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Panama

$164+ Cheap flights from Illinois to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — PTY
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Illinois to Panama

Cheapest flights from Illinois to Panama
Explore the most affordable flight options available from Illinois to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 pmSTL - PTY
1 stop18h 53mAmerican Airlines
Wed 12/312:53 pmPTY - STL
1 stop8h 42mAmerican Airlines
Deal found 12/15$660
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amSTL - PTY
1 stop13h 00mDelta
Wed 12/313:22 pmPTY - STL
1 stop9h 16mDelta
Deal found 12/17$668
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:30 amSTL - PTY
1 stop8h 08mUnited Airlines
Tue 1/64:41 pmPTY - STL
1 stop17h 41mUnited Airlines
Deal found 12/16$692
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:53 pmSTL - PTY
2 stops22h 01mAmerican Airlines
Tue 1/64:31 pmPTY - STL
2 stops23h 33mAmerican Airlines
Deal found 12/16$723
This Copa Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:33 amORD - PTY
Nonstop5h 27mCopa Airlines
Wed 12/317:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Deal found 12/17$724
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:54 amORD - PTY
1 stop9h 44mUnited Airlines
Tue 1/64:41 pmPTY - ORD
1 stop18h 26mUnited Airlines
Deal found 12/16$748
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:35 amORD - PTY
1 stop8h 03mUnited Airlines
Wed 12/318:55 amPTY - ORD
1 stop10h 50mUnited Airlines
Deal found 12/16$757
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:23 pmORD - PTY
1 stop16h 22mUnited Airlines
Tue 12/308:55 amPTY - ORD
1 stop16h 19mUnited Airlines
Deal found 12/16$774
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:49 amORD - PTY
1 stop10h 18mUnited Airlines
Mon 12/2911:35 amPTY - ORD
1 stop12h 02mUnited Airlines
Deal found 12/16$775
This Copa Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
Sat 12/277:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Deal found 12/16$794
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amSTL - PTY
1 stop13h 00mDelta
Thu 1/18:00 amPTY - STL
1 stop12h 04mDelta
Deal found 12/15$812
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:08 pmORD - PTY
1 stop16h 37mUnited Airlines
Wed 12/248:55 amPTY - ORD
1 stop16h 19mUnited Airlines
Deal found 12/16$857

Find flight deals from Illinois to Panama

Keep the following information in mind while searching for Illinois to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$394
(Delta)

One-way from

$164
(Delta)

Popular in

May

Cheapest in

July

Average price

$603

Good round-trip deal

$464 or less

Good one-way deal

$220 or less
Provider with most accurate pricing for Chicago (CHI)-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago (CHI)-Panama City Tocumen Intl flights.
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From Illinois to Panama
Search Deals
One-way flight from Illinois to Panama
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Illinois to Panama.
Search Deals
Price to beat on a one-way flight from Illinois to Panama.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Illinois to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Illinois to Panama that are best for you.

Fly from

Illinois

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:38 pm

1 stop9h 18m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

5:35 am-12:15 pm

1 stop6h 40m

Panama City Tocumen Intl

Wed 5/6

1:55 pm-11:32 am

2 stops21h 37m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 3/16

7:00 pm-4:07 pm

2 stops21h 07m

Panama City Tocumen Intl

Mon 3/23

3:41 pm-9:21 am

1 stop17h 40m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/17

5:00 am-7:02 pm

2 stops14h 02m

Panama City Tocumen Intl

Mon 3/23

3:41 pm-9:21 am

1 stop17h 40m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

10:09 am-6:37 pm

1 stop8h 28m

Panama City Tocumen Intl

Sat 4/25

7:55 am-4:03 pm

1 stop8h 08m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/15

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/18

4:41 pm-9:23 am

1 stop17h 42m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

8:30 am-7:31 pm

1 stop11h 01m

Panama City Tocumen Intl

Fri 4/17

3:30 pm-9:28 am

1 stop17h 58m

$428

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/17

6:00 am-6:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Thu 3/19

11:35 am-10:16 pm

1 stop10h 41m

$439

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 3/16

7:00 pm-4:07 pm

2 stops21h 07m

Panama City Tocumen Intl

Thu 3/19

11:35 am-10:16 pm

1 stop10h 41m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 53 results
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Best time to book a flight from Illinois to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Illinois with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama

What is the cheapest month to book a flight from Illinois to Panama?

Currently, March is the cheapest month in which you can book a flight from Illinois to Panama (average of $398). Flying from Illinois to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IL to PA?

Find hourly flight availability from Illinois to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s optimal to fly from Illinois to Panama in the afternoon. By choosing this option you can save up to 48% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Illinois to Panama?

Use this chart to determine the cheapest time to fly round-trip from Illinois to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Illinois to Panama flight should consider departing on Saturday mornings when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Illinois to Panama

Explore weekly flight availability from Illinois to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 18, 2025.

The most flights from USIL to PA0 are scheduled on a Monday (8 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (3 on average).

Related info for your journey

Find useful and relevant information for your journey from Illinois to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Illinois to Panama?

    For as low as $398, United Airlines can have you in Panama from Illinois in 6h 40m. There are 2159 mi between Illinois and Panama. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Illinois to Panama one-way?

    The cheapest airlines for a one-way flight from Illinois to Panama are Avianca ($166), Copa Airlines ($225), and United Airlines ($433).

  • Can I find deals for flights from Illinois to Panama that include hotel bookings?

    Yes. In addition to deals on Illinois to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Illinois to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama.

  • Can I find deals for business class flights from Illinois to Panama?

    Yes. Cheapflights offers flight deals from Illinois to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Illinois to Panama?

    Currently, March is the cheapest month in which you can book a flight from Illinois to Panama (average of $398). Flying from Illinois to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Illinois to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Illinois to Panama

Discover the top 5 airlines that operate flights from Illinois to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$358Average$479FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$464Average$737FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$479Average$653FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$653FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$589Average$737FlexibilityNo cancel feeOn-time71%

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