How popular is this Santo Domingo to Panama City flight route?

This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 75 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $458. Another airline that can offer you cheap pricing is Copa Airlines.

What is the cheapest day to fly from Santo Domingo to Panama City?

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Thursday afternoons when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the cheapest flights from Santo Domingo to Panama City?

Looking at all options, your cheapest flight can be booked for $120. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $466 on average our data indicates $374 when flying from Santo Domingo to Panama City.

What are the most reliable airlines from Santo Domingo to Panama City?

Consider KLM (94%), Copa Airlines (94%) or Air France (93%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

What is the cheapest day to fly round-trip from Santo Domingo to Panama City?

Flying to your destination on a Sunday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Panama City. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from Santo Domingo to Panama City?

To save on the cost of your flight from Santo Domingo to Panama City, book at least 42 days before your planned departure. Booking around this time can save you about 136% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $399 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $743.

What is the cheapest month to fly from Santo Domingo to Panama City?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, October can be a great choice for travel to Panama City. Flights to Panama City from Santo Domingo in October are about $462 on average during October, but can be found for as low as $344.

What airports do I use to fly from Santo Domingo to Panama City?

If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 6 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 32m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

Can I find deals for business class flights from Santo Domingo to Panama City?

Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$228+ Flights from Santo Domingo to Panama City

Q: How much does it cost to fly round-trip from Santo Domingo to Panama City?

Airfare is typical for this route at the moment. Santo Domingo to Panama City flights typically cost between $335 and $521 in September. The cheapest round-trip price found within the last 3 days was $458 on Avianca (Sep 12-Sep 18).

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Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in October or September, booked 41 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Round-trip from	$458 (Priceline)
One-way from	$228 (Priceline)
Popular in	March
Cheapest in	October
Average price	$496
Good round-trip deal	$269 or less
Good one-way deal	$239 or less

From Santo Domingo Las Americas to Panama City Tocumen Intl

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One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 5% potential increase in price ($27 potential increase over avg. RT price).

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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

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Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

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Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Thu 8/2811:45 amSDQ - PTY

1 stop13h 25mAvianca

Wed 9/33:20 amPTY - SDQ

1 stop6h 30mAvianca

Deal found 7/29

$458

Mon 8/41:22 pmSDQ - PTY

2 stops20h 33mMultiple Airlines

Mon 8/1110:05 pmPTY - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/28

$504

Fri 8/296:17 pmSDQ - PTY

Nonstop2h 33mCopa Airlines

Mon 9/17:26 amPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 7/28

$522

Best flights from Santo Domingo to Panama City
Discover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Fri 9/126:10 pmSDQ - PTY

1 stop7h 35mAvianca

Thu 9/183:20 amPTY - SDQ

1 stop12h 55mAvianca

Deal found 7/29

$458

Mon 8/41:22 pmSDQ - PTY

2 stops20h 33mMultiple Airlines

Mon 8/1110:05 pmPTY - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/28

$504

Fri 8/296:17 pmSDQ - PTY

Nonstop2h 33mCopa Airlines

Mon 9/17:26 amPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 7/28

$522

Last-minute flights from Santo Domingo to Panama City
Discover last-minute flight deals from Santo Domingo to Panama City. Data last updated July 29, 2025 and is based on user searches.

Mon 8/411:45 amSDQ - PTY

1 stop5h 45mAvianca

Sun 8/103:20 amPTY - SDQ

1 stop6h 30mAvianca

Deal found 7/28

$458

Mon 8/41:22 pmSDQ - PTY

2 stops20h 33mMultiple Airlines

Mon 8/1110:05 pmPTY - SDQ

1 stop11h 45mMultiple Airlines

Deal found 7/28

$504

Tue 8/511:54 amSDQ - PTY

Nonstop2h 35mCopa Airlines

Sun 8/107:26 amPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 7/27

$657

Wed 8/61:10 pmSDQ - PTY

2 stops28h 02mUnited Airlines

Mon 8/117:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Deal found 7/27

$2,119

Thu 8/2811:45 amSDQ - PTY

1 stop13h 25mAvianca

Wed 9/33:20 amPTY - SDQ

1 stop6h 30mAvianca

Deal found 7/29

$458

Fri 8/296:17 pmSDQ - PTY

Nonstop2h 33mCopa Airlines

Mon 9/17:26 amPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 7/28

$522

One-way flights from Santo Domingo to Panama City
Search for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated July 29, 2025.

Mon 8/1811:45 amSDQ - PTY

1 stop10h 25mAvianca

Deal found 7/29

$228

Fri 9/122:10 amSDQ - PTY

1 stop7h 45mMultiple Airlines

Deal found 7/27

$287

Mon 8/118:57 amSDQ - PTY

Nonstop2h 33mCopa Airlines

Deal found 7/29

$548

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 9/12

6:10 pm-12:45 am

1 stop7h 35m

Panama City Tocumen Intl

Thu 9/18

3:20 am-5:15 pm

1 stop12h 55m

$458

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 8/4

1:22 pm-8:55 am

2 stops20h 33m

Panama City Tocumen Intl

Mon 8/11

10:05 pm-10:50 am

1 stop11h 45m

$504

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 8/29

6:17 pm-7:50 pm

Nonstop2h 33m

Panama City Tocumen Intl

Mon 9/1

7:26 am-10:58 am

Nonstop2h 32m

$522

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 8/18

11:45 am-9:10 pm

1 stop10h 25m

$228

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 9/12

2:10 am-8:55 am

1 stop7h 45m

$287

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 8/11

8:57 am-10:30 am

Nonstop2h 33m

$548

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 12% on airfare.

Weekly flight availability from Santo Domingo to Panama City

The most flights from SDQ to PTY are scheduled on a Tuesday (9 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (4 on average).

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,493 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,386 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What airports do I use to fly from Santo Domingo to Panama City?
If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 6 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 32m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.
How popular is this Santo Domingo to Panama City flight route?
This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 75 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?
Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $458. Another airline that can offer you cheap pricing is Copa Airlines.
What are the most reliable airlines from Santo Domingo to Panama City?
Consider KLM (94%), Copa Airlines (94%) or Air France (93%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.
What are the cheapest flights from Santo Domingo to Panama City?
Looking at all options, your cheapest flight can be booked for $120. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $466 on average our data indicates $374 when flying from Santo Domingo to Panama City.
Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.
Can I find deals for business class flights from Santo Domingo to Panama City?
Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to Panama City?
Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Panama City

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Other flights to Panama City

Top 2 airlines flying from Santo Domingo to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$281	Average$361	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$418	Average$495	FlexibilityNo cancel fee	On-time70%

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$228+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in October or September, booked 41 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama CityExplore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on July 25, 2025.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Weekly flight availability from Santo Domingo to Panama City

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Santo Domingo to Panama City?

How popular is this Santo Domingo to Panama City flight route?

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

What are the most reliable airlines from Santo Domingo to Panama City?

What are the cheapest flights from Santo Domingo to Panama City?

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

How can I find direct flights from Santo Domingo to Panama City?

Can I find deals for business class flights from Santo Domingo to Panama City?

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santo Domingo to Panama City

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Book with Flexibility

Travel Smart

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.