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Mesa

$71+ Cheap flights from Knoxville (TYS) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in January or August, booked 33 days in advance, depart on a Tuesday or Thursday and return on a Friday

Cheap flight deals from Knoxville to Mesa

Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated September 17, 2025.

Round-trip from

$143
(Cheapflightsfares)

One-way from

$71
(Cheapflightsfares)

Popular in

April

Cheapest in

January

Average price

$260
From Knoxville McGhee Tyson to Mesa
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One-way flight from Knoxville McGhee Tyson to Mesa
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Highest demand for flights based on searches. 13% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Mesa

Cheapest flights from Knoxville to Mesa
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Sun 12/144:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Deal found 9/16$143
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:20 amTYS - PHX
Nonstop3h 57mAllegiant Air
Fri 10/247:49 amPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/17$150
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:20 amTYS - PHX
Nonstop3h 57mAllegiant Air
Sat 10/182:34 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/16$155
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:00 amTYS - PHX
Nonstop3h 59mAllegiant Air
Sun 10/264:12 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/15$168
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1812:45 pmTYS - PHX
Nonstop3h 59mAllegiant Air
Sun 10/194:12 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/17$176
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - PHX
1 stop21h 47mMultiple Airlines
Fri 10/247:49 amPHX - TYS
Nonstop3h 30mMultiple Airlines
Deal found 9/15$188
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:20 amTYS - PHX
Nonstop3h 57mAllegiant Air
Mon 10/2711:49 amPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/15$189
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:40 pmTYS - PHX
1 stop5h 47mFrontier
Mon 9/297:00 amPHX - TYS
1 stop9h 45mFrontier
Deal found 9/15$194
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/232:23 pmTYS - PHX
Nonstop3h 59mAllegiant Air
Sun 10/264:12 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Deal found 9/17$198
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:20 amTYS - PHX
Nonstop3h 57mMultiple Airlines
Sat 10/254:14 pmPHX - TYS
1 stop18h 19mMultiple Airlines
Deal found 9/15$201

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.

Fly from

Knoxville

Fly to

Mesa

Route

Depart

Return

Price

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 10/20

4:53 pm-12:06 pm

1 stop22h 13m

Phoenix Sky Harbor Intl

Mon 10/27

11:49 am-6:19 pm

Nonstop3h 30m

$248

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 12/3

5:45 pm-11:52 pm

1 stop8h 07m

Phoenix Sky Harbor Intl

Sun 12/7

12:30 am-9:54 am

1 stop7h 24m

$280

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 10/24

6:04 pm-11:04 pm

1 stop8h 00m

Phoenix Sky Harbor Intl

Tue 10/28

10:59 pm-9:00 am

1 stop7h 01m

$283

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 10/17

8:10 pm-11:00 pm

1 stop5h 50m

Phoenix Sky Harbor Intl

Tue 10/28

2:01 pm-10:55 pm

1 stop5h 54m

$283

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 10/21

5:20 pm-9:15 pm

1 stop6h 55m

Phoenix Sky Harbor Intl

Wed 10/22

12:35 pm-10:50 pm

1 stop7h 15m

$288

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 10/23

2:23 pm-3:22 pm

Nonstop3h 59m

Phoenix Sky Harbor Intl

Wed 10/29

6:11 pm-1:33 pm

1 stop16h 22m

$309

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 12/30

6:57 pm-11:48 pm

1 stop6h 51m

Phoenix Sky Harbor Intl

Wed 1/7

3:00 pm-11:00 pm

1 stop6h 00m

$368

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 12/31

6:15 am-1:43 pm

1 stop9h 28m

Phoenix Sky Harbor Intl

Wed 1/7

12:25 pm-11:00 pm

1 stop8h 35m

$368

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 12/31

6:15 am-1:43 pm

1 stop9h 28m

Phoenix Sky Harbor Intl

Tue 1/6

2:15 pm-9:43 pm

1 stop5h 28m

$368

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sun 12/28

2:01 pm-4:06 pm

Nonstop4h 05m

Phoenix Sky Harbor Intl

Thu 1/8

1:16 pm-6:39 pm

Nonstop3h 23m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 20 results
1
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Best time to book a flight from Knoxville to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mesa

How far ahead should I book a flight from Knoxville to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Mesa. Price data was last updated on September 12, 2025.

Booking 33 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Mesa. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Mesa?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $258). Flying from Knoxville to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS9?

Find hourly flight availability from Knoxville to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Mesa as you normally would.

What is the cheapest day to fly from Knoxville to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Mesa. Price data was last updated on November 18, 2024.

Travelers seeking maximum savings on their Knoxville to Mesa flight should consider departing on Thursday mornings when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.8
Fair
3,173 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mesa?

    For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 5 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

  • How long is the flight from Knoxville to Mesa?

    Airlines like American Airlines, Delta, and United Airlines fly from Knoxville to Mesa in about 6h 55m. The time it takes to get you to your destination can typically vary by up to 1h 12m. The distance from Knoxville to Mesa is about 1594 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Knoxville to Mesa one-way?

    $71 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Frontier and American Airlines, with prices starting from $88 and $126, respectively.

  • What are the cheapest flights from Knoxville to Mesa?

    Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $219, our data indicates the cheapest price to be $117. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $143.

  • Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

  • Can I find deals for business class flights from Knoxville to Mesa?

    Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $258). Flying from Knoxville to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Knoxville to Mesa

Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$115Average$230FlexibilityNo cancel feeOn-time88%
DeltaCheapest$128Average$407FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$138Average$302FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$220Average$526FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$255Average$480FlexibilityNo cancel feeOn-time71%

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