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$152+ Cheap flights from Illinois to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — PTY
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Find flight deals from Illinois to Panama

Cheapest flights from Illinois to Panama
Explore the most affordable flight options available from Illinois to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/276:15 amSTL - PTY
1 stop12h 23mUnited Airlines
jue. 12/44:41 pmPTY - STL
1 stop18h 23mUnited Airlines
Deal found 10/30$394
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/26:42 pmSTL - PTY
2 stops19h 03mUnited Airlines
mié. 12/104:41 pmPTY - STL
1 stop18h 23mUnited Airlines
Deal found 10/30$398
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/36:15 amSTL - PTY
1 stop12h 23mUnited Airlines
sáb. 12/64:41 pmPTY - STL
1 stop18h 23mUnited Airlines
Deal found 10/29$411
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/277:11 amSTL - PTY
2 stops29h 32mAmerican Airlines
jue. 12/42:50 pmPTY - STL
2 stops18h 18mAmerican Airlines
Deal found 10/30$413
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/146:42 pmSTL - PTY
2 stops19h 03mUnited Airlines
dom. 12/214:41 pmPTY - STL
1 stop18h 08mUnited Airlines
Deal found 10/30$415
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/35:54 pmSTL - PTY
2 stops18h 53mAmerican Airlines
dom. 12/72:50 pmPTY - STL
2 stops20h 46mAmerican Airlines
Deal found 10/30$420
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/76:53 pmSTL - PTY
2 stops17h 54mAmerican Airlines
sáb. 12/132:50 pmPTY - STL
2 stops19h 00mAmerican Airlines
Deal found 10/28$432
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/292:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
mié. 12/37:56 amPTY - ORD
Nonstop5h 56mCopa Airlines
Deal found 10/30$451
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/54:20 pmORD - PTY
2 stops14h 46mMultiple Airlines
mié. 12/1010:25 amPTY - ORD
1 stop9h 11mMultiple Airlines
Deal found 10/29$462
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:53 pmSTL - PTY
2 stops19h 49mAmerican Airlines
dom. 12/72:50 pmPTY - STL
2 stops19h 42mAmerican Airlines
Deal found 10/30$465
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/110:20 pmORD - PTY
1 stop17h 35mMultiple Airlines
vie. 12/511:25 amPTY - ORD
2 stops13h 44mMultiple Airlines
Deal found 10/29$465
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/186:00 amMDW - PTY
1 stop7h 12mDelta
jue. 11/273:37 pmPTY - MDW
1 stop9h 03mDelta
Deal found 10/30$466

Cheap flight deals from Illinois to Panama

Keep the following information in mind while searching for Illinois to Panama flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$394
(United Airlines)

One-way from

$152
(Kiwi.com)

Popular in

October

Cheapest in

November

Average price

$700

Good round-trip deal

$437 or less

Good one-way deal

$162 or less
Provider with most accurate pricing for Chicago (CHI)-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Chicago (CHI)-Panama City Tocumen Intl flights.
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From Illinois to Panama
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One-way flight from Illinois to Panama
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High demand for flights, 1% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Illinois to Panama.
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Price to beat on a one-way flight from Illinois to Panama.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Illinois to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Illinois to Panama that are best for you.

Fly from

Illinois

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 12/2

6:15 am-5:07 pm

1 stop9h 52m

Panama City Tocumen Intl

mié. 12/10

4:41 pm-10:04 am

1 stop18h 23m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

jue. 11/27

6:15 am-7:38 pm

1 stop12h 23m

Panama City Tocumen Intl

jue. 12/4

4:41 pm-10:04 am

1 stop18h 23m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 12/2

5:56 pm-3:42 pm

2 stops20h 46m

Panama City Tocumen Intl

mié. 12/10

4:43 pm-8:41 am

2 stops16h 58m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 1/19

3:37 pm-1:27 pm

2 stops20h 50m

Panama City Tocumen Intl

vie. 1/23

4:50 pm-11:59 pm

1 stop8h 09m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

dom. 2/1

6:40 pm-5:07 pm

2 stops21h 27m

Panama City Tocumen Intl

jue. 2/5

8:55 am-3:52 pm

1 stop7h 57m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

vie. 1/23

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

mar. 1/27

4:41 pm-9:22 am

1 stop17h 41m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mié. 12/3

6:15 am-7:38 pm

1 stop12h 23m

Panama City Tocumen Intl

sáb. 12/6

4:41 pm-10:04 am

1 stop18h 23m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 2/10

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

sáb. 2/14

4:41 pm-9:23 am

1 stop17h 42m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

vie. 4/10

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

vie. 4/17

1:55 pm-9:59 am

2 stops20h 04m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 1/20

6:30 am-7:38 pm

2 stops12h 08m

Panama City Tocumen Intl

sáb. 1/24

4:41 pm-12:29 pm

2 stops20h 48m

$415

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 59 results
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Best time to book a flight from Illinois to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Illinois with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama

What is the cheapest month to book a flight from Illinois to Panama?

Currently, November is the cheapest month in which you can book a flight from Illinois to Panama (average of $392). Flying from Illinois to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IL to PA?

Find hourly flight availability from Illinois to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

It’s optimal to fly from Illinois to Panama in the afternoon. By choosing this option you can save up to 48% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Illinois to Panama?

Use this chart to determine the cheapest time to fly round-trip from Illinois to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Illinois to Panama flight should consider departing on Saturday mornings when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Illinois to Panama?

    For as low as $451, United Airlines can have you in Panama from Illinois in 5h 22m. There are 2330 mi between Illinois and Panama. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Illinois to Panama one-way?

    The cheapest airlines for a one-way flight from Illinois to Panama are United Airlines ($160), Delta ($164), and American Airlines ($170).

  • Can I find deals for flights from Illinois to Panama that include hotel bookings?

    Yes. In addition to deals on Illinois to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Illinois to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama.

  • Can I find deals for business class flights from Illinois to Panama?

    Yes. Cheapflights offers flight deals from Illinois to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Illinois to Panama?

    Currently, November is the cheapest month in which you can book a flight from Illinois to Panama (average of $392). Flying from Illinois to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Illinois to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Illinois to Panama

Discover the top 5 airlines that operate flights from Illinois to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$334Average$457FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$464Average$672FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$479Average$653FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$658FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$589Average$737FlexibilityNo cancel feeOn-time71%

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