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Panama City

$222+ Cheap flights from Santiago (SCL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — PTY
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Panama City Tocumen Intl are usually found in November or October, booked 40 days in advance, depart on a Friday or Sunday and return on a Thursday

Cheap flight deals from Santiago to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$470
(Avianca)

One-way from

$222
(Priceline)

Popular in

September

Cheapest in

November

Average price

$518

Good round-trip deal

$494 or less

Good one-way deal

$258 or less
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Panama City Tocumen Intl flights.
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From Santiago Arturo Merino Benitez to Panama City Tocumen Intl
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One-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl
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Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
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Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
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Find flight deals from Santiago to Panama City

Cheapest flights from Santiago to Panama City
Explore the most affordable flight options available from Santiago to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/243:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Sat 11/293:08 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 10/16$450
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Sat 12/67:11 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 10/16$460
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:29 amSCL - PTY
Nonstop6h 51mCopa Airlines
Sat 11/227:11 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 10/16$465
This Avianca deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/91:35 amSCL - PTY
1 stop14h 25mAvianca
Sat 11/152:55 amPTY - SCL
1 stop10h 25mAvianca
Deal found 10/15$470
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Sat 12/133:08 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 10/15$471
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Tue 1/206:45 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 10/15$505
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:29 amSCL - PTY
Nonstop6h 53mCopa Airlines
Sun 1/411:48 amPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 10/15$540
This Avianca deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2112:55 amSCL - PTY
1 stop17h 35mAvianca
Thu 10/302:55 amPTY - SCL
1 stop10h 25mAvianca
Deal found 10/14$542
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Fri 1/26:45 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 10/15$560
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Sun 11/1611:48 amPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 10/16$575
This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/121:35 amSCL - PTY
1 stop9h 15mMultiple Airlines
Thu 11/2011:25 amPTY - SCL
2 stops17h 00mMultiple Airlines
Deal found 10/16$579

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

Fly from

Santiago

Fly to

Panama City

Route

Depart

Return

Price

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 11/25

5:12 am-10:03 am

Nonstop6h 51m

Panama City Tocumen Intl

Sat 11/29

7:11 pm-3:43 am

Nonstop6h 32m

$450

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 11/14

1:29 am-6:20 am

Nonstop6h 51m

Panama City Tocumen Intl

Sat 11/22

7:11 pm-3:43 am

Nonstop6h 32m

$465

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Mon 12/15

3:23 am-8:16 am

Nonstop6h 53m

Panama City Tocumen Intl

Wed 12/24

9:28 pm-6:01 am

Nonstop6h 33m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 12/2

3:23 am-8:16 am

Nonstop6h 53m

Panama City Tocumen Intl

Sat 12/13

3:51 pm-12:24 am

Nonstop6h 33m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Mon 12/15

3:23 am-8:16 am

Nonstop6h 53m

Panama City Tocumen Intl

Fri 12/26

7:11 pm-3:43 am

Nonstop6h 32m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 12/9

3:23 am-8:16 am

Nonstop6h 53m

Panama City Tocumen Intl

Thu 12/11

7:11 pm-3:43 am

Nonstop6h 32m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 12/5

5:12 am-10:03 am

Nonstop6h 51m

Panama City Tocumen Intl

Sat 12/13

3:08 pm-11:41 pm

Nonstop6h 33m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 11/12

1:29 am-6:20 am

Nonstop6h 51m

Panama City Tocumen Intl

Thu 11/20

11:48 am-8:21 pm

Nonstop6h 33m

$471

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Thu 10/23

3:30 pm-12:10 am

1 stop10h 40m

$222

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 10/24

7:10 am-12:45 am

1 stop19h 35m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 19 results
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Compare providers for flights from Santiago to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to Panama City in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Panama City

How far ahead should I book a flight from Santiago to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Panama City. Price data was last updated on October 10, 2025.

The best time to book flights from Santiago to Panama City is 40 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Panama City?

Currently, July is the cheapest month in which you can book a flight from Santiago to Panama City (average of $260). Flying from Santiago to Panama City in September is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to PTY?

Find hourly flight availability from Santiago to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s typically best to fly out from Santiago to Panama City in the afternoon. Doing so could potentially save you 30% on the flight price compared to flying at noon, which is usually more expensive.

How much does it cost to fly round-trip from Santiago to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 16, 2025.
Read through reviews of airlines operating flights from Santiago to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,551 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,551 reviews
Copa Airlines
7.6
Good
1,551 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.6
Okay
2,452 reviews
Copa Airlines
7.6
Good
1,551 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Santiago to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santiago to Panama City?

    If you book a flight from Santiago to Panama City, you will be flying from Arturo Merino Benitez to Tocumen Intl. Flights to Panama City Tocumen Intl (PTY) from Santiago Arturo Merino Benitez (SCL) take 6h 42m for a nonstop flight. There are 7 flights from Arturo Merino Benitez to Panama City per day from 2 airlines.

  • How popular is this Santiago to Panama City flight route?

    This flight path from Santiago Arturo Merino Benitez to Panama City Tocumen Intl was viewed by 12 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Panama City?

    Airlines like Copa Airlines fly from Santiago to Panama City in about 6h 51m. The time it takes to get you to your destination is usually consistent. The distance between Santiago and Panama City is about 2986 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines flying from Santiago to Panama City round-trip?

    According to our current data, Avianca ($302), and Copa Airlines ($454) offers the cheapest pricing from Santiago to Panama City. Avianca is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santiago to Panama City?

    Consider Turkish Airlines (95%), KLM (94%) or Copa Airlines (88%) when booking your flight. These represent the most reliable airlines when flying from Santiago to Panama City.

  • What are the cheapest flights from Santiago to Panama City?

    On average you can expect to pay $768 for a flight from Santiago to Panama City. The cheapest flight overall is $191 while the most popular route, (Santiago Arturo Merino Benitez - Panama City Tocumen Intl) is currently priced at $471.

  • Can I find deals for flights from Santiago to Panama City that include hotel bookings?

    Yes. In addition to deals on Santiago to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Panama City.

  • Can I find deals for business class flights from Santiago to Panama City?

    Yes. Cheapflights offers flight deals from Santiago to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Santiago to Panama City (average of $260). Flying from Santiago to Panama City in September is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santiago to Panama City

Discover the top 2 airlines that operate flights from Santiago to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$302Average$484FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$454Average$614FlexibilityNo cancel feeOn-time70%

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