$84+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Aug 28 — Sep 41
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or October, booked 36 days in advance, depart on a Monday or Friday and return on a Monday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
This CheapOair deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Sun 9/64:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$138
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/199:11 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$165
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Thu 9/104:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$170
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$182
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/47:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$186
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:39 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 11/153:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$187
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$191
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Sun 9/134:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Thu 9/104:22 pm
PHX
- TYS
Nonstop3h 31m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$196
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Thu 9/34:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sat 10/33:38 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$206
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
This Justfly.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1410:00 am
TYS
- PHX
Nonstop4h 31m
Allegiant Air
Sun 1/171:21 pm
PHX
- TYS
Nonstop3h 21m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$226
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:33 am
TYS
- PHX
1 stop9h 21m
Delta
Mon 9/143:16 pm
PHX
- TYS
1 stop5h 39m
Delta
Deal found 7/26![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:00 am
TYS
- PHX
2 stops8h 28m
United Airlines
Wed 9/211:28 am
PHX
- TYS
1 stop6h 25m
United Airlines
Deal found 7/29![United Airlines logo]()
$324
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/254:45 pm
TYS
- PHX
2 stops7h 45m
Southwest
Wed 1/279:05 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 7/27![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:31 pm
TYS
- PHX
1 stop8h 50m
Delta
Mon 10/1911:32 pm
PHX
- TYS
1 stop7h 08m
Delta
Deal found 7/26![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm
TYS
- PHX
2 stops7h 00m
Southwest
Mon 10/2611:40 am
PHX
- TYS
2 stops8h 00m
Southwest
Deal found 7/25![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:18 pm
TYS
- PHX
1 stop7h 47m
Delta
Sun 10/1810:25 pm
PHX
- TYS
1 stop8h 52m
Delta
Deal found 7/27![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/99:45 am
TYS
- PHX
2 stops13h 39m
United Airlines
Mon 9/1412:15 pm
PHX
- TYS
1 stop6h 30m
United Airlines
Deal found 7/25![United Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:00 pm
TYS
- PHX
1 stop8h 36m
Delta
Sun 1/1711:59 pm
PHX
- TYS
1 stop8h 15m
Delta
Deal found 7/24![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am
TYS
- PHX
2 stops13h 07m
United Airlines
Sat 10/249:00 am
PHX
- TYS
1 stop8h 49m
United Airlines
Deal found 7/27![United Airlines logo]()
$424
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated July 29, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated July 29, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Multiple Airlines
Sat 8/226:57 pm
PHX
- TYS
1 stop15h 52m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:47 pm
TYS
- PHX
1 stop23h 40m
Multiple Airlines
Tue 8/1810:09 pm
PHX
- TYS
2 stops36h 40m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1511:16 am
TYS
- PHX
2 stops14h 00m
Multiple Airlines
Sun 8/164:51 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:40 am
TYS
- PHX
1 stop6h 26m
Delta
Tue 9/11:58 pm
PHX
- TYS
1 stop6h 02m
Delta
Deal found 7/28![Delta logo]()
$319
This Trip.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/232:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$208
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$191
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Thu 9/34:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:00 am
TYS
- PHX
1 stop17h 28m
Multiple Airlines
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:00 am
TYS
- PHX
2 stops19h 24m
Multiple Airlines
Thu 9/34:22 pm
PHX
- TYS
Nonstop3h 31m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$275
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$84
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$88
This Super.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$91
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:30 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$98
This CheapOair deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$115
This CheapOair deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:30 am
TYS
- PHX
1 stop27h 41m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$122
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated July 29, 2026.
Round-trip from | $138 (CheapOair) |
|---|---|
One-way from | $84 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $427 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 1/14
10:00 am-12:31 pm
Nonstop4h 31m
Phoenix Sky Harbor Intl
Sun 1/17
1:21 pm-6:42 pm
Nonstop3h 21m
$226
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
7:33 am-1:54 pm
1 stop9h 21m
Phoenix Sky Harbor Intl
Mon 9/14
3:16 pm-11:55 pm
1 stop5h 39m
$319
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 8/26
7:00 am-12:28 pm
2 stops8h 28m
Phoenix Sky Harbor Intl
Wed 9/2
11:28 am-8:53 pm
1 stop6h 25m
$324
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 1/25
4:45 pm-10:30 pm
2 stops7h 45m
Phoenix Sky Harbor Intl
Wed 1/27
9:05 am-6:40 pm
2 stops7h 35m
$329
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 10/16
4:31 pm-10:21 pm
1 stop8h 50m
Phoenix Sky Harbor Intl
Mon 10/19
11:32 pm-9:40 am
1 stop7h 08m
$349
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/15
5:18 pm-10:05 pm
1 stop7h 47m
Phoenix Sky Harbor Intl
Sun 10/18
10:25 pm-10:17 am
1 stop8h 52m
$369
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
7:25 pm-11:25 pm
2 stops7h 00m
Phoenix Sky Harbor Intl
Mon 10/26
11:40 am-10:40 pm
2 stops8h 00m
$374
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 1/14
12:00 pm-6:36 pm
1 stop8h 36m
Phoenix Sky Harbor Intl
Sun 1/17
11:59 pm-10:14 am
1 stop8h 15m
$374
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
9:45 am-8:24 pm
2 stops13h 39m
Phoenix Sky Harbor Intl
Mon 9/14
12:15 pm-9:45 pm
1 stop6h 30m
$424
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-8:49 pm
2 stops13h 07m
Phoenix Sky Harbor Intl
Sat 10/24
9:00 am-8:49 pm
1 stop8h 49m
$424
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Airfare is typical for this route at the moment.
Knoxville to Mesa flights typically cost between $138 and $254 in September.The cheapest round-trip price found within the last 5 days was $138 on Allegiant Air (Sep 3-Sep 6).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated July 29, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
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Knoxville and Mesa flights
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Top 6 airlines flying from Knoxville to Mesa
Discover the top 6 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$124 | Average$269 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$130 | Average$418 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$562 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$525 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$279 | Average$417 | FlexibilityNo cancel fee | On-time71% |