$78+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Jun 11 — Jun 181
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 66 days in advance, depart on a Friday or Thursday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/162:51 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 9/64:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 5/11![Allegiant Air logo]()
$152
This Cheapflightsfares deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Sun 9/64:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 5/11![Allegiant Air logo]()
$166
This Cheapflightsfares deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/12![Allegiant Air logo]()
$181
This Cheapflightsfares deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/10![Allegiant Air logo]()
$183
This Booking.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/162:51 pm
TYS
- PHX
Nonstop4h 10m
Multiple Airlines
Sun 9/66:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:47 pm
TYS
- PHX
1 stop25h 08m
Multiple Airlines
Thu 8/204:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$219
This Gotogate deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Multiple Airlines
Sun 9/66:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$222
This Cheapflightsfares deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:51 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Thu 8/204:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/11![Allegiant Air logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:00 am
TYS
- PHX
1 stop16h 49m
Multiple Airlines
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$243
This Priceline deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/184:27 pm
TYS
- PHX
1 stop10h 06m
Frontier
Sun 10/256:05 am
PHX
- TYS
1 stop6h 24m
Frontier
Deal found 5/12![Frontier logo]()
$250
This Mytrip deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:32 pm
TYS
- PHX
1 stop16h 39m
Frontier
Thu 8/206:53 pm
PHX
- TYS
1 stop21h 44m
Frontier
Deal found 5/11![Frontier logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:39 pm
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Sun 11/83:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/7![Allegiant Air logo]()
$254
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:30 am
TYS
- PHX
1 stop9h 27m
Delta
Mon 9/146:05 am
PHX
- TYS
1 stop6h 02m
Delta
Deal found 5/11![Delta logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:00 am
TYS
- PHX
1 stop27h 44m
Multiple Airlines
Thu 6/116:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
TYS
- PHX
1 stop8h 06m
United Airlines
Sun 6/711:50 pm
PHX
- TYS
1 stop6h 53m
United Airlines
Deal found 5/10![United Airlines logo]()
$433
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:05 am
TYS
- PHX
2 stops9h 20m
Southwest
Sun 11/85:10 am
PHX
- TYS
1 stop5h 00m
Southwest
Deal found 5/10![Southwest logo]()
$453
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:45 am
TYS
- PHX
1 stop9h 01m
Delta
Sat 8/110:57 pm
PHX
- TYS
1 stop8h 23m
Delta
Deal found 5/10![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:10 am
TYS
- PHX
2 stops7h 45m
Southwest
Sat 9/512:35 am
PHX
- TYS
2 stops10h 15m
Southwest
Deal found 5/11![Southwest logo]()
$463
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:30 am
TYS
- PHX
1 stop7h 31m
United Airlines
Mon 9/146:40 pm
PHX
- TYS
2 stops12h 28m
United Airlines
Deal found 5/9![United Airlines logo]()
$463
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:27 am
TYS
- PHX
1 stop7h 50m
Delta
Mon 6/11:27 pm
PHX
- TYS
1 stop7h 29m
Delta
Deal found 5/9![Delta logo]()
$472
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
TYS
- PHX
2 stops8h 55m
Southwest
Tue 7/219:05 am
PHX
- TYS
2 stops9h 10m
Southwest
Deal found 5/11![Southwest logo]()
$478
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
TYS
- PHX
2 stops14h 00m
United Airlines
Fri 8/281:34 pm
PHX
- TYS
1 stop6h 10m
United Airlines
Deal found 5/9![United Airlines logo]()
$488
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:25 am
TYS
- PHX
2 stops7h 50m
Southwest
Sun 10/2510:45 pm
PHX
- TYS
2 stops13h 35m
Southwest
Deal found 5/12![Southwest logo]()
$492
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated May 12, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated May 12, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Fri 5/295:15 am
PHX
- TYS
1 stop11h 09m
Frontier
Deal found 5/11![Frontier logo]()
$290
This Expedia deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Mon 6/15:15 am
PHX
- TYS
1 stop11h 18m
Frontier
Deal found 5/11![Frontier logo]()
$280
This Gotogate deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/72:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Thu 6/254:43 pm
PHX
- TYS
1 stop23h 54m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$309
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/72:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Thu 6/116:53 pm
PHX
- TYS
1 stop21h 44m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:00 am
TYS
- PHX
1 stop27h 44m
Multiple Airlines
Wed 6/1010:32 pm
PHX
- TYS
2 stops34h 27m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$326
This CheapOair deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- PHX
1 stop27h 49m
Frontier
Sun 6/146:53 pm
PHX
- TYS
1 stop21h 44m
Frontier
Deal found 5/10![Frontier logo]()
$260
This CheapOair deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- PHX
1 stop14h 13m
Frontier
Thu 6/114:43 pm
PHX
- TYS
1 stop23h 54m
Frontier
Deal found 5/12![Frontier logo]()
$325
This Cheapflightsfares deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:42 pm
TYS
- PHX
Nonstop3h 48m
Allegiant Air
Thu 6/184:20 pm
PHX
- TYS
Nonstop3h 32m
Allegiant Air
Deal found 5/8![Allegiant Air logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:42 pm
TYS
- PHX
Nonstop3h 48m
Multiple Airlines
Thu 6/186:40 am
PHX
- TYS
2 stops26h 19m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$311
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 5/12![Allegiant Air logo]()
$78
This Cheapflightsfares deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 5/9![Allegiant Air logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:47 pm
TYS
- PHX
1 stop25h 08m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$122
This Frontier deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:32 pm
TYS
- PHX
1 stop6h 00m
Frontier
Deal found 5/9![Frontier logo]()
$125
This Super.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:32 pm
TYS
- PHX
1 stop14h 08m
Frontier
Deal found 5/8![Frontier logo]()
$130
This Expedia deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- PHX
1 stop14h 25m
Frontier
Deal found 5/7![Frontier logo]()
$141
This Super.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:19 pm
TYS
- PHX
1 stop6h 10m
Frontier
Deal found 5/11![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:00 am
TYS
- PHX
1 stop19h 34m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$155
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated May 12, 2026.
Round-trip from | $219 (Kiwi.com) |
|---|---|
One-way from | $78 (Cheapflightsfares) |
Popular in | November |
Cheapest in | August |
Average price | $385 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
7:30 am-1:57 pm
1 stop9h 27m
Phoenix Sky Harbor Intl
Mon 9/14
6:05 am-3:07 pm
1 stop6h 02m
$358
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Sun 6/7
7:00 am-7:44 am
1 stop27h 44m
Phoenix Sky Harbor Intl
Thu 6/11
6:53 pm-7:37 pm
1 stop21h 44m
$375
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 7/31
6:45 am-12:46 pm
1 stop9h 01m
Phoenix Sky Harbor Intl
Sat 8/1
10:57 pm-10:20 am
1 stop8h 23m
$383
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 6/3
6:00 am-11:06 am
1 stop8h 06m
Phoenix Sky Harbor Intl
Sun 6/7
11:50 pm-9:43 am
1 stop6h 53m
$433
Quickest round-trip
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 11/5
7:05 am-2:25 pm
2 stops9h 20m
Phoenix Sky Harbor Intl
Sun 11/8
5:10 am-12:10 pm
1 stop5h 00m
$453
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Thu 8/13
7:10 am-11:55 am
2 stops7h 45m
Phoenix Sky Harbor Intl
Sat 9/5
12:35 am-1:50 pm
2 stops10h 15m
$463
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
6:30 am-11:01 am
1 stop7h 31m
Phoenix Sky Harbor Intl
Mon 9/14
6:40 pm-10:08 am
2 stops12h 28m
$463
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 5/25
7:27 am-12:17 pm
1 stop7h 50m
Phoenix Sky Harbor Intl
Mon 6/1
1:27 pm-11:56 pm
1 stop7h 29m
$472
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Fri 7/17
6:40 am-12:35 pm
2 stops8h 55m
Phoenix Sky Harbor Intl
Tue 7/21
9:05 am-9:15 pm
2 stops9h 10m
$478
KnoxvillePhoenix
TYS - PHX
TYSPHX
Knoxville McGhee Tyson
Mon 8/24
7:00 am-6:00 pm
2 stops14h 00m
Phoenix Sky Harbor Intl
Fri 8/28
1:34 pm-10:44 pm
1 stop6h 10m
$488
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 12, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Mesa flights
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Top 5 airlines flying from Knoxville to Mesa
Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$250 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$327 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$437 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$398 | FlexibilityNo cancel fee | On-time71% |