$92+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
May 31 — Jun 71
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 66 days in advance, depart on a Friday or Thursday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/162:51 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Thu 8/274:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:54 pm
TYS
- PHX
1 stop21h 43m
Multiple Airlines
Sun 8/164:51 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$206
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/202:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Thu 9/244:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$217
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- PHX
1 stop14h 12m
Frontier
Mon 6/85:15 am
PHX
- TYS
1 stop11h 18m
Frontier
Deal found 4/30![Frontier logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:32 pm
TYS
- PHX
1 stop16h 30m
Multiple Airlines
Sun 8/234:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$236
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:32 pm
TYS
- PHX
1 stop14h 08m
Frontier
Sun 7/124:48 pm
PHX
- TYS
1 stop23h 48m
Frontier
Deal found 4/30![Frontier logo]()
$241
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Sun 6/214:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:00 am
TYS
- PHX
1 stop17h 28m
Multiple Airlines
Thu 8/274:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$246
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Sun 7/194:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$248
This Expedia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Mon 6/15:15 am
PHX
- TYS
1 stop11h 18m
Frontier
Deal found 4/30![Frontier logo]()
$250
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Sun 6/214:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$253
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:32 pm
TYS
- PHX
1 stop16h 49m
Frontier
Fri 6/198:40 am
PHX
- TYS
1 stop7h 57m
Frontier
Deal found 4/30![Frontier logo]()
$261
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:36 am
TYS
- PHX
1 stop7h 13m
Delta
Mon 6/1511:59 pm
PHX
- TYS
1 stop8h 10m
Delta
Deal found 4/26![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:50 am
TYS
- PHX
2 stops9h 30m
Southwest
Tue 9/2212:35 am
PHX
- TYS
2 stops8h 30m
Southwest
Deal found 4/30![Southwest logo]()
$389
This Alaska Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
TYS
- PHX
2 stops14h 45m
Alaska Airlines
Mon 9/142:27 pm
PHX
- TYS
2 stops17h 49m
Alaska Airlines
Deal found 4/30![Alaska Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:25 pm
TYS
- PHX
1 stop6h 49m
United Airlines
Fri 10/3011:59 pm
PHX
- TYS
1 stop7h 01m
United Airlines
Deal found 4/28![United Airlines logo]()
$499
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:05 pm
TYS
- PHX
1 stop7h 50m
Southwest
Mon 9/215:05 am
PHX
- TYS
1 stop5h 20m
Southwest
Deal found 4/30![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:45 am
TYS
- PHX
1 stop9h 01m
Delta
Sun 8/210:14 am
PHX
- TYS
1 stop6h 51m
Delta
Deal found 4/26![Delta logo]()
$399
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:55 pm
TYS
- PHX
1 stop7h 15m
Southwest
Mon 8/35:05 am
PHX
- TYS
1 stop7h 40m
Southwest
Deal found 4/26![Southwest logo]()
$399
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- PHX
1 stop5h 55m
Southwest
Sun 8/168:30 am
PHX
- TYS
2 stops9h 15m
Southwest
Deal found 4/28![Southwest logo]()
$404
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:56 pm
TYS
- PHX
1 stop6h 33m
United Airlines
Sun 8/167:07 am
PHX
- TYS
1 stop6h 52m
United Airlines
Deal found 4/30![United Airlines logo]()
$499
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:10 am
TYS
- PHX
2 stops7h 45m
Southwest
Mon 10/55:05 am
PHX
- TYS
1 stop7h 15m
Southwest
Deal found 4/29![Southwest logo]()
$493
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated May 1, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated May 1, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:28 pm
TYS
- PHX
1 stop10h 14m
Frontier
Sun 5/36:50 am
PHX
- TYS
1 stop5h 43m
Frontier
Deal found 4/27![Frontier logo]()
$290
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:00 am
TYS
- PHX
Nonstop4h 06m
Allegiant Air
Thu 5/79:56 am
PHX
- TYS
Nonstop3h 24m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:00 am
TYS
- PHX
1 stop27h 44m
Multiple Airlines
Sat 5/306:51 pm
PHX
- TYS
2 stops37h 46m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:24 pm
TYS
- PHX
2 stops20h 45m
Multiple Airlines
Mon 6/15:15 am
PHX
- TYS
1 stop11h 18m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:36 am
TYS
- PHX
1 stop8h 58m
Delta
Tue 6/21:27 pm
PHX
- TYS
1 stop7h 34m
Delta
Deal found 4/28![Delta logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:00 am
TYS
- PHX
1 stop27h 44m
Multiple Airlines
Mon 6/112:05 pm
PHX
- TYS
2 stops25h 10m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$337
This Expedia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Mon 6/15:15 am
PHX
- TYS
1 stop11h 18m
Frontier
Deal found 4/30![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop14h 25m
Multiple Airlines
Mon 6/19:15 am
PHX
- TYS
2 stops28h 00m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop14h 25m
Multiple Airlines
Sat 5/306:51 pm
PHX
- TYS
1 stop16h 08m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:00 am
TYS
- PHX
1 stop27h 44m
Multiple Airlines
Wed 6/36:51 pm
PHX
- TYS
1 stop16h 01m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$325
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$92
This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Deal found 4/28![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:32 pm
TYS
- PHX
1 stop14h 13m
Frontier
Deal found 5/1![Frontier logo]()
$109
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- PHX
1 stop16h 33m
Frontier
Deal found 4/29![Frontier logo]()
$117
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:32 pm
TYS
- PHX
1 stop6h 00m
Frontier
Deal found 4/30![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:27 pm
TYS
- PHX
2 stops28h 06m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$127
This Super.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- PHX
1 stop21h 51m
Frontier
Deal found 4/29![Frontier logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:49 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:22 pm
TYS
- PHX
2 stops24h 01m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$139
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated May 1, 2026.
Round-trip from | $221 (CheapOair) |
|---|---|
One-way from | $92 (Cheapflightsfares) |
Popular in | November |
Cheapest in | August |
Average price | $383 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Sat 6/6
6:36 am-10:49 am
1 stop7h 13m
Phoenix Sky Harbor Intl
Mon 6/15
11:59 pm-11:09 am
1 stop8h 10m
$383
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Sat 9/19
6:50 am-1:20 pm
2 stops9h 30m
Phoenix Sky Harbor Intl
Tue 9/22
12:35 am-12:05 pm
2 stops8h 30m
$389
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 9/17
2:05 pm-6:55 pm
1 stop7h 50m
Phoenix Sky Harbor Intl
Mon 9/21
5:05 am-1:25 pm
1 stop5h 20m
$399
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Tue 7/28
6:45 am-12:46 pm
1 stop9h 01m
Phoenix Sky Harbor Intl
Sun 8/2
10:14 am-8:05 pm
1 stop6h 51m
$399
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Tue 7/28
6:55 pm-11:10 pm
1 stop7h 15m
Phoenix Sky Harbor Intl
Mon 8/3
5:05 am-3:45 pm
1 stop7h 40m
$399
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 8/12
7:00 am-9:55 am
1 stop5h 55m
Phoenix Sky Harbor Intl
Sun 8/16
8:30 am-8:45 pm
2 stops9h 15m
$404
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
6:00 am-5:45 pm
2 stops14h 45m
Phoenix Sky Harbor Intl
Mon 9/14
2:27 pm-11:16 am
2 stops17h 49m
$474
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 10/1
7:10 am-11:55 am
2 stops7h 45m
Phoenix Sky Harbor Intl
Mon 10/5
5:05 am-3:20 pm
1 stop7h 15m
$493
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 10/26
4:25 pm-8:14 pm
1 stop6h 49m
Phoenix Sky Harbor Intl
Fri 10/30
11:59 pm-10:00 am
1 stop7h 01m
$499
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 8/14
4:56 pm-8:29 pm
1 stop6h 33m
Phoenix Sky Harbor Intl
Sun 8/16
7:07 am-4:59 pm
1 stop6h 52m
$499
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
What is the cheapest time of day to fly from TYS to MS9?
Find hourly flight availability from Knoxville to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Mesa as you normally would.
How much does it cost to fly round-trip from Knoxville to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 1, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Mesa
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Complete your trip
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Search flights from Knoxville to Mesa by cabin class
Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on May 1, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Mesa flights
Consider these flights traveling from Knoxville to Mesa.
Top 5 airlines flying from Knoxville to Mesa
Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$70 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$115 | Average$247 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$128 | Average$343 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$437 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$403 | FlexibilityNo cancel fee | On-time71% |