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Mesa

$91+ Cheap flights from Knoxville (TYS) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in September or August, booked 67 days in advance, depart on a Friday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to Mesa

Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated January 14, 2026.

Round-trip from

$166
(Mytrip)

One-way from

$91
(Priceline)

Popular in

November

Cheapest in

September

Average price

$268
From Knoxville McGhee Tyson to Mesa
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One-way flight from Knoxville McGhee Tyson to Mesa
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Highest demand for flights based on searches. 10% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Knoxville to Mesa

Cheapest flights from Knoxville to Mesa
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This Mytrip deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/810:05 am
TYS
-
PHX
Nonstop4h 26m
Allegiant Air
Thu 2/2611:54 am
PHX
-
TYS
Nonstop3h 23m
Allegiant Air
Deal found 1/11$166
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/110:00 am
TYS
-
PHX
Nonstop4h 26m
Allegiant Air
Thu 2/1212:25 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 1/13$174
This Mytrip deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/264:30 pm
TYS
-
PHX
1 stop10h 10m
Frontier
Thu 1/299:22 am
PHX
-
TYS
1 stop28h 08m
Frontier
Deal found 1/12$179
This Gotogate deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/24:30 pm
TYS
-
PHX
1 stop6h 53m
Multiple Airlines
Thu 2/1212:25 pm
PHX
-
TYS
Nonstop3h 27m
Multiple Airlines
Deal found 1/12$184
This Mytrip deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/810:05 am
TYS
-
PHX
Nonstop4h 26m
Multiple Airlines
Thu 2/267:36 pm
PHX
-
TYS
1 stop20h 30m
Multiple Airlines
Deal found 1/11$189
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:30 am
TYS
-
PHX
Nonstop4h 34m
Allegiant Air
Tue 3/1011:06 am
PHX
-
TYS
Nonstop3h 28m
Allegiant Air
Deal found 1/12$201
This Booking.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Sun 4/269:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Deal found 1/12$208
This Booking.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Sun 4/129:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Deal found 1/13$221
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:30 am
TYS
-
PHX
Nonstop4h 34m
Allegiant Air
Sun 3/810:36 am
PHX
-
TYS
Nonstop3h 28m
Allegiant Air
Deal found 1/12$227
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/110:00 am
TYS
-
PHX
Nonstop4h 26m
Multiple Airlines
Thu 2/127:36 pm
PHX
-
TYS
1 stop21h 51m
Multiple Airlines
Deal found 1/13$229
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:30 am
TYS
-
PHX
Nonstop4h 34m
Multiple Airlines
Tue 3/104:27 pm
PHX
-
TYS
1 stop23h 36m
Multiple Airlines
Deal found 1/12$230

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.

Fly from

Knoxville

Fly to

Mesa

Route

Depart

Return

Price

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-8:42 am

1 stop14h 29m

Phoenix Sky Harbor Intl

Fri 2/27

7:23 pm-8:18 pm

2 stops22h 55m

$252

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sun 3/1

5:53 pm-1:44 pm

2 stops45h 51m

Phoenix Sky Harbor Intl

Sat 3/7

12:06 pm-5:34 pm

Nonstop3h 28m

$256

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 2/7

5:40 am-10:30 am

1 stop6h 50m

Phoenix Sky Harbor Intl

Sat 2/14

11:53 pm-9:24 am

1 stop7h 31m

$279

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 2/21

5:35 am-10:31 am

1 stop6h 56m

Phoenix Sky Harbor Intl

Wed 2/25

11:50 pm-9:04 am

1 stop7h 14m

$279

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 2/20

8:12 pm-12:41 am

1 stop6h 29m

Phoenix Sky Harbor Intl

Sun 2/22

11:55 am-5:22 pm

Nonstop3h 27m

$284

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 3/12

10:54 am-12:10 pm

Nonstop4h 16m

Phoenix Sky Harbor Intl

Mon 3/16

9:24 pm-7:03 pm

2 stops42h 39m

$297

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 3/11

6:35 am-11:45 am

2 stops8h 10m

Phoenix Sky Harbor Intl

Mon 3/16

11:55 pm-11:50 am

1 stop8h 55m

$298

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 2/7

11:07 am-6:06 pm

2 stops8h 59m

Phoenix Sky Harbor Intl

Sat 2/14

9:40 am-6:10 pm

1 stop6h 30m

$302

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 3/10

6:35 am-12:05 pm

2 stops8h 30m

Phoenix Sky Harbor Intl

Tue 3/17

8:40 am-8:05 pm

2 stops8h 25m

$308

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 1/26

4:30 pm-12:40 am

1 stop10h 10m

$91

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/11

Showing 1-10 of 19 results
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Best time to book a flight from Knoxville to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mesa

How far ahead should I book a flight from Knoxville to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Mesa. Price data was last updated on January 9, 2026.

Booking 36 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Mesa. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Mesa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated January 14, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,040 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,040 reviews
Delta
7.9
Good
8,040 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,156 reviews
Delta
7.9
Good
8,040 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,119 reviews
Delta
7.9
Good
8,040 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
702 reviews
Delta
7.9
Good
8,040 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mesa?

    For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 4 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

  • How long is the flight from Knoxville to Mesa?

    Airlines like Delta fly from Knoxville to Mesa in about 6h 50m. The time it takes to get you to your destination can typically vary by up to . The distance from Knoxville to Mesa is about 1594 mi.

  • What are the cheapest airlines to fly from Knoxville to Mesa one-way?

    $65 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $68 and $114, respectively.

  • What are the cheapest flights from Knoxville to Mesa?

    Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $193, our data indicates the cheapest price to be $100. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $174.

  • Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

  • Can I find deals for business class flights from Knoxville to Mesa?

    Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mesa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Knoxville to Mesa

Discover the top 4 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$115Average$232FlexibilityNo cancel feeOn-time88%
DeltaCheapest$128Average$341FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$228Average$490FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$253Average$415FlexibilityNo cancel feeOn-time71%

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