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Panama City

$119+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:29 pm
MCI
-
ECP
1 stop5h 30m
United Airlines
Tue 4/284:57 pm
ECP
-
MCI
1 stop5h 32m
United Airlines
Deal found 1/26$237
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:08 pm
MCI
-
ECP
2 stops7h 41m
American Airlines
Tue 3/38:20 am
ECP
-
MCI
1 stop7h 54m
American Airlines
Deal found 1/26$242
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:33 pm
MCI
-
ECP
1 stop5h 16m
American Airlines
Wed 4/84:40 pm
ECP
-
MCI
1 stop6h 38m
American Airlines
Deal found 1/26$243
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:38 pm
MCI
-
ECP
2 stops9h 08m
American Airlines
Wed 4/291:24 pm
ECP
-
MCI
1 stop9h 25m
American Airlines
Deal found 1/27$248
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:49 am
MCI
-
ECP
1 stop5h 54m
American Airlines
Thu 3/54:34 pm
ECP
-
MCI
1 stop7h 25m
American Airlines
Deal found 1/28$255
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:10 pm
MCI
-
ECP
1 stop3h 54m
Delta
Thu 4/166:46 pm
ECP
-
MCI
1 stop5h 04m
Delta
Deal found 1/28$257
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:33 pm
MCI
-
ECP
1 stop5h 16m
American Airlines
Thu 3/54:34 pm
ECP
-
MCI
1 stop7h 25m
American Airlines
Deal found 1/27$258
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:08 pm
MCI
-
ECP
2 stops7h 41m
American Airlines
Tue 3/108:20 am
ECP
-
MCI
1 stop7h 54m
American Airlines
Deal found 1/27$263
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:33 pm
MCI
-
ECP
1 stop5h 16m
American Airlines
Tue 3/248:20 am
ECP
-
MCI
1 stop7h 54m
American Airlines
Deal found 1/27$268
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:55 pm
SGF
-
ECP
1 stop4h 17m
Delta
Sat 5/25:49 am
ECP
-
SGF
1 stop5h 12m
Delta
Deal found 1/27$269
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:15 am
MCI
-
ECP
1 stop11h 05m
Southwest
Sat 3/2811:55 am
ECP
-
MCI
1 stop11h 00m
Southwest
Deal found 1/27$279
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:00 pm
SGF
-
ECP
1 stop3h 36m
Delta
Wed 5/68:21 am
ECP
-
SGF
1 stop6h 39m
Delta
Deal found 1/28$279

Find flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$237
(United Airlines)

One-way from

$119
(Delta)

Popular in

February

Cheapest in

October

Average price

$367

Good round-trip deal

$374 or less
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
Search Deals
From Missouri to Panama City NW Florida Beaches
Search Deals
One-way flight from Missouri to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($44 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Missouri to Panama City NW Florida Beaches.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 3/7

5:06 pm-10:39 pm

1 stop5h 33m

Panama City NW Florida Beaches

Tue 3/10

1:30 pm-7:56 pm

1 stop6h 26m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 4/1

6:33 pm-11:49 pm

1 stop5h 16m

Panama City NW Florida Beaches

Wed 4/8

1:24 pm-10:49 pm

1 stop9h 25m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/11

3:00 pm-9:59 pm

1 stop6h 59m

Panama City NW Florida Beaches

Wed 4/15

10:10 am-4:44 pm

1 stop6h 34m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 2/28

5:06 pm-10:39 pm

1 stop5h 33m

Panama City NW Florida Beaches

Tue 3/3

6:00 am-12:16 pm

1 stop6h 16m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Mon 3/2

6:28 am-2:24 pm

1 stop7h 56m

Panama City NW Florida Beaches

Fri 3/6

4:34 pm-11:59 pm

1 stop7h 25m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/25

4:29 pm-9:59 pm

1 stop5h 30m

Panama City NW Florida Beaches

Tue 4/28

4:57 pm-10:29 pm

1 stop5h 32m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Mon 3/2

6:16 pm-10:39 pm

1 stop4h 23m

Panama City NW Florida Beaches

Fri 3/6

2:05 pm-8:07 pm

1 stop6h 02m

$237

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/25

2:38 pm-11:46 pm

2 stops9h 08m

Panama City NW Florida Beaches

Wed 4/29

1:24 pm-10:49 pm

1 stop9h 25m

$248

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/11

7:10 pm-11:04 pm

1 stop3h 54m

Panama City NW Florida Beaches

Thu 4/16

6:46 pm-11:50 pm

1 stop5h 04m

$257

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Tue 4/21

3:03 pm-7:36 pm

1 stop4h 33m

Panama City NW Florida Beaches

Tue 4/28

5:10 pm-11:50 pm

1 stop6h 40m

$257

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 54 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $201). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Missouri to Panama City, Florida, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 11% versus a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How popular is this Missouri to Panama City, Florida flight route?

    The Missouri to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to Panama City, Florida?

    Departing from Missouri to Panama City, Florida will take you 5h 16m. Airlines will cover a distance of 797 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Panama City, Florida one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $88. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Missouri to Panama City, Florida for a low price.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • What are the cheapest flights from Missouri to Panama City, Florida?

    Looking for the cheapest flight from Missouri to Panama City, Florida? While on average our users pay $445, our data indicates the cheapest price to be $365. The most popular route (Lambert-St Louis - Panama City NW Florida Beaches), is priced around $289.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $201). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Alternative routes for Missouri to Panama City

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Top 4 airlines flying from Missouri to Panama City

Discover the top 4 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$176Average$320FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$186Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$226Average$379FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$228Average$429FlexibilityNo cancel feeOn-time63%

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