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$49+ Cheap flights from Indiana to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
IND — STL
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Indiana to Missouri

Keep the following information in mind while searching for Indiana to Missouri flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$110
(Frontier)

One-way from

$49
(Southwest)

Popular in

July

Cheapest in

November

Average price

$276

Good round-trip deal

$311 or less

Good one-way deal

$133 or less
Provider with most accurate pricing for Indianapolis-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Lambert-St Louis flights.
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From Indiana to Missouri
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One-way flight from Indiana to Missouri
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Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a round-trip flight from Indiana to Missouri.
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Price to beat on a one-way flight from Indiana to Missouri.
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Find flight deals from Indiana to Missouri

Cheapest flights from Indiana to Missouri
Explore the most affordable flight options available from Indiana to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:57 amCVG - STL
1 stop11h 36mFrontier
Mon 12/89:54 amSTL - CVG
1 stop8h 51mFrontier
Deal found 11/4$110
This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:55 pmCVG - STL
1 stop13h 04mFrontier
Wed 12/107:43 pmSTL - CVG
1 stop16h 30mFrontier
Deal found 11/6$111
This Booking.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:05 amCVG - STL
1 stop18h 28mFrontier
Sat 12/63:30 pmSTL - CVG
1 stop16h 09mFrontier
Deal found 11/5$121
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:49 pmMDW - STL
1 stop20h 18mFrontier
Fri 12/1210:42 amSTL - MDW
1 stop9h 00mFrontier
Deal found 11/5$135
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/91:55 pmMDW - STL
1 stop5h 30mSouthwest
Wed 12/108:25 amSTL - MDW
1 stop5h 10mSouthwest
Deal found 11/5$137
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/92:15 pmORD - STL
1 stop7h 20mSouthwest
Wed 12/108:25 amSTL - ORD
1 stop3h 50mSouthwest
Deal found 11/5$137
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:41 amORD - STL
Nonstop1h 27mAmerican Airlines
Wed 12/105:05 amSTL - ORD
Nonstop1h 30mAmerican Airlines
Deal found 11/6$144
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:01 pmORD - STL
1 stop19h 06mFrontier
Fri 12/1212:07 pmSTL - ORD
1 stop8h 48mFrontier
Deal found 11/6$147
This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/191:56 pmMDW - STL
1 stop9h 05mFrontier
Thu 11/203:14 pmSTL - MDW
1 stop7h 29mFrontier
Deal found 11/4$150
This Frontier deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/811:57 amCVG - STL
1 stop11h 36mFrontier
Thu 12/111:16 pmSTL - CVG
1 stop9h 42mFrontier
Deal found 11/3$150
This Expedia deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1912:37 pmORD - STL
1 stop10h 24mFrontier
Thu 11/203:14 pmSTL - ORD
1 stop8h 54mFrontier
Deal found 11/5$150
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:02 pmMDW - STL
1 stop4h 27mDelta
Sun 12/76:00 amSTL - MDW
1 stop5h 55mDelta
Deal found 11/5$157

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Indiana to Missouri that are best for you.

Fly from

Indiana

Fly to

Missouri

Route

Depart

Return

Price

CincinnatiSt. Louis

CVG - STL

CVGSTL

Cincinnati Cinci./N. Kentucky

Thu 12/4

8:55 pm-8:59 am

1 stop13h 04m

Lambert-St Louis

Wed 12/10

3:30 pm-10:52 am

1 stop18h 22m

$119

CincinnatiSt. Louis

CVG - STL

CVGSTL

Cincinnati Cinci./N. Kentucky

Thu 12/4

5:05 am-10:33 pm

1 stop18h 28m

Lambert-St Louis

Sat 12/6

3:30 pm-8:39 am

1 stop16h 09m

$121

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Mon 12/8

6:41 am-8:08 am

Nonstop1h 27m

Lambert-St Louis

Wed 12/10

5:05 am-6:35 am

Nonstop1h 30m

$144

CincinnatiSt. Louis

CVG - STL

CVGSTL

Cincinnati Cinci./N. Kentucky

Mon 12/8

11:57 am-10:33 pm

1 stop11h 36m

Lambert-St Louis

Thu 12/11

1:16 pm-11:58 pm

1 stop9h 42m

$150

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 12/4

5:13 pm-11:42 pm

1 stop6h 29m

Lambert-St Louis

Mon 12/8

5:12 pm-11:47 pm

1 stop6h 35m

$157

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 12/4

7:02 pm-11:29 pm

1 stop4h 27m

Lambert-St Louis

Sun 12/7

6:00 am-11:55 am

1 stop5h 55m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 12/31

5:31 pm-11:38 pm

1 stop6h 07m

Lambert-St Louis

Tue 1/13

5:00 pm-11:57 pm

1 stop6h 57m

$157

CincinnatiSt. Louis

CVG - STL

CVGSTL

Cincinnati Cinci./N. Kentucky

Mon 11/17

1:27 pm-9:07 am

1 stop20h 40m

Lambert-St Louis

Wed 11/19

7:45 pm-10:46 am

1 stop14h 01m

$159

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 12/4

10:50 am-12:15 pm

Nonstop1h 25m

Lambert-St Louis

Sun 12/7

5:27 pm-6:50 pm

Nonstop1h 23m

$162

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Tue 12/30

9:10 pm-10:43 pm

Nonstop1h 33m

Lambert-St Louis

Tue 1/13

6:40 pm-8:23 pm

Nonstop1h 43m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Missouri

What is the cheapest month to book a flight from Indiana to Missouri?

Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to MO?

Find hourly flight availability from Indiana to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

A simple way to save on the total cost of your ticket is to fly from Indiana to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Indiana to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Indiana to Missouri. Price data was last updated on November 18, 2024.

Travelers seeking maximum savings on their Indiana to Missouri flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Indiana to Missouri. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Indiana to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Indiana to Missouri?

    Departing from Indiana to Missouri will take you 1h 27m. There are 258 mi between Indiana and Missouri. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Missouri one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $49. United Airlines flights start at $49 while deals on Frontier start at $101 one-way.

  • Can I find deals for flights from Indiana to Missouri that include hotel bookings?

    Yes. In addition to deals on Indiana to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Missouri.

  • Can I find deals for business class flights from Indiana to Missouri?

    Yes. Cheapflights offers flight deals from Indiana to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Missouri?

    Currently, September is the cheapest month in which you can book a flight from Indiana to Missouri (average of $75). Flying from Indiana to Missouri in May is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indiana to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Missouri

Discover the top 4 airlines that operate flights from Indiana to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$178Average$324FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$369FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$395FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$221Average$333FlexibilityNo cancel feeOn-time63%

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