$92+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Sep 21 — Sep 281
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Friday or Wednesday and return on a Monday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/18![Allegiant Air logo]()
$169
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Sun 10/187:51 am -
Nonstop3h 27m
Deal found 8/17![Allegiant Air logo]()
$186
This Cheapflightsfares deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:39 pm -
Nonstop4h 01m
Thu 11/124:30 pm -
Nonstop3h 36m
Deal found 8/20![Allegiant Air logo]()
$199
This Cheapflightsfares deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/21![Allegiant Air logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop16h 24m
Thu 11/124:30 pm -
Nonstop3h 36m
Deal found 8/20![Multiple Airlines logo]()
$211
This Cheapflightsfares deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:52 pm -
Nonstop4h 01m
Sun 10/253:43 pm -
Nonstop3h 27m
Deal found 8/21![Allegiant Air logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
2 stops22h 21m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/18![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:03 pm -
1 stop23h 30m
Sun 10/187:51 am -
Nonstop3h 27m
Deal found 8/17![Multiple Airlines logo]()
$231
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:34 pm -
Nonstop3h 58m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/17![Allegiant Air logo]()
$233
This Cheapflightsfares deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:47 pm -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/20![Allegiant Air logo]()
$235
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop20h 18m
Mon 10/129:11 am -
Nonstop3h 27m
Deal found 8/21![Multiple Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 pm -
1 stop6h 37m
Wed 9/1611:28 am -
1 stop8h 21m
Deal found 8/17![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop7h 58m
Fri 11/134:32 pm -
1 stop5h 25m
Deal found 8/21![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:15 am -
2 stops7h 35m
Fri 10/3011:50 pm -
1 stop7h 00m
Deal found 8/18![Southwest logo]()
$354
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:55 pm -
1 stop7h 43m
Mon 10/1911:52 pm -
1 stop6h 53m
Deal found 8/20![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:40 pm -
2 stops9h 25m
Thu 11/125:40 am -
2 stops7h 20m
Deal found 8/20![Southwest logo]()
$390
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops15h 03m
Sat 10/37:30 am -
2 stops11h 25m
Deal found 8/21![United Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:40 pm -
2 stops9h 25m
Sun 11/85:40 am -
2 stops7h 20m
Deal found 8/18![Southwest logo]()
$435
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
2 stops15h 03m
Tue 10/2711:20 am -
1 stop6h 34m
Deal found 8/18![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
2 stops15h 03m
Sat 10/247:10 am -
1 stop6h 58m
Deal found 8/18![United Airlines logo]()
$439
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated August 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated August 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:55 pm -
2 stops25h 53m
Sun 8/304:16 pm -
Nonstop3h 36m
Deal found 8/17![Multiple Airlines logo]()
$282
This Cheapflightsfares deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm -
Nonstop3h 58m
Sun 9/64:22 pm -
Nonstop3h 31m
Deal found 8/19![Allegiant Air logo]()
$237
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:34 pm -
Nonstop3h 58m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/17![Allegiant Air logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:00 am -
1 stop12h 19m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/17![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:00 am -
2 stops18h 43m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/18![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
1 stop28h 00m
Wed 9/168:39 pm -
1 stop17h 39m
Deal found 8/18![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:30 am -
1 stop19h 17m
Wed 9/238:39 pm -
1 stop17h 39m
Deal found 8/18![Multiple Airlines logo]()
$286
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:39 pm -
Nonstop3h 47m
Deal found 8/18![Allegiant Air logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
1 stop28h 00m
Deal found 8/21![Multiple Airlines logo]()
$107
This Super.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm -
Nonstop3h 47m
Deal found 8/20![Allegiant Air logo]()
$111
This Super.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:34 pm -
Nonstop3h 58m
Deal found 8/19![Allegiant Air logo]()
$113
This Super.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/132:34 pm -
Nonstop3h 58m
Deal found 8/21![Allegiant Air logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
Nonstop4h 01m
Deal found 8/19![Allegiant Air logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop20h 18m
Deal found 8/20![Multiple Airlines logo]()
$143
This Cheapflightsfares deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
Nonstop4h 01m
Deal found 8/20![Allegiant Air logo]()
$147
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated August 22, 2026.
Round-trip from | $169 (Cheapflightsfares) |
|---|---|
One-way from | $92 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $208 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/8
6:30 am-11:48 pm
1 stop20h 18m
Phoenix Sky Harbor Intl
Mon 10/12
9:11 am-3:38 pm
Nonstop3h 27m
$297
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 9/15
6:00 pm-9:37 pm
1 stop6h 37m
Phoenix Sky Harbor Intl
Wed 9/16
11:28 am-10:49 pm
1 stop8h 21m
$319
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Sat 10/3
1:55 pm-6:38 pm
1 stop7h 43m
Phoenix Sky Harbor Intl
Mon 10/19
11:52 pm-9:45 am
1 stop6h 53m
$334
Quickest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Fri 11/13
6:00 am-11:58 am
1 stop7h 58m
Phoenix Sky Harbor Intl
Fri 11/13
4:32 pm-11:57 pm
1 stop5h 25m
$349
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 10/27
7:15 am-11:50 am
2 stops7h 35m
Phoenix Sky Harbor Intl
Fri 10/30
11:50 pm-9:50 am
1 stop7h 00m
$354
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 11/5
3:40 pm-11:05 pm
2 stops9h 25m
Phoenix Sky Harbor Intl
Thu 11/12
5:40 am-3:00 pm
2 stops7h 20m
$390
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 9/29
6:00 am-6:03 pm
2 stops15h 03m
Phoenix Sky Harbor Intl
Sat 10/3
7:30 am-9:55 pm
2 stops11h 25m
$429
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 11/5
3:40 pm-11:05 pm
2 stops9h 25m
Phoenix Sky Harbor Intl
Sun 11/8
5:40 am-3:00 pm
2 stops7h 20m
$435
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-10:45 pm
2 stops15h 03m
Phoenix Sky Harbor Intl
Tue 10/27
11:20 am-8:54 pm
1 stop6h 34m
$439
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-10:45 pm
2 stops15h 03m
Phoenix Sky Harbor Intl
Sat 10/24
7:10 am-5:08 pm
1 stop6h 58m
$439
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Airfare is below average for this route at the moment.
Knoxville to Mesa flights typically cost between $182 and $432 in October.The cheapest round-trip price found within the last 5 days was $169 on Allegiant Air (Oct 16-Oct 19).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated August 22, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on August 22, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Mesa flights
Consider these flights traveling from Knoxville to Mesa.
Top 6 airlines flying from Knoxville to Mesa
Discover the top 6 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$124 | Average$278 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$130 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$565 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$439 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$284 | Average$416 | FlexibilityNo cancel fee | On-time71% |