$92+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Jun 25 — Jul 21
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Thursday or Wednesday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Thu 9/104:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 5/23![Allegiant Air logo]()
$173
This Cheapflightsfares deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/58:31 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/25![Allegiant Air logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/23![Allegiant Air logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Thu 10/293:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/23![Allegiant Air logo]()
$226
This Cheapflightsfares deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 7/194:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
- PHX
Nonstop4h 01m
Multiple Airlines
Wed 10/2810:40 pm
PHX
- TYS
1 stop18h 59m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$239
This Cheapflightsfares deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 7/54:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/25![Allegiant Air logo]()
$245
This Cheapflightsfares deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/192:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Thu 7/234:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/24![Allegiant Air logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:52 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/23![Allegiant Air logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm
TYS
- PHX
1 stop15h 14m
Multiple Airlines
Thu 10/293:43 pm
PHX
- TYS
Nonstop3h 27m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:52 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Thu 10/293:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/23![Allegiant Air logo]()
$265
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 26, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 26, 2026.
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- PHX
1 stop5h 55m
Southwest
Tue 8/1812:35 am
PHX
- TYS
2 stops8h 30m
Southwest
Deal found 5/26![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:30 am
TYS
- PHX
1 stop9h 27m
Delta
Mon 9/1411:55 pm
PHX
- TYS
1 stop8h 10m
Delta
Deal found 5/22![Delta logo]()
$352
This CheapOair deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:32 pm
TYS
- PHX
1 stop16h 49m
Frontier
Mon 6/156:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/25![Frontier logo]()
$373
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
TYS
- PHX
2 stops10h 54m
United Airlines
Wed 8/261:34 pm
PHX
- TYS
1 stop5h 55m
United Airlines
Deal found 5/25![United Airlines logo]()
$434
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:30 am
TYS
- PHX
1 stop9h 28m
Delta
Sat 10/2411:55 pm
PHX
- TYS
1 stop6h 17m
Delta
Deal found 5/23![Delta logo]()
$358
This Southwest deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:10 am
TYS
- PHX
2 stops8h 55m
Southwest
Tue 9/18:20 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 5/22![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:20 pm
TYS
- PHX
1 stop7h 55m
Southwest
Fri 10/309:00 am
PHX
- TYS
1 stop6h 40m
Southwest
Deal found 5/24![Southwest logo]()
$383
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/253:59 pm
TYS
- PHX
1 stop8h 34m
Delta
Sun 6/2810:35 pm
PHX
- TYS
1 stop8h 03m
Delta
Deal found 5/21![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 pm
TYS
- PHX
1 stop7h 22m
United Airlines
Mon 9/146:41 pm
PHX
- TYS
2 stops12h 16m
United Airlines
Deal found 5/22![United Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:20 pm
TYS
- PHX
1 stop5h 55m
Southwest
Sat 10/317:45 am
PHX
- TYS
2 stops6h 55m
Southwest
Deal found 5/25![Southwest logo]()
$388
This Southwest deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:10 am
TYS
- PHX
2 stops8h 30m
Southwest
Thu 9/108:00 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 5/23![Southwest logo]()
$448
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated May 26, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated May 26, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:49 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 5/314:49 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/24![Allegiant Air logo]()
$369
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:32 pm
TYS
- PHX
1 stop22h 16m
Frontier
Fri 6/126:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/22![Frontier logo]()
$376
This CheapOair deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- PHX
1 stop14h 13m
Frontier
Sun 6/144:43 pm
PHX
- TYS
1 stop23h 54m
Frontier
Deal found 5/25![Frontier logo]()
$374
This CheapOair deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:32 pm
TYS
- PHX
1 stop16h 49m
Frontier
Mon 6/156:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/25![Frontier logo]()
$373
This CheapOair deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- PHX
1 stop19h 48m
Frontier
Fri 6/198:40 am
PHX
- TYS
1 stop7h 57m
Frontier
Deal found 5/23![Frontier logo]()
$378
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:32 pm
TYS
- PHX
1 stop22h 16m
Frontier
Mon 6/226:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/22![Frontier logo]()
$315
This Gotogate deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Sun 6/286:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$336
This Cheapflightsfares deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Sun 6/284:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$348
This CheapOair deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/268:32 pm
TYS
- PHX
1 stop22h 16m
Frontier
Mon 6/296:40 am
PHX
- TYS
1 stop9h 57m
Frontier
Deal found 5/24![Frontier logo]()
$305
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 26, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 26, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 5/25![Allegiant Air logo]()
$92
This Cheapflightsfares deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 5/24![Allegiant Air logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:54 pm
TYS
- PHX
1 stop25h 30m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:47 pm
TYS
- PHX
1 stop25h 12m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$129
This CheapOair deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:19 pm
TYS
- PHX
1 stop16h 52m
Frontier
Deal found 5/25![Frontier logo]()
$141
This CheapOair deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:19 pm
TYS
- PHX
1 stop16h 52m
Frontier
Deal found 5/22![Frontier logo]()
$151
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:37 am
TYS
- PHX
1 stop6h 28m
American Airlines
Deal found 5/25![American Airlines logo]()
$165
This Expedia deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:27 pm
TYS
- PHX
1 stop27h 35m
Frontier
Deal found 5/21![Frontier logo]()
$171
This Cheapflightsfares deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/272:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 5/22![Allegiant Air logo]()
$172
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated May 26, 2026.
Round-trip from | $173 (Cheapflightsfares) |
|---|---|
One-way from | $92 (Cheapflightsfares) |
Popular in | June |
Cheapest in | August |
Average price | $401 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 8/12
7:00 am-9:55 am
1 stop5h 55m
Phoenix Sky Harbor Intl
Tue 8/18
12:35 am-12:05 pm
2 stops8h 30m
$334
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
7:30 am-1:57 pm
1 stop9h 27m
Phoenix Sky Harbor Intl
Mon 9/14
11:55 pm-11:05 am
1 stop8h 10m
$352
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 10/21
11:30 am-5:58 pm
1 stop9h 28m
Phoenix Sky Harbor Intl
Sat 10/24
11:55 pm-9:12 am
1 stop6h 17m
$358
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/27
7:10 am-1:05 pm
2 stops8h 55m
Phoenix Sky Harbor Intl
Tue 9/1
8:20 am-6:55 pm
2 stops7h 35m
$362
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 6/12
8:32 pm-10:21 am
1 stop16h 49m
Phoenix Sky Harbor Intl
Mon 6/15
6:40 am-7:37 pm
1 stop9h 57m
$373
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 10/26
7:20 pm-12:15 am
1 stop7h 55m
Phoenix Sky Harbor Intl
Fri 10/30
9:00 am-6:40 pm
1 stop6h 40m
$383
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 10/26
7:20 pm-10:15 pm
1 stop5h 55m
Phoenix Sky Harbor Intl
Sat 10/31
7:45 am-5:40 pm
2 stops6h 55m
$388
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 6/25
3:59 pm-9:33 pm
1 stop8h 34m
Phoenix Sky Harbor Intl
Sun 6/28
10:35 pm-9:38 am
1 stop8h 03m
$399
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Tue 8/25
7:00 am-2:54 pm
2 stops10h 54m
Phoenix Sky Harbor Intl
Wed 8/26
1:34 pm-10:29 pm
1 stop5h 55m
$434
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 9/3
7:10 am-12:40 pm
2 stops8h 30m
Phoenix Sky Harbor Intl
Thu 9/10
8:00 am-6:35 pm
2 stops7h 35m
$448
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 26, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Mesa flights
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Top 5 airlines flying from Knoxville to Mesa
Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$253 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$457 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$402 | FlexibilityNo cancel fee | On-time71% |