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Odessa

$249+ Cheap flights from St. Louis (STL) to Odessa, TX

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAF
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from St. Louis to Odessa

Cheapest flights from St. Louis to Odessa
Explore the most affordable flight options available from St. Louis to Odessa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:17 amSTL - MAF
1 stop6h 36mAmerican Airlines
Sun 11/234:31 pmMAF - STL
1 stop6h 03mAmerican Airlines
Deal found 10/16$249
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:17 amSTL - MAF
1 stop4h 28mAmerican Airlines
Sat 11/225:00 amMAF - STL
1 stop3h 56mAmerican Airlines
Deal found 10/16$329
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:11 amSTL - MAF
1 stop4h 32mAmerican Airlines
Mon 11/35:00 amMAF - STL
1 stop3h 55mAmerican Airlines
Deal found 10/15$339
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amSTL - MAF
2 stops10h 31mDelta
Mon 11/312:33 pmMAF - STL
2 stops9h 05mDelta
Deal found 10/15$349
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:20 amSTL - MAF
1 stop7h 56mUnited Airlines
Sun 11/235:00 amMAF - STL
2 stops10h 46mUnited Airlines
Deal found 10/16$386
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:20 amSTL - MAF
1 stop6h 29mAmerican Airlines
Thu 10/235:00 amMAF - STL
1 stop4h 20mAmerican Airlines
Deal found 10/14$459
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:30 amSTL - MAF
2 stops9h 46mUnited Airlines
Sat 11/221:55 pmMAF - STL
1 stop7h 59mUnited Airlines
Deal found 10/16$485

Cheap flight deals from St. Louis to Odessa

Keep the following information in mind while searching for St. Louis to Odessa flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(American Airlines)

Popular in

November

Cheapest in

December

Average price

$278
Provider with most accurate pricing for Lambert-St Louis-Midland Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Midland Intl flights.
Search Deals
From Lambert-St Louis to Odessa
Search Deals
High demand for flights, 9% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Odessa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from St. Louis to Odessa that are best for you.

Fly from

St. Louis

Fly to

Odessa

Route

Depart

Return

Price

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

5:17 am-9:45 am

1 stop4h 28m

Midland Intl

Sun 11/23

5:00 am-10:39 am

1 stop5h 39m

$305

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

5:17 am-9:45 am

1 stop4h 28m

Midland Intl

Sat 11/22

5:00 am-8:56 am

1 stop3h 56m

$329

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 10/30

5:11 am-9:43 am

1 stop4h 32m

Midland Intl

Mon 11/3

5:00 am-8:55 am

1 stop3h 55m

$339

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 10/30

6:00 am-4:31 pm

2 stops10h 31m

Midland Intl

Mon 11/3

12:33 pm-9:38 pm

2 stops9h 05m

$349

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Thu 11/20

8:20 am-4:16 pm

1 stop7h 56m

Midland Intl

Sun 11/23

5:00 am-3:46 pm

2 stops10h 46m

$386

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Tue 3/31

5:59 pm-11:45 pm

1 stop5h 46m

Midland Intl

Wed 4/1

5:03 am-8:48 am

1 stop3h 45m

$415

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Tue 3/31

5:59 pm-11:45 pm

1 stop5h 46m

Midland Intl

Fri 4/3

12:29 pm-6:15 pm

1 stop5h 46m

$439

St. LouisMidland

STL - MAF

STLMAF

Lambert-St Louis

Tue 3/31

4:30 pm-10:03 pm

1 stop5h 33m

Midland Intl

Wed 4/1

5:00 am-2:18 pm

2 stops9h 18m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Best time to book a flight from St. Louis to Odessa

Have a flexible travel schedule? Discover the best time to fly to Odessa from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Odessa

What is the cheapest time of day to fly from STL to OD3?

Find hourly flight availability from St. Louis to Odessa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

When flying from St. Louis to Odessa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 36% versus a flight in the afternoon.

Reviews of airlines servicing Odessa

Get insights into the airlines that provide service to Odessa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Odessa. Reviews last updated October 16, 2025.
Read reviews from past customers who have flown Southwest and American Airlines from St. Louis to Odessa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,043 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Odessa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Odessa?

    Located just 12.7 mi from the city center, Lambert-St Louis is the airport most travelers will use when flying to Odessa from St. Louis. Booking flights from Lambert-St Louis (STL) to Odessa should be relatively easy as there are 0 daily outbound flights to Odessa from 3 different airlines.

  • How long is the flight from St. Louis to Odessa?

    A quick flight from St. Louis to Odessa can take about 4h 28m. American Airlines provides one of the quickest options available for as low as $305. St. Louis and Odessa are separated by a distance of 814 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from St. Louis to Odessa that include hotel bookings?

    Yes. In addition to deals on St. Louis to Odessa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Odessa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Odessa.

  • Can I find deals for business class flights from St. Louis to Odessa?

    Yes. Cheapflights offers flight deals from St. Louis to Odessa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for St. Louis to Odessa

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Top 3 airlines flying from St. Louis to Odessa

Discover the top 3 airlines that operate flights from St. Louis to Odessa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$196Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$333FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$290Average$367FlexibilityNo cancel feeOn-time63%

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