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$214+ Cheap flights from Iowa to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
feb. 21 — feb. 281
sáb. 2/21
sáb. 2/28
1 adult, Economy
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Cheap flight deals from Iowa to Panama

Cheapest flights from Iowa to Panama
Explore the most affordable flight options available from Iowa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 22, 2026.

This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/33:26 pm
DSM
-
PTY
2 stops21h 14m
American Airlines
mar. 3/101:40 pm
PTY
-
DSM
1 stop10h 16m
American Airlines
Deal found 1/21$477
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/267:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
sáb. 3/711:35 am
PTY
-
DSM
1 stop12h 09m
United Airlines
Deal found 1/19$483
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/62:04 pm
DSM
-
PTY
2 stops14h 06m
United Airlines
vie. 3/1310:55 pm
PTY
-
DSM
2 stops22h 45m
United Airlines
Deal found 1/20$487
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/98:10 am
DSM
-
PTY
1 stop10h 28m
United Airlines
vie. 2/134:41 pm
PTY
-
DSM
1 stop22h 36m
United Airlines
Deal found 1/20$492
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/73:04 pm
DSM
-
PTY
1 stop25h 03m
United Airlines
sáb. 2/144:41 pm
PTY
-
DSM
2 stops22h 46m
United Airlines
Deal found 1/19$497
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/86:45 pm
DSM
-
PTY
2 stops24h 17m
United Airlines
dom. 11/154:41 pm
PTY
-
DSM
1 stop30h 49m
United Airlines
Deal found 1/22$511
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/228:20 am
DSM
-
PTY
1 stop10h 17m
United Airlines
dom. 4/2610:00 am
PTY
-
DSM
1 stop12h 43m
United Airlines
Deal found 1/21$515
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/282:59 pm
DSM
-
PTY
1 stop22h 46m
United Airlines
jue. 3/58:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/21$534
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/46:15 am
OMA
-
PTY
1 stop7h 59m
United Airlines
mié. 5/137:55 am
PTY
-
OMA
1 stop14h 34m
United Airlines
Deal found 1/21$543
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/85:22 pm
OMA
-
PTY
2 stops20h 52m
United Airlines
lun. 4/133:30 pm
PTY
-
OMA
2 stops24h 50m
United Airlines
Deal found 1/19$547
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/262:54 pm
OMA
-
PTY
1 stop23h 20m
United Airlines
mar. 6/27:55 am
PTY
-
OMA
1 stop11h 20m
United Airlines
Deal found 1/22$553
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/275:15 pm
OMA
-
PTY
2 stops20h 59m
United Airlines
lun. 6/13:20 pm
PTY
-
OMA
1 stop27h 55m
United Airlines
Deal found 1/22$557

Find flight deals from Iowa to Panama

Keep the following information in mind while searching for Iowa to Panama flight deals. Data was last updated enero 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$477
(American Airlines)

One-way from

$214
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$453
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Iowa to Panama
Search Deals
One-way flight from Iowa to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($117 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($42 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 22, 2026.
Use the filters below to find and compare flights from Iowa to Panama that are best for you.

Fly from

Iowa

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 3/3

3:26 pm-1:40 pm

2 stops21h 14m

Panama City Tocumen Intl

mar. 3/10

1:40 pm-11:56 pm

1 stop10h 16m

$477

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 3/3

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

mar. 3/10

11:35 am-10:44 pm

1 stop11h 09m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

vie. 2/13

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

vie. 5/1

8:15 am-6:37 pm

1 stop10h 22m

Panama City Tocumen Intl

lun. 5/4

7:55 am-10:45 pm

1 stop14h 50m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 2/26

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

mar. 3/3

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 2/26

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

sáb. 3/7

11:35 am-10:44 pm

1 stop12h 09m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

vie. 3/6

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 2/17

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

sáb. 3/7

8:55 am-10:44 pm

1 stop14h 49m

$483

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

mar. 5/26

8:10 am-4:12 pm

1 stop8h 02m

Panama City Tocumen Intl

mar. 6/2

10:00 am-7:15 pm

1 stop9h 15m

$543

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

mié. 4/8

8:05 am-4:12 pm

1 stop8h 07m

Panama City Tocumen Intl

lun. 4/13

7:55 am-7:06 pm

1 stop11h 11m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 24 results
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Best time to book a flight from Iowa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama

What is the cheapest month to book a flight from Iowa to Panama?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Panama?

    American Airlines and United Airlines can get you from Iowa to Panama in just under 10h 46m. Your travel time can differ by up to 10h 28m. Airlines will cover a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Panama that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama.

  • Can I find deals for business class flights from Iowa to Panama?

    Yes. Cheapflights offers flight deals from Iowa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama (average of $411). Flying from Iowa to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Iowa to Panama

Discover the top 2 airlines that operate flights from Iowa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$425Average$481FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$634FlexibilityNo cancel feeOn-timeN/A

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