$70+ Cheap flights from Pittsburgh (PIT) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
PIT — STL
May 18 — May 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Pittsburgh to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Pittsburgh to Missouri
Cheapest
Best
Last-minute
One-way
Cheapest flights from Pittsburgh to MissouriExplore the most affordable flight options available from Pittsburgh to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
Explore the most affordable flight options available from Pittsburgh to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:50 am
PIT
- STL
Nonstop1h 50m
Southwest
Wed 5/1310:15 am
STL
- PIT
Nonstop1h 40m
Southwest
Deal found 4/17![Southwest logo]()
$217
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:56 pm
PIT
- STL
1 stop8h 58m
American Airlines
Tue 6/96:00 am
STL
- PIT
1 stop8h 04m
American Airlines
Deal found 4/14![American Airlines logo]()
$223
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:50 am
PIT
- STL
Nonstop1h 50m
Southwest
Sat 5/165:40 am
STL
- PIT
1 stop3h 25m
Southwest
Deal found 4/17![Southwest logo]()
$226
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:10 pm
PIT
- STL
Nonstop1h 50m
Southwest
Sat 5/306:55 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/14![Southwest logo]()
$227
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/233:56 pm
PIT
- STL
1 stop9h 00m
American Airlines
Mon 6/297:00 am
STL
- PIT
1 stop4h 33m
American Airlines
Deal found 4/15![American Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:50 pm
PIT
- STL
1 stop5h 09m
Delta
Tue 6/96:10 pm
STL
- PIT
1 stop4h 57m
Delta
Deal found 4/16![Delta logo]()
$235
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 am
PIT
- STL
Nonstop1h 50m
Southwest
Thu 5/147:40 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/16![Southwest logo]()
$241
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:45 pm
PIT
- STL
1 stop7h 30m
Southwest
Tue 6/167:10 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/13![Southwest logo]()
$246
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:12 am
PIT
- STL
1 stop8h 51m
American Airlines
Sat 5/99:10 am
STL
- PIT
1 stop4h 30m
American Airlines
Deal found 4/14![American Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:15 pm
PIT
- MCI
1 stop14h 14m
Multiple Airlines
Wed 5/136:24 pm
MCI
- PIT
2 stops26h 43m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/412:04 pm
PIT
- MCI
2 stops30h 25m
Multiple Airlines
Mon 6/810:35 am
MCI
- PIT
1 stop7h 45m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:35 am
PIT
- MCI
2 stops29h 23m
Multiple Airlines
Sun 5/33:37 pm
MCI
- PIT
1 stop7h 22m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$305
Best flights from Pittsburgh to MissouriDiscover carefully curated flight deals from Pittsburgh to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
Discover carefully curated flight deals from Pittsburgh to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:50 am
PIT
- STL
Nonstop1h 50m
Southwest
Wed 5/1310:15 am
STL
- PIT
Nonstop1h 40m
Southwest
Deal found 4/17![Southwest logo]()
$217
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:40 am
PIT
- STL
1 stop4h 08m
Delta
Mon 5/116:04 pm
STL
- PIT
1 stop3h 34m
Delta
Deal found 4/16![Delta logo]()
$235
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:11 pm
PIT
- STL
1 stop4h 05m
United Airlines
Fri 5/299:23 am
STL
- PIT
1 stop5h 00m
United Airlines
Deal found 4/13![United Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:10 pm
PIT
- STL
Nonstop1h 50m
Southwest
Sat 5/306:55 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/14![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:00 pm
PIT
- STL
1 stop5h 16m
Delta
Sat 5/166:45 am
STL
- PIT
1 stop3h 56m
Delta
Deal found 4/15![Delta logo]()
$255
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:45 pm
PIT
- STL
1 stop5h 53m
Delta
Mon 5/256:45 am
STL
- PIT
1 stop3h 28m
Delta
Deal found 4/14![Delta logo]()
$255
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 am
PIT
- STL
Nonstop1h 50m
Southwest
Mon 5/187:40 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/13![Southwest logo]()
$265
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:15 am
PIT
- STL
Nonstop1h 50m
Southwest
Mon 5/1110:15 am
STL
- PIT
Nonstop1h 40m
Southwest
Deal found 4/13![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:45 am
PIT
- JLN
1 stop5h 52m
United Airlines
Wed 5/69:06 am
JLN
- PIT
1 stop5h 15m
United Airlines
Deal found 4/17![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:05 am
PIT
- SGF
1 stop4h 35m
United Airlines
Wed 6/36:00 am
SGF
- PIT
2 stops7h 03m
United Airlines
Deal found 4/17![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:25 pm
PIT
- SGF
1 stop7h 04m
Delta
Tue 9/156:45 pm
SGF
- PIT
1 stop4h 37m
Delta
Deal found 4/14![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:50 pm
PIT
- MCI
1 stop6h 00m
Southwest
Mon 5/115:50 pm
MCI
- PIT
1 stop3h 25m
Southwest
Deal found 4/16![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:50 pm
PIT
- MCI
1 stop6h 00m
Southwest
Sat 6/65:20 pm
MCI
- PIT
1 stop4h 15m
Southwest
Deal found 4/13![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:06 pm
PIT
- MCI
2 stops9h 53m
United Airlines
Wed 6/36:00 am
MCI
- PIT
1 stop6h 09m
United Airlines
Deal found 4/15![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:05 pm
PIT
- MCI
1 stop6h 53m
Delta
Mon 10/126:42 pm
MCI
- PIT
1 stop4h 37m
Delta
Deal found 4/16![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:35 pm
PIT
- MCI
1 stop6h 32m
United Airlines
Sun 10/118:00 am
MCI
- PIT
1 stop4h 09m
United Airlines
Deal found 4/14![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:35 pm
PIT
- MCI
1 stop7h 10m
Southwest
Tue 8/1811:20 am
MCI
- PIT
1 stop5h 15m
Southwest
Deal found 4/18![Southwest logo]()
$357
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:40 pm
PIT
- MCI
1 stop4h 51m
Delta
Sun 5/317:05 am
MCI
- PIT
1 stop4h 39m
Delta
Deal found 4/14![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/291:05 pm
PIT
- SGF
1 stop6h 36m
United Airlines
Wed 9/26:15 am
SGF
- PIT
1 stop8h 37m
United Airlines
Deal found 4/16![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:54 am
PIT
- JLN
1 stop5h 43m
United Airlines
Sat 5/29:06 am
JLN
- PIT
1 stop6h 49m
United Airlines
Deal found 4/13![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:25 am
PIT
- MCI
1 stop7h 10m
Southwest
Sun 7/195:05 am
MCI
- PIT
1 stop4h 00m
Southwest
Deal found 4/18![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:25 pm
PIT
- SGF
1 stop6h 22m
United Airlines
Mon 5/44:50 pm
SGF
- PIT
1 stop5h 54m
United Airlines
Deal found 4/14![United Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:35 pm
PIT
- MCI
1 stop5h 55m
Southwest
Sun 10/49:55 am
MCI
- PIT
1 stop7h 30m
Southwest
Deal found 4/16![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:50 pm
PIT
- SGF
1 stop6h 42m
United Airlines
Sun 5/36:00 am
SGF
- PIT
1 stop6h 11m
United Airlines
Deal found 4/15![United Airlines logo]()
$424
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:45 am
PIT
- MCI
2 stops7h 15m
Southwest
Sun 6/148:30 am
MCI
- PIT
1 stop3h 35m
Southwest
Deal found 4/16![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:00 am
PIT
- SGF
1 stop4h 43m
United Airlines
Tue 9/155:40 am
SGF
- PIT
2 stops11h 46m
United Airlines
Deal found 4/14![United Airlines logo]()
$438
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:55 am
PIT
- MCI
1 stop3h 45m
Southwest
Sun 5/108:25 am
MCI
- PIT
2 stops5h 40m
Southwest
Deal found 4/15![Southwest logo]()
$432
Last-minute flights from Pittsburgh to MissouriDiscover last-minute flight deals from Pittsburgh to Missouri. Data last updated April 18, 2026 and is based on user searches.
Discover last-minute flight deals from Pittsburgh to Missouri. Data last updated April 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:35 am
PIT
- MCI
2 stops29h 23m
Multiple Airlines
Sun 5/33:37 pm
MCI
- PIT
1 stop7h 22m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$305
This Trip.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:59 am
PIT
- STL
1 stop14h 20m
Frontier
Sun 5/34:59 pm
STL
- PIT
1 stop15h 31m
Frontier
Deal found 4/15![Frontier logo]()
$253
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:12 am
PIT
- STL
1 stop8h 51m
American Airlines
Sat 5/99:10 am
STL
- PIT
1 stop4h 30m
American Airlines
Deal found 4/14![American Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:15 pm
PIT
- MCI
1 stop14h 14m
Multiple Airlines
Wed 5/136:24 pm
MCI
- PIT
2 stops26h 43m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:50 am
PIT
- STL
Nonstop1h 50m
Southwest
Wed 5/1310:15 am
STL
- PIT
Nonstop1h 40m
Southwest
Deal found 4/17![Southwest logo]()
$217
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:09 pm
PIT
- STL
1 stop8h 10m
American Airlines
Wed 5/135:51 am
STL
- PIT
1 stop9h 57m
American Airlines
Deal found 4/17![American Airlines logo]()
$223
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:50 am
PIT
- STL
Nonstop1h 50m
Southwest
Sat 5/165:40 am
STL
- PIT
1 stop3h 25m
Southwest
Deal found 4/17![Southwest logo]()
$226
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:09 pm
PIT
- STL
1 stop9h 47m
American Airlines
Wed 5/206:54 pm
STL
- PIT
1 stop4h 29m
American Airlines
Deal found 4/15![American Airlines logo]()
$229
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 am
PIT
- STL
Nonstop1h 50m
Southwest
Thu 5/147:40 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/16![Southwest logo]()
$241
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:50 pm
PIT
- STL
1 stop5h 09m
Delta
Mon 5/256:45 am
STL
- PIT
1 stop3h 28m
Delta
Deal found 4/16![Delta logo]()
$235
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:25 am
PIT
- STL
1 stop8h 55m
Southwest
Mon 5/257:40 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/15![Southwest logo]()
$251
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:10 pm
PIT
- STL
Nonstop1h 50m
Southwest
Sat 5/306:55 pm
STL
- PIT
Nonstop1h 35m
Southwest
Deal found 4/14![Southwest logo]()
$227
One-way flights from Pittsburgh to MissouriSearch for one-way flight options from Pittsburgh to Missouri. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
Search for one-way flight options from Pittsburgh to Missouri. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:15 pm
PIT
- STL
1 stop6h 06m
Frontier
Deal found 4/14![Frontier logo]()
$70
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:05 pm
PIT
- STL
1 stop29h 16m
Frontier
Deal found 4/13![Frontier logo]()
$91
This Trip.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:59 am
PIT
- STL
1 stop14h 20m
Frontier
Deal found 4/17![Frontier logo]()
$99
This Trip.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:44 am
PIT
- STL
1 stop15h 37m
Frontier
Deal found 4/16![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:15 pm
PIT
- STL
2 stops37h 40m
Frontier
Deal found 4/16![Frontier logo]()
$108
This Frontier deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:09 pm
PIT
- STL
1 stop6h 00m
Frontier
Deal found 4/15![Frontier logo]()
$109
This Priceline deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:00 pm
PIT
- STL
1 stop6h 21m
Frontier
Deal found 4/14![Frontier logo]()
$111
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:09 pm
PIT
- STL
1 stop6h 00m
Frontier
Deal found 4/14![Frontier logo]()
$115
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/233:56 pm
PIT
- STL
1 stop9h 00m
American Airlines
Deal found 4/14![American Airlines logo]()
$117
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:20 pm
PIT
- STL
1 stop6h 36m
Delta
Deal found 4/17![Delta logo]()
$118
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:10 pm
PIT
- STL
Nonstop1h 50m
Southwest
Deal found 4/13![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:15 pm
PIT
- STL
1 stop29h 06m
Frontier
Deal found 4/13![Frontier logo]()
$121
Find flight deals from Pittsburgh to Missouri
Keep the following information in mind while searching for Pittsburgh to Missouri flight deals. Data was last updated April 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $217 (Southwest) |
One-way from | $70 (Frontier) |
Popular in | October |
Cheapest in | November |
Average price | $349 |
Good round-trip deal | $378 or less |
Good one-way deal | $172 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Pittsburgh to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Pittsburgh to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Tue 5/12
6:50 am-7:40 am
Nonstop1h 50m
Lambert-St Louis
Wed 5/13
10:15 am-12:55 pm
Nonstop1h 40m
$217
Quickest round-trip
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Wed 5/27
7:10 pm-8:00 pm
Nonstop1h 50m
Lambert-St Louis
Sat 5/30
6:55 pm-9:30 pm
Nonstop1h 35m
$227
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Sat 5/9
5:40 am-8:48 am
1 stop4h 08m
Lambert-St Louis
Mon 5/11
6:04 pm-10:38 pm
1 stop3h 34m
$235
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Thu 5/14
1:00 pm-5:16 pm
1 stop5h 16m
Lambert-St Louis
Sat 5/16
6:45 am-11:41 am
1 stop3h 56m
$255
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Thu 5/21
4:45 pm-9:38 pm
1 stop5h 53m
Lambert-St Louis
Mon 5/25
6:45 am-11:13 am
1 stop3h 28m
$255
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Thu 5/14
6:55 am-7:45 am
Nonstop1h 50m
Lambert-St Louis
Mon 5/18
7:40 pm-10:15 pm
Nonstop1h 35m
$265
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Sat 5/9
7:15 am-8:05 am
Nonstop1h 50m
Lambert-St Louis
Mon 5/11
10:15 am-12:55 pm
Nonstop1h 40m
$265
PittsburghSt. Louis
PIT - STL
PITSTL
Pittsburgh
Thu 5/28
6:11 pm-9:16 pm
1 stop4h 05m
Lambert-St Louis
Fri 5/29
9:23 am-3:23 pm
1 stop5h 00m
$281
PittsburghKansas City
PIT - MCI
PITMCI
Pittsburgh
Thu 5/7
6:50 pm-11:50 pm
1 stop6h 00m
Kansas City
Mon 5/11
5:50 pm-10:15 pm
1 stop3h 25m
$321
PittsburghKansas City
PIT - MCI
PITMCI
Pittsburgh
Mon 6/1
6:50 pm-11:50 pm
1 stop6h 00m
Kansas City
Sat 6/6
5:20 pm-10:35 pm
1 stop4h 15m
$321
Showing 1-10 of 52 resultsSorted by cheapest first
Best time to book a flight from Pittsburgh to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Pittsburgh with our price prediction graph.
PIT-STL
PIT-MCI
PIT-JLN
PIT-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Pittsburgh to Missouri
PIT-USMO
PIT-STL
PIT-MCI
PIT-JLN
PIT-SGF
What is the cheapest month to book a flight from Pittsburgh to Missouri?
Currently, November is the cheapest month in which you can book a flight from Pittsburgh to Missouri (average of $116). Flying from Pittsburgh to Missouri in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PIT to MO?
Find hourly flight availability from Pittsburgh to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 18, 2026.
It’s optimal to fly from Pittsburgh to Missouri at noon. By choosing this option you can save up to 29% on the cost of your flight, compared to a flight in the morning.
How much does it cost to fly round-trip from Pittsburgh to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 18, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Pittsburgh to Missouri by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Pittsburgh to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Pittsburgh to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Pittsburgh to Missouri by cabin class
Find flights from Pittsburgh to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Pittsburgh and Missouri flights
Browse other Pittsburgh and Missouri flight options. Last updated on April 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Pittsburgh to Missouri flights
Consider these flights traveling from Pittsburgh to Missouri.
Top 4 airlines flying from Pittsburgh to Missouri
Discover the top 4 airlines that operate flights from Pittsburgh to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$170 | Average$350 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$424 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$221 | Average$385 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$421 | FlexibilityNo cancel fee | On-timeN/A |