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Panama City

$114+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — ECP
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:27 pmSGF - ECP
1 stop7h 26mAmerican Airlines
Wed 12/2412:40 pmECP - SGF
1 stop6h 14mAmerican Airlines
Deal found 12/16$354
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:25 amSTL - ECP
1 stop7h 25mSouthwest
Mon 12/294:15 pmECP - STL
1 stop7h 20mSouthwest
Deal found 12/16$409
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:09 amMCI - ECP
1 stop8h 01mUnited Airlines
Tue 12/232:55 pmECP - MCI
1 stop7h 35mUnited Airlines
Deal found 12/17$409
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:00 pmSGF - ECP
1 stop5h 24mAmerican Airlines
Mon 12/296:46 amECP - SGF
1 stop4h 51mAmerican Airlines
Deal found 12/15$428
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:13 pmSTL - ECP
1 stop5h 49mDelta
Sun 1/46:00 amECP - STL
1 stop6h 21mDelta
Deal found 12/16$435
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:35 pmSTL - ECP
1 stop7h 00mSouthwest
Mon 12/224:15 pmECP - STL
1 stop4h 40mSouthwest
Deal found 12/16$444
This Southwest deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:25 amSTL - ECP
1 stop7h 25mSouthwest
Sun 12/216:35 pmECP - STL
1 stop5h 30mSouthwest
Deal found 12/15$467
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amSTL - ECP
1 stop8h 23mAmerican Airlines
Sun 12/217:15 amECP - STL
2 stops12h 16mAmerican Airlines
Deal found 12/15$472
This Southwest deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:25 amSTL - ECP
1 stop7h 25mSouthwest
Tue 12/306:35 pmECP - STL
1 stop5h 30mSouthwest
Deal found 12/17$475
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/211:59 pmSTL - ECP
2 stops9h 54mAmerican Airlines
Mon 12/227:15 amECP - STL
2 stops9h 55mAmerican Airlines
Deal found 12/17$477
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:00 amMCI - ECP
1 stop9h 50mSouthwest
Fri 1/98:00 amECP - MCI
1 stop6h 20mSouthwest
Deal found 12/16$562
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:20 amMCI - ECP
2 stops8h 15mSouthwest
Fri 1/98:00 amECP - MCI
2 stops8h 45mSouthwest
Deal found 12/16$563

Find flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$237
(Delta)

One-way from

$114
(United Airlines)

Popular in

March

Cheapest in

October

Average price

$302
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
Search Deals
From Missouri to Panama City NW Florida Beaches
Search Deals
One-way flight from Missouri to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 4/1

1:19 pm-7:48 pm

1 stop6h 29m

Panama City NW Florida Beaches

Wed 4/8

7:00 am-12:10 pm

1 stop5h 10m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Thu 2/26

5:15 am-11:55 am

1 stop6h 40m

Panama City NW Florida Beaches

Sun 3/1

3:40 pm-11:00 pm

1 stop7h 20m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 3/4

1:23 pm-6:52 pm

1 stop5h 29m

Panama City NW Florida Beaches

Sun 3/8

6:45 pm-12:06 am

1 stop5h 21m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Tue 2/10

7:00 am-11:08 am

1 stop4h 08m

Panama City NW Florida Beaches

Tue 2/24

2:14 pm-8:41 pm

1 stop6h 27m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Tue 4/21

6:42 pm-10:46 pm

1 stop4h 04m

Panama City NW Florida Beaches

Tue 4/28

7:45 am-1:51 pm

1 stop6h 06m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 5/2

9:17 am-9:56 pm

2 stops12h 39m

Panama City NW Florida Beaches

Thu 5/7

2:15 pm-9:59 pm

1 stop7h 44m

$242

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 4/1

6:33 pm-11:49 pm

1 stop5h 16m

Panama City NW Florida Beaches

Wed 4/8

2:53 pm-11:40 pm

2 stops8h 47m

$242

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/25

5:47 am-1:30 pm

2 stops7h 43m

Panama City NW Florida Beaches

Wed 4/29

9:56 am-5:45 pm

1 stop7h 49m

$242

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Tue 4/21

5:47 am-3:17 pm

2 stops9h 30m

Panama City NW Florida Beaches

Tue 4/28

5:00 pm-9:44 pm

1 stop4h 44m

$254

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/27

6:00 am-11:08 am

1 stop5h 08m

Panama City NW Florida Beaches

Thu 1/29

12:15 pm-5:50 pm

1 stop5h 35m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 45 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $206). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Missouri to Panama City, Florida, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 11% versus a flight in the morning.

What is the cheapest day to fly from Missouri to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Panama City. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How long is the flight from Missouri to Panama City, Florida?

    Departing from Missouri to Panama City, Florida will take you 6h 19m. Airlines will cover a distance of 644 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Panama City, Florida one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $88. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Missouri to Panama City, Florida for a low price.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $206). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Panama City

Discover the top 4 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$176Average$330FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$370FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$226Average$432FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$228Average$429FlexibilityNo cancel feeOn-time63%

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