$145+ Cheap flights from South Dakota to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — STL
Oct 2 — Oct 91
Round-trip
1 adult, Economy
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Cheapest flights from South Dakota to MissouriExplore the most affordable flight options available from South Dakota to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
Explore the most affordable flight options available from South Dakota to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:50 pm -
1 stop4h 50m
Sat 9/129:00 am -
1 stop7h 33m
Deal found 9/1![United Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:56 pm -
1 stop5h 08m
Tue 10/611:31 am -
2 stops9h 42m
Deal found 9/1![American Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:56 pm -
1 stop5h 08m
Tue 10/65:00 am -
1 stop6h 34m
Deal found 9/1![American Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
1 stop6h 15m
Mon 9/215:18 pm -
1 stop7h 11m
Deal found 8/29![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:00 am -
1 stop4h 37m
Mon 10/56:25 pm -
1 stop4h 46m
Deal found 8/29![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:56 pm -
1 stop6h 11m
Sun 9/135:43 am -
1 stop6h 33m
Deal found 8/30![American Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:35 am -
1 stop6h 36m
Sun 9/207:11 pm -
1 stop4h 33m
Deal found 8/30![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:07 pm -
1 stop5h 16m
Wed 9/305:28 am -
1 stop5h 19m
Deal found 8/28![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:07 pm -
1 stop5h 20m
Sun 9/275:43 am -
1 stop5h 04m
Deal found 9/2![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am -
1 stop4h 37m
Mon 9/217:11 pm -
1 stop4h 22m
Deal found 8/30![United Airlines logo]()
$341
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:32 am -
1 stop6h 39m
Fri 11/276:45 pm -
1 stop4h 44m
Deal found 8/30![United Airlines logo]()
$347
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:07 pm -
1 stop5h 20m
Sun 9/205:43 am -
1 stop5h 04m
Deal found 8/31![American Airlines logo]()
$349
Best flights from South Dakota to MissouriDiscover carefully curated flight deals from South Dakota to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
Discover carefully curated flight deals from South Dakota to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:41 pm -
1 stop5h 46m
Sat 10/311:01 am -
2 stops9h 44m
Deal found 8/28![American Airlines logo]()
$286
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
1 stop4h 23m
Sun 10/45:36 pm -
1 stop5h 35m
Deal found 8/28![United Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:56 pm -
1 stop5h 08m
Tue 10/65:00 am -
1 stop6h 34m
Deal found 9/1![American Airlines logo]()
$290
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:00 am -
1 stop4h 37m
Mon 10/56:25 pm -
1 stop4h 46m
Deal found 8/29![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:59 pm -
1 stop5h 25m
Tue 9/221:03 pm -
1 stop6h 39m
Deal found 8/31![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:35 am -
1 stop6h 59m
Sun 9/206:55 pm -
1 stop4h 49m
Deal found 9/1![United Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am -
1 stop4h 37m
Mon 9/217:11 pm -
1 stop4h 22m
Deal found 8/30![United Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:07 pm -
1 stop5h 20m
Sun 9/205:43 am -
1 stop5h 04m
Deal found 8/31![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:32 am -
1 stop6h 39m
Fri 11/276:45 pm -
1 stop4h 44m
Deal found 8/30![United Airlines logo]()
$347
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:56 pm -
2 stops11h 31m
Sun 10/45:43 am -
1 stop6h 33m
Deal found 8/28![American Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:20 pm -
1 stop7h 39m
Sat 10/311:40 pm -
1 stop6h 24m
Deal found 8/30![United Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:46 pm -
1 stop7h 02m
Sat 10/35:06 pm -
1 stop6h 38m
Deal found 8/29![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:04 pm -
1 stop6h 11m
Wed 9/301:48 pm -
1 stop6h 32m
Deal found 8/28![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:59 pm -
1 stop5h 25m
Fri 10/26:44 am -
1 stop5h 32m
Deal found 8/31![American Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/144:10 pm -
1 stop6h 42m
Wed 11/185:20 pm -
1 stop6h 10m
Deal found 9/1![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:00 am -
1 stop4h 38m
Sat 10/314:39 pm -
1 stop5h 04m
Deal found 9/1![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am -
1 stop6h 37m
Mon 9/217:11 pm -
1 stop4h 33m
Deal found 9/2![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1812:56 pm -
1 stop6h 10m
Sun 9/207:51 pm -
1 stop4h 38m
Deal found 9/1![American Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:00 am -
2 stops8h 33m
Tue 11/175:02 pm -
1 stop4h 41m
Deal found 8/28![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:58 pm -
1 stop4h 32m
Wed 9/96:00 am -
1 stop4h 27m
Deal found 8/29![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:53 pm -
1 stop6h 31m
Sun 11/296:34 am -
1 stop5h 59m
Deal found 8/28![American Airlines logo]()
$732
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:04 pm -
1 stop6h 40m
Thu 10/156:00 am -
1 stop4h 50m
Deal found 8/31![United Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:48 pm -
1 stop4h 42m
Sun 9/206:00 am -
1 stop6h 55m
Deal found 9/1![United Airlines logo]()
$533
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:48 pm -
1 stop4h 42m
Thu 9/175:13 pm -
1 stop6h 20m
Deal found 8/28![United Airlines logo]()
$594
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:17 am -
2 stops9h 43m
Mon 10/126:00 am -
1 stop4h 28m
Deal found 8/31![United Airlines logo]()
$666
Last-minute flights from South Dakota to MissouriDiscover last-minute flight deals from South Dakota to Missouri. Data last updated September 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Dakota to Missouri. Data last updated September 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:56 pm -
1 stop6h 11m
Sun 9/135:43 am -
1 stop6h 33m
Deal found 8/30![American Airlines logo]()
$305
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:55 pm -
1 stop5h 29m
Sat 9/125:28 am -
1 stop6h 48m
Deal found 8/29![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:50 pm -
1 stop4h 50m
Sat 9/129:00 am -
1 stop7h 33m
Deal found 9/1![United Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:56 pm -
1 stop5h 08m
Tue 10/611:31 am -
2 stops9h 42m
Deal found 9/1![American Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:07 pm -
1 stop5h 20m
Sun 9/205:43 am -
1 stop5h 04m
Deal found 8/31![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am -
1 stop4h 37m
Mon 9/217:11 pm -
1 stop4h 22m
Deal found 8/30![United Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
1 stop6h 15m
Mon 9/215:18 pm -
1 stop7h 11m
Deal found 8/29![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:35 am -
1 stop6h 36m
Sun 9/207:11 pm -
1 stop4h 33m
Deal found 8/30![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:07 pm -
1 stop5h 20m
Sun 9/275:43 am -
1 stop5h 04m
Deal found 9/2![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:07 pm -
1 stop5h 16m
Wed 9/305:28 am -
1 stop5h 19m
Deal found 8/28![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:00 am -
1 stop4h 37m
Mon 10/56:25 pm -
1 stop4h 46m
Deal found 8/29![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:56 pm -
1 stop5h 08m
Tue 10/65:00 am -
1 stop6h 34m
Deal found 9/1![American Airlines logo]()
$290
One-way flights from South Dakota to MissouriSearch for one-way flight options from South Dakota to Missouri. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
Search for one-way flight options from South Dakota to Missouri. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:55 am -
3 stops51h 15m
Deal found 8/31![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:39 pm -
1 stop15h 23m
Deal found 9/1![Allegiant Air logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/218:52 pm -
2 stops40h 18m
Deal found 8/31![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:02 pm -
3 stops45h 15m
Deal found 9/2![Multiple Airlines logo]()
$260
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:48 pm -
1 stop6h 09m
Deal found 8/31![American Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:39 pm -
1 stop4h 49m
Deal found 8/31![American Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:26 pm -
2 stops31h 22m
Deal found 8/31![Multiple Airlines logo]()
$265
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:00 am -
1 stop4h 37m
Deal found 8/29![United Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:55 am -
1 stop6h 36m
Deal found 8/31![Delta logo]()
$274
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:16 am -
2 stops11h 13m
Deal found 8/31![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:34 pm -
1 stop19h 08m
Deal found 9/1![Allegiant Air logo]()
$288
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:12 am -
1 stop4h 26m
Deal found 8/29![United Airlines logo]()
$323
Find flight deals from South Dakota to Missouri
Keep the following information in mind while searching for South Dakota to Missouri flight deals. Data was last updated September 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (American Airlines) |
One-way from | $145 (Kiwi.com) |
Popular in | May |
Cheapest in | December |
Average price | $388 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Dakota to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
Use the filters below to find and compare flights from South Dakota to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Wed 9/30
6:41 pm-12:27 am
1 stop5h 46m
Lambert-St Louis
Sat 10/3
11:01 am-8:45 pm
2 stops9h 44m
$286
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Wed 9/30
7:50 am-12:13 pm
1 stop4h 23m
Lambert-St Louis
Sun 10/4
5:36 pm-11:11 pm
1 stop5h 35m
$290
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Tue 9/29
12:56 pm-6:04 pm
1 stop5h 08m
Lambert-St Louis
Tue 10/6
5:00 am-11:34 am
1 stop6h 34m
$290
Sioux FallsSpringfield
FSD Sioux Falls Joe Foss Field - SGF Springfield-Branson
FSDSGF
Sioux Falls Joe Foss Field
Mon 9/28
6:00 am-10:37 am
1 stop4h 37m
Springfield-Branson
Mon 10/5
6:25 pm-11:11 pm
1 stop4h 46m
$299
Sioux FallsKansas City
FSD Sioux Falls Joe Foss Field - MCI Kansas City
FSDMCI
Sioux Falls Joe Foss Field
Fri 9/18
5:59 pm-11:24 pm
1 stop5h 25m
Kansas City
Tue 9/22
1:03 pm-7:42 pm
1 stop6h 39m
$314
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Wed 9/16
9:35 am-4:34 pm
1 stop6h 59m
Lambert-St Louis
Sun 9/20
6:55 pm-11:44 pm
1 stop4h 49m
$329
Quickest round-trip
Rapid CityKansas City
RAP Rapid City - MCI Kansas City
RAPMCI
Rapid City
Thu 9/17
7:00 am-12:37 pm
1 stop4h 37m
Kansas City
Mon 9/21
7:11 pm-10:33 pm
1 stop4h 22m
$341
Sioux FallsKansas City
FSD Sioux Falls Joe Foss Field - MCI Kansas City
FSDMCI
Sioux Falls Joe Foss Field
Fri 11/27
9:32 am-4:11 pm
1 stop6h 39m
Kansas City
Fri 11/27
6:45 pm-11:29 pm
1 stop4h 44m
$347
Rapid CitySt. Louis
RAP Rapid City - STL Lambert-St Louis
RAPSTL
Rapid City
Wed 9/16
6:07 pm-12:27 am
1 stop5h 20m
Lambert-St Louis
Sun 9/20
5:43 am-9:47 am
1 stop5h 04m
$349
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Wed 10/28
1:20 pm-8:59 pm
1 stop7h 39m
Lambert-St Louis
Sat 10/31
1:40 pm-8:04 pm
1 stop6h 24m
$351
Showing 1-10 of 43 resultsSorted by cheapest first
Best time to book a flight from South Dakota to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Dakota with our price prediction graph.
FSD-STL
RAP-SGF
FSD-MCI
RAP-STL
FSD-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Dakota to Missouri
USSD-USMO
FSD-STL
RAP-SGF
FSD-MCI
RAP-STL
What is the cheapest month to book a flight from South Dakota to Missouri?
Currently, December is the cheapest month in which you can book a flight from South Dakota to Missouri (average of $329). Flying from South Dakota to Missouri in June is currently the most expensive (average of $617). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 2, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Dakota to Missouri have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from South Dakota to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Dakota to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Dakota to Missouri by cabin class
Find flights from South Dakota to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Dakota and Missouri flights
Browse other South Dakota and Missouri flight options. Last updated on September 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Dakota after your stay in Missouri
South Dakota to Missouri flights
Consider these flights traveling from South Dakota to Missouri.
Top 3 airlines flying from South Dakota to Missouri
Discover the top 3 airlines that operate flights from South Dakota to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$192 | Average$423 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$208 | Average$356 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$348 | FlexibilityNo cancel fee | On-time71% |