$306+ Cheap flights from Buffalo (BUF) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Jun 12 — Jun 191
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama City with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
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Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
This Expedia deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Wed 6/33:50 pm
PTY
- BUF
2 stops20h 52m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$570
This Travelocity deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 pm
BUF
- PTY
2 stops15h 35m
Multiple Airlines
Tue 5/263:50 pm
PTY
- BUF
2 stops31h 09m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$577
This Orbitz deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 pm
BUF
- PTY
2 stops15h 35m
Multiple Airlines
Sun 5/245:30 am
PTY
- BUF
2 stops26h 28m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$580
This Expedia deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:02 pm
BUF
- PTY
2 stops15h 28m
Multiple Airlines
Sat 8/223:50 pm
PTY
- BUF
2 stops15h 00m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:40 pm
BUF
- PTY
1 stop9h 24m
United Airlines
Wed 9/210:55 pm
PTY
- BUF
2 stops17h 01m
United Airlines
Deal found 5/11![United Airlines logo]()
$627
This Expedia deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:00 pm
BUF
- PTY
2 stops19h 30m
Multiple Airlines
Sun 10/253:50 pm
PTY
- BUF
2 stops21h 38m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$645
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:40 pm
BUF
- PTY
1 stop9h 24m
United Airlines
Sat 8/223:30 pm
PTY
- BUF
2 stops16h 38m
United Airlines
Deal found 5/12![United Airlines logo]()
$657
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:58 pm
BUF
- PTY
2 stops21h 16m
United Airlines
Wed 9/23:30 pm
PTY
- BUF
2 stops16h 44m
United Airlines
Deal found 5/11![United Airlines logo]()
$627
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:15 am
BUF
- PTY
1 stop7h 35m
Delta
Wed 6/102:24 pm
PTY
- BUF
1 stop8h 35m
Delta
Deal found 5/10![Delta logo]()
$676
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:40 pm
BUF
- PTY
1 stop9h 24m
United Airlines
Sat 8/223:30 pm
PTY
- BUF
2 stops16h 38m
United Airlines
Deal found 5/13![United Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:00 pm
BUF
- PTY
2 stops24h 37m
United Airlines
Wed 6/103:30 pm
PTY
- BUF
2 stops24h 11m
United Airlines
Deal found 5/8![United Airlines logo]()
$680
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
BUF
- PTY
1 stop14h 31m
United Airlines
Mon 6/83:30 pm
PTY
- BUF
2 stops24h 11m
United Airlines
Deal found 5/11![United Airlines logo]()
$680
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated May 13, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated May 13, 2026 and is based on user searches.
This Travelocity deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 pm
BUF
- PTY
2 stops15h 35m
Multiple Airlines
Tue 5/263:50 pm
PTY
- BUF
2 stops31h 09m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$577
This Orbitz deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 pm
BUF
- PTY
2 stops15h 35m
Multiple Airlines
Sun 5/245:30 am
PTY
- BUF
2 stops26h 28m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$580
This Expedia deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Wed 6/33:50 pm
PTY
- BUF
2 stops20h 52m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$570
This Orbitz deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Fri 6/123:50 pm
PTY
- BUF
2 stops15h 10m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$673
This Travelocity deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Sun 6/73:50 pm
PTY
- BUF
2 stops16h 08m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$677
This Travelocity deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Thu 6/113:50 pm
PTY
- BUF
2 stops26h 22m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$685
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:15 am
BUF
- PTY
1 stop7h 35m
Delta
Wed 6/102:24 pm
PTY
- BUF
1 stop8h 35m
Delta
Deal found 5/11![Delta logo]()
$676
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:00 pm
BUF
- PTY
2 stops20h 14m
United Airlines
Wed 6/103:30 pm
PTY
- BUF
2 stops24h 11m
United Airlines
Deal found 5/12![United Airlines logo]()
$680
This Expedia deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:00 pm
BUF
- PTY
2 stops15h 30m
Multiple Airlines
Mon 6/83:10 pm
PTY
- BUF
2 stops26h 55m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$675
This Expedia deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:41 pm
BUF
- PTY
3 stops25h 14m
Multiple Airlines
Wed 6/173:50 pm
PTY
- BUF
2 stops15h 10m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$679
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/211:35 am
BUF
- PTY
2 stops34h 02m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$306
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:04 pm
BUF
- PTY
2 stops23h 08m
United Airlines
Deal found 5/10![United Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:50 pm
BUF
- PTY
1 stop30h 44m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:03 am
BUF
- PTY
2 stops31h 56m
Delta
Deal found 5/12![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 pm
BUF
- PTY
2 stops19h 44m
American Airlines
Deal found 5/12![American Airlines logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/262:50 pm
BUF
- PTY
3 stops34h 45m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:49 pm
BUF
- PTY
2 stops22h 21m
American Airlines
Deal found 5/12![American Airlines logo]()
$494
This business-class.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure business-class.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:42 am
BUF
- PTY
1 stop9h 49m
Copa Airlines
Deal found 5/12![Copa Airlines logo]()
$804
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $570 (Expedia) |
One-way from | $306 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Mon 8/31
5:58 pm-2:14 pm
2 stops21h 16m
Panama City Tocumen Intl
Wed 9/2
3:30 pm-9:14 am
2 stops16h 44m
$627
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Mon 8/17
7:40 pm-4:04 am
1 stop9h 24m
Panama City Tocumen Intl
Sat 8/22
3:30 pm-9:08 am
2 stops16h 38m
$657
Quickest round-trip
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Tue 6/2
6:15 am-12:50 pm
1 stop7h 35m
Panama City Tocumen Intl
Wed 6/10
2:24 pm-11:59 pm
1 stop8h 35m
$676
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Tue 6/2
7:00 pm-6:37 pm
2 stops24h 37m
Panama City Tocumen Intl
Wed 6/10
3:30 pm-4:41 pm
2 stops24h 11m
$680
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Thu 6/4
6:00 am-7:31 pm
1 stop14h 31m
Panama City Tocumen Intl
Mon 6/8
3:30 pm-4:41 pm
2 stops24h 11m
$680
Cheapest one-way
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Thu 7/2
11:35 am-8:37 pm
2 stops34h 02m
$306
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Wed 6/24
6:04 pm-4:12 pm
2 stops23h 08m
$317
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Wed 6/24
2:50 pm-8:34 pm
1 stop30h 44m
$322
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Fri 6/26
6:03 am-12:59 pm
2 stops31h 56m
$336
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Fri 6/26
2:50 pm-12:35 am
3 stops34h 45m
$490
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated May 13, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.9
Boarding
8.1
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.9
Boarding
8.1
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on May 13, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Buffalo to Panama City
Discover the top airline that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$517 | Average$671 | FlexibilityNo cancel fee | On-timeN/A |