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Panama City

$198+ Cheap flights from Buffalo (BUF) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Buffalo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$510
(American Airlines)

One-way from

$198
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$563
From Buffalo to Panama City Tocumen Intl
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One-way flight from Buffalo to Panama City Tocumen Intl
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Buffalo to Panama City

Cheapest flights from Buffalo to Panama City
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:42 pmBUF - PTY
2 stops20h 21mAmerican Airlines
Thu 11/62:49 pmPTY - BUF
2 stops20h 18mAmerican Airlines
Deal found 9/15$510
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/144:01 pmBUF - PTY
2 stops23h 02mAmerican Airlines
Tue 10/213:15 pmPTY - BUF
2 stops20h 09mAmerican Airlines
Deal found 9/16$520
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:55 pmBUF - PTY
2 stops25h 42mUnited Airlines
Tue 10/2110:00 amPTY - BUF
2 stops22h 43mUnited Airlines
Deal found 9/16$522
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amBUF - PTY
1 stop8h 55mUnited Airlines
Thu 11/610:00 amPTY - BUF
1 stop12h 58mUnited Airlines
Deal found 9/15$526
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/127:38 pmBUF - PTY
2 stops19h 25mAmerican Airlines
Sun 10/193:15 pmPTY - BUF
2 stops18h 49mAmerican Airlines
Deal found 9/14$527
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Fri 12/511:55 pmPTY - BUF
2 stops21h 20mUnited Airlines
Deal found 9/15$529
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:30 pmBUF - PTY
2 stops19h 25mUnited Airlines
Sat 11/88:55 amPTY - BUF
2 stops24h 54mUnited Airlines
Deal found 9/17$568
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amBUF - PTY
1 stop7h 56mDelta
Tue 10/212:21 pmPTY - BUF
1 stop8h 18mDelta
Deal found 9/16$606
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:30 amBUF - PTY
1 stop8h 20mUnited Airlines
Sun 10/1910:00 amPTY - BUF
2 stops22h 53mUnited Airlines
Deal found 9/14$611

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Buffalo

Fly to

Panama City

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 2/6

6:00 am-8:04 pm

1 stop14h 04m

Panama City Tocumen Intl

Wed 2/11

3:27 pm-11:57 pm

1 stop8h 30m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 1/8

8:30 am-7:38 pm

2 stops11h 08m

Panama City Tocumen Intl

Thu 1/15

4:41 pm-2:14 pm

2 stops21h 33m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 2/6

6:21 am-3:35 pm

2 stops9h 14m

Panama City Tocumen Intl

Wed 2/11

4:40 pm-12:02 pm

2 stops19h 22m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 10/14

5:55 pm-2:14 pm

2 stops21h 19m

Panama City Tocumen Intl

Tue 10/21

10:00 am-9:43 am

2 stops22h 43m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/23

7:38 pm-2:03 pm

2 stops19h 25m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-11:22 am

2 stops19h 07m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/30

6:23 pm-2:03 pm

2 stops20h 40m

Panama City Tocumen Intl

Thu 11/6

2:49 pm-11:48 am

1 stop20h 59m

$524

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 11/27

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Fri 12/5

11:55 pm-9:15 pm

2 stops21h 20m

$529

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 11/1

10:53 am-1:00 am

2 stops15h 07m

$198

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/23

12:15 pm-9:10 pm

3 stops33h 55m

$198

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/23

6:30 am-1:50 pm

1 stop8h 20m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 12 results
1
2

Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

What is the cheapest month to book a flight from Buffalo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $478). Flying from Buffalo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to PTY?

Find hourly flight availability from Buffalo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s optimal to fly from Buffalo to Panama City in the afternoon. By choosing this option you can save up to 39% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Panama City?

    Delta, United Airlines, and American Airlines can get you from Buffalo to Panama City in just under 9h 14m. Your travel time can differ by up to 4h 50m. Airlines will cover a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Buffalo to Panama City round-trip?

    United Airlines, at $441, was found to be the cheapest airline from Buffalo to Panama City. An alternate airline flying to your destination would be Delta. United Airlines is currently priced 29% below the average price you’ll pay for this route.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $478). Flying from Buffalo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Buffalo to Panama City

Discover the top 2 airlines that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$441Average$497FlexibilityNo cancel feeOn-time69%
DeltaCheapest$445Average$650FlexibilityNo cancel feeOn-timeN/A

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