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Panama City

$273+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 41 days in advance, depart on a Thursday or Friday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:20 pm
SDQ
-
PTY
1 stop5h 35m
Avianca
Fri 2/279:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/25$452
This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:45 pm
SDQ
-
PTY
1 stop7h 55m
Avianca
Fri 2/279:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/25$453
This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/512:20 pm
SDQ
-
PTY
1 stop5h 35m
Avianca
Mon 2/95:50 pm
PTY
-
SDQ
1 stop16h 35m
Avianca
Deal found 1/25$454
This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:45 pm
SDQ
-
PTY
1 stop7h 55m
Avianca
Wed 3/49:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/25$455
This Priceline deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/75:45 pm
SDQ
-
PTY
1 stop8h 15m
Avianca
Sat 12/192:55 am
PTY
-
SDQ
1 stop12h 55m
Avianca
Deal found 1/25$477
This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:53 pm
SDQ
-
PTY
2 stops31h 47m
Multiple Airlines
Thu 2/262:55 am
PTY
-
SDQ
1 stop12h 55m
Multiple Airlines
Deal found 1/25$479
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/119:28 am
SDQ
-
PTY
1 stop6h 27m
Multiple Airlines
Tue 3/172:55 am
PTY
-
SDQ
2 stops12h 25m
Multiple Airlines
Deal found 1/24$497
This Avianca deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1212:20 pm
SDQ
-
PTY
1 stop13h 40m
Avianca
Thu 2/199:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/25$501
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:45 am
SDQ
-
PTY
1 stop5h 45m
Avianca
Wed 10/289:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/26$505
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:45 am
SDQ
-
PTY
1 stop5h 45m
Avianca
Mon 11/29:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/26$506
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:45 pm
SDQ
-
PTY
1 stop7h 55m
Avianca
Mon 3/99:45 am
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 1/26$507

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$452
(Mytrip)

One-way from

$273
(Avianca)

Popular in

January

Cheapest in

May

Average price

$524

Good round-trip deal

$270 or less

Good one-way deal

$210 or less
Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.
Search Deals
From Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 2/24

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Fri 2/27

5:50 pm-11:25 am

1 stop16h 35m

$455

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 2/24

5:53 pm-12:40 am

2 stops31h 47m

Panama City Tocumen Intl

Fri 2/27

5:50 pm-11:25 am

1 stop16h 35m

$483

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 3/4

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Wed 3/11

2:55 am-4:50 pm

1 stop12h 55m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 3/6

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Fri 3/13

2:55 am-4:50 pm

1 stop12h 55m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/3

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Mon 3/9

2:55 am-11:25 am

1 stop7h 30m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 3/9

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Mon 3/16

5:50 pm-11:25 am

1 stop16h 35m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/10

12:20 pm-4:55 pm

1 stop5h 35m

Panama City Tocumen Intl

Wed 3/11

9:45 am-4:50 pm

1 stop6h 05m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 3/8

5:45 pm-1:00 am

1 stop8h 15m

Panama City Tocumen Intl

Wed 3/11

5:50 pm-11:25 am

1 stop16h 35m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 3/4

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Wed 3/11

9:45 am-4:50 pm

1 stop6h 05m

$507

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 3/7

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Mon 3/9

9:45 am-4:50 pm

1 stop6h 05m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 22 results
1
2
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  • Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on January 23, 2026.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $160). Flying from Santo Domingo to Panama City in September is currently the most expensive (average of $316). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 26, 2026.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 19% on airfare.

What is the cheapest day to fly from Santo Domingo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Thursday at noon when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 26, 2026.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,492 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 9 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 35m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 22 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca fly from Santo Domingo to Panama City in about 16h 05m. The time it takes to get you to your destination can typically vary by up to . There are 917 mi between Santo Domingo and Panama City.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $281. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider Webjet Linhas Aereas (92%), Turkish Airlines (92%) or Copa Airlines (90%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $148. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $471 on average, our data indicates $416 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $160). Flying from Santo Domingo to Panama City in September is currently the most expensive (average of $316). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$281Average$340FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$361Average$524FlexibilityNo cancel feeOn-time70%

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