$49+ Cheap flights from Indiana to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
IND — STL
Mar 29 — Apr 51
1 adult, Economy
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Find cheap flights from Indiana to Missouri with Cheapflights
1. Tell us where you want to go
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Cheapest flights from Indiana to MissouriExplore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 27, 2026.
Explore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 27, 2026.
This Frontier deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/102:26 pm
CVG
- STL
1 stop10h 32m
Frontier
Fri 4/178:39 am
STL
- CVG
1 stop9h 44m
Frontier
Deal found 2/25![Frontier logo]()
$160
This Frontier deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:35 am
CVG
- MCI
1 stop13h 23m
Frontier
Mon 4/2011:13 am
MCI
- CVG
1 stop6h 23m
Frontier
Deal found 2/26![Frontier logo]()
$161
This Trip.com deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:20 am
CVG
- STL
1 stop27h 29m
Frontier
Wed 3/114:51 pm
STL
- CVG
1 stop6h 50m
Frontier
Deal found 2/24![Frontier logo]()
$170
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:50 pm
ORD
- COU
Nonstop1h 29m
American Airlines
Mon 3/236:30 pm
COU
- ORD
Nonstop1h 35m
American Airlines
Deal found 2/23![American Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:40 pm
ORD
- SGF
Nonstop1h 51m
American Airlines
Sun 4/57:36 am
SGF
- ORD
Nonstop1h 51m
American Airlines
Deal found 2/25![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:00 am
ORD
- SGF
Nonstop1h 41m
American Airlines
Sat 10/317:42 pm
SGF
- ORD
Nonstop1h 48m
American Airlines
Deal found 2/24![American Airlines logo]()
$190
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/212:27 pm
ORD
- COU
Nonstop1h 31m
American Airlines
Tue 4/215:21 pm
COU
- ORD
1 stop15h 29m
American Airlines
Deal found 2/25![American Airlines logo]()
$191
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:08 pm
ORD
- COU
Nonstop1h 51m
United Airlines
Sun 7/268:00 am
COU
- ORD
Nonstop1h 40m
United Airlines
Deal found 2/26![United Airlines logo]()
$193
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:58 pm
ORD
- COU
Nonstop1h 35m
United Airlines
Mon 3/232:41 pm
COU
- ORD
Nonstop1h 28m
United Airlines
Deal found 2/26![United Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:41 pm
CVG
- STL
1 stop15h 56m
Frontier
Wed 3/188:12 pm
STL
- CVG
1 stop17h 12m
Frontier
Deal found 2/23![Frontier logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:00 am
ORD
- SGF
Nonstop1h 51m
American Airlines
Tue 4/2110:54 am
SGF
- ORD
1 stop10h 19m
American Airlines
Deal found 2/25![American Airlines logo]()
$202
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:40 pm
ORD
- SGF
Nonstop1h 58m
United Airlines
Sun 3/226:08 pm
SGF
- ORD
Nonstop1h 58m
United Airlines
Deal found 2/24![United Airlines logo]()
$204
Best flights from Indiana to MissouriDiscover carefully curated flight deals from Indiana to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 27, 2026.
Discover carefully curated flight deals from Indiana to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 27, 2026.
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:50 pm
ORD
- COU
Nonstop1h 43m
United Airlines
Sat 4/411:30 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 2/23![United Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/108:00 am
ORD
- COU
Nonstop1h 28m
American Airlines
Sat 3/146:50 pm
COU
- ORD
Nonstop1h 35m
American Airlines
Deal found 2/23![American Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:59 pm
IND
- MCI
1 stop4h 04m
Delta
Wed 4/86:05 am
MCI
- IND
1 stop4h 28m
Delta
Deal found 2/23![Delta logo]()
$232
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:15 am
MDW
- STL
1 stop4h 50m
Southwest
Sun 4/264:40 pm
STL
- MDW
Nonstop1h 10m
Southwest
Deal found 2/23![Southwest logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:42 pm
SDF
- MCI
1 stop23h 47m
Spirit Airlines
Tue 3/3112:24 pm
MCI
- SDF
2 stops21h 50m
Spirit Airlines
Deal found 2/23![Spirit Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:50 pm
ORD
- COU
Nonstop1h 43m
United Airlines
Mon 4/2011:30 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 2/27![United Airlines logo]()
$179
This Alaska Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
ORD
- MCI
1 stop17h 59m
Alaska Airlines
Mon 4/206:15 am
MCI
- ORD
1 stop24h 24m
Alaska Airlines
Deal found 2/26![Alaska Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:13 pm
ORD
- COU
Nonstop1h 43m
United Airlines
Sun 4/58:00 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 2/24![United Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:27 pm
ORD
- COU
Nonstop1h 31m
American Airlines
Thu 4/166:00 am
COU
- ORD
Nonstop1h 43m
American Airlines
Deal found 2/23![American Airlines logo]()
$222
This Delta deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:13 am
IND
- MCI
1 stop4h 38m
Delta
Sat 4/1810:36 am
MCI
- IND
1 stop3h 40m
Delta
Deal found 2/26![Delta logo]()
$243
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1212:40 pm
ORD
- COU
Nonstop1h 26m
United Airlines
Sun 3/158:00 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 2/23![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:50 am
MDW
- MCI
Nonstop1h 30m
Southwest
Sun 5/36:05 pm
MCI
- MDW
1 stop6h 15m
Southwest
Deal found 2/26![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:15 am
ORD
- COU
Nonstop1h 31m
American Airlines
Sun 4/196:00 am
COU
- ORD
Nonstop1h 43m
American Airlines
Deal found 2/27![American Airlines logo]()
$249
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:20 pm
MDW
- STL
1 stop4h 05m
Delta
Mon 4/136:19 am
STL
- MDW
2 stops6h 24m
Delta
Deal found 2/24![Delta logo]()
$263
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/263:35 pm
ORD
- SGF
Nonstop1h 58m
United Airlines
Mon 3/306:30 pm
SGF
- ORD
Nonstop1h 48m
United Airlines
Deal found 2/26![United Airlines logo]()
$218
This Southwest deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:40 am
MDW
- STL
Nonstop1h 15m
Southwest
Mon 4/275:40 am
STL
- MDW
Nonstop1h 10m
Southwest
Deal found 2/24![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/178:50 am
ORD
- SGF
Nonstop1h 56m
United Airlines
Sat 3/217:45 am
SGF
- ORD
Nonstop1h 55m
United Airlines
Deal found 2/24![United Airlines logo]()
$218
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:13 am
IND
- MCI
1 stop4h 38m
Delta
Sun 3/296:35 am
MCI
- IND
1 stop3h 39m
Delta
Deal found 2/24![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:40 am
SDF
- MCI
2 stops6h 35m
Southwest
Wed 4/155:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Deal found 2/26![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/148:50 am
ORD
- SGF
Nonstop1h 56m
United Airlines
Wed 3/1811:21 am
SGF
- ORD
Nonstop1h 49m
United Airlines
Deal found 2/27![United Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:04 pm
ORD
- STL
2 stops6h 09m
Delta
Mon 5/412:23 pm
STL
- ORD
2 stops8h 17m
Delta
Deal found 2/24![Delta logo]()
$268
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:13 pm
CVG
- STL
1 stop8h 43m
American Airlines
Mon 5/187:05 am
STL
- CVG
1 stop6h 33m
American Airlines
Deal found 2/25![American Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:00 am
MDW
- MCI
2 stops6h 35m
Southwest
Sun 4/1210:20 pm
MCI
- MDW
Nonstop1h 25m
Southwest
Deal found 2/23![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
MDW
- MCI
1 stop5h 20m
Delta
Thu 4/236:30 am
MCI
- MDW
1 stop6h 13m
Delta
Deal found 2/23![Delta logo]()
$270
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/279:55 pm
MDW
- STL
Nonstop1h 15m
Southwest
Mon 3/309:50 pm
STL
- MDW
Nonstop1h 10m
Southwest
Deal found 2/25![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:30 am
ORD
- MCI
Nonstop1h 54m
United Airlines
Wed 4/2211:30 am
MCI
- ORD
Nonstop1h 43m
United Airlines
Deal found 2/23![United Airlines logo]()
$241
This Mytrip deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1312:09 pm
SDF
- MCI
3 stops24h 20m
Spirit Airlines
Tue 3/1712:24 pm
MCI
- SDF
2 stops21h 50m
Spirit Airlines
Deal found 2/26![Spirit Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:29 pm
IND
- MCI
1 stop6h 32m
Delta
Sun 5/36:00 am
MCI
- IND
1 stop4h 42m
Delta
Deal found 2/24![Delta logo]()
$281
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1910:30 am
ORD
- MCI
Nonstop1h 54m
United Airlines
Mon 4/206:45 pm
MCI
- ORD
Nonstop1h 50m
United Airlines
Deal found 2/23![United Airlines logo]()
$241
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:30 pm
MDW
- STL
1 stop5h 10m
Southwest
Sun 4/55:20 am
STL
- MDW
Nonstop1h 10m
Southwest
Deal found 2/26![Southwest logo]()
$297
Last-minute flights from Indiana to MissouriDiscover last-minute flight deals from Indiana to Missouri. Data last updated February 27, 2026 and is based on user searches.
Discover last-minute flight deals from Indiana to Missouri. Data last updated February 27, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:20 am
CVG
- STL
1 stop27h 29m
Frontier
Wed 3/114:51 pm
STL
- CVG
1 stop6h 50m
Frontier
Deal found 2/24![Frontier logo]()
$170
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:00 am
ORD
- COU
Nonstop1h 33m
United Airlines
Sun 3/158:00 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 2/24![United Airlines logo]()
$209
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:35 pm
ORD
- SGF
Nonstop1h 58m
United Airlines
Mon 3/166:08 pm
SGF
- ORD
Nonstop1h 58m
United Airlines
Deal found 2/25![United Airlines logo]()
$219
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:40 pm
ORD
- SGF
Nonstop1h 58m
United Airlines
Sun 3/226:08 pm
SGF
- ORD
Nonstop1h 58m
United Airlines
Deal found 2/24![United Airlines logo]()
$204
This Expedia deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:45 am
CVG
- STL
1 stop18h 34m
Frontier
Wed 3/184:51 pm
STL
- CVG
1 stop13h 32m
Frontier
Deal found 2/27![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:05 am
MDW
- MCI
1 stop11h 20m
Frontier
Wed 3/1811:45 am
MCI
- MDW
1 stop10h 34m
Frontier
Deal found 2/23![Frontier logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:41 pm
CVG
- STL
1 stop15h 56m
Frontier
Wed 3/188:12 pm
STL
- CVG
1 stop17h 12m
Frontier
Deal found 2/23![Frontier logo]()
$197
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:58 pm
ORD
- COU
Nonstop1h 35m
United Airlines
Mon 3/232:41 pm
COU
- ORD
Nonstop1h 28m
United Airlines
Deal found 2/26![United Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:50 pm
ORD
- COU
Nonstop1h 29m
American Airlines
Mon 3/236:30 pm
COU
- ORD
Nonstop1h 35m
American Airlines
Deal found 2/23![American Airlines logo]()
$179
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/263:35 pm
ORD
- SGF
Nonstop1h 58m
United Airlines
Mon 3/306:30 pm
SGF
- ORD
Nonstop1h 48m
United Airlines
Deal found 2/26![United Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:43 pm
ORD
- SGF
Nonstop1h 47m
American Airlines
Sun 3/297:36 am
SGF
- ORD
Nonstop1h 51m
American Airlines
Deal found 2/26![American Airlines logo]()
$189
This Frontier deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:01 am
ORD
- MCI
1 stop11h 22m
Frontier
Thu 4/3011:53 am
MCI
- ORD
1 stop10h 46m
Frontier
Deal found 2/25![Frontier logo]()
$215
One-way flights from Indiana to MissouriSearch for one-way flight options from Indiana to Missouri. Find affordable one-way fares based on user searches. Data last updated February 27, 2026.
Search for one-way flight options from Indiana to Missouri. Find affordable one-way fares based on user searches. Data last updated February 27, 2026.
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:55 pm
MDW
- STL
Nonstop1h 10m
Southwest
Deal found 2/27![Southwest logo]()
$49
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:00 am
ORD
- STL
Nonstop1h 25m
United Airlines
Deal found 2/25![United Airlines logo]()
$49
This Southwest deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:00 am
MDW
- STL
Nonstop1h 15m
Southwest
Deal found 2/24![Southwest logo]()
$58
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:15 am
MDW
- STL
Nonstop1h 15m
Southwest
Deal found 2/27![Southwest logo]()
$59
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:30 pm
ORD
- STL
Nonstop1h 26m
United Airlines
Deal found 2/25![United Airlines logo]()
$59
This Southwest deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:05 pm
MDW
- STL
1 stop5h 15m
Southwest
Deal found 2/24![Southwest logo]()
$68
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:05 pm
ORD
- STL
1 stop6h 15m
Southwest
Deal found 2/23![Southwest logo]()
$68
This Southwest deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:40 pm
ORD
- STL
1 stop6h 15m
Southwest
Deal found 2/24![Southwest logo]()
$69
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:41 pm
CVG
- STL
1 stop15h 56m
Frontier
Deal found 2/23![Frontier logo]()
$71
This Trip.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:50 pm
CVG
- STL
1 stop18h 29m
Frontier
Deal found 2/23![Frontier logo]()
$73
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:17 pm
CVG
- MCI
1 stop18h 49m
Frontier
Deal found 2/23![Frontier logo]()
$74
This Kiwi.com deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:17 pm
CVG
- STL
1 stop24h 15m
Frontier
Deal found 2/25![Frontier logo]()
$74
Find flight deals from Indiana to Missouri
Keep the following information in mind while searching for Indiana to Missouri flight deals. Data was last updated February 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $160 (Frontier) |
One-way from | $49 (Southwest) |
Popular in | February |
Cheapest in | November |
Average price | $574 |
Good round-trip deal | $430 or less |
Good one-way deal | $204 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indiana to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
Use the filters below to find and compare flights from Indiana to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Thu 4/2
10:50 pm-12:33 am
Nonstop1h 43m
Columbia Regional
Sat 4/4
11:30 am-1:00 pm
Nonstop1h 30m
$179
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Fri 4/17
10:50 pm-12:33 am
Nonstop1h 43m
Columbia Regional
Mon 4/20
11:30 am-1:00 pm
Nonstop1h 30m
$179
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Fri 4/3
8:13 pm-9:56 pm
Nonstop1h 43m
Columbia Regional
Sun 4/5
8:00 am-9:30 am
Nonstop1h 30m
$179
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Tue 3/10
8:00 am-9:28 am
Nonstop1h 28m
Columbia Regional
Sat 3/14
6:50 pm-8:25 pm
Nonstop1h 35m
$209
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Thu 3/12
12:40 pm-2:06 pm
Nonstop1h 26m
Columbia Regional
Sun 3/15
8:00 am-9:30 am
Nonstop1h 30m
$209
ChicagoSpringfield
ORD - SGF
ORDSGF
Chicago O'Hare Intl
Thu 3/26
3:35 pm-5:33 pm
Nonstop1h 58m
Springfield-Branson
Mon 3/30
6:30 pm-8:18 pm
Nonstop1h 48m
$218
ChicagoSpringfield
ORD - SGF
ORDSGF
Chicago O'Hare Intl
Tue 3/17
8:50 am-10:46 am
Nonstop1h 56m
Springfield-Branson
Sat 3/21
7:45 am-9:40 am
Nonstop1h 55m
$218
ChicagoSpringfield
ORD - SGF
ORDSGF
Chicago O'Hare Intl
Sat 3/14
8:50 am-10:46 am
Nonstop1h 56m
Springfield-Branson
Wed 3/18
11:21 am-1:10 pm
Nonstop1h 49m
$219
ChicagoColumbia
ORD - COU
ORDCOU
Chicago O'Hare Intl
Thu 4/9
2:27 pm-3:58 pm
Nonstop1h 31m
Columbia Regional
Thu 4/16
6:00 am-7:43 am
Nonstop1h 43m
$222
IndianapolisKansas City
IND - MCI
INDMCI
Indianapolis
Wed 4/1
7:59 pm-11:03 pm
1 stop4h 04m
Kansas City
Wed 4/8
6:05 am-11:33 am
1 stop4h 28m
$232
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indiana to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Indiana with our price prediction graph.
ORD-COU
IND-MCI
MDW-STL
SDF-MCI
ORD-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indiana to Missouri
USIN-USMO
ORD-COU
IND-MCI
MDW-STL
SDF-MCI
What is the cheapest month to book a flight from Indiana to Missouri?
Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in March is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IN to MO?
Find hourly flight availability from Indiana to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 27, 2026.
A simple way to save on the total cost of your ticket is to fly from Indiana to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 79% on your trip compared to booking a flight in the evening.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 27, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Indiana to Missouri. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Feb 2026
DEN - BDL
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Feb 2026
DEN - BDL
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Feb 2026
DEN - BDL
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Feb 2026
DEN - BDL
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Feb 2026
DEN - BDL
Related info for your journey
Find useful and relevant information for your journey from Indiana to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Indiana to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Indiana to Missouri by cabin class
Find flights from Indiana to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indiana and Missouri flights
Browse other Indiana and Missouri flight options. Last updated on February 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Indiana after your stay in Missouri
Indiana to Missouri flights
Consider these flights traveling from Indiana to Missouri.
Top 4 airlines flying from Indiana to Missouri
Discover the top 4 airlines that operate flights from Indiana to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$178 | Average$333 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$198 | Average$317 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$213 | Average$366 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$221 | Average$329 | FlexibilityNo cancel fee | On-time63% |