$81+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Aug 24 — Aug 311
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or October, booked 36 days in advance, depart on a Thursday or Wednesday and return on a Monday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/234:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/20![Allegiant Air logo]()
$145
This Cheapflightsfares deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/199:11 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$172
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$177
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/199:11 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$182
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/47:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$186
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Sun 9/134:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:29 pm
TYS
- PHX
2 stops31h 36m
Multiple Airlines
Sun 8/164:51 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
- PHX
Nonstop3h 47m
Multiple Airlines
Wed 8/2610:09 pm
PHX
- TYS
2 stops41h 56m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$203
This Expedia deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Sun 9/134:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$205
This Cheapflightsfares deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/187:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$213
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:33 am
TYS
- PHX
1 stop9h 21m
Delta
Mon 9/143:16 pm
PHX
- TYS
1 stop5h 39m
Delta
Deal found 7/23![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:20 pm
TYS
- PHX
1 stop7h 20m
Southwest
Tue 10/275:30 am
PHX
- TYS
1 stop7h 10m
Southwest
Deal found 7/21![Southwest logo]()
$311
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/77:00 am
TYS
- PHX
2 stops10h 54m
United Airlines
Mon 1/117:00 am
PHX
- TYS
1 stop8h 37m
United Airlines
Deal found 7/22![United Airlines logo]()
$416
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:10 pm
TYS
- PHX
1 stop8h 20m
Southwest
Wed 12/99:00 am
PHX
- TYS
2 stops8h 45m
Southwest
Deal found 7/23![Southwest logo]()
$316
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/711:30 am
TYS
- PHX
1 stop9h 28m
Delta
Mon 1/111:40 pm
PHX
- TYS
1 stop7h 22m
Delta
Deal found 7/24![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:45 pm
TYS
- PHX
2 stops7h 10m
Southwest
Wed 8/268:20 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 7/23![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:57 pm
TYS
- PHX
1 stop7h 24m
Delta
Tue 10/1311:05 pm
PHX
- TYS
1 stop8h 12m
Delta
Deal found 7/20![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:35 am
TYS
- PHX
1 stop6h 33m
Delta
Sun 8/305:45 am
PHX
- TYS
1 stop6h 45m
Delta
Deal found 7/20![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm
TYS
- PHX
2 stops7h 00m
Southwest
Sun 10/185:05 am
PHX
- TYS
1 stop13h 15m
Southwest
Deal found 7/23![Southwest logo]()
$371
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm
TYS
- PHX
2 stops7h 00m
Southwest
Mon 10/2611:40 am
PHX
- TYS
2 stops8h 00m
Southwest
Deal found 7/25![Southwest logo]()
$374
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:10 am
TYS
- PHX
2 stops7h 45m
Southwest
Sat 8/2212:35 am
PHX
- TYS
2 stops8h 50m
Southwest
Deal found 7/20![Southwest logo]()
$380
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:00 pm
TYS
- PHX
2 stops9h 55m
Southwest
Tue 10/1310:25 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 7/20![Southwest logo]()
$421
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated July 25, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated July 25, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$177
This CheapOair deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:19 pm
TYS
- PHX
1 stop22h 25m
Frontier
Thu 8/134:48 pm
PHX
- TYS
1 stop23h 36m
Frontier
Deal found 7/20![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:47 pm
TYS
- PHX
1 stop11h 18m
Multiple Airlines
Thu 8/135:01 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:29 pm
TYS
- PHX
2 stops31h 36m
Multiple Airlines
Sun 8/164:51 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:54 am
TYS
- PHX
2 stops39h 30m
Multiple Airlines
Wed 8/264:48 pm
PHX
- TYS
1 stop18h 01m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$254
This Cheapflightsfares deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/234:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/20![Allegiant Air logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
- PHX
Nonstop3h 47m
Multiple Airlines
Wed 8/2610:09 pm
PHX
- TYS
2 stops41h 56m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
- PHX
Nonstop3h 47m
Multiple Airlines
Sun 8/236:57 pm
PHX
- TYS
2 stops20h 46m
Multiple Airlines
Deal found 7/21![Multiple Airlines logo]()
$265
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
This CheapOair deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/232:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$81
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$84
This CheapOair deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$96
This Cheapflightsfares deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:30 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:49 pm
TYS
- PHX
2 stops25h 10m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am
TYS
- PHX
1 stop19h 39m
Multiple Airlines
Deal found 7/21![Multiple Airlines logo]()
$115
This Cheapflightsfares deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:39 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 7/21![Allegiant Air logo]()
$118
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated July 25, 2026.
Round-trip from | $145 (Cheapflightsfares) |
|---|---|
One-way from | $81 (CheapOair) |
Popular in | June |
Cheapest in | August |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
7:33 am-1:54 pm
1 stop9h 21m
Phoenix Sky Harbor Intl
Mon 9/14
3:16 pm-11:55 pm
1 stop5h 39m
$311
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Tue 10/20
4:20 pm-8:40 pm
1 stop7h 20m
Phoenix Sky Harbor Intl
Tue 10/27
5:30 am-3:40 pm
1 stop7h 10m
$311
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 12/7
4:10 pm-10:30 pm
1 stop8h 20m
Phoenix Sky Harbor Intl
Wed 12/9
9:00 am-7:45 pm
2 stops8h 45m
$316
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/20
5:45 pm-9:55 pm
2 stops7h 10m
Phoenix Sky Harbor Intl
Wed 8/26
8:20 am-6:55 pm
2 stops7h 35m
$321
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 1/7
11:30 am-6:58 pm
1 stop9h 28m
Phoenix Sky Harbor Intl
Mon 1/11
1:40 pm-11:02 pm
1 stop7h 22m
$329
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Tue 10/6
6:57 pm-11:21 pm
1 stop7h 24m
Phoenix Sky Harbor Intl
Tue 10/13
11:05 pm-10:17 am
1 stop8h 12m
$339
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 8/26
8:35 am-12:08 pm
1 stop6h 33m
Phoenix Sky Harbor Intl
Sun 8/30
5:45 am-3:30 pm
1 stop6h 45m
$369
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-11:25 pm
2 stops7h 00m
Phoenix Sky Harbor Intl
Sun 10/18
5:05 am-9:20 pm
1 stop13h 15m
$371
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
7:25 pm-11:25 pm
2 stops7h 00m
Phoenix Sky Harbor Intl
Mon 10/26
11:40 am-10:40 pm
2 stops8h 00m
$374
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/20
7:10 am-11:55 am
2 stops7h 45m
Phoenix Sky Harbor Intl
Sat 8/22
12:35 am-12:25 pm
2 stops8h 50m
$380
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Airfare is below average for this route at the moment.
Knoxville to Mesa flights typically cost between $214 and $378 in August.The cheapest round-trip price found within the last 5 days was $145 on Allegiant Air (Aug 20-Aug 23).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated July 25, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Mesa flights
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Top 6 airlines flying from Knoxville to Mesa
Discover the top 6 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$124 | Average$276 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$130 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$562 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$269 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$525 | FlexibilityNo cancel fee | On-time63% |