HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$198+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:05 amDSM - PTY
1 stop12h 33mUnited Airlines
Sat 12/68:55 amPTY - DSM
1 stop14h 34mUnited Airlines
Deal found 11/5$462
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Thu 11/274:41 pmPTY - DSM
1 stop30h 39mUnited Airlines
Deal found 11/5$471
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:10 amDSM - PTY
2 stops31h 33mAmerican Airlines
Sat 12/62:50 pmPTY - DSM
2 stops20h 40mAmerican Airlines
Deal found 11/3$474
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:50 pmDSM - PTY
2 stops21h 17mUnited Airlines
Fri 12/264:41 pmPTY - DSM
1 stop30h 49mUnited Airlines
Deal found 11/5$475
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:10 amDSM - PTY
2 stops31h 33mAmerican Airlines
Sun 12/74:43 pmPTY - DSM
2 stops20h 40mAmerican Airlines
Deal found 11/3$479
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2411:30 amDSM - PTY
2 stops25h 13mAmerican Airlines
Thu 11/272:43 pmPTY - DSM
2 stops20h 57mAmerican Airlines
Deal found 11/5$516
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:50 pmDSM - PTY
2 stops21h 17mUnited Airlines
Mon 12/224:41 pmPTY - DSM
1 stop30h 49mUnited Airlines
Deal found 11/3$517
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:46 pmDSM - PTY
2 stops21h 21mUnited Airlines
Mon 3/233:41 pmPTY - DSM
1 stop22h 39mUnited Airlines
Deal found 11/6$518
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:10 amOMA - PTY
1 stop8h 02mDelta
Thu 12/43:46 pmPTY - OMA
1 stop9h 30mDelta
Deal found 11/4$582
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/183:38 pmOMA - PTY
2 stops21h 11mAmerican Airlines
Thu 12/42:50 pmPTY - OMA
2 stops18h 47mAmerican Airlines
Deal found 11/4$586
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/282:02 pmCID - PTY
2 stops22h 41mAmerican Airlines
Tue 12/22:43 pmPTY - CID
2 stops27h 39mAmerican Airlines
Deal found 11/6$626
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:00 amOMA - PTY
2 stops12h 38mUnited Airlines
Thu 11/204:41 pmPTY - OMA
3 stops24h 30mUnited Airlines
Deal found 11/6$629

Cheap flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$462
(Delta)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$571
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($43 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

Sun 3/8

11:35 am-10:36 pm

1 stop11h 01m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/2

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-10:24 pm

1 stop8h 04m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 1/12

6:30 am-3:38 pm

1 stop8h 08m

Panama City Tocumen Intl

Thu 1/15

2:27 pm-11:29 pm

1 stop10h 02m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 12/13

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Fri 12/26

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

8:08 am-5:07 pm

1 stop7h 59m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:36 pm

1 stop14h 41m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

8:08 am-5:07 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 3/6

11:35 am-10:36 pm

1 stop12h 01m

$462

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 3/11

6:00 am-1:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Mon 3/16

11:35 am-10:18 pm

1 stop10h 43m

$522

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Thu 4/2

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Thu 4/9

10:00 am-10:10 pm

1 stop12h 10m

$522

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 4/1

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 4/14

7:55 am-10:10 pm

1 stop14h 15m

$522

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 1/14

8:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Wed 1/21

11:35 am-6:54 pm

1 stop8h 19m

$522

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 37 results
1
2
3
4

Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, December is the cheapest month in which you can book a flight from Iowa to Panama (average of $401). Flying from Iowa to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to PA?

Find hourly flight availability from Iowa to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s typically best to fly out from Iowa to Panama at noon. Doing so could potentially save you 57% on the flight price compared to flying in the morning, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    United Airlines, Delta, and American Airlines can get you from Iowa to Panama in just under 7h 10m. Your travel time can differ by up to 3h 20m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Panama one-way?

    The cheapest airlines for a one-way flight from Iowa to Panama are United Airlines ($198), American Airlines ($198), and Delta ($288).

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, December is the cheapest month in which you can book a flight from Iowa to Panama (average of $401). Flying from Iowa to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to San Salvador flights
John F Kennedy Intl to San José flights
Newark to San José flights
Los Angeles to Guatemala City flights
John F Kennedy Intl to Panama City flights
Dulles Intl to San Salvador flights
John F Kennedy Intl to Guatemala City flights
John F Kennedy Intl to San Salvador flights
Newark to Panama City flights
Los Angeles to San José flights
Hobby to San Salvador flights
LaGuardia to San José flights
George Bush Intcntl to San Salvador flights
Dallas/Fort Worth to San Salvador flights
Dulles Intl to San José flights
O'Hare Intl to San José flights
Newark to Guatemala City flights
Newark to Liberia flights
Miami to Managua flights
Dulles Intl to Panama City flights
Baltimore to San Salvador flights
John F Kennedy Intl to Liberia flights
Miami to Panama City flights
Hobby to San José flights
Atlanta to San José flights
LaGuardia to Panama City flights
Newark to San Salvador flights
Reagan-National to San Salvador flights
Dulles Intl to Guatemala City flights
Atlanta to Panama City flights
Ontario to San Salvador flights
Boston to San José flights
Los Angeles to Panama City flights
Baltimore to San José flights
Miami to San Salvador flights
Denver to San José flights
San Francisco to Panama City flights
Reagan-National to San José flights
George Bush Intcntl to San José flights
Dallas/Fort Worth to San José flights
O'Hare Intl to Guatemala City flights
Dallas/Fort Worth to Guatemala City flights
LaGuardia to San Salvador flights
Los Angeles to Liberia flights
Boston to Panama City flights
Denver to Liberia flights
O'Hare Intl to Panama City flights
LaGuardia to Liberia flights
O'Hare Intl to Liberia flights
Hobby to San Pedro Sula flights

Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$414Average$489FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$612FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.