$85+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Jun 22 — Jun 291
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Thursday or Wednesday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$160
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Sun 9/134:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$165
This Cheapflightsfares deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$174
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 8/164:51 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Thu 10/223:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19![Allegiant Air logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19![Allegiant Air logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Multiple Airlines
Sat 10/246:36 pm
PHX
- TYS
1 stop17h 53m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$232
This Cheapflightsfares deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 7/194:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Multiple Airlines
Tue 10/273:14 pm
PHX
- TYS
2 stops42h 57m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Thu 10/223:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19![Allegiant Air logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm
TYS
- PHX
1 stop15h 14m
Multiple Airlines
Sat 10/246:36 pm
PHX
- TYS
1 stop15h 35m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$246
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
This Frontier deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:19 pm
TYS
- PHX
1 stop6h 13m
Frontier
Fri 8/78:40 am
PHX
- TYS
1 stop7h 44m
Frontier
Deal found 5/22![Frontier logo]()
$359
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:45 pm
TYS
- PHX
2 stops7h 10m
Southwest
Sun 8/165:55 am
PHX
- TYS
1 stop11h 50m
Southwest
Deal found 5/18![Southwest logo]()
$409
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:02 pm
TYS
- PHX
1 stop7h 50m
United Airlines
Fri 8/216:55 pm
PHX
- TYS
2 stops12h 42m
United Airlines
Deal found 5/18![United Airlines logo]()
$488
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:51 am
TYS
- PHX
1 stop8h 58m
Delta
Sun 6/711:59 pm
PHX
- TYS
1 stop6h 39m
Delta
Deal found 5/19![Delta logo]()
$577
This KAYAK deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/81:54 pm
TYS
- PHX
1 stop9h 00m
American Airlines
Thu 6/1112:52 pm
PHX
- TYS
1 stop8h 07m
American Airlines
Deal found 5/18![American Airlines logo]()
$582
This Southwest deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:40 am
TYS
- PHX
2 stops9h 35m
Southwest
Fri 8/77:55 am
PHX
- TYS
2 stops7h 40m
Southwest
Deal found 5/22![Southwest logo]()
$424
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:40 am
TYS
- PHX
2 stops8h 25m
Southwest
Thu 7/911:35 am
PHX
- TYS
2 stops6h 35m
Southwest
Deal found 5/18![Southwest logo]()
$468
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:00 am
TYS
- PHX
2 stops8h 20m
Southwest
Wed 7/157:30 am
PHX
- TYS
2 stops9h 50m
Southwest
Deal found 5/19![Southwest logo]()
$497
This United Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:56 pm
TYS
- PHX
1 stop8h 03m
United Airlines
Fri 8/710:06 am
PHX
- TYS
2 stops9h 28m
United Airlines
Deal found 5/20![United Airlines logo]()
$622
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:56 pm
TYS
- PHX
1 stop8h 03m
United Airlines
Mon 6/2211:50 pm
PHX
- TYS
1 stop6h 53m
United Airlines
Deal found 5/18![United Airlines logo]()
$629
This Southwest deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1712:45 pm
TYS
- PHX
2 stops11h 00m
Southwest
Wed 6/245:05 am
PHX
- TYS
1 stop6h 00m
Southwest
Deal found 5/20![Southwest logo]()
$558
This Southwest deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:40 am
TYS
- PHX
2 stops9h 00m
Southwest
Sun 6/288:20 am
PHX
- TYS
2 stops9h 55m
Southwest
Deal found 5/22![Southwest logo]()
$567
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated May 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated May 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:31 am
TYS
- PHX
2 stops34h 44m
Multiple Airlines
Sun 7/54:20 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$342
This Cheapflightsfares deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/72:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Sun 6/144:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 5/19![Allegiant Air logo]()
$339
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:32 pm
TYS
- PHX
1 stop16h 49m
Frontier
Fri 6/198:40 am
PHX
- TYS
1 stop7h 57m
Frontier
Deal found 5/22![Frontier logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:32 pm
TYS
- PHX
1 stop14h 13m
Multiple Airlines
Wed 6/2410:32 pm
PHX
- TYS
2 stops34h 27m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$366
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:32 pm
TYS
- PHX
1 stop22h 16m
Frontier
Mon 6/226:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/22![Frontier logo]()
$315
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Sun 6/284:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$330
This Gotogate deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Sun 6/286:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$336
This Gotogate deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/282:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Sun 7/56:53 pm
PHX
- TYS
1 stop21h 43m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$324
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/162:51 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:47 pm
TYS
- PHX
1 stop25h 08m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$98
This Expedia deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:19 pm
TYS
- PHX
1 stop16h 52m
Frontier
Deal found 5/20![Frontier logo]()
$136
This CheapOair deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:32 pm
TYS
- PHX
1 stop19h 48m
Frontier
Deal found 5/23![Frontier logo]()
$141
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:19 pm
TYS
- PHX
1 stop16h 52m
Frontier
Deal found 5/22![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$160
This Frontier deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:19 pm
TYS
- PHX
1 stop6h 13m
Frontier
Deal found 5/21![Frontier logo]()
$165
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:40 am
TYS
- PHX
1 stop6h 31m
Delta
Deal found 5/20![Delta logo]()
$175
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- PHX
1 stop16h 33m
Frontier
Deal found 5/18![Frontier logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:00 am
TYS
- PHX
2 stops15h 33m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$182
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated May 23, 2026.
Round-trip from | $160 (Cheapflightsfares) |
|---|---|
One-way from | $85 (Cheapflightsfares) |
Popular in | June |
Cheapest in | August |
Average price | $401 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 8/3
8:19 pm-11:32 pm
1 stop6h 13m
Phoenix Sky Harbor Intl
Fri 8/7
8:40 am-7:24 pm
1 stop7h 44m
$359
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/13
5:45 pm-9:55 pm
2 stops7h 10m
Phoenix Sky Harbor Intl
Sun 8/16
5:55 am-8:45 pm
1 stop11h 50m
$409
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 7/31
6:40 am-1:15 pm
2 stops9h 35m
Phoenix Sky Harbor Intl
Fri 8/7
7:55 am-6:35 pm
2 stops7h 40m
$424
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 7/2
6:40 am-12:05 pm
2 stops8h 25m
Phoenix Sky Harbor Intl
Thu 7/9
11:35 am-9:10 pm
2 stops6h 35m
$468
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 8/17
6:02 pm-10:52 pm
1 stop7h 50m
Phoenix Sky Harbor Intl
Fri 8/21
6:55 pm-10:37 am
2 stops12h 42m
$488
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Sat 7/11
7:00 am-12:20 pm
2 stops8h 20m
Phoenix Sky Harbor Intl
Wed 7/15
7:30 am-8:20 pm
2 stops9h 50m
$497
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 6/17
12:45 pm-8:45 pm
2 stops11h 00m
Phoenix Sky Harbor Intl
Wed 6/24
5:05 am-2:05 pm
1 stop6h 00m
$558
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 6/25
6:40 am-12:40 pm
2 stops9h 00m
Phoenix Sky Harbor Intl
Sun 6/28
8:20 am-9:15 pm
2 stops9h 55m
$567
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 6/4
7:51 am-1:49 pm
1 stop8h 58m
Phoenix Sky Harbor Intl
Sun 6/7
11:59 pm-9:38 am
1 stop6h 39m
$577
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 6/8
1:54 pm-7:54 pm
1 stop9h 00m
Phoenix Sky Harbor Intl
Thu 6/11
12:52 pm-11:59 pm
1 stop8h 07m
$582
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 23, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on May 23, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 23, 2026.
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Knoxville to Mesa flights
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Top 5 airlines flying from Knoxville to Mesa
Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$250 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$366 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$437 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$402 | FlexibilityNo cancel fee | On-time71% |