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$198+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$461
(United Airlines)

One-way from

$198
(Delta)

Popular in

June

Cheapest in

December

Average price

$441
From Iowa to Panama
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One-way flight from Iowa to Panama
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Highest demand for flights based on searches. 15% potential increase in price ($108 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($45 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Thu 11/68:55 amPTY - DSM
1 stop14h 25mUnited Airlines
Deal found 9/15$461
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:15 amDSM - PTY
1 stop12h 22mUnited Airlines
Sat 10/183:30 pmPTY - DSM
2 stops19h 02mUnited Airlines
Deal found 9/15$466
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/113:05 pmDSM - PTY
1 stop23h 09mUnited Airlines
Tue 10/2110:00 amPTY - DSM
1 stop12h 28mUnited Airlines
Deal found 9/13$470
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/115:15 pmDSM - PTY
1 stop19h 41mDelta
Wed 10/222:21 pmPTY - DSM
2 stops18h 59mDelta
Deal found 9/13$475
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/113:05 pmDSM - PTY
1 stop23h 09mUnited Airlines
Mon 10/203:30 pmPTY - DSM
1 stop22h 43mUnited Airlines
Deal found 9/13$479
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/105:56 pmDSM - PTY
2 stops43h 00mDelta
Wed 10/222:21 pmPTY - DSM
1 stop8h 09mDelta
Deal found 9/13$481
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:15 amDSM - PTY
1 stop12h 22mUnited Airlines
Sun 10/193:30 pmPTY - DSM
2 stops22h 53mUnited Airlines
Deal found 9/13$508
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:42 pmDSM - PTY
2 stops20h 21mAmerican Airlines
Thu 11/62:49 pmPTY - DSM
2 stops20h 51mAmerican Airlines
Deal found 9/15$509
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/113:05 pmDSM - PTY
1 stop23h 09mUnited Airlines
Thu 10/2310:00 amPTY - DSM
1 stop12h 22mUnited Airlines
Deal found 9/13$512
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1211:06 amDSM - PTY
2 stops25h 50mDelta
Thu 10/232:21 pmPTY - DSM
2 stops18h 59mDelta
Deal found 9/13$513
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:00 amOMA - PTY
1 stop7h 45mUnited Airlines
Tue 11/48:55 amPTY - OMA
1 stop10h 54mUnited Airlines
Deal found 9/15$541
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amOMA - PTY
1 stop7h 45mUnited Airlines
Wed 11/54:41 pmPTY - OMA
1 stop30h 26mUnited Airlines
Deal found 9/14$551

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 10/15

6:39 pm-12:56 pm

1 stop18h 17m

Panama City Tocumen Intl

Wed 10/22

2:21 pm-10:30 pm

1 stop8h 09m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/30

6:05 am-1:45 pm

1 stop7h 40m

Panama City Tocumen Intl

Thu 11/6

8:55 am-10:20 pm

1 stop14h 25m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/1

2:07 pm-1:53 pm

2 stops22h 46m

Panama City Tocumen Intl

Wed 4/1

3:50 pm-12:31 pm

2 stops20h 41m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 10/15

6:39 pm-12:56 pm

1 stop18h 17m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-9:20 am

2 stops18h 59m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Sat 2/14

11:55 pm-9:51 pm

2 stops22h 56m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 10/11

8:00 am-6:37 pm

2 stops10h 37m

Panama City Tocumen Intl

Tue 10/21

3:30 pm-10:32 am

2 stops19h 02m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 10/17

3:30 pm-12:11 pm

2 stops20h 41m

$466

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Sun 2/22

5:15 pm-2:45 pm

2 stops20h 30m

Panama City Tocumen Intl

Thu 2/26

4:41 pm-12:35 pm

2 stops20h 54m

$526

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 3/11

6:00 am-5:49 pm

1 stop11h 49m

Panama City Tocumen Intl

Mon 3/16

3:00 pm-11:59 pm

1 stop32h 59m

$531

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 29 results
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, October is the cheapest month in which you can book a flight from Iowa to Panama (average of $478). Flying from Iowa to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to PA?

Find hourly flight availability from Iowa to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Iowa to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    Delta, United Airlines, and American Airlines can get you from Iowa to Panama in just under 7h 40m. Your travel time can differ by up to 11h 44m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Panama one-way?

    The cheapest airlines for a one-way flight from Iowa to Panama are Delta ($198), American Airlines ($198), and United Airlines ($248).

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Panama (average of $478). Flying from Iowa to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Panama

Discover the top 3 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$411Average$484FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$632FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$445Average$544FlexibilityNo cancel feeOn-time71%

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