$103+ Cheap flights from Knoxville (TYS) to Mesa, AZ
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or January, booked 36 days in advance, depart on a Friday or Wednesday and return on a Wednesday
Cheap flight deals from Knoxville to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MesaExplore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop16h 24m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 9/2![Multiple Airlines logo]()
$204
This CheapOair deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm -
Nonstop4h 01m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 9/2![Allegiant Air logo]()
$209
This Cheapflightsfares deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Thu 10/293:43 pm -
Nonstop3h 27m
Deal found 9/4![Allegiant Air logo]()
$214
This Cheapflightsfares deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:39 pm -
Nonstop4h 01m
Sun 11/153:20 pm -
Nonstop3h 36m
Deal found 8/31![Allegiant Air logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 9/3![Allegiant Air logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop20h 12m
Sun 11/153:20 pm -
Nonstop3h 36m
Deal found 9/4![Multiple Airlines logo]()
$219
This CheapOair deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/31![Allegiant Air logo]()
$241
This CheapOair deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Sun 10/187:51 am -
Nonstop3h 27m
Deal found 9/3![Allegiant Air logo]()
$242
Best flights from Knoxville to MesaDiscover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Knoxville to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am -
1 stop6h 30m
Fri 10/211:52 pm -
1 stop6h 53m
Deal found 9/3![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:40 pm -
2 stops8h 25m
Tue 11/175:55 am -
2 stops7h 35m
Deal found 9/1![Southwest logo]()
$374
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:15 pm -
2 stops7h 25m
Wed 11/49:05 am -
2 stops8h 40m
Deal found 8/31![Southwest logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/244:53 pm -
1 stop6h 56m
Mon 9/281:33 pm -
1 stop5h 41m
Deal found 9/3![United Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/113:40 pm -
1 stop6h 20m
Mon 12/149:05 am -
2 stops8h 40m
Deal found 9/4![Southwest logo]()
$394
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/712:20 pm -
1 stop10h 45m
Mon 1/118:10 pm -
2 stops11h 40m
Deal found 9/1![United Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:45 pm -
2 stops9h 24m
Mon 9/286:40 pm -
2 stops12h 05m
Deal found 9/2![United Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:40 pm -
2 stops8h 25m
Sun 11/156:20 am -
2 stops12h 10m
Deal found 9/4![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:40 pm -
2 stops9h 25m
Sun 11/85:40 am -
2 stops7h 20m
Deal found 9/3![Southwest logo]()
$453
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
1 stop9h 53m
Sat 10/248:30 am -
1 stop6h 35m
Deal found 9/2![United Airlines logo]()
$469
Last-minute flights from Knoxville to MesaDiscover last-minute flight deals from Knoxville to Mesa. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Mesa. Data last updated September 5, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
Nonstop4h 01m
Thu 10/293:43 pm -
Nonstop3h 27m
Deal found 9/2![Allegiant Air logo]()
$215
This CheapOair deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 8/31![Allegiant Air logo]()
$241
This CheapOair deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
Nonstop4h 01m
Sun 10/187:51 am -
Nonstop3h 27m
Deal found 9/2![Allegiant Air logo]()
$248
This Cheapflightsfares deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Thu 10/293:43 pm -
Nonstop3h 27m
Deal found 9/4![Allegiant Air logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Mon 10/199:11 am -
Nonstop3h 27m
Deal found 9/3![Allegiant Air logo]()
$216
This CheapOair deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop4h 01m
Sun 10/187:51 am -
Nonstop3h 27m
Deal found 9/3![Allegiant Air logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:03 pm -
1 stop17h 14m
Thu 10/293:43 pm -
Nonstop3h 27m
Deal found 9/4![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop16h 24m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 9/2![Multiple Airlines logo]()
$204
This CheapOair deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:52 pm -
Nonstop4h 01m
Sun 11/14:43 pm -
Nonstop3h 27m
Deal found 9/2![Allegiant Air logo]()
$209
One-way flights from Knoxville to MesaSearch for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
Search for one-way flight options from Knoxville to Mesa. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop20h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:09 pm -
1 stop22h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:29 pm -
1 stop27h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:42 pm -
1 stop17h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$130
This Cheapflightsfares deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:10 am -
Nonstop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Allegiant Air logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:39 pm -
Nonstop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Allegiant Air logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:09 pm -
1 stop17h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop16h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:01 pm -
1 stop13h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$144
This Cheapflightsfares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
Nonstop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Allegiant Air logo]()
$147
This Mytrip deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
Nonstop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Allegiant Air logo]()
$156
Find flight deals from Knoxville to Mesa
Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated September 5, 2026.
Round-trip from | $204 (Kiwi.com) |
|---|---|
One-way from | $103 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $324 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 10/27
5:26 pm-10:09 pm
1 stop7h 43m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$160
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Thu 10/1
3:45 pm-7:28 pm
1 stop6h 43m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$160
Quickest round-trip
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Mon 11/9
7:22 pm-11:26 pm
1 stop6h 04m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$160
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 9/29
10:42 am-5:35 pm
1 stop9h 53m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$160
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Mon 10/5
7:25 pm-11:30 pm
2 stops7h 05m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$165
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Tue 11/3
7:05 am-12:40 pm
2 stops7h 35m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$165
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Sat 10/3
10:42 am-5:14 pm
2 stops9h 32m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$165
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Sat 10/10
5:43 pm-8:10 am
2 stops41h 27m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$188
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Wed 10/28
1:56 pm-6:16 pm
1 stop7h 20m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$190
KnoxvillePhoenix
TYS Knoxville McGhee Tyson - PHX Phoenix Sky Harbor Intl
TYSPHX
Knoxville McGhee Tyson
Wed 10/28
7:15 am-11:20 am
2 stops7h 05m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$195
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
TYS-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Mesa
TYS-MS9
TYS-PHX
How much does it cost to fly round-trip from Knoxville to Mesa?
Airfare is below average for this route at the moment.
Knoxville to Mesa flights typically cost between $242 and $448 in October.The cheapest round-trip price found within the last 5 days was $204 on Multiple Airlines (Oct 29-Nov 1).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated September 5, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Mesa flights
Browse other Knoxville and Mesa flight options. Last updated on September 5, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Popular flight searches
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Knoxville to Mesa flights
Consider these flights traveling from Knoxville to Mesa.
Top 6 airlines flying from Knoxville to Mesa
Discover the top 6 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$125 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$127 | Average$288 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$148 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$557 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$439 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$284 | Average$419 | FlexibilityNo cancel fee | On-time71% |