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Panama City

$79+ Cheap flights from Missouri to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated July 31, 2025.

Round-trip from

$157
(Southwest)

One-way from

$79
(Southwest)

Popular in

March

Cheapest in

January

Average price

$399

Good round-trip deal

$228 or less
From Missouri to Panama City NW Florida Beaches
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One-way flight from Missouri to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 9% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Missouri to Panama City NW Florida Beaches.
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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/198:25 amSTL - ECP
Nonstop1h 45mSouthwest
Sat 8/233:15 pmECP - STL
Nonstop1h 50mSouthwest
Deal found 7/28$157
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/35:11 pmSTL - ECP
1 stop5h 55mDelta
Tue 9/95:02 pmECP - STL
1 stop5h 00mDelta
Deal found 7/29$177
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/244:32 pmSTL - ECP
1 stop7h 09mAmerican Airlines
Sun 8/315:30 amECP - STL
1 stop6h 41mAmerican Airlines
Deal found 7/31$187
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/102:14 pmMCI - ECP
1 stop5h 34mDelta
Sat 9/135:02 pmECP - MCI
1 stop6h 42mDelta
Deal found 7/31$227
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/78:20 amSTL - ECP
1 stop8h 00mUnited Airlines
Sat 9/1311:09 amECP - STL
1 stop7h 41mUnited Airlines
Deal found 7/29$232
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:01 amMCI - ECP
1 stop6h 12mAmerican Airlines
Wed 9/312:01 pmECP - MCI
2 stops11h 06mAmerican Airlines
Deal found 7/30$232
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2511:50 amMCI - ECP
2 stops9h 10mSouthwest
Wed 8/277:00 amECP - MCI
2 stops7h 55mSouthwest
Deal found 7/31$252
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:38 pmSGF - ECP
1 stop4h 28mDelta
Fri 8/229:24 amECP - SGF
1 stop5h 45mDelta
Deal found 7/31$254
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/88:30 amMCI - ECP
1 stop7h 50mUnited Airlines
Sat 9/132:26 pmECP - MCI
2 stops9h 01mUnited Airlines
Deal found 7/31$307
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/154:18 pmSGF - ECP
1 stop5h 39mAmerican Airlines
Tue 8/1912:06 pmECP - SGF
2 stops9h 19mAmerican Airlines
Deal found 7/31$309
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/218:55 amSGF - ECP
1 stop7h 25mUnited Airlines
Thu 8/285:06 pmECP - SGF
1 stop4h 51mUnited Airlines
Deal found 7/31$470

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/19

8:25 am-10:10 am

Nonstop1h 45m

Panama City NW Florida Beaches

Sat 8/23

3:15 pm-5:05 pm

Nonstop1h 50m

$157

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 9/3

5:11 pm-11:06 pm

1 stop5h 55m

Panama City NW Florida Beaches

Tue 9/9

5:02 pm-10:02 pm

1 stop5h 00m

$177

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 8/24

6:00 am-12:48 pm

1 stop6h 48m

Panama City NW Florida Beaches

Sun 8/31

5:30 am-12:11 pm

1 stop6h 41m

$187

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 9/10

2:14 pm-7:48 pm

1 stop5h 34m

Panama City NW Florida Beaches

Sat 9/13

5:02 pm-11:44 pm

1 stop6h 42m

$227

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 9/7

8:20 am-4:20 pm

1 stop8h 00m

Panama City NW Florida Beaches

Sat 9/13

11:09 am-6:50 pm

1 stop7h 41m

$232

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 8/30

6:01 am-12:13 pm

1 stop6h 12m

Panama City NW Florida Beaches

Wed 9/3

12:01 pm-11:07 pm

2 stops11h 06m

$232

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Mon 8/25

11:50 am-9:00 pm

2 stops9h 10m

Panama City NW Florida Beaches

Wed 8/27

7:00 am-2:55 pm

2 stops7h 55m

$252

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Fri 8/15

6:38 pm-11:06 pm

1 stop4h 28m

Panama City NW Florida Beaches

Fri 8/22

9:24 am-3:09 pm

1 stop5h 45m

$254

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Mon 9/8

8:30 am-4:20 pm

1 stop7h 50m

Panama City NW Florida Beaches

Sat 9/13

2:26 pm-11:27 pm

2 stops9h 01m

$307

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Fri 8/15

4:18 pm-9:57 pm

1 stop5h 39m

Panama City NW Florida Beaches

Tue 8/19

12:06 pm-9:25 pm

2 stops9h 19m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Showing 1-10 of 21 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ECP?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

When flying from Missouri to Panama City, Florida, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Missouri to Panama City. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    For a flight from Missouri to Panama City, you will be flying into NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How popular is this Missouri to Panama City, Florida flight route?

    The Missouri to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to Panama City, Florida one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $79. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Missouri to Panama City, Florida for a low price.

  • What are the most popular routes from Missouri to Panama City, Florida?

    When deciding which route to take from Missouri to Panama City, Florida consider Lambert-St Louis - Panama City NW Florida Beaches, Kansas City - Panama City NW Florida Beaches or Springfield-Branson - Panama City NW Florida Beaches as they are the most popular.

  • What are the cheapest flights from Missouri to Panama City, Florida?

    Looking for the cheapest flight from Missouri to Panama City, Florida? While on average our users pay $313, our data indicates the cheapest price to be $167. The most popular route (Lambert-St Louis - Panama City NW Florida Beaches), is priced around $157.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $346). Flying from Missouri to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to Panama City

Discover the top 5 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$102Average$233FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$372FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$220Average$375FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$472FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$263Average$453FlexibilityNo cancel feeOn-time63%

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