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$213+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Jan 7 — Jan 141
Wed 1/7
Wed 1/14
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

This Delta deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:34 amDSM - PTY
1 stop13h 25mDelta
Fri 12/263:22 pmPTY - DSM
1 stop8h 09mDelta
Deal found 12/7$462
This United Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:46 pmDSM - PTY
2 stops21h 21mUnited Airlines
Mon 3/233:41 pmPTY - DSM
2 stops22h 46mUnited Airlines
Deal found 12/7$508
This United Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:15 pmOMA - PTY
2 stops22h 52mUnited Airlines
Mon 12/298:55 amPTY - OMA
1 stop11h 24mUnited Airlines
Deal found 12/7$746
This American Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:31 pmOMA - PTY
2 stops19h 23mAmerican Airlines
Mon 12/294:55 pmPTY - OMA
2 stops16h 56mAmerican Airlines
Deal found 12/7$776

Find flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated December 8, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$462
(United Airlines)

One-way from

$213
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$1,033
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($41 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 1/21

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Wed 1/28

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

5:35 am-1:55 pm

1 stop7h 20m

Panama City Tocumen Intl

Wed 2/11

3:20 pm-10:29 pm

1 stop8h 09m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/22

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Thu 1/29

11:35 am-10:30 pm

1 stop11h 55m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/5

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Fri 2/13

8:55 am-10:20 pm

1 stop14h 25m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/1

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 4/1

7:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

Fri 3/6

11:35 am-10:44 pm

1 stop12h 09m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Fri 2/13

8:55 am-10:20 pm

1 stop14h 25m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

6:48 pm-2:45 pm

2 stops18h 57m

Panama City Tocumen Intl

Tue 2/17

4:41 pm-2:27 pm

2 stops22h 46m

$466

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Mon 2/2

6:06 am-2:45 pm

1 stop7h 39m

Panama City Tocumen Intl

Thu 2/5

8:55 am-6:54 pm

1 stop10h 59m

$522

Cedar RapidsPanama City

CID - PTY

CIDPTY

Cedar Rapids

Tue 2/3

10:07 am-1:27 pm

2 stops26h 20m

Panama City Tocumen Intl

Thu 3/5

4:05 pm-9:33 am

2 stops18h 28m

$526

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/6

Showing 1-10 of 27 results
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to PA?

Find hourly flight availability from Iowa to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.

It’s typically best to fly out from Iowa to Panama at noon. Doing so could potentially save you 58% on the flight price compared to flying in the morning, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    United Airlines, Delta, and American Airlines can get you from Iowa to Panama in just under 7h 20m. Your travel time can differ by up to 11h 59m. Airlines will cover a distance of 2386 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$420Average$485FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$616FlexibilityNo cancel feeOn-timeN/A

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