HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$244+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Apr 17 — Apr 241
Fri 4/17
Fri 4/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.

This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/268:20 am
DSM
-
PTY
1 stop10h 17m
United Airlines
Mon 5/47:55 am
PTY
-
DSM
1 stop14h 50m
United Airlines
Deal found 3/13$553
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:06 pm
DSM
-
PTY
2 stops24h 40m
American Airlines
Mon 5/41:49 pm
PTY
-
DSM
2 stops21h 37m
American Airlines
Deal found 3/13$554
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:21 pm
DSM
-
PTY
2 stops22h 53m
United Airlines
Fri 4/1710:00 am
PTY
-
DSM
1 stop12h 43m
United Airlines
Deal found 3/13$557
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am
DSM
-
PTY
2 stops13h 16m
United Airlines
Wed 9/3010:00 am
PTY
-
DSM
1 stop12h 30m
United Airlines
Deal found 3/15$573
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:20 am
DSM
-
PTY
2 stops13h 11m
United Airlines
Tue 5/53:30 pm
PTY
-
DSM
2 stops19h 07m
United Airlines
Deal found 3/14$577
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:20 pm
DSM
-
PTY
2 stops21h 26m
American Airlines
Fri 5/81:49 pm
PTY
-
DSM
2 stops21h 21m
American Airlines
Deal found 3/17$580
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:02 pm
DSM
-
PTY
2 stops22h 44m
American Airlines
Sun 4/261:49 pm
PTY
-
DSM
2 stops20h 37m
American Airlines
Deal found 3/16$582
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:31 pm
DSM
-
PTY
1 stop18h 31m
Delta
Thu 5/72:15 pm
PTY
-
DSM
1 stop8h 17m
Delta
Deal found 3/15$583
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:20 am
DSM
-
PTY
1 stop29h 54m
United Airlines
Sun 4/2610:55 pm
PTY
-
DSM
2 stops15h 30m
United Airlines
Deal found 3/13$588
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:15 am
DSM
-
PTY
1 stop7h 57m
United Airlines
Thu 5/710:00 am
PTY
-
DSM
1 stop12h 45m
United Airlines
Deal found 3/16$605
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:07 pm
OMA
-
PTY
2 stops19h 39m
American Airlines
Wed 5/271:14 pm
PTY
-
OMA
2 stops23h 37m
American Airlines
Deal found 3/16$627
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:14 pm
CID
-
PTY
2 stops23h 32m
American Airlines
Tue 5/191:49 pm
PTY
-
CID
2 stops19h 04m
American Airlines
Deal found 3/14$627

Find flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated March 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$553
(United Airlines)

One-way from

$244
(American Airlines)

Popular in

December

Cheapest in

April

Average price

$735
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($124 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($41 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 4/10

8:04 am-4:04 am

2 stops20h 00m

Panama City Tocumen Intl

Fri 4/17

10:55 pm-2:28 pm

2 stops15h 33m

$557

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 4/26

2:02 pm-12:46 pm

2 stops22h 44m

Panama City Tocumen Intl

Mon 5/4

1:49 pm-2:47 pm

2 stops24h 58m

$557

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 4/26

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Mon 5/4

3:30 pm-10:37 am

2 stops19h 07m

$557

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 4/21

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Tue 4/28

10:00 am-10:43 pm

1 stop12h 43m

$573

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 4/17

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Thu 4/23

7:55 am-10:43 pm

1 stop14h 48m

$573

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 4/26

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Tue 5/5

10:00 am-10:45 pm

1 stop12h 45m

$573

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 9/11

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 9/15

10:00 am-10:26 pm

1 stop12h 26m

$573

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 5/1

8:15 am-6:37 pm

1 stop10h 22m

Panama City Tocumen Intl

Fri 5/8

10:00 am-10:45 pm

1 stop12h 45m

$573

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 4/24

8:04 am-4:04 am

2 stops20h 00m

Panama City Tocumen Intl

Tue 4/28

3:30 pm-2:25 pm

2 stops22h 55m

$577

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Thu 9/3

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 9/9

10:00 am-7:19 pm

1 stop9h 19m

$633

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Showing 1-10 of 36 resultsSorted by cheapest first
1
2
3
4

Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    United Airlines and American Airlines can get you from Iowa to Panama in just under 20h. Your travel time can differ by up to 2h 44m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Newark to San José flights
John F Kennedy Intl to San José flights
Dulles Intl to San Salvador flights
Los Angeles to San Salvador flights
John F Kennedy Intl to Panama City flights
Los Angeles to Guatemala City flights
Hobby to San Salvador flights
John F Kennedy Intl to San Salvador flights
George Bush Intcntl to San Salvador flights
John F Kennedy Intl to Guatemala City flights
Newark to Panama City flights
Newark to Guatemala City flights
LaGuardia to San José flights
Dulles Intl to Panama City flights
Newark to Liberia flights
Miami to Panama City flights
Atlanta to San José flights
Dallas/Fort Worth to San Salvador flights
John F Kennedy Intl to Liberia flights
Los Angeles to San José flights
Dulles Intl to San José flights
Fort Lauderdale to San José flights
Hobby to San José flights
Dallas/Fort Worth to San José flights
Reagan-National to San Salvador flights
Los Angeles to Liberia flights
Baltimore to San Salvador flights
San Francisco to San José flights
Atlanta to Panama City flights
Miami to Managua flights
Dulles Intl to Guatemala City flights
Miami to San José flights
Miami to San Salvador flights
Ontario to San Salvador flights
Los Angeles to Panama City flights
LaGuardia to Guatemala City flights
LaGuardia to San Salvador flights
Baltimore to Panama City flights
George Bush Intcntl to Guatemala City flights
George Bush Intcntl to San Pedro Sula flights
Fort Lauderdale to Guatemala City flights
Miami to Guatemala City flights
George Bush Intcntl to San José flights
Dallas/Fort Worth to Panama City flights
John F Kennedy Intl to San Pedro Sula flights
Orlando to Panama City flights

Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$364Average$573FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$441Average$482FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.