HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Odessa

$337+ Cheap flights from St. Louis (STL) to Odessa, TX

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAF
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Odessa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from St. Louis to Odessa

Cheapest flights from St. Louis to Odessa
Explore the most affordable flight options available from St. Louis to Odessa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:17 amSTL - MAF
1 stop4h 28mAmerican Airlines
Sun 11/236:05 amMAF - STL
1 stop4h 34mAmerican Airlines
Deal found 11/5$337
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:20 amSTL - MAF
1 stop5h 37mUnited Airlines
Sat 11/221:55 pmMAF - STL
1 stop7h 59mUnited Airlines
Deal found 11/5$407
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:15 amSTL - MAF
1 stop7h 42mUnited Airlines
Sun 11/239:39 amMAF - STL
2 stops10h 00mUnited Airlines
Deal found 11/5$412
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/711:35 amSTL - MAF
1 stop4h 26mAmerican Airlines
Wed 11/126:05 amMAF - STL
1 stop4h 34mAmerican Airlines
Deal found 11/6$691
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:25 pmSTL - MAF
2 stops5h 45mSouthwest
Wed 11/126:15 amMAF - STL
1 stop3h 55mSouthwest
Deal found 11/6$692
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:40 amSTL - MAF
1 stop5h 40mSouthwest
Sun 11/910:00 amMAF - STL
1 stop3h 35mSouthwest
Deal found 11/6$752

Cheap flight deals from St. Louis to Odessa

Keep the following information in mind while searching for St. Louis to Odessa flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$337
(American Airlines)

Popular in

November

Cheapest in

December

Average price

$468
Provider with most accurate pricing for Lambert-St Louis-Midland Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Midland Intl flights.
Search Deals
From Lambert-St Louis to Odessa
Search Deals
High demand for flights, 8% potential price rise
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Odessa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from St. Louis to Odessa that are best for you.

Fly from

St. Louis

Fly to

Odessa

Route

Depart

Return

Price

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

5:17 am-9:45 am

1 stop4h 28m

Midland Intl

Sun 11/23

6:05 am-10:39 am

1 stop4h 34m

$337

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

8:20 am-1:57 pm

1 stop5h 37m

Midland Intl

Sat 11/22

1:55 pm-9:54 pm

1 stop7h 59m

$407

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

6:15 am-1:57 pm

1 stop7h 42m

Midland Intl

Sun 11/23

9:39 am-7:39 pm

2 stops10h 00m

$412

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Best time to book a flight from St. Louis to Odessa

Have a flexible travel schedule? Discover the best time to fly to Odessa from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Odessa

What is the cheapest time of day to fly from STL to OD3?

Find hourly flight availability from St. Louis to Odessa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

When flying from St. Louis to Odessa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 36% versus a flight in the afternoon.

How much does it cost to fly round-trip from St. Louis to Odessa?

Reviews of airlines servicing Odessa

Get insights into the airlines that provide service to Odessa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Odessa. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Southwest and American Airlines from St. Louis to Odessa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Odessa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Odessa?

    Located just 12.7 mi from the city center, Lambert-St Louis is the airport most travelers will use when flying to Odessa from St. Louis. Booking flights from Lambert-St Louis (STL) to Odessa should be relatively easy as there are 0 daily outbound flights to Odessa from 3 different airlines.

  • How long is the flight from St. Louis to Odessa?

    A quick flight from St. Louis to Odessa can take about 4h 28m. American Airlines provides one of the quickest options available for as low as $337. St. Louis and Odessa are separated by a distance of 814 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from St. Louis to Odessa that include hotel bookings?

    Yes. In addition to deals on St. Louis to Odessa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Odessa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Odessa.

  • Can I find deals for business class flights from St. Louis to Odessa?

    Yes. Cheapflights offers flight deals from St. Louis to Odessa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Odessa

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Hobby flights
St. Louis to Hobby flights
Kansas City to Dallas/Fort Worth flights
St. Louis to Dallas/Fort Worth flights
Kansas City to George Bush Intcntl flights
St. Louis to George Bush Intcntl flights
St. Louis to Love Field flights
Kansas City to Love Field flights
Kansas City to Austin flights
St. Louis to Austin flights
St. Louis to San Antonio flights
Kansas City to San Antonio flights
Springfield to Hobby flights
Columbia to Dallas/Fort Worth flights
Springfield to George Bush Intcntl flights
Springfield to Dallas/Fort Worth flights
St. Louis to Midland flights
Springfield to San Antonio flights
Joplin to George Bush Intcntl flights
Columbia to Hobby flights
Kansas City to Brownsville flights
Kansas City to Lubbock flights
Kansas City to El Paso flights
St. Louis to Brownsville flights
Kansas City to Harlingen flights
Columbia to George Bush Intcntl flights
Springfield to Austin flights
St. Louis to McAllen flights
Columbia to Austin flights
St. Louis to Harlingen flights
Kansas City to Corpus Christi flights
Joplin to Dallas/Fort Worth flights
St. Louis to El Paso flights
Springfield to El Paso flights
Springfield to Love Field flights
St. Louis to Amarillo flights
St. Louis to Corpus Christi flights
Kansas City to McAllen flights
Springfield to Corpus Christi flights
St. Louis to Lubbock flights
St. Louis to Tyler flights
Kansas City to Killeen flights
Joplin to Austin flights
Springfield to McAllen flights
Columbia to San Antonio flights
St. Louis to Abilene flights
St. Louis to Killeen flights
Kansas City to Amarillo flights
Kirksville to Hobby flights

Top 3 airlines flying from St. Louis to Odessa

Discover the top 3 airlines that operate flights from St. Louis to Odessa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$196Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$333FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$290Average$367FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.