HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$131+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in July or September, booked 27 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$300
(Mytrip)

One-way from

$131
(FlightHub)

Popular in

March

Cheapest in

July

Average price

$476

Good round-trip deal

$264 or less

Good one-way deal

$199 or less
From Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:10 pmSDQ - PTY
1 stop7h 00mAvianca
Mon 7/143:25 amPTY - SDQ
1 stop6h 25mAvianca
Deal found 6/11$300
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/296:10 pmSDQ - PTY
1 stop7h 35mMultiple Airlines
Sun 9/215:25 pmPTY - SDQ
2 stops30h 59mMultiple Airlines
Deal found 6/11$413
This Copa Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/118:55 amSDQ - PTY
Nonstop2h 35mCopa Airlines
Mon 7/146:55 pmPTY - SDQ
Nonstop2h 32mCopa Airlines
Deal found 6/9$498
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/263:20 pmSDQ - PTY
2 stops15h 53mUnited Airlines
Sat 8/29:13 amPTY - SDQ
2 stops15h 37mUnited Airlines
Deal found 6/11$2,528
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:09 pmSDQ - PTY
2 stops23h 40mDelta
Tue 10/72:12 pmPTY - SDQ
2 stops26h 40mDelta
Deal found 6/10$6,384

Cheapflights Fare Finder

Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 7/8

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

Tue 7/15

9:55 am-5:15 pm

1 stop6h 20m

$300

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 8/29

6:10 pm-12:45 am

1 stop7h 35m

Panama City Tocumen Intl

Sun 9/21

5:25 pm-1:24 am

2 stops30h 59m

$413

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 7/11

8:55 am-10:30 am

Nonstop2h 35m

Panama City Tocumen Intl

Mon 7/14

6:55 pm-10:27 pm

Nonstop2h 32m

$498

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 7/26

3:20 pm-6:13 am

2 stops15h 53m

Panama City Tocumen Intl

Sat 8/2

9:13 am-1:50 am

2 stops15h 37m

$2,528

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/3

2:09 pm-12:49 pm

2 stops23h 40m

Panama City Tocumen Intl

Tue 10/7

2:12 pm-5:52 pm

2 stops26h 40m

$6,384

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 7/10

6:10 pm-10:10 am

1 stop17h 00m

$131

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 6/22

8:55 am-12:10 am

3 stops16h 15m

$249

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 6/30

7:00 am-2:25 pm

1 stop8h 25m

$273

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 7/10

5:39 pm-7:14 pm

Nonstop2h 35m

$536

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 7/26

1:10 pm-2:14 pm

2 stops26h 04m

$1,102

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on June 9, 2025.

The best time to book flights from Santo Domingo to Panama City is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 13% on airfare.

Weekly flight availability from Santo Domingo to Panama City

Explore weekly flight availability from Santo Domingo to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 12, 2025.

The most flights from SDQ to PTY are scheduled on a Monday (9 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (4 on average).

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2025.
See what other customers who have flown with Delta, Copa Airlines and United Airlines from Santo Domingo to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.
Avianca
6.7
Okay
2,345 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Sep 2023

AVL - LGA

Landing in Syracuse was ruff no bad weather just bad piloting. A/C barely. Working from LGA to Syracuse.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 7 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 35m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 86 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $300. Other airlines that can offer you cheap pricing are Copa Airlines, from $498, and United Airlines, from $2,528. Avianca is 34% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $131. American Airlines flights start at $273 while deals on Copa Airlines start at $536 one-way.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider Copa Airlines (92%), KLM (92%) or Air France (92%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $165. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $393 on average our data indicates $300 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$281Average$345FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$394Average$486FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.