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Panama City

$104+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$104
(Delta)

Popular in

March

Cheapest in

October

Average price

$466
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
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From Missouri to Panama City NW Florida Beaches
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One-way flight from Missouri to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amSTL - ECP
1 stop6h 47mDelta
Thu 12/116:00 amECP - STL
1 stop4h 45mDelta
Deal found 11/1$207
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:15 amSTL - ECP
1 stop5h 35mSouthwest
Thu 12/1110:00 amECP - STL
2 stops7h 25mSouthwest
Deal found 11/1$212
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:58 pmSGF - ECP
1 stop4h 09mDelta
Mon 12/810:00 amECP - SGF
1 stop5h 23mDelta
Deal found 11/1$249
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/144:02 pmSGF - ECP
1 stop4h 30mDelta
Thu 11/2011:11 amECP - SGF
1 stop7h 07mDelta
Deal found 11/2$309
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/258:20 amSTL - ECP
1 stop7h 43mUnited Airlines
Wed 12/105:00 pmECP - STL
1 stop4h 58mUnited Airlines
Deal found 10/31$314
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:32 amSGF - ECP
1 stop6h 49mAmerican Airlines
Sun 12/146:30 amECP - SGF
1 stop5h 03mAmerican Airlines
Deal found 11/2$319
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/169:33 amSTL - ECP
1 stop3h 14mDelta
Thu 11/209:23 amECP - STL
1 stop6h 44mDelta
Deal found 11/1$338
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:22 pmSTL - ECP
1 stop4h 55mDelta
Wed 12/318:02 amECP - STL
1 stop4h 19mDelta
Deal found 11/2$339
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMCI - ECP
1 stop6h 53mAmerican Airlines
Wed 12/247:15 amECP - MCI
1 stop6h 01mAmerican Airlines
Deal found 11/3$339
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:58 pmSGF - ECP
1 stop4h 09mDelta
Sat 11/159:23 amECP - SGF
1 stop5h 54mDelta
Deal found 11/2$339
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:00 amSTL - ECP
2 stops8h 07mAmerican Airlines
Thu 11/201:19 pmECP - STL
1 stop8h 26mAmerican Airlines
Deal found 11/1$343
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:34 pmSGF - ECP
1 stop5h 15mAmerican Airlines
Sat 11/1510:30 amECP - SGF
2 stops10h 17mAmerican Airlines
Deal found 11/2$344

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 12/4

6:00 am-12:47 pm

1 stop6h 47m

Panama City NW Florida Beaches

Thu 12/11

6:00 am-10:45 am

1 stop4h 45m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 12/4

10:15 am-3:50 pm

1 stop5h 35m

Panama City NW Florida Beaches

Thu 12/11

10:00 am-5:25 pm

2 stops7h 25m

$212

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Mon 12/1

6:58 pm-11:07 pm

1 stop4h 09m

Panama City NW Florida Beaches

Mon 12/8

10:00 am-3:23 pm

1 stop5h 23m

$249

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

Sun 1/25

4:54 pm-10:00 pm

1 stop5h 06m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

6:00 am-11:10 am

1 stop5h 10m

Panama City NW Florida Beaches

Sun 1/25

12:15 pm-5:50 pm

1 stop5h 35m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

7:00 am-5:33 pm

2 stops10h 33m

Panama City NW Florida Beaches

Sun 1/25

12:03 pm-6:34 pm

1 stop6h 31m

$294

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 1/29

11:20 am-9:59 pm

2 stops10h 39m

Panama City NW Florida Beaches

Fri 1/30

4:54 pm-10:00 pm

1 stop5h 06m

$294

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Fri 11/14

6:58 pm-11:07 pm

1 stop4h 09m

Panama City NW Florida Beaches

Tue 11/18

9:23 am-3:17 pm

1 stop5h 54m

$309

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Sat 11/15

4:02 pm-10:37 pm

1 stop6h 35m

Panama City NW Florida Beaches

Tue 11/18

9:23 am-3:17 pm

1 stop5h 54m

$309

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 11/25

8:20 am-4:03 pm

1 stop7h 43m

Panama City NW Florida Beaches

Wed 12/10

5:00 pm-9:58 pm

1 stop4h 58m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 48 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

When flying from Missouri to Panama City, Florida, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 10% versus a flight in the morning.

What is the cheapest day to fly from Missouri to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Panama City. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How popular is this Missouri to Panama City, Florida flight route?

    The Missouri to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to Panama City, Florida?

    Departing from Missouri to Panama City, Florida will take you 5h 35m. Airlines will cover a distance of 635 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $52). Flying from Missouri to Panama City, Florida in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 4 airlines flying from Missouri to Panama City

Discover the top 4 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$186Average$347FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$381FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$228Average$436FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$248Average$437FlexibilityNo cancel feeOn-time69%

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