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$32+ Cheap flights from Indiana to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
IND — STL
Jan 1 — Jan 81
Thu 1/1
Thu 1/8
1 adult, Economy
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Cheap flight deals from Indiana to Missouri

Cheapest flights from Indiana to Missouri
Explore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 2, 2025.

This Delta deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:31 pmORD - STL
1 stop6h 07mDelta
Thu 12/256:29 amSTL - ORD
1 stop6h 25mDelta
Deal found 11/30$157
This Southwest deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:25 amMDW - STL
Nonstop1h 10mSouthwest
Thu 1/110:15 amSTL - MDW
Nonstop1h 10mSouthwest
Deal found 12/1$168
This Mytrip deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:05 amCVG - STL
1 stop18h 28mFrontier
Tue 1/65:11 pmSTL - CVG
1 stop22h 44mFrontier
Deal found 11/30$172
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:14 amORD - STL
Nonstop1h 34mAmerican Airlines
Wed 1/76:52 amSTL - ORD
1 stop6h 30mAmerican Airlines
Deal found 12/1$174
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:14 amORD - STL
Nonstop1h 34mAmerican Airlines
Thu 1/15:00 amSTL - ORD
1 stop5h 45mAmerican Airlines
Deal found 12/1$178
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:00 amORD - COU
Nonstop1h 39mAmerican Airlines
Sat 12/273:19 pmCOU - ORD
Nonstop1h 31mAmerican Airlines
Deal found 12/1$179
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:14 amORD - STL
Nonstop1h 34mAmerican Airlines
Tue 1/136:46 pmSTL - ORD
Nonstop1h 34mAmerican Airlines
Deal found 11/30$183
This Priceline deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:15 amCVG - MCI
1 stop9h 22mFrontier
Mon 12/2211:13 amMCI - CVG
1 stop6h 01mFrontier
Deal found 11/30$184
This Frontier deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1311:57 amCVG - STL
1 stop11h 36mFrontier
Mon 1/121:07 pmSTL - CVG
1 stop9h 47mFrontier
Deal found 11/30$187
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2412:56 pmORD - STL
Nonstop1h 30mUnited Airlines
Wed 12/319:55 amSTL - ORD
Nonstop1h 35mUnited Airlines
Deal found 11/29$187
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:39 pmORD - STL
1 stop21h 01mMultiple Airlines
Tue 1/135:11 pmSTL - ORD
1 stop24h 41mMultiple Airlines
Deal found 12/1$188
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:45 pmORD - SGF
Nonstop1h 53mUnited Airlines
Mon 1/56:20 pmSGF - ORD
Nonstop1h 51mUnited Airlines
Deal found 11/30$189

Find flight deals from Indiana to Missouri

Keep the following information in mind while searching for Indiana to Missouri flight deals. Data was last updated December 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$135
(Kiwi.com)

One-way from

$32
(Southwest)

Popular in

September

Cheapest in

November

Average price

$388

Good round-trip deal

$305 or less

Good one-way deal

$201 or less
Provider with most accurate pricing for Indianapolis-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Lambert-St Louis flights.
Search Deals
From Indiana to Missouri
Search Deals
One-way flight from Indiana to Missouri
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Indiana to Missouri.
Search Deals
Price to beat on a one-way flight from Indiana to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 2, 2025.
Use the filters below to find and compare flights from Indiana to Missouri that are best for you.

Fly from

Indiana

Fly to

Missouri

Route

Depart

Return

Price

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 1/14

6:05 am-10:34 pm

1 stop16h 29m

Lambert-St Louis

Wed 1/21

5:42 pm-10:41 am

1 stop16h 59m

$146

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Sat 1/17

8:50 am-10:20 am

Nonstop1h 30m

Lambert-St Louis

Wed 1/21

6:00 am-7:27 am

Nonstop1h 27m

$151

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 1/8

9:25 am-11:02 am

Nonstop1h 37m

Lambert-St Louis

Mon 1/12

3:11 pm-4:55 pm

Nonstop1h 44m

$152

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 1/8

6:10 am-2:48 pm

1 stop8h 38m

Lambert-St Louis

Sun 1/11

5:11 pm-11:09 pm

1 stop29h 58m

$156

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Tue 1/13

5:31 pm-11:39 pm

1 stop6h 08m

Lambert-St Louis

Wed 1/14

6:00 am-10:27 am

1 stop4h 27m

$157

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Fri 1/16

7:16 pm-11:25 pm

1 stop4h 09m

Lambert-St Louis

Fri 1/23

3:45 pm-10:22 pm

1 stop6h 37m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 12/25

4:24 pm-5:54 pm

Nonstop1h 30m

Lambert-St Louis

Wed 12/31

9:55 am-11:30 am

Nonstop1h 35m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 12/24

5:31 pm-11:38 pm

1 stop6h 07m

Lambert-St Louis

Thu 12/25

6:29 am-12:54 pm

1 stop6h 25m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 12/31

6:35 am-11:12 am

1 stop4h 37m

Lambert-St Louis

Tue 1/13

6:10 am-11:47 am

1 stop5h 37m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 1/8

1:55 pm-8:43 pm

1 stop6h 48m

Lambert-St Louis

Mon 1/12

6:35 am-1:08 pm

1 stop6h 33m

$157

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Missouri

What is the cheapest month to book a flight from Indiana to Missouri?

Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to MO?

Find hourly flight availability from Indiana to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 2, 2025.

A simple way to save on the total cost of your ticket is to fly from Indiana to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Indiana to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Indiana to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indiana to Missouri flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 2, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Indiana to Missouri. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,253 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Southwest
8.0
Very good
4,253 reviews
Southwest
8.0
Very good
4,253 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Delta
7.9
Good
8,011 reviews
Southwest
8.0
Very good
4,253 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
United Airlines
7.4
Good
9,063 reviews
Southwest
8.0
Very good
4,253 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
American Airlines
7.2
Good
11,045 reviews
Southwest
8.0
Very good
4,253 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Related info for your journey

Find useful and relevant information for your journey from Indiana to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Indiana to Missouri?

    Departing from Indiana to Missouri will take you 1h 30m. There are 258 mi between Indiana and Missouri. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Missouri one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $440. Delta flights start at $460 while deals on United Airlines start at $512 one-way.

  • Can I find deals for flights from Indiana to Missouri that include hotel bookings?

    Yes. In addition to deals on Indiana to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Missouri.

  • Can I find deals for business class flights from Indiana to Missouri?

    Yes. Cheapflights offers flight deals from Indiana to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Missouri?

    Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indiana to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Missouri

Discover the top 4 airlines that operate flights from Indiana to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$178Average$332FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$374FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$345FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$221Average$325FlexibilityNo cancel feeOn-time63%

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