How long is the flight from Columbus Airport to Panama City, Florida?

Airlines like United Airlines, Delta, and Southwest fly from Columbus Airport to Panama City, Florida in about 4h 43m. The time it takes to get you to your destination can typically vary by up to 3h 27m. The distance from Columbus Airport to Panama City, Florida is about 686 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Columbus Airport to Panama City, Florida round-trip?

Currently priced at $116, Allegiant Air will fly you from Columbus Airport to Panama City, Florida and back. In addition to Allegiant Air, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $163 and $259, respectively. Allegiant Air is priced at 69% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

What are the most popular airlines that fly from Columbus Airport to Panama City, Florida?

Delta, Southwest and American Airlines are the most popular airlines when flying from Columbus Airport to Panama City, Florida.

Most accurate provider : When it comes to deals on Columbus Airport-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbus Airport-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbus Airport-Panama City, Florida flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Columbus Airport-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbus Airport-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airport do you fly into for flights to Panama City from Columbus?

Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly into when you book flights from Columbus to Panama City. 4 airlines have flights to NW Florida Beaches from Columbus on a regular basis. Booking flights from Columbus to Panama City NW Florida Beaches should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

Can I find deals for flights from Columbus to Panama City that include hotel bookings?

Yes. In addition to deals on Columbus to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbus to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Panama City.

Can I find deals for business class flights from Columbus to Panama City?

Yes. Cheapflights offers flight deals from Columbus to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$159+ Flights from Columbus Airport to Panama City, FL

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Find cheap flights from Columbus to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Columbus to Panama City NW Florida Beaches are usually found in September or November, booked 64 days in advance, depart on a Wednesday or Tuesday and return on a Tuesday

Cheap flight deals from Columbus to Panama City

Cheapest flights from Columbus to Panama City
Explore the most affordable flight options available from Columbus to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Wed 12/244:45 pmCMH - ECP

1 stop6h 09mUnited Airlines

Wed 12/312:10 pmECP - CMH

1 stop5h 37mUnited Airlines

Deal found 12/23

$403

Tue 12/308:35 amCMH - ECP

2 stops8h 00mSouthwest

Tue 1/68:00 amECP - CMH

2 stops8h 30mSouthwest

Deal found 12/23

$448

Mon 12/296:20 amCMH - ECP

1 stop3h 55mSouthwest

Wed 12/314:25 pmECP - CMH

1 stop3h 45mSouthwest

Deal found 12/25

$457

Tue 12/233:20 pmCMH - ECP

1 stop7h 00mSouthwest

Sun 12/287:30 amECP - CMH

1 stop3h 30mSouthwest

Deal found 12/23

$462

Tue 12/307:00 amCMH - ECP

1 stop4h 17mDelta

Sun 1/47:02 pmECP - CMH

1 stop4h 11mDelta

Deal found 12/24

$504

Wed 12/3112:05 pmCMH - ECP

2 stops8h 00mSouthwest

Sun 1/46:35 pmECP - CMH

1 stop4h 30mSouthwest

Deal found 12/23

$516

Sat 12/2710:50 amCMH - ECP

2 stops7h 35mSouthwest

Sat 1/312:10 pmECP - CMH

1 stop10h 40mSouthwest

Deal found 12/25

$527

Thu 12/256:25 amCMH - ECP

1 stop3h 55mSouthwest

Thu 1/14:25 pmECP - CMH

1 stop3h 45mSouthwest

Deal found 12/24

$536

Best flights from Columbus to Panama City
Discover carefully curated flight deals from Columbus to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 25, 2025.

Tue 2/36:30 amCMH - ECP

1 stop6h 32mUnited Airlines

Fri 2/61:10 pmECP - CMH

1 stop8h 19mUnited Airlines

Deal found 12/23

$336

Sat 2/1412:32 pmCMH - ECP

1 stop4h 43mDelta

Thu 2/199:26 amECP - CMH

1 stop4h 38mDelta

Deal found 12/24

$341

Tue 2/311:00 amCMH - ECP

2 stops8h 10mSouthwest

Fri 2/67:35 amECP - CMH

1 stop3h 30mSouthwest

Deal found 12/23

$341

Sat 1/319:04 amCMH - ECP

1 stop5h 06mAmerican Airlines

Sat 2/712:03 pmECP - CMH

2 stops8h 27mAmerican Airlines

Deal found 12/23

$346

Thu 1/224:41 pmCMH - ECP

1 stop6h 18mUnited Airlines

Mon 1/261:10 pmECP - CMH

1 stop8h 19mUnited Airlines

Deal found 12/25

$341

Sat 2/144:45 pmCMH - ECP

1 stop6h 12mAmerican Airlines

Thu 2/197:19 amECP - CMH

2 stops7h 14mAmerican Airlines

Deal found 12/24

$346

Thu 1/226:40 amCMH - ECP

2 stops9h 15mSouthwest

Mon 1/2610:30 amECP - CMH

2 stops9h 15mSouthwest

Deal found 12/25

$351

Sun 3/87:07 amCMH - ECP

1 stop4h 13mDelta

Sat 3/145:30 pmECP - CMH

1 stop5h 58mDelta

Deal found 12/23

$355

Thu 3/123:35 pmCMH - ECP

1 stop6h 00mSouthwest

Sun 3/155:25 amECP - CMH

1 stop6h 05mSouthwest

Deal found 12/25

$355

Last-minute flights from Columbus to Panama City
Discover last-minute flight deals from Columbus to Panama City. Data last updated December 25, 2025 and is based on user searches.

Wed 12/244:45 pmCMH - ECP

1 stop6h 09mUnited Airlines

Wed 12/312:10 pmECP - CMH

1 stop5h 37mUnited Airlines

Deal found 12/23

$403

Wed 1/146:05 pmCMH - ECP

1 stop5h 46mDelta

Sun 1/186:00 amECP - CMH

1 stop5h 00mDelta

Deal found 12/25

$394

Wed 1/1412:15 pmCMH - ECP

2 stops6h 55mSouthwest

Sun 1/188:00 amECP - CMH

2 stops9h 15mSouthwest

Deal found 12/25

$404

Fri 1/165:45 amCMH - ECP

1 stop4h 45mSouthwest

Sun 1/183:45 pmECP - CMH

1 stop4h 00mSouthwest

Deal found 12/23

$402

Sat 1/176:05 pmCMH - ECP

1 stop5h 46mDelta

Mon 1/196:09 pmECP - CMH

1 stop4h 55mDelta

Deal found 12/23

$390

Thu 1/226:40 amCMH - ECP

2 stops9h 15mSouthwest

Mon 1/2610:30 amECP - CMH

2 stops9h 15mSouthwest

Deal found 12/25

$351

Sat 1/3112:13 pmCMH - ECP

1 stop4h 34mDelta

Sat 2/74:45 pmECP - CMH

1 stop6h 19mDelta

Deal found 12/24

$341

Sat 1/319:04 amCMH - ECP

1 stop5h 06mAmerican Airlines

Sat 2/712:03 pmECP - CMH

2 stops7h 28mAmerican Airlines

Deal found 12/24

$346

One-way flights from Columbus to Panama City
Search for one-way flight options from Columbus to Panama City. Find affordable one-way fares based on user searches. Data last updated December 25, 2025.

Wed 1/216:00 amCMH - ECP

1 stop3h 39mDelta

Deal found 12/25

$159

Tue 2/242:35 pmCMH - ECP

2 stops9h 02mAmerican Airlines

Deal found 12/25

$164

Thu 1/226:00 amCMH - ECP

1 stop6h 08mDelta

Deal found 12/22

$171

Thu 1/226:25 amCMH - ECP

2 stops12h 08mAmerican Airlines

Deal found 12/22

$176

Sun 1/256:34 pmCMH - ECP

1 stop5h 06mDelta

Deal found 12/25

$178

Fri 1/236:00 amCMH - ECP

2 stops6h 33mAmerican Airlines

Deal found 12/24

$183

Fri 1/236:34 pmCMH - ECP

1 stop5h 04mDelta

Deal found 12/25

$193

Wed 1/217:00 amCMH - ECP

2 stops10h 12mUnited Airlines

Deal found 12/22

$199

Sat 2/284:43 pmCMH - ECP

1 stop6h 13mUnited Airlines

Deal found 12/25

$206

Sat 2/2110:27 amCMH - ECP

2 stops12h 29mUnited Airlines

Deal found 12/25

$211

Thu 3/196:22 amCMH - ECP

1 stop7h 16mAmerican Airlines

Deal found 12/23

$213

Sun 1/255:45 amCMH - ECP

2 stops11h 27mUnited Airlines

Deal found 12/25

$218

Find flight deals from Columbus to Panama City

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$336 (United Airlines)
One-way from	$159 (Delta)
Popular in	March
Cheapest in	September
Average price	$445

Provider with most accurate pricing for Columbus-Panama City NW Florida Beaches flight deals.

Search Deals

Provider most trusted by Cheapflights users for Columbus-Panama City NW Florida Beaches flights.

Search Deals

From Columbus to Panama City NW Florida Beaches

Search Deals

One-way flight from Columbus to Panama City NW Florida Beaches

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Tue 2/3

6:30 am-12:02 pm

1 stop6h 32m

Panama City NW Florida Beaches

Fri 2/6

1:10 pm-10:29 pm

1 stop8h 19m

$336

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Sat 2/14

12:32 pm-4:15 pm

1 stop4h 43m

Panama City NW Florida Beaches

Thu 2/19

9:26 am-3:04 pm

1 stop4h 38m

$341

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Tue 2/3

11:00 am-6:10 pm

2 stops8h 10m

Panama City NW Florida Beaches

Fri 2/6

7:35 am-12:05 pm

1 stop3h 30m

$341

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Thu 1/22

4:41 pm-9:59 pm

1 stop6h 18m

Panama City NW Florida Beaches

Mon 1/26

1:10 pm-10:29 pm

1 stop8h 19m

$341

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Sat 1/31

9:04 am-1:10 pm

1 stop5h 06m

Panama City NW Florida Beaches

Sat 2/7

12:03 pm-9:30 pm

2 stops8h 27m

$346

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Sat 2/14

4:45 pm-9:57 pm

1 stop6h 12m

Panama City NW Florida Beaches

Thu 2/19

7:19 am-3:33 pm

2 stops7h 14m

$346

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Thu 1/22

6:40 am-2:55 pm

2 stops9h 15m

Panama City NW Florida Beaches

Mon 1/26

10:30 am-8:45 pm

2 stops9h 15m

$351

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Sun 3/8

7:07 am-10:20 am

1 stop4h 13m

Panama City NW Florida Beaches

Sat 3/14

5:30 pm-12:28 am

1 stop5h 58m

$355

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Thu 3/12

3:35 pm-8:35 pm

1 stop6h 00m

Panama City NW Florida Beaches

Sun 3/15

5:25 am-12:30 pm

1 stop6h 05m

$355

ColumbusPanama City

CMH - ECP

CMHECP

Columbus

Wed 1/21

5:00 pm-10:40 pm

1 stop6h 40m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 16 results

Compare providers for flights from Columbus to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbus to Panama City in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Columbus Airport-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbus Airport-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbus Airport-Panama City, Florida flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Columbus Airport-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbus Airport-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbus to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Columbus with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Panama City

How far ahead should I book a flight from Columbus Airport to Panama City, Florida?

To ensure you get the cheapest price possible for a flight from Columbus Airport to Panama City, Florida, you should look to book at least 64 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Columbus Airport to Panama City, Florida?

Currently, September is the cheapest month in which you can book a flight from Columbus Airport to Panama City, Florida (average of $120). Flying from Columbus Airport to Panama City, Florida in October is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to ECP?

When flying from Columbus Airport to Panama City, Florida, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 7% versus a flight at noon.

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Columbus Airport to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,258 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,012 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,058 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Allegiant Air

7.2

Good

702 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly into for flights to Panama City from Columbus?
Panama City NW Florida Beaches (ECP), located 16.0 mi from the city center, is the airport you fly into when you book flights from Columbus to Panama City. 4 airlines have flights to NW Florida Beaches from Columbus on a regular basis. Booking flights from Columbus to Panama City NW Florida Beaches should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.
How long is the flight from Columbus Airport to Panama City, Florida?
Airlines like United Airlines, Delta, and Southwest fly from Columbus Airport to Panama City, Florida in about 4h 43m. The time it takes to get you to your destination can typically vary by up to 3h 27m. The distance from Columbus Airport to Panama City, Florida is about 686 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Columbus Airport to Panama City, Florida round-trip?
Currently priced at $116, Allegiant Air will fly you from Columbus Airport to Panama City, Florida and back. In addition to Allegiant Air, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $163 and $259, respectively. Allegiant Air is priced at 69% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Columbus to Panama City that include hotel bookings?
Yes. In addition to deals on Columbus to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbus to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Panama City.
Can I find deals for business class flights from Columbus to Panama City?
Yes. Cheapflights offers flight deals from Columbus to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbus Airport to Panama City, Florida?
Currently, September is the cheapest month in which you can book a flight from Columbus Airport to Panama City, Florida (average of $120). Flying from Columbus Airport to Panama City, Florida in October is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 4 airlines flying from Columbus to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$116	Average$377	FlexibilityNo cancel fee	On-time88%
Delta	Cheapest$239	Average$354	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$259	Average$417	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$286	Average$386	FlexibilityNo cancel fee	On-time63%

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$159+ Cheap flights from Columbus (CMH) to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbus to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Columbus to Panama City NW Florida Beaches are usually found in September or November, booked 64 days in advance, depart on a Wednesday or Tuesday and return on a Tuesday

Cheap flight deals from Columbus to Panama City

Cheapest flights from Columbus to Panama CityExplore the most affordable flight options available from Columbus to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Explore the most affordable flight options available from Columbus to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Find flight deals from Columbus to Panama City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to Panama City that are best for you.

Compare providers for flights from Columbus to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbus to Panama City in December.

Best time to book a flight from Columbus to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Columbus with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Panama City

How far ahead should I book a flight from Columbus Airport to Panama City, Florida?

What is the cheapest month to book a flight from Columbus Airport to Panama City, Florida?

What is the cheapest time of day to fly from CMH to ECP?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Columbus Airport to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Columbus?

How long is the flight from Columbus Airport to Panama City, Florida?

What are the cheapest airlines flying from Columbus Airport to Panama City, Florida round-trip?

Can I find deals for flights from Columbus to Panama City that include hotel bookings?

How can I find direct flights from Columbus to Panama City?

Can I find deals for business class flights from Columbus to Panama City?

What is the cheapest month to book a flight from Columbus Airport to Panama City, Florida?

Traveling to a place near Panama City?

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Alternative routes for Columbus to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Columbus to Panama City

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Cheapest flights from Columbus to Panama City
Explore the most affordable flight options available from Columbus to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.