?

Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$319+ Flights from Knoxville to Panama

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Cheap flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Mon 12/225:15 pmTYS - PTY

1 stop23h 52mUnited Airlines

Mon 12/294:41 pmPTY - TYS

1 stop18h 30mUnited Airlines

Deal found 12/17

$743

Sat 12/207:00 amTYS - PTY

1 stop12h 38mUnited Airlines

Mon 12/228:55 amPTY - TYS

1 stop14h 47mUnited Airlines

Deal found 12/16

$773

Mon 12/225:40 pmTYS - PTY

2 stops20h 13mAmerican Airlines

Mon 12/292:53 pmPTY - TYS

1 stop9h 45mAmerican Airlines

Deal found 12/16

$790

Sat 12/207:29 pmTYS - PTY

2 stops18h 24mAmerican Airlines

Mon 12/224:55 pmPTY - TYS

1 stop7h 43mAmerican Airlines

Deal found 12/16

$800

Best flights from Knoxville to Panama
Discover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Sat 4/187:00 amTYS - PTY

1 stop12h 37mUnited Airlines

Wed 4/2210:00 amPTY - TYS

1 stop8h 34mUnited Airlines

Deal found 12/16

$456

Fri 1/306:20 amTYS - PTY

1 stop9h 18mAmerican Airlines

Fri 2/64:50 pmPTY - TYS

2 stops19h 56mAmerican Airlines

Deal found 12/16

$460

Fri 2/204:28 pmTYS - PTY

2 stops21h 22mAmerican Airlines

Sat 2/282:50 pmPTY - TYS

2 stops20h 27mAmerican Airlines

Deal found 12/17

$480

Fri 1/309:05 amTYS - PTY

1 stop29h 40mUnited Airlines

Fri 2/64:41 pmPTY - TYS

1 stop27h 09mUnited Airlines

Deal found 12/16

$565

Sat 1/106:51 pmTYS - PTY

2 stops18h 36mAmerican Airlines

Sat 1/175:00 pmPTY - TYS

2 stops18h 03mAmerican Airlines

Deal found 12/17

$540

Fri 2/204:55 pmTYS - PTY

1 stop21h 50mUnited Airlines

Sat 2/284:41 pmPTY - TYS

1 stop27h 14mUnited Airlines

Deal found 12/17

$565

Sun 1/46:25 pmTYS - PTY

2 stops19h 28mAmerican Airlines

Sun 1/184:50 pmPTY - TYS

2 stops17h 59mAmerican Airlines

Deal found 12/17

$545

Thu 3/266:00 amTYS - PTY

1 stop9h 22mAmerican Airlines

Sat 4/41:44 pmPTY - TYS

2 stops20h 36mAmerican Airlines

Deal found 12/17

$620

Last-minute flights from Knoxville to Panama
Discover last-minute flight deals from Knoxville to Panama. Data last updated December 18, 2025 and is based on user searches.

Sat 12/207:00 amTYS - PTY

1 stop12h 38mUnited Airlines

Mon 12/228:55 amPTY - TYS

1 stop14h 47mUnited Airlines

Deal found 12/16

$773

Mon 12/225:15 pmTYS - PTY

1 stop23h 52mUnited Airlines

Mon 12/294:41 pmPTY - TYS

1 stop18h 30mUnited Airlines

Deal found 12/17

$743

Sun 1/46:25 pmTYS - PTY

2 stops19h 28mAmerican Airlines

Sun 1/184:50 pmPTY - TYS

2 stops17h 59mAmerican Airlines

Deal found 12/17

$545

Sat 1/106:51 pmTYS - PTY

2 stops18h 36mAmerican Airlines

Sat 1/175:00 pmPTY - TYS

2 stops18h 03mAmerican Airlines

Deal found 12/17

$540

Fri 1/306:20 amTYS - PTY

1 stop9h 18mAmerican Airlines

Fri 2/64:50 pmPTY - TYS

2 stops19h 56mAmerican Airlines

Deal found 12/16

$460

Fri 1/309:05 amTYS - PTY

1 stop29h 40mUnited Airlines

Fri 2/64:41 pmPTY - TYS

1 stop27h 09mUnited Airlines

Deal found 12/16

$565

Fri 1/308:30 amTYS - PTY

3 stops34h 25mMultiple Airlines

Fri 2/65:50 pmPTY - TYS

2 stops23h 19mMultiple Airlines

Deal found 12/16

$669

One-way flights from Knoxville to Panama
Search for one-way flight options from Knoxville to Panama. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Thu 12/252:46 pmTYS - PTY

2 stops23h 07mAmerican Airlines

Deal found 12/17

$319

Thu 12/257:00 amTYS - PTY

1 stop12h 38mUnited Airlines

Deal found 12/17

$335

Tue 12/235:15 amTYS - PTY

1 stop8h 38mAmerican Airlines

Deal found 12/16

$405

Tue 12/237:00 amTYS - PTY

1 stop10h 07mUnited Airlines

Deal found 12/17

$409

Find flight deals from Knoxville to Panama

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$456 (United Airlines)
One-way from	$319 (American Airlines)
Popular in	December
Cheapest in	September
Average price	$754

Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.

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From Knoxville McGhee Tyson to Panama

Search Deals

One-way flight from Knoxville McGhee Tyson to Panama

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($71 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 4/18

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Wed 4/22

10:00 am-7:34 pm

1 stop8h 34m

$456

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 1/30

6:20 am-3:38 pm

1 stop9h 18m

Panama City Tocumen Intl

Fri 2/6

4:50 pm-12:46 pm

2 stops19h 56m

$460

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/20

4:28 pm-1:50 pm

2 stops21h 22m

Panama City Tocumen Intl

Sat 2/28

2:50 pm-11:17 am

2 stops20h 27m

$480

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 1/10

6:51 pm-1:27 pm

2 stops18h 36m

Panama City Tocumen Intl

Sat 1/17

5:00 pm-11:03 am

2 stops18h 03m

$540

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-10:49 am

2 stops17h 59m

$545

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 1/30

9:05 am-2:45 pm

1 stop29h 40m

Panama City Tocumen Intl

Fri 2/6

4:41 pm-7:50 pm

1 stop27h 09m

$565

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/20

4:55 pm-2:45 pm

1 stop21h 50m

Panama City Tocumen Intl

Sat 2/28

4:41 pm-7:55 pm

1 stop27h 14m

$565

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 3/26

6:00 am-2:22 pm

1 stop9h 22m

Panama City Tocumen Intl

Sat 4/4

1:44 pm-11:20 am

2 stops20h 36m

$620

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 12/25

2:46 pm-1:53 pm

2 stops23h 07m

$319

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 12/25

7:00 am-7:38 pm

1 stop12h 38m

$335

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 12 results

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $359). Flying from Knoxville to Panama in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA?

When flying from Knoxville to Panama, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 69% versus a flight in the morning.

Reviews of airlines servicing Panama

Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

9,091 reviews

Reviews

1 / 20

4.0

Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

United Airlines

7.4

Good

9,091 reviews

United Airlines

7.4

Good

9,091 reviews

Reviews

1 / 20

4.0

Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

American Airlines

7.2

Good

11,054 reviews

United Airlines

7.4

Good

9,091 reviews

Reviews

1 / 20

4.0

Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Related info for your journey

What airport do you fly from for flights from Knoxville to Panama?
For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.
How long is the flight from Knoxville to Panama?
Airlines like United Airlines and American Airlines fly from Knoxville to Panama in about 9h 18m. The time it takes to get you to your destination can typically vary by up to 3h 19m. Airlines will cover a distance of 1869 mi. Both multi-stop and nonstop flights can be found to your destination and back.
Can I find deals for flights from Knoxville to Panama that include hotel bookings?
Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Panama?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.
Can I find deals for business class flights from Knoxville to Panama?
Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Panama?
Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $359). Flying from Knoxville to Panama in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Panama

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$387	Average$513	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$461	Average$617	FlexibilityNo cancel fee	On-time71%

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$319+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Panama with Cheapflights

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3. Compare prices and book

Cheap flight deals from Knoxville to Panama

Cheapest flights from Knoxville to PanamaExplore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

What is the cheapest time of day to fly from TYS to PA?

Find hourly flight availability from Knoxville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Reviews of airlines servicing Panama

Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Knoxville to Panama?

How long is the flight from Knoxville to Panama?

Can I find deals for flights from Knoxville to Panama that include hotel bookings?

How can I find direct flights from Knoxville to Panama?

Can I find deals for business class flights from Knoxville to Panama?

What is the cheapest month to book a flight from Knoxville to Panama?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Panama

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Panama

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Travel Smart

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.