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$63+ Cheap flights from Indiana to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
IND — MCI
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Indiana to Missouri

Cheapest flights from Indiana to Missouri
Explore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:10 pmORD - STL
Nonstop1h 26mAmerican Airlines
Tue 1/136:00 amSTL - ORD
Nonstop1h 27mAmerican Airlines
Deal found 12/16$188
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:50 pmORD - STL
Nonstop1h 28mUnited Airlines
Tue 1/611:20 amSTL - ORD
Nonstop1h 35mUnited Airlines
Deal found 12/14$193
This Southwest deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:25 amMDW - STL
Nonstop1h 15mSouthwest
Tue 1/63:05 pmSTL - MDW
1 stop5h 00mSouthwest
Deal found 12/14$203
This Frontier deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:23 amORD - STL
1 stop11h 10mFrontier
Thu 1/110:42 amSTL - ORD
1 stop7h 51mFrontier
Deal found 12/15$208
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/303:50 pmORD - COU
Nonstop1h 35mUnited Airlines
Sat 1/38:05 amCOU - ORD
Nonstop1h 46mUnited Airlines
Deal found 12/15$209
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:10 pmORD - STL
Nonstop1h 33mUnited Airlines
Thu 12/258:05 amSTL - ORD
Nonstop1h 35mUnited Airlines
Deal found 12/16$215
This Orbitz deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:05 amCVG - STL
1 stop18h 28mFrontier
Sun 1/410:57 amSTL - CVG
1 stop7h 21mFrontier
Deal found 12/14$217
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:07 amORD - STL
Nonstop1h 28mAmerican Airlines
Thu 12/259:08 amSTL - ORD
Nonstop1h 27mAmerican Airlines
Deal found 12/16$226
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:57 pmORD - STL
Nonstop1h 26mAmerican Airlines
Tue 1/68:13 amSTL - ORD
1 stop5h 09mAmerican Airlines
Deal found 12/14$233
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amORD - MCI
1 stop6h 26mAmerican Airlines
Wed 12/315:12 amMCI - ORD
Nonstop1h 47mAmerican Airlines
Deal found 12/15$237
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:50 pmORD - COU
Nonstop1h 35mUnited Airlines
Wed 12/318:05 amCOU - ORD
Nonstop1h 46mUnited Airlines
Deal found 12/16$239
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:46 pmORD - SGF
Nonstop1h 42mAmerican Airlines
Thu 1/15:58 pmSGF - ORD
Nonstop1h 51mAmerican Airlines
Deal found 12/15$249

Find flight deals from Indiana to Missouri

Keep the following information in mind while searching for Indiana to Missouri flight deals. Data was last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$134
(Kiwi.com)

One-way from

$63
(Trip.com)

Popular in

September

Cheapest in

November

Average price

$388

Good round-trip deal

$347 or less

Good one-way deal

$226 or less
Provider with most accurate pricing for Indianapolis-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Lambert-St Louis flights.
Search Deals
From Indiana to Missouri
Search Deals
One-way flight from Indiana to Missouri
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Indiana to Missouri.
Search Deals
Price to beat on a one-way flight from Indiana to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Indiana to Missouri that are best for you.

Fly from

Indiana

Fly to

Missouri

Route

Depart

Return

Price

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 1/8

9:55 am-11:15 am

Nonstop1h 20m

Lambert-St Louis

Mon 1/12

5:55 pm-7:05 pm

Nonstop1h 10m

$171

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Mon 1/12

9:25 pm-10:58 pm

Nonstop1h 33m

Lambert-St Louis

Mon 1/26

6:40 pm-8:23 pm

Nonstop1h 43m

$171

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 1/8

9:55 am-11:15 am

Nonstop1h 20m

Lambert-St Louis

Thu 1/8

5:55 pm-7:05 pm

Nonstop1h 10m

$171

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Tue 1/27

9:55 am-11:15 am

Nonstop1h 20m

Lambert-St Louis

Mon 2/2

1:10 pm-2:15 pm

Nonstop1h 05m

$171

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Tue 1/20

9:50 am-4:45 pm

1 stop6h 55m

Lambert-St Louis

Wed 1/21

6:35 am-12:49 pm

1 stop6h 14m

$173

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 1/8

4:49 pm-6:14 pm

Nonstop1h 25m

Lambert-St Louis

Mon 1/12

6:44 pm-8:15 pm

Nonstop1h 31m

$173

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Tue 1/13

9:50 am-3:00 pm

1 stop5h 10m

Lambert-St Louis

Tue 1/20

7:10 am-11:59 am

1 stop4h 49m

$173

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Wed 1/21

10:46 am-4:07 pm

1 stop5h 21m

Lambert-St Louis

Wed 1/28

1:00 pm-5:29 pm

1 stop4h 29m

$173

ChicagoColumbia

ORD - COU

ORDCOU

Chicago O'Hare Intl

Mon 1/12

1:17 pm-2:48 pm

Nonstop1h 31m

Columbia Regional

Mon 1/19

3:19 pm-4:49 pm

Nonstop1h 30m

$179

ChicagoColumbia

ORD - COU

ORDCOU

Chicago O'Hare Intl

Sat 1/10

1:17 pm-2:48 pm

Nonstop1h 31m

Columbia Regional

Sat 1/17

6:00 am-7:36 am

Nonstop1h 36m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Missouri

What is the cheapest month to book a flight from Indiana to Missouri?

Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to MO?

Find hourly flight availability from Indiana to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

A simple way to save on the total cost of your ticket is to fly from Indiana to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Indiana to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Indiana to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indiana to Missouri flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Indiana to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 16, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Indiana to Missouri. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,008 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,092 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,049 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Indiana to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to Missouri flight route?

    Flights from Indiana to Missouri have been viewed 6 times in the past calendar month.

  • How long is the flight from Indiana to Missouri?

    Departing from Indiana to Missouri will take you 1h 20m. There are 251 mi between Indiana and Missouri. Generally, flights for this route are nonstop.

  • What are the cheapest airlines to fly from Indiana to Missouri one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $94. American Airlines flights start at $98 while deals on Delta start at $100 one-way.

  • Can I find deals for flights from Indiana to Missouri that include hotel bookings?

    Yes. In addition to deals on Indiana to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Missouri.

  • Can I find deals for business class flights from Indiana to Missouri?

    Yes. Cheapflights offers flight deals from Indiana to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Missouri?

    Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indiana to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Missouri

Discover the top 4 airlines that operate flights from Indiana to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$178Average$333FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$356FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$335FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$221Average$326FlexibilityNo cancel feeOn-time63%

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