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Panama City

$271+ Cheap flights from Santiago (SCL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — PTY
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Panama City Tocumen Intl are usually found in November or March, booked 86 days in advance, depart on a Wednesday or Friday and return on a Monday

Cheap flight deals from Santiago to Panama City

Cheapest flights from Santiago to Panama City
Explore the most affordable flight options available from Santiago to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This Copa Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1111:17 am
SCL
-
PTY
Nonstop6h 54m
Copa Airlines
Mon 6/153:08 pm
PTY
-
SCL
Nonstop6h 35m
Copa Airlines
Deal found 4/19$560
This Avianca deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:20 pm
SCL
-
PTY
1 stop10h 15m
Avianca
Wed 5/273:10 pm
PTY
-
SCL
1 stop12h 35m
Avianca
Deal found 4/20$561
This Copa Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:09 am
SCL
-
PTY
Nonstop6h 54m
Copa Airlines
Mon 6/223:08 pm
PTY
-
SCL
Nonstop6h 35m
Copa Airlines
Deal found 4/20$575
This Avianca deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2612:30 am
SCL
-
PTY
1 stop14h 45m
Avianca
Mon 5/43:10 pm
PTY
-
SCL
1 stop12h 35m
Avianca
Deal found 4/21$585
This FlightHub deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:30 am
SCL
-
PTY
1 stop14h 45m
Avianca
Sun 6/710:10 am
PTY
-
SCL
1 stop12h 10m
Avianca
Deal found 4/20$594
This FlightHub deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:30 am
SCL
-
PTY
1 stop14h 45m
Avianca
Sun 5/174:25 am
PTY
-
SCL
1 stop17h 55m
Avianca
Deal found 4/19$595
This FlightHub deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:40 am
SCL
-
PTY
1 stop8h 35m
Avianca
Sun 5/1010:10 am
PTY
-
SCL
1 stop12h 10m
Avianca
Deal found 4/20$596
This Copa Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:09 am
SCL
-
PTY
Nonstop6h 54m
Copa Airlines
Tue 6/2311:48 am
PTY
-
SCL
Nonstop6h 35m
Copa Airlines
Deal found 4/20$600
This FlightHub deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 am
SCL
-
PTY
1 stop11h 20m
Avianca
Wed 4/294:25 am
PTY
-
SCL
1 stop8h 50m
Avianca
Deal found 4/19$603

Find flight deals from Santiago to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$560
(Copa Airlines)

One-way from

$271
(Cheapflightsfares)

Popular in

September

Cheapest in

November

Average price

$540

Good round-trip deal

$520 or less

Good one-way deal

$345 or less
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Panama City Tocumen Intl flights.
Search Deals
From Santiago Arturo Merino Benitez to Panama City Tocumen Intl
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 6/5

11:17 am-5:11 pm

Nonstop6h 54m

Panama City Tocumen Intl

Sun 6/21

3:51 pm-11:26 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 5/10

11:17 am-5:11 pm

Nonstop6h 54m

Panama City Tocumen Intl

Sun 5/17

3:08 pm-10:43 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 5/31

2:22 am-8:16 am

Nonstop6h 54m

Panama City Tocumen Intl

Sun 6/7

11:48 am-7:23 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Mon 6/8

11:17 am-5:11 pm

Nonstop6h 54m

Panama City Tocumen Intl

Mon 6/15

3:08 pm-10:43 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 6/2

12:38 am-6:32 am

Nonstop6h 54m

Panama City Tocumen Intl

Wed 6/10

7:25 pm-3:00 am

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 5/24

4:09 am-10:03 am

Nonstop6h 54m

Panama City Tocumen Intl

Sun 6/7

3:08 pm-10:43 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 6/10

2:22 am-8:16 am

Nonstop6h 54m

Panama City Tocumen Intl

Sun 6/14

3:51 pm-11:26 pm

Nonstop6h 35m

$560

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 6/5

11:17 am-5:11 pm

Nonstop6h 54m

Panama City Tocumen Intl

Fri 6/12

11:48 am-7:23 pm

Nonstop6h 35m

$610
Quickest round-trip

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 9/23

1:06 am-5:55 am

Nonstop6h 49m

Panama City Tocumen Intl

Wed 9/30

9:28 pm-5:59 am

Nonstop6h 31m

$610

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 7/1

12:43 am-6:32 am

Nonstop6h 49m

Panama City Tocumen Intl

Mon 7/13

3:08 pm-10:43 pm

Nonstop6h 35m

$610

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/18

Showing 1-10 of 19 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Santiago-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Panama City

How far ahead should I book a flight from Santiago to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Panama City. Price data was last updated on April 17, 2026.

The best time to book flights from Santiago to Panama City is 86 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Panama City?

Currently, November is the cheapest month in which you can book a flight from Santiago to Panama City (average of $486). Flying from Santiago to Panama City in September is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to PTY?

Find hourly flight availability from Santiago to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 23, 2026.

When flying from Santiago to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Santiago to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 23, 2026.
Read through reviews of airlines operating flights from Santiago to Panama City, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,580 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,580 reviews
Copa Airlines
7.5
Good
1,580 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santiago to Panama City?

    If you book a flight from Santiago to Panama City, you will be flying from Arturo Merino Benitez to Tocumen Intl. Flights to Panama City Tocumen Intl (PTY) from Santiago Arturo Merino Benitez (SCL) take 6h 46m for a nonstop flight. There are 11 flights from Arturo Merino Benitez to Panama City per day from 1 airline.

  • How popular is this Santiago to Panama City flight route?

    This flight path from Santiago Arturo Merino Benitez to Panama City Tocumen Intl was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Panama City?

    Airlines like Copa Airlines fly from Santiago to Panama City in about 6h 54m. The time it takes to get you to your destination is usually consistent. The distance between Santiago and Panama City is about 2986 mi. Generally, flights for this route are nonstop.

  • What is the cheapest airline to fly from Santiago to Panama City round-trip?

    According to our current data, Copa Airlines ($450), offers the cheapest pricing from Santiago to Panama City. Copa Airlines is 19% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santiago to Panama City?

    Consider KLM (98%), Copa Airlines (94%) or United Airlines (94%) when booking your flight. These represent the most reliable airlines when flying from Santiago to Panama City.

  • What are the cheapest flights from Santiago to Panama City?

    On average you can expect to pay $1,285 for a flight from Santiago to Panama City. The cheapest flight overall is $196 while the most popular route, (Santiago Arturo Merino Benitez - Panama City Tocumen Intl) is currently priced at $560.

  • Can I find deals for flights from Santiago to Panama City that include hotel bookings?

    Yes. In addition to deals on Santiago to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Panama City.

  • Can I find deals for business class flights from Santiago to Panama City?

    Yes. Cheapflights offers flight deals from Santiago to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Panama City?

    Currently, November is the cheapest month in which you can book a flight from Santiago to Panama City (average of $486). Flying from Santiago to Panama City in September is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Santiago to Panama City

Discover the top airline that operate flights from Santiago to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$450Average$598FlexibilityNo cancel feeOn-time70%

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