$90+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Sep 15 — Sep 221
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Friday or Wednesday and return on a Monday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/12![Allegiant Air logo]()
$153
This Cheapflightsfares deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm -
Nonstop4h 01m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 8/15![Allegiant Air logo]()
$179
This CheapOair deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm -
Nonstop3h 58m
Sun 9/64:22 pm -
Nonstop3h 31m
Deal found 8/11![Allegiant Air logo]()
$192
This Cheapflightsfares deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:52 pm -
Nonstop4h 01m
Sun 10/253:43 pm -
Nonstop3h 27m
Deal found 8/12![Allegiant Air logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop11h 05m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 8/15![Multiple Airlines logo]()
$206
This Cheapflightsfares deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:29 pm -
Nonstop4h 01m
Sun 11/153:20 pm -
Nonstop3h 36m
Deal found 8/15![Allegiant Air logo]()
$224
This CheapOair deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm -
Nonstop3h 47m
Sun 8/234:16 pm -
Nonstop3h 36m
Deal found 8/10![Allegiant Air logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:00 am -
1 stop28h 00m
Sat 10/313:40 pm -
1 stop19h 31m
Deal found 8/11![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:42 pm -
1 stop16h 07m
Thu 11/54:30 pm -
Nonstop3h 36m
Deal found 8/13![Multiple Airlines logo]()
$230
This Cheapflightsfares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm -
Nonstop3h 58m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/14![Allegiant Air logo]()
$235
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 16, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 16, 2026.
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/145:30 am -
1 stop6h 59m
Tue 1/197:05 am -
1 stop8h 08m
Deal found 8/10![Delta logo]()
$263
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am -
1 stop7h 08m
Sun 9/66:00 am -
1 stop6h 54m
Deal found 8/11![United Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:45 am -
1 stop7h 57m
Sat 10/1011:52 pm -
1 stop6h 53m
Deal found 8/12![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:00 am -
1 stop6h 20m
Tue 12/1511:59 pm -
1 stop8h 21m
Deal found 8/11![Delta logo]()
$335
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:00 pm -
1 stop8h 36m
Sun 1/1711:59 pm -
1 stop8h 15m
Deal found 8/10![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:53 pm -
1 stop8h 06m
Sun 10/1111:52 pm -
1 stop6h 53m
Deal found 8/15![United Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
2 stops15h 03m
Sat 10/2410:25 am -
1 stop8h 30m
Deal found 8/13![United Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
2 stops15h 03m
Tue 10/279:55 am -
2 stops11h 04m
Deal found 8/13![United Airlines logo]()
$408
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated August 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated August 16, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm -
Nonstop3h 47m
Sun 8/234:16 pm -
Nonstop3h 36m
Deal found 8/10![Allegiant Air logo]()
$226
This CheapOair deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm -
Nonstop3h 58m
Sun 9/64:22 pm -
Nonstop3h 31m
Deal found 8/11![Allegiant Air logo]()
$192
This Cheapflightsfares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:34 pm -
Nonstop3h 58m
Sun 9/134:22 pm -
Nonstop3h 31m
Deal found 8/14![Allegiant Air logo]()
$235
This Expedia deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/132:34 pm -
Nonstop3h 58m
Thu 9/174:22 pm -
Nonstop3h 31m
Deal found 8/10![Allegiant Air logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
1 stop28h 00m
Thu 9/174:22 pm -
Nonstop3h 31m
Deal found 8/10![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:18 pm -
2 stops24h 59m
Thu 9/174:22 pm -
Nonstop3h 31m
Deal found 8/11![Multiple Airlines logo]()
$288
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:50 pm -
1 stop8h 19m
Mon 9/217:10 am -
1 stop6h 48m
Deal found 8/12![United Airlines logo]()
$282
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:45 am -
1 stop7h 41m
Mon 9/2811:52 pm -
1 stop6h 53m
Deal found 8/12![United Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
2 stops6h 45m
Mon 9/2811:05 pm -
1 stop11h 00m
Deal found 8/12![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:00 am -
1 stop28h 00m
Sat 10/313:40 pm -
1 stop19h 31m
Deal found 8/11![Multiple Airlines logo]()
$228
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated August 16, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated August 16, 2026.
This CheapOair deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Deal found 8/12![Allegiant Air logo]()
$90
This Jetabroad deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:10 am -
Nonstop4h 01m
Deal found 8/11![Allegiant Air logo]()
$112
This Cheapflightsfares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:34 pm -
Nonstop3h 58m
Deal found 8/14![Allegiant Air logo]()
$126
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:00 pm -
1 stop8h 25m
Deal found 8/11![Southwest logo]()
$131
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am -
2 stops8h 30m
Deal found 8/10![Southwest logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
2 stops30h 52m
Deal found 8/12![Multiple Airlines logo]()
$137
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:35 pm -
1 stop7h 25m
Deal found 8/11![American Airlines logo]()
$143
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:45 pm -
2 stops7h 15m
Deal found 8/11![Southwest logo]()
$147
This Expedia deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
Nonstop4h 01m
Deal found 8/11![Allegiant Air logo]()
$148
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated August 16, 2026.
Round-trip from | $153 (Cheapflightsfares) |
|---|---|
One-way from | $90 (CheapOair) |
Popular in | June |
Cheapest in | August |
Average price | $208 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 1/14
5:30 am-10:29 am
1 stop6h 59m
Phoenix Sky Harbor Intl
Tue 1/19
7:05 am-5:13 pm
1 stop8h 08m
$263
Quickest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 9/3
7:00 am-11:08 am
1 stop7h 08m
Phoenix Sky Harbor Intl
Sun 9/6
6:00 am-3:54 pm
1 stop6h 54m
$327
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 10/6
5:45 am-10:42 am
1 stop7h 57m
Phoenix Sky Harbor Intl
Sat 10/10
11:52 pm-9:45 am
1 stop6h 53m
$330
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Sun 12/13
6:00 am-10:20 am
1 stop6h 20m
Phoenix Sky Harbor Intl
Tue 12/15
11:59 pm-10:20 am
1 stop8h 21m
$335
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 1/14
12:00 pm-6:36 pm
1 stop8h 36m
Phoenix Sky Harbor Intl
Sun 1/17
11:59 pm-10:14 am
1 stop8h 15m
$337
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Wed 10/7
4:53 pm-9:59 pm
1 stop8h 06m
Phoenix Sky Harbor Intl
Sun 10/11
11:52 pm-9:45 am
1 stop6h 53m
$376
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-10:45 pm
2 stops15h 03m
Phoenix Sky Harbor Intl
Sat 10/24
10:25 am-9:55 pm
1 stop8h 30m
$403
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/22
10:42 am-10:45 pm
2 stops15h 03m
Phoenix Sky Harbor Intl
Tue 10/27
9:55 am-11:59 pm
2 stops11h 04m
$408
Cheapest one-way
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 10/27
9:00 am-2:28 pm
1 stop8h 28m
$131
Quickest one-way
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Wed 9/9
10:45 am-3:20 pm
1 stop7h 35m
$131
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Airfare is below average for this route at the moment.
Knoxville to Mesa flights typically cost between $179 and $386 in October.The cheapest round-trip price found within the last 5 days was $153 on Allegiant Air (Oct 16-Oct 19).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated August 16, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on August 16, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Mesa flights
Consider these flights traveling from Knoxville to Mesa.
Top 6 airlines flying from Knoxville to Mesa
Discover the top 6 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$124 | Average$277 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$130 | Average$418 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$565 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$439 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$284 | Average$414 | FlexibilityNo cancel fee | On-time71% |