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Mesa

$84+ Cheap flights from Knoxville (TYS) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in September or August, booked 67 days in advance, depart on a Friday or Saturday and return on a Wednesday

Cheap flight deals from Knoxville to Mesa

Cheapest flights from Knoxville to Mesa
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Expedia deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
-
PHX
1 stop6h 28m
Frontier
Mon 3/26:00 am
PHX
-
TYS
1 stop11h 18m
Frontier
Deal found 1/26$195
This Booking.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1510:54 am
TYS
-
PHX
Nonstop4h 16m
Allegiant Air
Thu 3/2610:06 am
PHX
-
TYS
Nonstop3h 28m
Allegiant Air
Deal found 1/25$199
This WAYA deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/228:30 am
TYS
-
PHX
Nonstop4h 35m
Multiple Airlines
Fri 2/278:52 am
PHX
-
TYS
1 stop7h 14m
Multiple Airlines
Deal found 1/26$205
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
-
PHX
1 stop15h 21m
Multiple Airlines
Tue 3/36:51 pm
PHX
-
TYS
2 stops38h 43m
Multiple Airlines
Deal found 1/26$210
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:13 pm
TYS
-
PHX
1 stop16h 54m
Frontier
Thu 2/197:36 pm
PHX
-
TYS
1 stop21h 51m
Frontier
Deal found 1/24$214
This Booking.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/159:00 am
TYS
-
PHX
Nonstop4h 35m
Allegiant Air
Thu 2/1911:55 am
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 1/25$218
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Sun 4/129:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Deal found 1/26$226
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
-
PHX
1 stop7h 50m
Multiple Airlines
Mon 3/25:15 pm
PHX
-
TYS
2 stops47h 11m
Multiple Airlines
Deal found 1/26$233
This Booking.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Thu 4/99:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Deal found 1/25$235
This Expedia deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
-
PHX
1 stop7h 50m
Frontier
Mon 3/26:00 am
PHX
-
TYS
1 stop11h 18m
Frontier
Deal found 1/26$236

Find flight deals from Knoxville to Mesa

Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated January 27, 2026.

Round-trip from

$195
(Expedia)

One-way from

$84
(Priceline)

Popular in

November

Cheapest in

September

Average price

$269
From Knoxville McGhee Tyson to Mesa
Search Deals
One-way flight from Knoxville McGhee Tyson to Mesa
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.

Fly from

Knoxville

Fly to

Mesa

Route

Depart

Return

Price

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-12:41 am

1 stop6h 28m

Phoenix Sky Harbor Intl

Mon 3/2

6:00 am-7:18 pm

1 stop11h 18m

$195

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 2/27

6:51 pm-8:12 am

1 stop15h 21m

Phoenix Sky Harbor Intl

Tue 3/3

6:51 pm-11:34 am

2 stops38h 43m

$210

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sun 2/15

9:00 am-11:35 am

Nonstop4h 35m

Phoenix Sky Harbor Intl

Thu 2/19

11:55 am-5:22 pm

Nonstop3h 27m

$218

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 2/27

6:51 pm-12:41 am

1 stop7h 50m

Phoenix Sky Harbor Intl

Mon 3/2

6:00 am-7:18 pm

1 stop11h 18m

$236

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 4/8

4:09 pm-9:45 pm

1 stop8h 36m

Phoenix Sky Harbor Intl

Wed 4/15

6:00 am-5:48 pm

1 stop8h 48m

$277

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 2/21

4:29 pm-10:43 pm

1 stop8h 14m

Phoenix Sky Harbor Intl

Tue 2/24

12:59 am-11:57 am

1 stop8h 58m

$279

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 2/18

4:04 pm-11:51 pm

1 stop9h 47m

Phoenix Sky Harbor Intl

Wed 2/25

2:11 pm-11:59 pm

1 stop7h 48m

$279

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 3/10

2:25 pm-7:15 pm

1 stop7h 50m

Phoenix Sky Harbor Intl

Tue 3/17

8:40 am-8:05 pm

2 stops8h 25m

$282

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 4/15

4:30 pm-8:19 pm

1 stop6h 49m

Phoenix Sky Harbor Intl

Wed 4/22

10:30 am-7:56 pm

1 stop6h 26m

$293

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 4/18

4:30 pm-8:19 pm

1 stop6h 49m

Phoenix Sky Harbor Intl

Sat 4/25

12:43 pm-10:29 pm

1 stop6h 46m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 21 results
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Best time to book a flight from Knoxville to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mesa

How far ahead should I book a flight from Knoxville to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Mesa. Price data was last updated on January 23, 2026.

Booking 36 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Mesa. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Mesa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,121 reviews
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,207 reviews
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,198 reviews
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
706 reviews
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Frontier
5.7
Fair
3,056 reviews
Delta
7.9
Good
8,121 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mesa?

    For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 5 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

  • How long is the flight from Knoxville to Mesa?

    Airlines like Frontier, Allegiant Air, and American Airlines fly from Knoxville to Mesa in about 4h 35m. The time it takes to get you to your destination can typically vary by up to 4h 01m. The distance from Knoxville to Mesa is about 1594 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Knoxville to Mesa one-way?

    $65 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $71 and $114, respectively.

  • What are the cheapest flights from Knoxville to Mesa?

    Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $187, our data indicates the cheapest price to be $100. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $205.

  • Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

  • Can I find deals for business class flights from Knoxville to Mesa?

    Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mesa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Knoxville to Mesa

Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$70Average$268FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$110Average$226FlexibilityNo cancel feeOn-time88%
DeltaCheapest$128Average$316FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$170Average$468FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$250Average$412FlexibilityNo cancel feeOn-time71%

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