HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$230+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/27. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in October or November, booked 41 days in advance, depart on a Thursday or Friday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$471
(Gotogate)

One-way from

$230
(Priceline)

Popular in

March

Cheapest in

October

Average price

$479

Good round-trip deal

$322 or less

Good one-way deal

$219 or less
From Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:10 pmSDQ - PTY
1 stop15h 45mAvianca
Fri 10/2410:05 pmPTY - SDQ
1 stop11h 45mAvianca
Deal found 9/10$474
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:10 pmSDQ - PTY
1 stop15h 45mAvianca
Sat 11/12:55 amPTY - SDQ
1 stop12h 55mAvianca
Deal found 9/10$475
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:45 pmSDQ - PTY
1 stop16h 05mAvianca
Mon 12/152:55 amPTY - SDQ
1 stop7h 30mAvianca
Deal found 9/10$477
This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:10 pmSDQ - PTY
1 stop15h 45mAvianca
Tue 9/169:55 amPTY - SDQ
1 stop6h 20mAvianca
Deal found 9/9$480
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:10 pmSDQ - PTY
1 stop17h 00mAvianca
Sat 10/119:55 amPTY - SDQ
1 stop6h 20mAvianca
Deal found 9/10$498
This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:45 pmSDQ - PTY
1 stop16h 05mAvianca
Wed 1/142:55 amPTY - SDQ
1 stop7h 30mAvianca
Deal found 9/11$500
This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:45 pmSDQ - PTY
1 stop7h 55mAvianca
Fri 11/142:55 amPTY - SDQ
1 stop7h 30mAvianca
Deal found 9/11$501
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1311:45 amSDQ - PTY
1 stop5h 45mAvianca
Sat 9/209:55 amPTY - SDQ
1 stop6h 20mAvianca
Deal found 9/11$513
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/43:35 pmSDQ - PTY
2 stops30h 35mMultiple Airlines
Sat 10/119:55 amPTY - SDQ
1 stop6h 20mMultiple Airlines
Deal found 9/11$517
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:20 pmSDQ - PTY
2 stops17h 05mMultiple Airlines
Sat 10/119:55 amPTY - SDQ
1 stop6h 20mMultiple Airlines
Deal found 9/10$519
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:09 pmSDQ - PTY
Nonstop2h 33mCopa Airlines
Sun 9/286:55 pmPTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 9/10$522

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 10/15

6:10 pm-12:45 am

1 stop7h 35m

Panama City Tocumen Intl

Tue 10/21

3:20 am-5:15 pm

1 stop12h 55m

$474

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 10/4

11:45 am-12:10 am

1 stop13h 25m

Panama City Tocumen Intl

Sat 10/11

9:55 am-5:15 pm

1 stop6h 20m

$474

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/17

6:10 pm-8:55 am

1 stop15h 45m

Panama City Tocumen Intl

Sat 10/18

3:20 am-5:15 pm

1 stop12h 55m

$474

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/24

6:10 pm-8:55 am

1 stop15h 45m

Panama City Tocumen Intl

Sat 11/1

2:55 am-4:50 pm

1 stop12h 55m

$475

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 11/10

5:45 pm-12:40 am

1 stop7h 55m

Panama City Tocumen Intl

Sat 11/22

9:45 am-4:50 pm

1 stop6h 05m

$477

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 12/30

5:45 pm-1:00 am

1 stop8h 15m

Panama City Tocumen Intl

Thu 1/15

9:45 am-4:50 pm

1 stop6h 05m

$500

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 12/30

5:45 pm-1:00 am

1 stop8h 15m

Panama City Tocumen Intl

Tue 1/13

2:55 am-4:50 pm

1 stop12h 55m

$500

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 10/5

11:57 am-1:29 pm

Nonstop2h 32m

Panama City Tocumen Intl

Sat 10/11

12:44 pm-4:15 pm

Nonstop2h 31m

$522

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/17

11:57 am-1:29 pm

Nonstop2h 32m

Panama City Tocumen Intl

Sun 10/19

12:44 pm-4:15 pm

Nonstop2h 31m

$522

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 9/25

11:56 am-1:29 pm

Nonstop2h 33m

Panama City Tocumen Intl

Tue 9/30

6:55 pm-10:26 pm

Nonstop2h 31m

$522

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 16 results
1
2

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on August 29, 2025.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 40% on airfare.

What is the cheapest day to fly from Santo Domingo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on September 7, 2025.

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Thursday afternoons when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 7 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 31m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 61 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca fly from Santo Domingo to Panama City in about 7h 35m. The time it takes to get you to your destination can typically vary by up to . There are 917 mi between Santo Domingo and Panama City.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $281. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is 39% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider KLM (96%), Air France (96%) or Copa Airlines (95%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $171. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $475 on average, our data indicates $566 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$281Average$373FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$418Average$498FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.