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Panama City

$215+ Cheap flights from Santiago (SCL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to Panama City Tocumen Intl are usually found in November or March, booked 60 days in advance, depart on a Sunday or Tuesday and return on a Thursday

Cheap flight deals from Santiago to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$455
(Copa Airlines)

One-way from

$215
(Mytrip)

Popular in

January

Cheapest in

November

Average price

$586

Good round-trip deal

$501 or less

Good one-way deal

$285 or less
From Santiago Arturo Merino Benitez to Panama City Tocumen Intl
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One-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl
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Highest demand for flights based on searches. 4% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
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Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
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Find flight deals from Santiago to Panama City

Cheapest flights from Santiago to Panama City
Explore the most affordable flight options available from Santiago to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/14:47 amSCL - PTY
Nonstop6h 52mCopa Airlines
Tue 10/73:32 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 9/14$455
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2312:55 amSCL - PTY
1 stop17h 35mAvianca
Mon 9/293:25 amPTY - SCL
1 stop9h 00mAvianca
Deal found 9/14$456
This Avianca deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/284:25 pmSCL - PTY
1 stop10h 35mAvianca
Mon 11/32:55 amPTY - SCL
1 stop10h 25mAvianca
Deal found 9/12$457
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/161:12 amSCL - PTY
Nonstop6h 53mCopa Airlines
Thu 11/273:33 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 9/15$470
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:24 amSCL - PTY
Nonstop6h 53mCopa Airlines
Sat 12/611:48 amPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 9/15$497
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2012:55 amSCL - PTY
1 stop17h 35mAvianca
Tue 9/233:20 amPTY - SCL
1 stop9h 05mAvianca
Deal found 9/15$498
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/101:13 amSCL - PTY
Nonstop6h 52mCopa Airlines
Sat 10/183:32 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Deal found 9/14$512
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/81:35 amSCL - PTY
1 stop9h 15mAvianca
Thu 11/205:55 pmPTY - SCL
1 stop9h 35mAvianca
Deal found 9/15$535
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Sat 12/133:08 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Deal found 9/15$540
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/301:08 amSCL - PTY
Nonstop6h 52mCopa Airlines
Sat 1/313:51 pmPTY - SCL
Nonstop6h 41mCopa Airlines
Deal found 9/14$555
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2012:55 amSCL - PTY
1 stop22h 15mMultiple Airlines
Wed 9/2411:00 amPTY - SCL
2 stops25h 50mMultiple Airlines
Deal found 9/15$561

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

Fly from

Santiago

Fly to

Panama City

Route

Depart

Return

Price

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Thu 10/30

5:11 am-10:03 am

Nonstop6h 52m

Panama City Tocumen Intl

Thu 11/6

11:48 am-8:21 pm

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 11/14

12:20 pm-5:11 pm

Nonstop6h 51m

Panama City Tocumen Intl

Mon 11/17

6:51 pm-3:24 am

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 10/28

5:11 am-10:03 am

Nonstop6h 52m

Panama City Tocumen Intl

Tue 11/4

9:28 pm-6:01 am

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sat 11/1

12:20 pm-5:11 pm

Nonstop6h 51m

Panama City Tocumen Intl

Wed 11/5

7:11 pm-3:43 am

Nonstop6h 32m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Fri 10/3

4:47 am-9:39 am

Nonstop6h 52m

Panama City Tocumen Intl

Wed 11/5

9:28 pm-6:01 am

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 9/30

1:13 am-6:05 am

Nonstop6h 52m

Panama City Tocumen Intl

Tue 10/7

3:08 pm-11:40 pm

Nonstop6h 32m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 10/14

12:29 pm-5:20 pm

Nonstop6h 51m

Panama City Tocumen Intl

Tue 10/21

7:11 pm-3:42 am

Nonstop6h 31m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Wed 11/12

1:29 am-6:20 am

Nonstop6h 51m

Panama City Tocumen Intl

Mon 11/17

3:08 pm-11:41 pm

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Tue 11/25

12:20 pm-5:11 pm

Nonstop6h 51m

Panama City Tocumen Intl

Sat 11/29

11:48 am-8:21 pm

Nonstop6h 33m

$455

SantiagoPanama City

SCL - PTY

SCLPTY

Santiago Arturo Merino Benitez

Sun 10/12

3:35 am-8:25 am

Nonstop6h 50m

Panama City Tocumen Intl

Fri 10/17

3:32 pm-12:04 am

Nonstop6h 32m

$455

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 15 results
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Best time to book a flight from Santiago to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Panama City

How far ahead should I book a flight from Santiago to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to Panama City. Price data was last updated on September 12, 2025.

The best time to book flights from Santiago to Panama City is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santiago to Panama City (average of $478). Flying from Santiago to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to PTY?

Find hourly flight availability from Santiago to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

It’s typically best to fly out from Santiago to Panama City in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Santiago to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Boarding

7.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Santiago to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santiago to Panama City?

    If you book a flight from Santiago to Panama City, you will be flying from Arturo Merino Benitez to Tocumen Intl. Flights to Panama City Tocumen Intl (PTY) from Santiago Arturo Merino Benitez (SCL) take 6h 43m for a nonstop flight. There are 7 flights from Arturo Merino Benitez to Panama City per day from 2 airlines.

  • How popular is this Santiago to Panama City flight route?

    This flight path from Santiago Arturo Merino Benitez to Panama City Tocumen Intl was viewed by 12 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Panama City?

    Airlines like Copa Airlines fly from Santiago to Panama City in about 6h 52m. The time it takes to get you to your destination is usually consistent. The distance between Santiago and Panama City is about 2986 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines flying from Santiago to Panama City round-trip?

    According to our current data, Avianca ($302), and Copa Airlines ($442) offers the cheapest pricing from Santiago to Panama City. Avianca is 44% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santiago to Panama City?

    Consider Turkish Airlines (97%), KLM (95%) or Copa Airlines (92%) when booking your flight. These represent the most reliable airlines when flying from Santiago to Panama City.

  • What are the cheapest flights from Santiago to Panama City?

    On average you can expect to pay $827 for a flight from Santiago to Panama City. The cheapest flight overall is $192 while the most popular route, (Santiago Arturo Merino Benitez - Panama City Tocumen Intl) is currently priced at $455.

  • Can I find deals for flights from Santiago to Panama City that include hotel bookings?

    Yes. In addition to deals on Santiago to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Panama City.

  • Can I find deals for business class flights from Santiago to Panama City?

    Yes. Cheapflights offers flight deals from Santiago to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Santiago to Panama City (average of $478). Flying from Santiago to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santiago to Panama City

Discover the top 2 airlines that operate flights from Santiago to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$302Average$480FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$442Average$660FlexibilityNo cancel feeOn-time70%

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