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$214+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:52 am
DSM
-
PTY
1 stop8h 15m
United Airlines
Fri 3/68:55 am
PTY
-
DSM
1 stop14h 32m
United Airlines
Deal found 2/11$493
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
Thu 2/268:55 am
PTY
-
DSM
1 stop14h 25m
United Airlines
Deal found 2/10$525
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
DSM
-
PTY
2 stops14h 54m
United Airlines
Sun 4/267:55 am
PTY
-
DSM
1 stop14h 48m
United Airlines
Deal found 2/10$529
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
OMA
-
PTY
1 stop7h 59m
United Airlines
Tue 4/2110:00 am
PTY
-
OMA
1 stop9h 06m
United Airlines
Deal found 2/10$553
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:22 am
OMA
-
PTY
1 stop7h 52m
United Airlines
Mon 6/13:30 pm
PTY
-
OMA
1 stop27h 49m
United Airlines
Deal found 2/10$563
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:44 pm
DSM
-
PTY
2 stops16h 56m
American Airlines
Mon 3/231:40 pm
PTY
-
DSM
2 stops23h 25m
American Airlines
Deal found 2/10$572
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:15 am
OMA
-
PTY
1 stop12h 22m
United Airlines
Wed 4/227:55 am
PTY
-
OMA
1 stop14h 33m
United Airlines
Deal found 2/11$573
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:22 pm
OMA
-
PTY
2 stops20h 52m
United Airlines
Wed 4/2210:00 am
PTY
-
OMA
2 stops24h 37m
United Airlines
Deal found 2/9$577
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:02 pm
OMA
-
PTY
2 stops21h 10m
United Airlines
Sun 5/317:55 am
PTY
-
OMA
1 stop11h 24m
United Airlines
Deal found 2/10$582
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:02 pm
DSM
-
PTY
2 stops22h 38m
American Airlines
Sat 3/74:05 pm
PTY
-
DSM
2 stops26h 55m
American Airlines
Deal found 2/9$586
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:15 am
OMA
-
PTY
1 stop12h 22m
United Airlines
Sun 4/1910:00 am
PTY
-
OMA
1 stop9h 06m
United Airlines
Deal found 2/11$593
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:24 pm
CID
-
PTY
2 stops20h 50m
United Airlines
Sat 4/183:30 pm
PTY
-
CID
2 stops21h 17m
United Airlines
Deal found 2/11$597

Find flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$493
(United Airlines)

One-way from

$214
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$461
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($47 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 4/25

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Sat 5/2

7:55 am-10:45 pm

1 stop14h 50m

$493

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 3/28

6:12 am-6:38 pm

1 stop12h 26m

Panama City Tocumen Intl

Wed 4/8

7:55 am-10:43 pm

1 stop14h 48m

$493

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:27 pm

1 stop14h 32m

$493

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 4/26

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Mon 5/4

10:00 am-10:45 pm

1 stop12h 45m

$493

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 4/7

6:05 am-4:12 pm

2 stops10h 07m

Panama City Tocumen Intl

Tue 4/21

10:00 am-10:28 pm

1 stop12h 28m

$553

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 4/8

8:05 am-6:37 pm

1 stop10h 32m

Panama City Tocumen Intl

Tue 4/21

10:00 am-7:06 pm

1 stop9h 06m

$553

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 5/26

8:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 6/2

7:55 am-7:19 pm

1 stop11h 24m

$553

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 4/22

6:05 am-4:12 pm

2 stops10h 07m

Panama City Tocumen Intl

Mon 4/27

10:00 am-7:06 pm

1 stop9h 06m

$553

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Tue 4/7

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 4/23

7:55 am-10:28 pm

1 stop14h 33m

$553

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

Wed 4/8

8:05 am-6:37 pm

1 stop10h 32m

Panama City Tocumen Intl

Mon 4/20

10:00 am-7:06 pm

1 stop9h 06m

$553

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 37 results
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    United Airlines and American Airlines can get you from Iowa to Panama in just under 10h 17m. Your travel time can differ by up to 9h 30m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Dallas/Fort Worth to San José flights
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Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$441Average$481FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$573FlexibilityNo cancel feeOn-timeN/A

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