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Panama City

$84+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated June 16, 2025.

Round-trip from

$187
(Delta)

One-way from

$84
(Southwest)

Popular in

December

Cheapest in

January

Average price

$392

Good round-trip deal

$270 or less
From Missouri to Panama City NW Florida Beaches
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One-way flight from Missouri to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Missouri to Panama City NW Florida Beaches.
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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/33:36 pmSTL - ECP
1 stop4h 12mDelta
Tue 9/99:24 amECP - STL
1 stop5h 13mDelta
Deal found 6/14$187
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/259:10 amSTL - ECP
1 stop6h 25mSouthwest
Sat 8/3010:55 amECP - STL
Nonstop1h 50mSouthwest
Deal found 6/15$192
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:02 amSTL - ECP
2 stops11h 34mAmerican Airlines
Tue 9/911:36 amECP - STL
1 stop6h 51mAmerican Airlines
Deal found 6/14$212
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/125:24 pmMCI - ECP
1 stop4h 09mDelta
Wed 7/167:25 amECP - MCI
1 stop7h 06mDelta
Deal found 6/13$227
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/132:55 pmMCI - ECP
1 stop3h 55mSouthwest
Mon 8/184:20 pmECP - MCI
2 stops6h 25mSouthwest
Deal found 6/13$232
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:00 amSGF - ECP
1 stop6h 40mDelta
Sat 11/89:23 amECP - SGF
1 stop5h 27mDelta
Deal found 6/14$249
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:36 pmSGF - ECP
2 stops10h 51mAmerican Airlines
Sat 11/82:45 pmECP - SGF
1 stop7h 11mAmerican Airlines
Deal found 6/14$254
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/93:00 pmMCI - ECP
1 stop6h 57mAmerican Airlines
Fri 8/1512:06 pmECP - MCI
2 stops8h 42mAmerican Airlines
Deal found 6/14$272
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/154:45 pmSGF - ECP
1 stop5h 04mUnited Airlines
Sun 11/236:30 amECP - SGF
1 stop7h 29mUnited Airlines
Deal found 6/14$319
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/39:17 amSTL - ECP
2 stops10h 59mUnited Airlines
Tue 9/96:30 amECP - STL
2 stops9h 14mUnited Airlines
Deal found 6/14$348
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1011:33 amMCI - ECP
2 stops8h 43mUnited Airlines
Tue 9/306:30 amECP - MCI
1 stop5h 23mUnited Airlines
Deal found 6/15$408

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 9/3

5:11 pm-11:06 pm

1 stop5h 55m

Panama City NW Florida Beaches

Tue 9/9

9:24 am-4:06 pm

1 stop6h 42m

$187

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/25

9:10 am-3:35 pm

1 stop6h 25m

Panama City NW Florida Beaches

Sat 8/30

10:55 am-12:45 pm

Nonstop1h 50m

$192

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 9/3

6:02 am-5:36 pm

2 stops11h 34m

Panama City NW Florida Beaches

Tue 9/9

11:36 am-6:27 pm

1 stop6h 51m

$212

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 7/12

5:24 pm-9:33 pm

1 stop4h 09m

Panama City NW Florida Beaches

Wed 7/16

7:25 am-2:31 pm

1 stop7h 06m

$227

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 8/13

2:55 pm-6:50 pm

1 stop3h 55m

Panama City NW Florida Beaches

Mon 8/18

4:20 pm-10:45 pm

2 stops6h 25m

$232

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Wed 11/5

6:00 am-12:40 pm

1 stop6h 40m

Panama City NW Florida Beaches

Sat 11/8

9:23 am-2:50 pm

1 stop5h 27m

$249

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Wed 11/5

12:36 pm-11:27 pm

2 stops10h 51m

Panama City NW Florida Beaches

Sat 11/8

2:45 pm-9:56 pm

1 stop7h 11m

$254

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 8/9

3:00 pm-9:57 pm

1 stop6h 57m

Panama City NW Florida Beaches

Fri 8/15

12:06 pm-8:48 pm

2 stops8h 42m

$272

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Sat 11/15

9:00 am-1:57 pm

1 stop4h 57m

Panama City NW Florida Beaches

Sun 11/23

6:30 am-1:59 pm

1 stop7h 29m

$319

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 9/3

9:17 am-8:16 pm

2 stops10h 59m

Panama City NW Florida Beaches

Tue 9/9

6:30 am-3:44 pm

2 stops9h 14m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Showing 1-10 of 22 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2025.

When flying from Missouri to Panama City, Florida, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Missouri to Panama City, Florida

Explore weekly flight availability from Missouri to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 16, 2025.

The most flights from USMO to ECP are scheduled on a Saturday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 16, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Missouri to Panama City. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,278 reviews

Crew

8.6

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,278 reviews
Southwest
8.0
Very good
4,278 reviews

Crew

8.6

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,963 reviews
Southwest
8.0
Very good
4,278 reviews

Crew

8.6

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,801 reviews
Southwest
8.0
Very good
4,278 reviews

Crew

8.6

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,278 reviews

Crew

8.6

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How popular is this Missouri to Panama City, Florida flight route?

    The Missouri to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to Panama City, Florida one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $84. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Missouri to Panama City, Florida for a low price.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • What are the cheapest flights from Missouri to Panama City, Florida?

    Looking for the cheapest flight from Missouri to Panama City, Florida? While on average our users pay $379, our data indicates the cheapest price to be $241. The most popular route (Lambert-St Louis - Panama City NW Florida Beaches), is priced around $187.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Missouri to Panama City

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Top 5 airlines flying from Missouri to Panama City

Discover the top 5 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$182Average$364FlexibilityNo cancel feeOn-time71%
DeltaCheapest$186Average$372FlexibilityNo cancel feeOn-timeN/A
Allegiant AirCheapest$192Average$233FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$256Average$458FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$303Average$456FlexibilityNo cancel feeOn-time63%

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