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Panama City

$231+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or August, booked 41 days in advance, depart on a Thursday or Friday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:35 am
SDQ
-
PTY
1 stop11h 45m
Multiple Airlines
Wed 4/298:40 am
PTY
-
SDQ
1 stop6h 47m
Multiple Airlines
Deal found 3/6$488
This FlightHub deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:45 pm
SDQ
-
PTY
1 stop7h 55m
Avianca
Fri 4/33:05 am
PTY
-
SDQ
1 stop7h 45m
Avianca
Deal found 3/8$500
This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:50 pm
SDQ
-
PTY
1 stop7h 15m
Avianca
Sat 4/253:05 am
PTY
-
SDQ
1 stop7h 45m
Avianca
Deal found 3/9$504
This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:45 pm
SDQ
-
PTY
1 stop13h 20m
Avianca
Fri 4/103:05 am
PTY
-
SDQ
1 stop7h 45m
Avianca
Deal found 3/9$506
This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:50 pm
SDQ
-
PTY
1 stop7h 15m
Avianca
Sat 6/133:05 am
PTY
-
SDQ
1 stop7h 45m
Avianca
Deal found 3/9$507
This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:50 pm
SDQ
-
PTY
1 stop15h 25m
Avianca
Tue 4/284:25 am
PTY
-
SDQ
1 stop12h 30m
Avianca
Deal found 3/9$509
This Avianca deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:50 pm
SDQ
-
PTY
1 stop15h 25m
Avianca
Sun 5/173:05 am
PTY
-
SDQ
1 stop13h 50m
Avianca
Deal found 3/6$525
This Avianca deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:45 pm
SDQ
-
PTY
1 stop16h 30m
Avianca
Mon 4/65:55 pm
PTY
-
SDQ
1 stop16h 55m
Avianca
Deal found 3/7$544
This Avianca deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:50 pm
SDQ
-
PTY
1 stop6h 45m
Avianca
Fri 5/2910:10 am
PTY
-
SDQ
1 stop6h 45m
Avianca
Deal found 3/10$562
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:35 am
SDQ
-
PTY
1 stop11h 45m
Multiple Airlines
Mon 4/205:55 pm
PTY
-
SDQ
2 stops29h 57m
Multiple Airlines
Deal found 3/11$564

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$488
(Kiwi.com)

One-way from

$231
(Super.com)

Popular in

March

Cheapest in

May

Average price

$548

Good round-trip deal

$288 or less

Good one-way deal

$188 or less
Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.
Search Deals
From Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 5/26

6:04 am-7:39 am

Nonstop2h 35m

Panama City Tocumen Intl

Tue 6/16

9:42 am-1:13 pm

Nonstop2h 31m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/21

12:38 pm-2:15 pm

Nonstop2h 37m

Panama City Tocumen Intl

Sun 4/26

8:11 am-11:41 am

Nonstop2h 30m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 4/6

12:38 pm-2:15 pm

Nonstop2h 37m

Panama City Tocumen Intl

Mon 4/13

8:11 am-11:41 am

Nonstop2h 30m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 5/14

8:45 am-10:20 am

Nonstop2h 35m

Panama City Tocumen Intl

Sun 5/17

7:26 pm-10:56 pm

Nonstop2h 30m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 7/13

12:43 pm-2:15 pm

Nonstop2h 32m

Panama City Tocumen Intl

Mon 7/20

12:44 pm-4:15 pm

Nonstop2h 31m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 4/23

8:43 am-10:20 am

Nonstop2h 37m

Panama City Tocumen Intl

Thu 4/30

7:24 am-10:54 am

Nonstop2h 30m

$572
Quickest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 4/20

12:08 pm-1:45 pm

Nonstop2h 37m

Panama City Tocumen Intl

Mon 4/27

7:26 pm-10:47 pm

Nonstop2h 21m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/24

8:48 am-10:30 am

Nonstop2h 42m

Panama City Tocumen Intl

Mon 3/30

10:55 pm-2:16 am

Nonstop2h 21m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 7/31

8:53 am-10:25 am

Nonstop2h 32m

Panama City Tocumen Intl

Sun 8/2

7:26 pm-10:56 pm

Nonstop2h 30m

$572

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 7/12

6:42 pm-8:14 pm

Nonstop2h 32m

Panama City Tocumen Intl

Sun 7/19

7:26 pm-10:56 pm

Nonstop2h 30m

$572

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3
  • Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on March 6, 2026.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $160). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 11, 2026.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 20% on airfare.

What is the cheapest day to fly from Santo Domingo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on February 21, 2026.

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Friday afternoons when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 11, 2026.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,569 reviews
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,499 reviews
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 9 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 32m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 35m. The time it takes to get you to your destination is usually consistent. There are 917 mi between Santo Domingo and Panama City. All flights are typically nonstop.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $281. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is 44% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider Turkish Airlines (95%), Copa Airlines (92%) or KLM (91%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $171. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $466 on average, our data indicates $350 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $160). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$281Average$329FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$372Average$530FlexibilityNo cancel feeOn-time70%

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