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Panama City

$342+ Cheap flights from Greenville to Panama City, FL (GSP - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — ECP
Jan 16 — Jan 231
Fri 1/16
Fri 1/23
1 adult, Economy
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Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:45 amGSP - ECP
1 stop8h 35mUnited Airlines
Sun 1/42:55 pmECP - GSP
1 stop6h 02mUnited Airlines
Deal found 12/16$608

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$327
(Delta)

One-way from

$250
(United Airlines)

Popular in

October

Cheapest in

June

Average price

$423
Provider with most accurate pricing for Greenville-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City NW Florida Beaches flights.
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From Greenville to Panama City NW Florida Beaches
Search Deals
One-way flight from Greenville to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($161 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Greenville

Fly to

Panama City

Route

Depart

Return

Price

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 2/21

6:50 am-12:04 pm

1 stop6h 14m

Panama City NW Florida Beaches

Wed 2/25

6:30 am-3:36 pm

1 stop8h 06m

$342

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 1/16

5:40 am-9:12 am

1 stop4h 32m

Panama City NW Florida Beaches

Mon 1/19

6:09 pm-11:50 pm

1 stop4h 41m

$344

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 1/5

7:00 am-10:37 am

1 stop4h 37m

Panama City NW Florida Beaches

Thu 1/8

12:03 pm-7:07 pm

1 stop6h 04m

$366

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 4/24

3:00 pm-5:50 pm

1 stop3h 50m

Panama City NW Florida Beaches

Mon 4/27

7:05 pm-11:40 pm

1 stop3h 35m

$423

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 1/16

8:20 am-6:45 pm

2 stops11h 25m

Panama City NW Florida Beaches

Mon 1/19

7:35 am-11:55 am

1 stop3h 20m

$549

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Wed 1/7

5:12 pm-7:50 pm

1 stop3h 38m

Panama City NW Florida Beaches

Sat 1/10

5:14 pm-11:55 pm

1 stop5h 41m

$577

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Wed 12/31

6:45 am-2:20 pm

1 stop8h 35m

Panama City NW Florida Beaches

Sun 1/4

2:55 pm-9:57 pm

1 stop6h 02m

$608

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 1/5

1:05 pm-12:02 pm

2 stops23h 57m

Panama City NW Florida Beaches

Thu 1/8

6:30 am-3:35 pm

1 stop8h 05m

$627

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 4/24

4:55 pm-9:56 pm

1 stop6h 01m

Panama City NW Florida Beaches

Mon 4/27

4:55 pm-9:58 am

2 stops16h 03m

$687

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City, Florida?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City, Florida (average of $65). Flying from Greenville to Panama City, Florida in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to ECP?

Find hourly flight availability from Greenville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 17, 2025.

It’s typically best to fly out from Greenville to Panama City, Florida in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 17, 2025.
Peruse reviews from past customers who have flown with Delta from Greenville to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City, Florida?

    There are many flights that can get you from Greenville to Panama City, Florida in 3h 59m. Fly via Delta, United Airlines, or Southwest to get the fastest option. Greenville and Panama City, Florida are separated by a distance of 376 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Greenville to Panama City, Florida round-trip?

    Our cheapest airline available from Greenville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $254 on this airline. Delta is currently priced 37% below the average price you’ll pay for this route.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City, Florida?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City, Florida (average of $65). Flying from Greenville to Panama City, Florida in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Greenville to Panama City

Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$266Average$369FlexibilityNo cancel feeOn-timeN/A

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