$49+ Cheap flights from Indiana to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
IND — STL
May 17 — May 241
Round-trip
1 adult, Economy
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Cheapest flights from Indiana to MissouriExplore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
Explore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:46 pm
CVG
- MCI
1 stop5h 43m
Frontier
Mon 6/156:16 pm
MCI
- CVG
1 stop15h 58m
Frontier
Deal found 4/14![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:46 pm
CVG
- MCI
1 stop5h 43m
Frontier
Mon 6/86:24 pm
MCI
- CVG
1 stop15h 50m
Frontier
Deal found 4/14![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:54 pm
CVG
- MCI
1 stop5h 27m
Frontier
Fri 6/126:16 pm
MCI
- CVG
1 stop16h 31m
Frontier
Deal found 4/14![Frontier logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:54 pm
CVG
- MCI
1 stop5h 27m
Frontier
Sat 6/136:16 pm
MCI
- CVG
1 stop15h 58m
Frontier
Deal found 4/14![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:14 pm
IND
- MCI
1 stop6h 15m
Frontier
Mon 6/16:24 pm
MCI
- IND
2 stops17h 37m
Frontier
Deal found 4/16![Frontier logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:14 pm
IND
- MCI
1 stop6h 15m
Multiple Airlines
Sat 5/306:24 pm
MCI
- IND
2 stops38h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$173
This Priceline deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:20 pm
CVG
- STL
1 stop6h 59m
Frontier
Sun 5/311:28 am
STL
- CVG
1 stop5h 48m
Frontier
Deal found 4/14![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:30 pm
ORD
- STL
1 stop6h 51m
Frontier
Sun 5/104:19 pm
STL
- ORD
1 stop6h 54m
Frontier
Deal found 4/14![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
MDW
- STL
2 stops17h 19m
Frontier
Mon 5/48:23 pm
STL
- MDW
1 stop14h 46m
Frontier
Deal found 4/13![Frontier logo]()
$182
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:40 pm
ORD
- STL
1 stop6h 16m
Delta
Tue 6/161:59 pm
STL
- ORD
1 stop4h 30m
Delta
Deal found 4/14![Delta logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:46 pm
CVG
- STL
1 stop22h 50m
Frontier
Fri 5/84:19 pm
STL
- CVG
1 stop6h 36m
Frontier
Deal found 4/13![Frontier logo]()
$183
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:19 pm
ORD
- STL
1 stop3h 50m
Delta
Tue 5/1210:19 am
STL
- ORD
1 stop6h 10m
Delta
Deal found 4/13![Delta logo]()
$184
Best flights from Indiana to MissouriDiscover carefully curated flight deals from Indiana to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
Discover carefully curated flight deals from Indiana to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:45 pm
MDW
- STL
Nonstop1h 15m
Southwest
Sat 5/96:55 pm
STL
- MDW
Nonstop1h 10m
Southwest
Deal found 4/12![Southwest logo]()
$191
This Frontier deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2812:12 pm
CVG
- STL
1 stop6h 21m
Frontier
Mon 6/14:19 pm
STL
- CVG
1 stop6h 19m
Frontier
Deal found 4/16![Frontier logo]()
$225
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:34 am
CVG
- MCI
1 stop7h 41m
Delta
Sat 6/133:42 pm
MCI
- CVG
1 stop7h 45m
Delta
Deal found 4/15![Delta logo]()
$227
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:08 pm
ORD
- COU
Nonstop1h 51m
United Airlines
Sun 6/78:00 am
COU
- ORD
Nonstop1h 40m
United Airlines
Deal found 4/13![United Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:20 pm
ORD
- COU
Nonstop1h 36m
American Airlines
Thu 11/127:39 pm
COU
- ORD
Nonstop1h 42m
American Airlines
Deal found 4/13![American Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:45 pm
MDW
- STL
Nonstop1h 15m
Southwest
Sat 6/65:40 am
STL
- MDW
Nonstop1h 05m
Southwest
Deal found 4/15![Southwest logo]()
$191
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:25 am
ORD
- STL
2 stops7h 21m
Delta
Tue 5/198:53 am
STL
- ORD
2 stops9h 12m
Delta
Deal found 4/12![Delta logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:46 pm
CVG
- STL
1 stop21h 09m
Frontier
Sun 5/176:55 pm
STL
- CVG
1 stop15h 46m
Frontier
Deal found 4/12![Frontier logo]()
$232
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:55 pm
MDW
- STL
Nonstop1h 10m
Southwest
Tue 8/258:45 pm
STL
- MDW
Nonstop1h 05m
Southwest
Deal found 4/12![Southwest logo]()
$217
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:08 pm
ORD
- COU
Nonstop1h 51m
United Airlines
Sat 6/63:05 pm
COU
- ORD
Nonstop1h 41m
United Airlines
Deal found 4/15![United Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:55 pm
ORD
- COU
Nonstop1h 34m
American Airlines
Mon 5/184:28 pm
COU
- ORD
Nonstop1h 42m
American Airlines
Deal found 4/16![American Airlines logo]()
$254
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/138:08 pm
ORD
- COU
Nonstop1h 51m
United Airlines
Wed 6/173:05 pm
COU
- ORD
Nonstop1h 41m
United Airlines
Deal found 4/13![United Airlines logo]()
$239
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:52 am
ORD
- STL
1 stop4h 13m
Delta
Sat 5/210:50 am
STL
- ORD
1 stop5h 28m
Delta
Deal found 4/14![Delta logo]()
$245
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:05 am
MDW
- STL
Nonstop1h 25m
Southwest
Tue 6/95:40 am
STL
- MDW
Nonstop1h 05m
Southwest
Deal found 4/16![Southwest logo]()
$228
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:34 pm
ORD
- COU
1 stop5h 12m
American Airlines
Sun 6/216:00 am
COU
- ORD
Nonstop1h 38m
American Airlines
Deal found 4/17![American Airlines logo]()
$264
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:15 am
ORD
- STL
1 stop4h 38m
Delta
Mon 12/144:40 pm
STL
- ORD
1 stop4h 30m
Delta
Deal found 4/14![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:45 am
MDW
- STL
1 stop5h 15m
Southwest
Tue 5/266:40 pm
STL
- MDW
1 stop3h 35m
Southwest
Deal found 4/13![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:45 pm
ORD
- SGF
Nonstop1h 50m
United Airlines
Mon 5/46:22 pm
SGF
- ORD
Nonstop1h 43m
United Airlines
Deal found 4/13![United Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:27 pm
ORD
- COU
Nonstop1h 31m
American Airlines
Sun 5/36:00 am
COU
- ORD
Nonstop1h 43m
American Airlines
Deal found 4/16![American Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:04 pm
ORD
- STL
1 stop3h 40m
Delta
Wed 5/612:23 pm
STL
- ORD
2 stops8h 17m
Delta
Deal found 4/15![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/19:10 pm
MDW
- STL
Nonstop1h 15m
Southwest
Mon 7/62:25 pm
STL
- MDW
1 stop3h 25m
Southwest
Deal found 4/15![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:01 pm
ORD
- STL
Nonstop1h 31m
United Airlines
Mon 5/118:30 pm
STL
- ORD
Nonstop1h 31m
United Airlines
Deal found 4/15![United Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:48 pm
ORD
- COU
1 stop5h 18m
American Airlines
Sun 8/165:17 pm
COU
- ORD
1 stop5h 53m
American Airlines
Deal found 4/16![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:35 am
MDW
- STL
2 stops6h 20m
Southwest
Tue 6/96:05 pm
STL
- MDW
1 stop5h 45m
Southwest
Deal found 4/14![Southwest logo]()
$239
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:05 pm
ORD
- COU
Nonstop1h 43m
United Airlines
Mon 5/48:00 am
COU
- ORD
Nonstop1h 30m
United Airlines
Deal found 4/15![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:00 pm
ORD
- SGF
2 stops8h 19m
Delta
Mon 6/16:49 pm
SGF
- ORD
1 stop5h 10m
Delta
Deal found 4/15![Delta logo]()
$274
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:02 pm
ORD
- SGF
Nonstop2h 00m
United Airlines
Sun 5/36:00 am
SGF
- ORD
Nonstop1h 47m
United Airlines
Deal found 4/14![United Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:41 pm
ORD
- STL
1 stop5h 40m
Delta
Sat 5/234:00 pm
STL
- ORD
1 stop5h 46m
Delta
Deal found 4/16![Delta logo]()
$284
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:55 am
ORD
- SGF
Nonstop1h 53m
United Airlines
Sat 5/26:00 am
SGF
- ORD
Nonstop1h 47m
United Airlines
Deal found 4/12![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 pm
CVG
- STL
1 stop5h 40m
Southwest
Wed 8/127:15 am
STL
- CVG
2 stops6h 40m
Southwest
Deal found 4/15![Southwest logo]()
$280
Last-minute flights from Indiana to MissouriDiscover last-minute flight deals from Indiana to Missouri. Data last updated April 17, 2026 and is based on user searches.
Discover last-minute flight deals from Indiana to Missouri. Data last updated April 17, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:20 pm
CVG
- STL
1 stop6h 59m
Frontier
Sun 5/311:28 am
STL
- CVG
1 stop5h 48m
Frontier
Deal found 4/14![Frontier logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
MDW
- STL
2 stops17h 19m
Frontier
Mon 5/48:23 pm
STL
- MDW
1 stop14h 46m
Frontier
Deal found 4/13![Frontier logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:16 am
ORD
- STL
2 stops14h 03m
Multiple Airlines
Mon 5/48:23 pm
STL
- ORD
1 stop11h 32m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:29 pm
CVG
- STL
2 stops16h 21m
Multiple Airlines
Sat 5/95:27 pm
STL
- CVG
1 stop16h 37m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:46 pm
CVG
- STL
1 stop22h 50m
Frontier
Fri 5/84:19 pm
STL
- CVG
1 stop6h 36m
Frontier
Deal found 4/13![Frontier logo]()
$183
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:59 am
MDW
- STL
1 stop5h 16m
Delta
Tue 5/128:53 am
STL
- MDW
2 stops9h 40m
Delta
Deal found 4/13![Delta logo]()
$189
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:30 pm
ORD
- STL
1 stop6h 51m
Frontier
Sun 5/104:19 pm
STL
- ORD
1 stop6h 54m
Frontier
Deal found 4/14![Frontier logo]()
$181
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:19 pm
ORD
- STL
1 stop3h 50m
Delta
Tue 5/1210:19 am
STL
- ORD
1 stop6h 10m
Delta
Deal found 4/13![Delta logo]()
$184
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:13 pm
MDW
- STL
1 stop4h 08m
Delta
Tue 5/128:53 am
STL
- MDW
2 stops9h 40m
Delta
Deal found 4/14![Delta logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:14 pm
IND
- MCI
1 stop6h 15m
Frontier
Mon 6/16:24 pm
MCI
- IND
2 stops17h 37m
Frontier
Deal found 4/16![Frontier logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:14 pm
IND
- MCI
1 stop6h 15m
Multiple Airlines
Sat 5/306:24 pm
MCI
- IND
2 stops38h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:07 pm
MDW
- STL
1 stop28h 24m
Frontier
Fri 6/55:27 pm
STL
- MDW
1 stop28h 35m
Frontier
Deal found 4/13![Frontier logo]()
$188
One-way flights from Indiana to MissouriSearch for one-way flight options from Indiana to Missouri. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
Search for one-way flight options from Indiana to Missouri. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:15 am
MDW
- STL
Nonstop1h 15m
Southwest
Deal found 4/14![Southwest logo]()
$49
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/177:04 pm
ORD
- STL
Nonstop1h 22m
American Airlines
Deal found 4/14![American Airlines logo]()
$49
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:55 am
ORD
- STL
1 stop6h 00m
Southwest
Deal found 4/13![Southwest logo]()
$59
This Trip.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:46 pm
CVG
- STL
1 stop22h 50m
Frontier
Deal found 4/13![Frontier logo]()
$60
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:46 pm
CVG
- MCI
1 stop5h 43m
Frontier
Deal found 4/13![Frontier logo]()
$63
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2312:24 pm
CVG
- STL
1 stop6h 06m
Frontier
Deal found 4/13![Frontier logo]()
$63
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/112:54 pm
CVG
- MCI
1 stop5h 27m
Frontier
Deal found 4/13![Frontier logo]()
$64
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:35 am
MDW
- STL
2 stops6h 20m
Southwest
Deal found 4/13![Southwest logo]()
$64
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:55 am
ORD
- STL
1 stop9h 20m
Southwest
Deal found 4/15![Southwest logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:54 pm
CVG
- MCI
1 stop5h 27m
Frontier
Deal found 4/12![Frontier logo]()
$65
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:14 pm
IND
- MCI
1 stop6h 07m
Frontier
Deal found 4/14![Frontier logo]()
$65
This Trip.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:12 pm
CVG
- STL
1 stop21h 43m
Frontier
Deal found 4/13![Frontier logo]()
$66
Find flight deals from Indiana to Missouri
Keep the following information in mind while searching for Indiana to Missouri flight deals. Data was last updated April 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $121 (Kiwi.com) |
One-way from | $49 (Southwest) |
Popular in | September |
Cheapest in | November |
Average price | $311 |
Good round-trip deal | $307 or less |
Good one-way deal | $183 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indiana to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Indiana to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Sat 5/9
12:45 pm-2:00 pm
Nonstop1h 15m
Lambert-St Louis
Sat 5/9
6:55 pm-8:05 pm
Nonstop1h 10m
$191
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Sat 5/30
12:45 pm-2:00 pm
Nonstop1h 15m
Lambert-St Louis
Sat 6/6
5:40 am-6:45 am
Nonstop1h 05m
$191
Quickest round-trip
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Mon 8/17
8:55 pm-10:05 pm
Nonstop1h 10m
Lambert-St Louis
Tue 8/25
8:45 pm-9:50 pm
Nonstop1h 05m
$217
CincinnatiSt. Louis
CVG - STL
CVGSTL
Cincinnati Cinci./N. Kentucky
Thu 5/28
12:12 pm-5:33 pm
1 stop6h 21m
Lambert-St Louis
Mon 6/1
4:19 pm-11:38 pm
1 stop6h 19m
$225
CincinnatiKansas City
CVG - MCI
CVGMCI
Cincinnati Cinci./N. Kentucky
Tue 6/9
5:34 am-12:15 pm
1 stop7h 41m
Kansas City
Sat 6/13
3:42 pm-12:27 am
1 stop7h 45m
$227
ChicagoSt. Louis
ORD - STL
ORDSTL
Chicago O'Hare Intl
Tue 5/12
9:25 am-4:46 pm
2 stops7h 21m
Lambert-St Louis
Tue 5/19
8:53 am-6:05 pm
2 stops9h 12m
$228
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Sun 6/7
8:05 am-9:30 am
Nonstop1h 25m
Lambert-St Louis
Tue 6/9
5:40 am-6:45 am
Nonstop1h 05m
$228
CincinnatiSt. Louis
CVG - STL
CVGSTL
Cincinnati Cinci./N. Kentucky
Fri 5/15
12:46 pm-8:55 am
1 stop21h 09m
Lambert-St Louis
Sun 5/17
6:55 pm-11:41 am
1 stop15h 46m
$232
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Tue 5/26
7:45 am-1:00 pm
1 stop5h 15m
Lambert-St Louis
Tue 5/26
6:40 pm-10:15 pm
1 stop3h 35m
$237
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Wed 7/1
9:10 pm-10:25 pm
Nonstop1h 15m
Lambert-St Louis
Mon 7/6
2:25 pm-5:50 pm
1 stop3h 25m
$238
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indiana to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Indiana with our price prediction graph.
MDW-STL
ORD-STL
CVG-STL
CVG-MCI
IND-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indiana to Missouri
USIN-USMO
MDW-STL
ORD-STL
CVG-STL
CVG-MCI
What is the cheapest month to book a flight from Indiana to Missouri?
Currently, October is the cheapest month in which you can book a flight from Indiana to Missouri (average of $72). Flying from Indiana to Missouri in March is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IN to MO?
Find hourly flight availability from Indiana to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Indiana to Missouri as you normally would.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 17, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Indiana to Missouri. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Indiana to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Indiana to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Indiana to Missouri by cabin class
Find flights from Indiana to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indiana and Missouri flights
Browse other Indiana and Missouri flight options. Last updated on April 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Indiana after your stay in Missouri
Indiana to Missouri flights
Consider these flights traveling from Indiana to Missouri.
Top 4 airlines flying from Indiana to Missouri
Discover the top 4 airlines that operate flights from Indiana to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$178 | Average$336 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$355 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$221 | Average$327 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$228 | Average$341 | FlexibilityNo cancel fee | On-time69% |