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$359+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Jun 13 — Jun 201
Sat 6/13
Sat 6/20
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.

This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:35 am
OMA
-
PTY
1 stop7h 21m
Delta
Tue 11/103:30 pm
PTY
-
OMA
1 stop9h 37m
Delta
Deal found 5/13$623
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am
OMA
-
PTY
1 stop7h 45m
United Airlines
Tue 11/108:55 am
PTY
-
OMA
2 stops12h 30m
United Airlines
Deal found 5/13$627
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:00 am
CID
-
PTY
2 stops20h 04m
United Airlines
Tue 8/183:30 pm
PTY
-
CID
2 stops22h 24m
United Airlines
Deal found 5/12$627
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:35 am
DSM
-
PTY
1 stop7h 24m
Delta
Sat 7/42:27 pm
PTY
-
DSM
1 stop8h 04m
Delta
Deal found 5/13$633
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:15 pm
OMA
-
PTY
2 stops18h 21m
American Airlines
Tue 11/102:43 pm
PTY
-
OMA
2 stops23h 30m
American Airlines
Deal found 5/13$637
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:50 pm
DSM
-
PTY
2 stops19h 24m
United Airlines
Tue 6/910:00 am
PTY
-
DSM
1 stop12h 40m
United Airlines
Deal found 5/10$637
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:15 am
DSM
-
PTY
1 stop29h 59m
United Airlines
Tue 5/193:30 pm
PTY
-
DSM
2 stops22h 54m
United Airlines
Deal found 5/13$648
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:15 am
OMA
-
PTY
1 stop9h 57m
United Airlines
Fri 7/247:55 am
PTY
-
OMA
1 stop11h 26m
United Airlines
Deal found 5/13$653
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:20 am
DSM
-
PTY
1 stop12h 17m
United Airlines
Sat 6/1310:55 pm
PTY
-
DSM
2 stops23h 56m
United Airlines
Deal found 5/12$654
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:33 pm
CID
-
PTY
2 stops20h 12m
United Airlines
Tue 11/104:41 pm
PTY
-
CID
2 stops20h 11m
United Airlines
Deal found 5/12$657
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:42 am
LSE
-
PTY
2 stops28h 03m
United Airlines
Tue 11/1010:00 am
PTY
-
LSE
2 stops23h 56m
United Airlines
Deal found 5/12$657
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:00 pm
OMA
-
PTY
2 stops21h 12m
United Airlines
Wed 6/173:30 pm
PTY
-
OMA
2 stops19h 16m
United Airlines
Deal found 5/13$667

Find flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated May 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$623
(Delta)

One-way from

$359
(Delta)

Popular in

December

Cheapest in

February

Average price

$461
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($115 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($41 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 11/3

5:35 am-1:56 pm

1 stop7h 21m

Panama City Tocumen Intl

Tue 11/10

3:30 pm-12:07 am

1 stop9h 37m

$623

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 11/3

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Tue 11/10

8:55 am-10:10 pm

1 stop14h 15m

$623
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 6/27

5:35 am-12:59 pm

1 stop7h 24m

Panama City Tocumen Intl

Sat 7/4

2:27 pm-10:31 pm

1 stop8h 04m

$633

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 6/2

6:50 pm-2:14 pm

2 stops19h 24m

Panama City Tocumen Intl

Tue 6/9

10:00 am-10:40 pm

1 stop12h 40m

$637

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Sat 9/12

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 9/28

10:00 am-7:24 pm

1 stop9h 24m

$653

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Mon 7/20

6:15 am-4:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Fri 7/24

7:55 am-7:21 pm

1 stop11h 26m

$653

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 6/6

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Sat 6/13

10:55 pm-10:51 pm

2 stops23h 56m

$654

Cedar RapidsPanama City

CID - PTY

CIDPTY

Cedar Rapids

Sat 11/7

5:33 pm-2:45 pm

2 stops20h 12m

Panama City Tocumen Intl

Tue 11/10

10:00 am-12:25 am

2 stops15h 25m

$657

La CrossePanama City

LSE - PTY

LSEPTY

La Crosse

Sat 11/7

9:42 am-2:45 pm

2 stops28h 03m

Panama City Tocumen Intl

Tue 11/10

10:00 am-8:56 am

2 stops23h 56m

$657

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 6/10

7:00 pm-4:12 pm

2 stops21h 12m

Panama City Tocumen Intl

Wed 6/17

3:30 pm-10:46 am

2 stops19h 16m

$667

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/9

Showing 1-10 of 28 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, August is the cheapest month in which you can book a flight from Iowa to Panama (average of $441). Flying from Iowa to Panama in December is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    Delta and United Airlines can get you from Iowa to Panama in just under 7h 21m. Your travel time can differ by up to 5h 17m. Airlines will cover a distance of 2443 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Panama (average of $441). Flying from Iowa to Panama in December is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Miami to Guatemala City flights
George Bush Intcntl to San Pedro Sula flights
George Bush Intcntl to Guatemala City flights
Dallas/Fort Worth to Guatemala City flights
Newark to Liberia flights
San Francisco to San José flights
Los Angeles to Panama City flights
San Francisco to San Salvador flights
Atlanta to Guatemala City flights
Miami to San Pedro Sula flights
John F Kennedy Intl to San Pedro Sula flights
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Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$461Average$492FlexibilityNo cancel feeOn-time69%

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