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Mexico City Federal District

$186+ Cheap flights from Knoxville (TYS) to Mexico City Federal District

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico City Federal District

Cheapest flights from Knoxville to Mexico City Federal District
Explore the most affordable flight options available from Knoxville to Mexico City Federal District. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:23 amTYS - MEX
1 stop7h 07mAmerican Airlines
Mon 1/58:00 amMEX - TYS
1 stop13h 21mAmerican Airlines
Deal found 12/22$889
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:26 pmTYS - MEX
2 stops28h 54mMultiple Airlines
Mon 1/58:30 amMEX - TYS
2 stops7h 25mMultiple Airlines
Deal found 12/22$943
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:45 amTYS - MEX
1 stop17h 05mUnited Airlines
Sat 1/35:45 amMEX - TYS
1 stop13h 05mUnited Airlines
Deal found 12/22$1,259
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:23 amTYS - MEX
1 stop7h 07mAmerican Airlines
Sat 1/36:00 amMEX - TYS
1 stop16h 45mAmerican Airlines
Deal found 12/21$1,332
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amTYS - MEX
2 stops9h 25mDelta
Sat 1/38:25 amMEX - TYS
2 stops8h 49mDelta
Deal found 12/21$1,746

Find flight deals from Knoxville to Mexico City Federal District

Keep the following information in mind while searching for Knoxville to Mexico City Federal District flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$422
(Kiwi.com)

One-way from

$186
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$846
Provider with most accurate pricing for Knoxville McGhee Tyson-Mexico City Benito Juarez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Mexico City Benito Juarez flights.
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From Knoxville McGhee Tyson to Mexico City Federal District
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One-way flight from Knoxville McGhee Tyson to Mexico City Federal District
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Highest demand for flights based on searches. 17% potential increase in price ($136 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico City Federal District that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico City Federal District that are best for you.

Fly from

Knoxville

Fly to

Mexico City Federal District

Route

Depart

Return

Price

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 2/4

4:47 pm-11:35 pm

3 stops31h 48m

Mexico City Benito Juarez

Wed 2/11

11:10 am-12:12 pm

2 stops24h 02m

$458

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sun 1/18

8:18 pm-5:05 pm

1 stop21h 47m

Mexico City Benito Juarez

Sun 1/25

11:10 am-5:28 pm

1 stop29h 18m

$494

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Mon 2/9

12:55 pm-7:45 pm

1 stop7h 50m

Mexico City Benito Juarez

Wed 3/11

11:10 am-10:44 am

2 stops21h 34m

$521

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 5/12

5:40 pm-9:21 pm

1 stop5h 41m

Mexico City Benito Juarez

Mon 5/18

7:05 am-6:15 pm

1 stop9h 10m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 2/5

5:36 pm-12:10 am

1 stop7h 34m

Mexico City Benito Juarez

Tue 3/10

7:00 am-3:31 pm

1 stop6h 31m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 2/3

10:07 am-3:15 pm

1 stop6h 08m

Mexico City Benito Juarez

Wed 3/11

3:30 pm-9:16 am

1 stop15h 46m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 2/4

8:25 am-8:50 pm

1 stop13h 25m

Mexico City Benito Juarez

Wed 3/11

11:30 am-11:51 pm

1 stop10h 21m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 2/5

4:06 pm-8:50 pm

1 stop5h 44m

Mexico City Benito Juarez

Wed 3/11

1:05 pm-11:51 pm

1 stop8h 46m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Mon 2/9

4:06 pm-8:50 pm

1 stop5h 44m

Mexico City Benito Juarez

Mon 3/9

8:40 am-11:51 pm

2 stops13h 11m

$555

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Mon 2/2

10:07 am-6:55 pm

2 stops9h 48m

Mexico City Benito Juarez

Tue 3/10

7:05 am-9:06 pm

2 stops12h 01m

$555

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 15 results
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Best time to book a flight from Knoxville to Mexico City Federal District

Have a flexible travel schedule? Discover the best time to fly to Mexico City Federal District from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico City Federal District

What is the cheapest month to book a flight from Knoxville to Mexico City Federal District?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Mexico City Federal District (average of $271). Flying from Knoxville to Mexico City Federal District in December is currently the most expensive (average of $611). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mexico City Federal District

Get insights into the airlines that provide service to Mexico City Federal District. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City Federal District. Reviews last updated December 23, 2025.
Get a feel of what it's like to fly with Delta, Aeromexico, and American Airlines from Knoxville to Mexico City Federal District by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,013 reviews
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Aeromexico
7.4
Good
1,624 reviews
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,013 reviews

Comfort

7.9

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico City Federal District. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mexico City Federal District?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Mexico City Federal District. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Mexico City Federal District?

    Delta can get you from Knoxville to Mexico City Federal District in just under 5h 41m. Your travel time can differ by up to . Airlines will cover a distance of 1455 mi.

  • Can I find deals for flights from Knoxville to Mexico City Federal District that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico City Federal District flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico City Federal District?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico City Federal District.

  • Can I find deals for business class flights from Knoxville to Mexico City Federal District?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico City Federal District by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico City Federal District?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Mexico City Federal District (average of $271). Flying from Knoxville to Mexico City Federal District in December is currently the most expensive (average of $611). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico City Federal District

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Mexico City Federal District

Discover the top 3 airlines that operate flights from Knoxville to Mexico City Federal District. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$318Average$582FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$685FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$487Average$550FlexibilityNo cancel feeOn-timeN/A

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