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Panama City

$230+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 41 days in advance, depart on a Thursday or Friday and return on a Saturday

Cheap flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$477
(Priceline)

One-way from

$230
(Priceline)

Popular in

September

Cheapest in

May

Average price

$521

Good round-trip deal

$416 or less

Good one-way deal

$211 or less
Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.
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From Santo Domingo Las Americas to Panama City Tocumen Intl
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One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
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Highest demand for flights based on searches. 3% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
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Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
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Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Priceline deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:45 pmSDQ - PTY
1 stop16h 05mAvianca
Wed 11/195:50 pmPTY - SDQ
1 stop16h 35mAvianca
Deal found 10/25$477
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:45 pmSDQ - PTY
1 stop7h 55mAvianca
Thu 11/209:45 amPTY - SDQ
1 stop6h 05mAvianca
Deal found 10/28$501
This Priceline deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:45 pmSDQ - PTY
1 stop16h 05mAvianca
Tue 12/162:55 amPTY - SDQ
1 stop12h 55mAvianca
Deal found 10/26$514
This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2811:55 amSDQ - PTY
Nonstop2h 37mCopa Airlines
Mon 12/812:44 pmPTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 10/28$525
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:39 pmSDQ - PTY
Nonstop2h 35mCopa Airlines
Mon 11/1710:55 pmPTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 10/27$536
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:45 pmSDQ - PTY
1 stop8h 15mAvianca
Sat 11/292:55 amPTY - SDQ
1 stop12h 55mAvianca
Deal found 10/28$540
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:55 amSDQ - PTY
Nonstop2h 37mCopa Airlines
Fri 11/216:55 pmPTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 10/27$543
This Priceline deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:45 pmSDQ - PTY
1 stop16h 05mAvianca
Sun 11/162:55 amPTY - SDQ
1 stop12h 55mAvianca
Deal found 10/27$547
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:28 amSDQ - PTY
2 stops26h 02mMultiple Airlines
Thu 12/112:55 amPTY - SDQ
1 stop12h 55mMultiple Airlines
Deal found 10/27$563
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:28 amSDQ - PTY
1 stop6h 27mMultiple Airlines
Tue 12/162:55 amPTY - SDQ
2 stops12h 25mMultiple Airlines
Deal found 10/26$568
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:45 pmSDQ - PTY
1 stop7h 55mMultiple Airlines
Fri 11/212:55 pmPTY - SDQ
2 stops8h 02mMultiple Airlines
Deal found 10/27$581

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/26

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Thu 12/11

2:55 am-4:50 pm

1 stop12h 55m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 11/14

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Fri 11/21

9:45 am-4:50 pm

1 stop6h 05m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/19

5:45 pm-8:50 am

1 stop16h 05m

Panama City Tocumen Intl

Thu 11/27

9:45 am-4:50 pm

1 stop6h 05m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 11/25

5:45 pm-1:00 am

1 stop8h 15m

Panama City Tocumen Intl

Tue 12/2

9:45 am-4:50 pm

1 stop6h 05m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/12

12:20 pm-4:55 pm

1 stop5h 35m

Panama City Tocumen Intl

Tue 2/17

2:55 am-4:50 pm

1 stop12h 55m

$501

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/19

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Wed 11/26

9:45 am-4:50 pm

1 stop6h 05m

$501

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/5

12:20 pm-4:55 pm

1 stop5h 35m

Panama City Tocumen Intl

Wed 2/11

5:50 pm-11:25 am

1 stop16h 35m

$508

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 11/23

8:55 am-10:30 am

Nonstop2h 35m

Panama City Tocumen Intl

Sun 11/30

7:28 am-10:58 am

Nonstop2h 30m

$525

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/19

8:55 am-10:30 am

Nonstop2h 35m

Panama City Tocumen Intl

Sat 11/29

12:44 pm-4:15 pm

Nonstop2h 31m

$525

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 12/6

8:55 am-10:30 am

Nonstop2h 35m

Panama City Tocumen Intl

Sat 1/3

7:26 pm-10:55 pm

Nonstop2h 29m

$525

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 22 results
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Compare providers for flights from Santo Domingo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on October 24, 2025.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $161). Flying from Santo Domingo to Panama City in February is currently the most expensive (average of $416). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 31% on airfare.

What is the cheapest day to fly from Santo Domingo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Saturday afternoons when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,562 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,562 reviews
Copa Airlines
7.6
Good
1,562 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.6
Okay
2,468 reviews
Copa Airlines
7.6
Good
1,562 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 5 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 33m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 45 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca fly from Santo Domingo to Panama City in about 7h 55m. The time it takes to get you to your destination can typically vary by up to . There are 917 mi between Santo Domingo and Panama City.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $281. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is 41% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider KLM (93%), Air France (92%) or Copa Airlines (92%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $171. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $469 on average, our data indicates $588 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $161). Flying from Santo Domingo to Panama City in February is currently the most expensive (average of $416). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$281Average$373FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$421Average$521FlexibilityNo cancel feeOn-time70%

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