HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$68+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$207
(Southwest)

One-way from

$68
(United Airlines)

Popular in

March

Cheapest in

January

Average price

$374

Good round-trip deal

$192 or less
From Missouri to Panama City NW Florida Beaches
Search Deals
One-way flight from Missouri to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Missouri to Panama City NW Florida Beaches.
Search Deals

Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:52 pmSTL - ECP
1 stop4h 18mDelta
mié. 10/299:29 amECP - STL
1 stop6h 26mDelta
Deal found 9/14$177
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/138:35 amSTL - ECP
Nonstop1h 45mSouthwest
mar. 10/214:05 pmECP - STL
1 stop6h 00mSouthwest
Deal found 9/16$207
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/275:00 amSTL - ECP
2 stops8h 20mSouthwest
sáb. 11/18:00 amECP - STL
1 stop6h 30mSouthwest
Deal found 9/16$212
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/196:00 amSTL - ECP
1 stop7h 21mAmerican Airlines
jue. 10/233:38 pmECP - STL
1 stop5h 13mAmerican Airlines
Deal found 9/14$228
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/188:25 amSTL - ECP
1 stop5h 26mUnited Airlines
sáb. 10/255:08 pmECP - STL
1 stop4h 50mUnited Airlines
Deal found 9/15$238
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/2412:25 pmSTL - ECP
2 stops9h 23mUnited Airlines
mié. 10/295:00 pmECP - STL
1 stop5h 22mUnited Airlines
Deal found 9/14$246
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/246:00 amSTL - ECP
1 stop4h 15mDelta
vie. 1/26:59 pmECP - STL
1 stop4h 40mDelta
Deal found 9/14$248
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/86:34 pmSGF - ECP
1 stop5h 19mAmerican Airlines
sáb. 11/152:37 pmECP - SGF
1 stop7h 56mAmerican Airlines
Deal found 9/15$249
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:45 pmSTL - ECP
1 stop3h 50mSouthwest
mié. 10/293:15 pmECP - STL
Nonstop1h 45mSouthwest
Deal found 9/14$253
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/112:08 pmSGF - ECP
2 stops10h 00mAmerican Airlines
sáb. 11/82:37 pmECP - SGF
1 stop7h 56mAmerican Airlines
Deal found 9/15$271
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/94:28 pmSGF - ECP
1 stop7h 21mAmerican Airlines
sáb. 11/156:47 amECP - SGF
1 stop4h 49mAmerican Airlines
Deal found 9/15$274
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/159:00 amSGF - ECP
1 stop4h 47mUnited Airlines
dom. 11/235:04 pmECP - SGF
1 stop4h 42mUnited Airlines
Deal found 9/17$275

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

vie. 10/24

6:52 pm-11:10 pm

1 stop4h 18m

Panama City NW Florida Beaches

mié. 10/29

9:29 am-3:55 pm

1 stop6h 26m

$177

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

lun. 10/13

8:35 am-10:20 am

Nonstop1h 45m

Panama City NW Florida Beaches

mar. 10/21

4:05 pm-10:05 pm

1 stop6h 00m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

mié. 12/3

10:15 am-2:40 pm

1 stop4h 25m

Panama City NW Florida Beaches

sáb. 12/6

10:15 am-5:00 pm

1 stop6h 45m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

mié. 12/3

9:30 am-2:47 pm

1 stop5h 17m

Panama City NW Florida Beaches

sáb. 12/6

10:29 am-8:51 pm

2 stops10h 22m

$212

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

sáb. 10/18

8:25 am-1:51 pm

1 stop5h 26m

Panama City NW Florida Beaches

sáb. 10/25

5:08 pm-9:58 pm

1 stop4h 50m

$238

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

vie. 10/24

12:25 pm-9:48 pm

2 stops9h 23m

Panama City NW Florida Beaches

mié. 10/29

5:00 pm-10:22 pm

1 stop5h 22m

$246

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

sáb. 11/8

6:34 pm-11:53 pm

1 stop5h 19m

Panama City NW Florida Beaches

sáb. 11/15

2:37 pm-10:33 pm

1 stop7h 56m

$249

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

vie. 10/24

6:45 pm-10:35 pm

1 stop3h 50m

Panama City NW Florida Beaches

mié. 10/29

3:15 pm-5:00 pm

Nonstop1h 45m

$253

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

sáb. 11/1

12:08 pm-10:08 pm

2 stops10h 00m

Panama City NW Florida Beaches

sáb. 11/8

2:37 pm-10:33 pm

1 stop7h 56m

$271

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

dom. 11/9

4:28 pm-11:49 pm

1 stop7h 21m

Panama City NW Florida Beaches

sáb. 11/15

6:47 am-11:36 am

1 stop4h 49m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 45 results
1
2
3
...
5

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $459). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

When flying from Missouri to Panama City, Florida, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How popular is this Missouri to Panama City, Florida flight route?

    The Missouri to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to Panama City, Florida?

    Departing from Missouri to Panama City, Florida will take you 1h 45m. Airlines will cover a distance of 635 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Panama City, Florida one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $89. However, be on the lookout for offers from Southwest and American Airlines, as they are both options that can get you from Missouri to Panama City, Florida for a low price.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • What are the cheapest flights from Missouri to Panama City, Florida?

    Looking for the cheapest flight from Missouri to Panama City, Florida? While on average our users pay $398, our data indicates the cheapest price to be $167. The most popular route (Lambert-St Louis - Panama City NW Florida Beaches), is priced around $207.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $459). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Miami flights
Newark to Fort Lauderdale flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
LaGuardia to Miami flights
Newark to Miami flights
Newark to Orlando flights
John F Kennedy Intl to Fort Lauderdale flights
LaGuardia to Orlando flights
Boston to Orlando flights
John F Kennedy Intl to West Palm Beach flights
Dulles Intl to Orlando flights
Dallas/Fort Worth to Orlando flights
Dulles Intl to Miami flights
Boston to Fort Lauderdale flights
Philadelphia to Orlando flights
O'Hare Intl to Orlando flights
Los Angeles to Orlando flights
Newark to West Palm Beach flights
Los Angeles to Miami flights
Reagan-National to Miami flights
Newark to Tampa flights
Baltimore to Fort Lauderdale flights
Dallas/Fort Worth to Miami flights
Reagan-National to Orlando flights
Baltimore to Orlando flights
John F Kennedy Intl to Tampa flights
Boston to Miami flights
Philadelphia to Fort Lauderdale flights
O'Hare Intl to Miami flights
Denver to Orlando flights
Seattle to Orlando flights
O'Hare Intl to Fort Lauderdale flights
Atlanta to Miami flights
Providence to Orlando flights
Hobby to Orlando flights
Minneapolis to Orlando flights
Cleveland to Orlando flights
Boston to Tampa flights
LaGuardia to West Palm Beach flights
Dallas/Fort Worth to Fort Lauderdale flights
Los Angeles to Fort Lauderdale flights
LaGuardia to Tampa flights
Baltimore to Miami flights
Philadelphia to Miami flights
Raleigh to Miami flights
Dulles Intl to Tampa flights
Detroit to Orlando flights
Detroit to Fort Lauderdale flights
Minneapolis to Miami flights

Top 5 airlines flying from Missouri to Panama City

Discover the top 5 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$102Average$233FlexibilityNo cancel feeOn-time88%
DeltaCheapest$186Average$367FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$386FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$230Average$440FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$256Average$472FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.