$98+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Jul 19 — Jul 261
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Thursday or Wednesday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 19, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 19, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/199:11 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/18![Allegiant Air logo]()
$179
This Cheapflightsfares deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/117:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/19![Allegiant Air logo]()
$204
This Cheapflightsfares deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Thu 10/223:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:54 pm
TYS
- PHX
1 stop27h 05m
Multiple Airlines
Thu 8/274:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$213
This Booking.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:19 pm
TYS
- PHX
1 stop6h 08m
Multiple Airlines
Sun 8/94:51 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$226
This Cheapflightsfares deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/19![Allegiant Air logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm
TYS
- PHX
Nonstop4h 01m
Multiple Airlines
Wed 11/47:40 am
PHX
- TYS
1 stop27h 39m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$251
This Cheapflightsfares deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 8/24:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/16![Allegiant Air logo]()
$254
This Cheapflightsfares deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Mon 10/129:11 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/19![Allegiant Air logo]()
$258
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 19, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am
TYS
- PHX
1 stop8h 07m
Multiple Airlines
Wed 11/46:55 pm
PHX
- TYS
2 stops16h 24m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:45 pm
TYS
- PHX
2 stops7h 10m
Southwest
Sat 8/157:05 am
PHX
- TYS
2 stops7h 35m
Southwest
Deal found 6/18![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:30 pm
TYS
- PHX
1 stop6h 06m
Delta
Fri 11/1311:00 am
PHX
- TYS
1 stop7h 40m
Delta
Deal found 6/18![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
TYS
- PHX
1 stop8h 56m
United Airlines
Wed 8/196:00 am
PHX
- TYS
1 stop6h 54m
United Airlines
Deal found 6/18![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:45 pm
TYS
- PHX
2 stops11h 00m
Southwest
Tue 7/149:05 am
PHX
- TYS
2 stops9h 15m
Southwest
Deal found 6/16![Southwest logo]()
$395
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:41 pm
TYS
- PHX
1 stop6h 00m
Delta
Sun 8/233:00 pm
PHX
- TYS
1 stop5h 52m
Delta
Deal found 6/17![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 pm
TYS
- PHX
1 stop6h 29m
United Airlines
Mon 9/146:41 pm
PHX
- TYS
2 stops12h 16m
United Airlines
Deal found 6/17![United Airlines logo]()
$430
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:50 pm
TYS
- PHX
2 stops11h 00m
Southwest
Tue 10/277:45 am
PHX
- TYS
2 stops7h 45m
Southwest
Deal found 6/17![Southwest logo]()
$404
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am
TYS
- PHX
2 stops13h 07m
United Airlines
Sat 10/2411:52 pm
PHX
- TYS
1 stop7h 07m
United Airlines
Deal found 6/17![United Airlines logo]()
$444
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated June 19, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated June 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:41 pm
TYS
- PHX
Nonstop3h 49m
Multiple Airlines
Tue 7/144:48 pm
PHX
- TYS
1 stop23h 36m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$314
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:19 pm
TYS
- PHX
1 stop28h 09m
Frontier
Tue 7/146:53 pm
PHX
- TYS
1 stop21h 31m
Frontier
Deal found 6/16![Frontier logo]()
$295
This Cheapflightsfares deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/19![Allegiant Air logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 7/264:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$284
This CheapOair deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/178:19 pm
TYS
- PHX
1 stop22h 24m
Frontier
Sun 7/194:48 pm
PHX
- TYS
1 stop23h 36m
Frontier
Deal found 6/17![Frontier logo]()
$270
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:19 pm
TYS
- PHX
1 stop28h 09m
Frontier
Fri 7/246:40 am
PHX
- TYS
1 stop9h 44m
Frontier
Deal found 6/16![Frontier logo]()
$292
This CheapOair deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:19 pm
TYS
- PHX
1 stop6h 13m
Frontier
Tue 7/284:48 pm
PHX
- TYS
1 stop23h 36m
Frontier
Deal found 6/19![Frontier logo]()
$267
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
TYS
- PHX
1 stop6h 01m
Delta
Tue 7/2810:55 am
PHX
- TYS
1 stop7h 43m
Delta
Deal found 6/19![Delta logo]()
$311
This Cheapflightsfares deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 8/24:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/16![Allegiant Air logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Thu 8/65:01 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$287
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated June 19, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated June 19, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 6/16![Allegiant Air logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:53 pm
TYS
- PHX
2 stops37h 12m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$114
This Priceline deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:19 pm
TYS
- PHX
1 stop6h 08m
Frontier
Deal found 6/19![Frontier logo]()
$120
This Super.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$130
This CheapOair deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:39 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 6/17![Allegiant Air logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$135
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated June 19, 2026.
Round-trip from | $179 (Cheapflightsfares) |
|---|---|
One-way from | $98 (Cheapflightsfares) |
Popular in | June |
Cheapest in | August |
Average price | $532 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/29
6:30 am-11:37 am
1 stop8h 07m
Phoenix Sky Harbor Intl
Wed 11/4
6:55 pm-1:19 pm
2 stops16h 24m
$339
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/13
5:45 pm-9:55 pm
2 stops7h 10m
Phoenix Sky Harbor Intl
Sat 8/15
7:05 am-5:40 pm
2 stops7h 35m
$349
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 11/12
2:30 pm-6:36 pm
1 stop6h 06m
Phoenix Sky Harbor Intl
Fri 11/13
11:00 am-8:40 pm
1 stop7h 40m
$369
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 7/8
12:45 pm-8:45 pm
2 stops11h 00m
Phoenix Sky Harbor Intl
Tue 7/14
9:05 am-9:20 pm
2 stops9h 15m
$395
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 8/21
7:41 pm-10:41 pm
1 stop6h 00m
Phoenix Sky Harbor Intl
Sun 8/23
3:00 pm-11:52 pm
1 stop5h 52m
$399
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
12:50 pm-8:50 pm
2 stops11h 00m
Phoenix Sky Harbor Intl
Tue 10/27
7:45 am-6:30 pm
2 stops7h 45m
$404
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 8/17
7:00 am-12:56 pm
1 stop8h 56m
Phoenix Sky Harbor Intl
Wed 8/19
6:00 am-3:54 pm
1 stop6h 54m
$425
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
6:00 pm-9:29 pm
1 stop6h 29m
Phoenix Sky Harbor Intl
Mon 9/14
6:41 pm-9:57 am
2 stops12h 16m
$430
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-8:49 pm
2 stops13h 07m
Phoenix Sky Harbor Intl
Sat 10/24
11:52 pm-9:59 am
1 stop7h 07m
$444
Cheapest one-way
Quickest one-way
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 7/2
2:41 pm-3:30 pm
Nonstop3h 49m
$158
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated June 19, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Food
7.2
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Top destinations
Alternative routes for Knoxville to Mesa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Mesa by cabin class
Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on June 19, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Mesa flights
Consider these flights traveling from Knoxville to Mesa.
Top 5 airlines flying from Knoxville to Mesa
Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$266 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$457 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$406 | FlexibilityNo cancel fee | On-time71% |