$190+ Cheap flights from San Francisco to Panama City, FL (SFO - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/7. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — ECP
Apr 9 — Apr 161
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Panama City
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Best
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Cheapest flights from San Francisco to Panama CityExplore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:20 am
SFO
- ECP
1 stop8h 09m
American Airlines
Tue 4/2111:43 am
ECP
- SFO
1 stop9h 24m
American Airlines
Deal found 3/5![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:00 pm
SFO
- ECP
1 stop7h 12m
Delta
Tue 4/215:10 pm
ECP
- SFO
1 stop7h 49m
Delta
Deal found 3/8![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:55 am
SFO
- ECP
2 stops9h 50m
Southwest
Tue 5/512:05 pm
ECP
- SFO
1 stop10h 50m
Southwest
Deal found 3/5![Southwest logo]()
$380
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/611:35 pm
SFO
- ECP
1 stop7h 05m
Delta
Tue 4/145:27 pm
ECP
- SFO
1 stop17h 33m
Delta
Deal found 3/9![Delta logo]()
$391
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:56 pm
SFO
- ECP
1 stop7h 57m
United Airlines
Sat 5/233:30 pm
ECP
- SFO
1 stop9h 26m
United Airlines
Deal found 3/9![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:56 pm
SFO
- ECP
1 stop7h 48m
United Airlines
Wed 5/62:14 pm
ECP
- SFO
1 stop10h 29m
United Airlines
Deal found 3/8![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:20 pm
SFO
- ECP
1 stop6h 44m
Delta
Wed 4/86:00 am
ECP
- SFO
1 stop8h 49m
Delta
Deal found 3/9![Delta logo]()
$409
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:30 am
SFO
- ECP
1 stop7h 33m
American Airlines
Tue 5/57:00 am
ECP
- SFO
2 stops12h 40m
American Airlines
Deal found 3/6![American Airlines logo]()
$413
Best flights from San Francisco to Panama CityDiscover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
Discover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:00 am
SFO
- ECP
1 stop9h 12m
United Airlines
Tue 5/56:30 am
ECP
- SFO
1 stop7h 48m
United Airlines
Deal found 3/5![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:55 am
SFO
- ECP
2 stops9h 50m
Southwest
Tue 5/512:05 pm
ECP
- SFO
1 stop10h 50m
Southwest
Deal found 3/5![Southwest logo]()
$380
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:45 pm
SFO
- ECP
1 stop7h 05m
Delta
Sun 5/242:50 pm
ECP
- SFO
1 stop7h 51m
Delta
Deal found 3/9![Delta logo]()
$479
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:45 am
SFO
- ECP
1 stop10h 38m
United Airlines
Tue 4/214:57 pm
ECP
- SFO
1 stop7h 33m
United Airlines
Deal found 3/7![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:50 am
SFO
- ECP
2 stops10h 50m
Southwest
Tue 4/217:55 am
ECP
- SFO
2 stops11h 35m
Southwest
Deal found 3/7![Southwest logo]()
$418
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:50 pm
SFO
- ECP
1 stop8h 40m
Southwest
Mon 6/155:55 pm
ECP
- SFO
2 stops8h 35m
Southwest
Deal found 3/6![Southwest logo]()
$443
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:00 am
SFO
- ECP
1 stop9h 18m
United Airlines
Wed 5/66:30 am
ECP
- SFO
1 stop10h 23m
United Airlines
Deal found 3/9![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1110:50 pm
SFO
- ECP
1 stop8h 48m
United Airlines
Sat 4/186:30 am
ECP
- SFO
1 stop10h 23m
United Airlines
Deal found 3/6![United Airlines logo]()
$479
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:55 am
SFO
- ECP
2 stops12h 05m
Southwest
Sun 4/52:50 pm
ECP
- SFO
1 stop7h 00m
Southwest
Deal found 3/9![Southwest logo]()
$483
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:55 am
SFO
- ECP
2 stops9h 50m
Southwest
Tue 4/217:55 am
ECP
- SFO
2 stops11h 35m
Southwest
Deal found 3/7![Southwest logo]()
$507
Last-minute flights from San Francisco to Panama CityDiscover last-minute flight deals from San Francisco to Panama City. Data last updated March 10, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Panama City. Data last updated March 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/611:35 pm
SFO
- ECP
1 stop7h 05m
Delta
Tue 4/145:27 pm
ECP
- SFO
1 stop17h 33m
Delta
Deal found 3/9![Delta logo]()
$391
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:20 pm
SFO
- ECP
1 stop6h 44m
Delta
Wed 4/86:00 am
ECP
- SFO
1 stop8h 49m
Delta
Deal found 3/9![Delta logo]()
$409
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:35 pm
SFO
- ECP
1 stop8h 05m
Delta
Tue 4/145:27 pm
ECP
- SFO
1 stop17h 33m
Delta
Deal found 3/9![Delta logo]()
$421
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:30 pm
SFO
- ECP
1 stop8h 33m
American Airlines
Tue 4/2111:43 am
ECP
- SFO
1 stop9h 24m
American Airlines
Deal found 3/9![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:00 pm
SFO
- ECP
1 stop7h 12m
Delta
Tue 4/215:10 pm
ECP
- SFO
1 stop7h 49m
Delta
Deal found 3/10![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:30 am
SFO
- ECP
1 stop7h 33m
American Airlines
Tue 5/57:00 am
ECP
- SFO
2 stops12h 40m
American Airlines
Deal found 3/6![American Airlines logo]()
$413
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:55 am
SFO
- ECP
2 stops9h 50m
Southwest
Tue 5/512:05 pm
ECP
- SFO
1 stop10h 50m
Southwest
Deal found 3/5![Southwest logo]()
$380
One-way flights from San Francisco to Panama CitySearch for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
Search for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:30 pm
SFO
- ECP
1 stop8h 33m
American Airlines
Deal found 3/8![American Airlines logo]()
$190
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:55 am
SFO
- ECP
2 stops11h 00m
Southwest
Deal found 3/8![Southwest logo]()
$195
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/712:45 am
SFO
- ECP
1 stop8h 17m
United Airlines
Deal found 3/9![United Airlines logo]()
$200
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:24 am
SFO
- ECP
1 stop9h 09m
American Airlines
Deal found 3/9![American Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:00 am
SFO
- ECP
2 stops10h 15m
Southwest
Deal found 3/9![Southwest logo]()
$224
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:30 pm
SFO
- ECP
1 stop8h 47m
Delta
Deal found 3/6![Delta logo]()
$260
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:35 pm
SFO
- ECP
1 stop8h 05m
Delta
Deal found 3/9![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:42 pm
SFO
- ECP
2 stops21h 16m
United Airlines
Deal found 3/6![United Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2012:45 am
SFO
- ECP
1 stop8h 17m
United Airlines
Deal found 3/8![United Airlines logo]()
$428
Find flight deals from San Francisco to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $359 (American Airlines) |
One-way from | $190 (American Airlines) |
Popular in | December |
Cheapest in | August |
Average price | $510 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Wed 4/29
5:00 am-4:12 pm
1 stop9h 12m
Panama City NW Florida Beaches
Tue 5/5
6:30 am-12:18 pm
1 stop7h 48m
$359
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Tue 4/14
12:45 am-1:23 pm
1 stop10h 38m
Panama City NW Florida Beaches
Tue 4/21
4:57 pm-10:30 pm
1 stop7h 33m
$379
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Wed 4/29
5:55 am-5:45 pm
2 stops9h 50m
Panama City NW Florida Beaches
Tue 5/5
12:05 pm-8:55 pm
1 stop10h 50m
$380
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Mon 4/13
8:50 am-9:40 pm
2 stops10h 50m
Panama City NW Florida Beaches
Tue 4/21
7:55 am-5:30 pm
2 stops11h 35m
$418
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Mon 6/8
10:50 pm-9:30 am
1 stop8h 40m
Panama City NW Florida Beaches
Mon 6/15
5:55 pm-12:30 am
2 stops8h 35m
$443
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Tue 5/5
5:00 am-4:18 pm
1 stop9h 18m
Panama City NW Florida Beaches
Wed 5/6
6:30 am-2:53 pm
1 stop10h 23m
$459
Quickest round-trip
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Sat 5/16
1:45 pm-10:50 pm
1 stop7h 05m
Panama City NW Florida Beaches
Sun 5/24
2:50 pm-8:41 pm
1 stop7h 51m
$479
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Sat 4/11
10:50 pm-9:38 am
1 stop8h 48m
Panama City NW Florida Beaches
Sat 4/18
6:30 am-2:53 pm
1 stop10h 23m
$479
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Wed 4/1
5:55 am-8:00 pm
2 stops12h 05m
Panama City NW Florida Beaches
Sun 4/5
2:50 pm-7:50 pm
1 stop7h 00m
$483
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Wed 4/15
5:55 am-5:45 pm
2 stops9h 50m
Panama City NW Florida Beaches
Tue 4/21
7:55 am-5:30 pm
2 stops11h 35m
$507
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Panama City in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from San Francisco with our price prediction graph.
SFO-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 10, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Francisco to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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San Francisco and Panama City flights
Browse other San Francisco and Panama City flight options. Last updated on March 10, 2026.
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Top 4 airlines flying from San Francisco to Panama City
Discover the top 4 airlines that operate flights from San Francisco to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$496 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$342 | Average$496 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$437 | Average$527 | FlexibilityNo cancel fee | On-time63% |