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$209+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$476
(United Airlines)

One-way from

$209
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$453
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Iowa to Panama
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One-way flight from Iowa to Panama
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Highest demand for flights based on searches. 12% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($47 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
Fri 3/68:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/13$476
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:59 pm
DSM
-
PTY
1 stop22h 46m
United Airlines
Sat 3/78:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/13$492
This KAYAK deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/308:10 am
DSM
-
PTY
1 stop10h 28m
Copa Airlines
Fri 2/274:41 pm
PTY
-
DSM
1 stop30h 34m
Copa Airlines
Deal found 1/13$495
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/303:35 pm
DSM
-
PTY
2 stops22h 10m
United Airlines
Fri 2/274:41 pm
PTY
-
DSM
1 stop30h 34m
United Airlines
Deal found 1/13$497
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/313:04 pm
DSM
-
PTY
1 stop27h 34m
United Airlines
Fri 2/274:41 pm
PTY
-
DSM
1 stop30h 34m
United Airlines
Deal found 1/13$501
This United Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
Sat 3/78:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/12$525
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:15 pm
OMA
-
PTY
2 stops20h 59m
United Airlines
Tue 6/27:55 am
PTY
-
OMA
1 stop11h 20m
United Airlines
Deal found 1/13$547
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:54 pm
OMA
-
PTY
1 stop25h 18m
United Airlines
Tue 6/27:55 am
PTY
-
OMA
1 stop11h 20m
United Airlines
Deal found 1/13$553
This United Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:15 am
OMA
-
PTY
1 stop9h 57m
United Airlines
Wed 4/227:55 am
PTY
-
OMA
1 stop11h 11m
United Airlines
Deal found 1/12$563
This United Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/85:27 pm
CID
-
PTY
2 stops20h 18m
United Airlines
Thu 2/124:41 pm
PTY
-
CID
2 stops19h 03m
United Airlines
Deal found 1/11$567
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:11 am
OMA
-
PTY
1 stop7h 34m
United Airlines
Tue 2/248:55 am
PTY
-
OMA
1 stop14h 32m
United Airlines
Deal found 1/13$583
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/101:50 pm
OMA
-
PTY
2 stops23h 55m
United Airlines
Wed 2/188:55 am
PTY
-
OMA
1 stop10h 59m
United Airlines
Deal found 1/13$587

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 2/27

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:44 pm

1 stop14h 49m

$476

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/2

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-10:29 pm

1 stop8h 09m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Wed 2/25

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 5/1

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-10:29 pm

1 stop8h 09m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/2

8:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Mon 5/4

10:00 am-10:30 pm

1 stop12h 30m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:44 pm

1 stop14h 49m

$483

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Mon 5/25

12:07 pm-12:10 pm

2 stops24h 03m

Panama City Tocumen Intl

Tue 6/2

1:10 pm-11:27 am

2 stops22h 17m

$547

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 5/26

5:15 pm-2:14 pm

2 stops20h 59m

Panama City Tocumen Intl

Tue 6/2

7:55 am-7:15 pm

1 stop11h 20m

$547

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 5/27

5:15 pm-2:14 pm

2 stops20h 59m

Panama City Tocumen Intl

Mon 6/1

3:20 pm-10:30 am

2 stops19h 10m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 37 results
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    United Airlines, Delta, and American Airlines can get you from Iowa to Panama in just under 7h 10m. Your travel time can differ by up to 16h 53m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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O'Hare Intl to Liberia flights
Denver to San José flights
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Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$421Average$470FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$605FlexibilityNo cancel feeOn-timeN/A

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