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Mesa

$64+ Cheap flights from Knoxville (TYS) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in September or August, booked 67 days in advance, depart on a Friday or Thursday and return on a Wednesday

Find flight deals from Knoxville to Mesa

Cheapest flights from Knoxville to Mesa
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Priceline deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - PHX
1 stop9h 52mFrontier
Mon 12/157:00 amPHX - TYS
1 stop6h 57mFrontier
Deal found 11/11$130
This Priceline deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - PHX
1 stop9h 52mFrontier
Thu 12/187:00 amPHX - TYS
1 stop6h 31mFrontier
Deal found 11/11$137
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/112:50 pmTYS - PHX
2 stops28h 17mMultiple Airlines
Thu 12/44:56 pmPHX - TYS
Nonstop3h 26mMultiple Airlines
Deal found 11/12$183
This Cheapflightsfares deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Sun 12/144:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Deal found 11/10$188
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - PHX
1 stop9h 52mMultiple Airlines
Thu 12/184:56 pmPHX - TYS
Nonstop3h 26mMultiple Airlines
Deal found 11/11$197
This Cheapflightsfares deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Thu 12/184:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Deal found 11/11$198
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:00 amTYS - PHX
1 stop16h 11mMultiple Airlines
Fri 11/2810:11 pmPHX - TYS
1 stop18h 59mMultiple Airlines
Deal found 11/11$206
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:30 amTYS - PHX
2 stops37h 56mMultiple Airlines
Thu 12/44:56 pmPHX - TYS
Nonstop3h 26mMultiple Airlines
Deal found 11/12$208
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:34 pmTYS - PHX
2 stops21h 41mMultiple Airlines
Mon 12/157:00 amPHX - TYS
1 stop6h 57mMultiple Airlines
Deal found 11/11$218
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:10 pmTYS - PHX
Nonstop4h 05mMultiple Airlines
Tue 12/307:00 amPHX - TYS
1 stop6h 51mMultiple Airlines
Deal found 11/11$219
This FlightHub deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:14 pmTYS - PHX
Nonstop4h 13mMultiple Airlines
Thu 11/274:37 pmPHX - TYS
1 stop21h 16mMultiple Airlines
Deal found 11/11$221

Cheap flight deals from Knoxville to Mesa

Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated November 13, 2025.

Round-trip from

$134
(Expedia)

One-way from

$64
(Cheapflightsfares)

Popular in

November

Cheapest in

September

Average price

$404
From Knoxville McGhee Tyson to Mesa
Search Deals
One-way flight from Knoxville McGhee Tyson to Mesa
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.

Fly from

Knoxville

Fly to

Mesa

Route

Depart

Return

Price

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 1/29

12:19 pm-7:14 pm

1 stop8h 55m

Phoenix Sky Harbor Intl

Tue 2/3

6:00 am-1:54 pm

1 stop5h 54m

$279

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 12/9

6:00 pm-12:16 am

1 stop8h 16m

Phoenix Sky Harbor Intl

Sat 12/13

6:00 am-2:50 pm

1 stop6h 50m

$287

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 12/6

8:35 am-1:27 pm

1 stop6h 52m

Phoenix Sky Harbor Intl

Sat 12/13

6:00 am-2:50 pm

1 stop6h 50m

$297

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 1/31

11:07 am-6:06 pm

2 stops8h 59m

Phoenix Sky Harbor Intl

Sat 2/7

11:30 am-7:50 pm

1 stop6h 20m

$302

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 12/25

1:10 pm-3:15 pm

Nonstop4h 05m

Phoenix Sky Harbor Intl

Sat 1/3

10:46 pm-10:15 am

3 stops33h 29m

$325

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 11/28

2:59 pm-11:17 pm

1 stop10h 18m

Phoenix Sky Harbor Intl

Tue 12/2

7:51 pm-1:11 pm

2 stops39h 20m

$371

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Tue 3/10

7:00 am-11:31 am

1 stop7h 31m

Phoenix Sky Harbor Intl

Wed 3/11

7:30 pm-10:48 am

2 stops12h 18m

$372

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 1/29

6:59 am-12:24 pm

1 stop7h 25m

Phoenix Sky Harbor Intl

Tue 2/3

12:53 pm-11:44 pm

2 stops8h 51m

$382

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 12/11

4:52 pm-12:44 am

1 stop9h 52m

$71

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 12/22

4:46 pm-9:26 pm

1 stop6h 40m

$72

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 18 results
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Best time to book a flight from Knoxville to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mesa

How far ahead should I book a flight from Knoxville to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Mesa. Price data was last updated on November 7, 2025.

Booking 66 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Mesa. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Mesa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $156). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS9?

Find hourly flight availability from Knoxville to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

One of the essential ways to save on airfare from Knoxville to Mesa is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight at noon could potentially save you up to 65% on airfare.

What is the cheapest day to fly from Knoxville to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Mesa. Price data was last updated on November 18, 2024.

Travelers seeking maximum savings on their Knoxville to Mesa flight should consider departing on Thursday at noon when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated November 13, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
698 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mesa?

    For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 4 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

  • How long is the flight from Knoxville to Mesa?

    Airlines like American Airlines and Delta fly from Knoxville to Mesa in about 8h 16m. The time it takes to get you to your destination can typically vary by up to 39m. The distance from Knoxville to Mesa is about 1594 mi. This flight may include one or multiple stops.

  • What are the cheapest flights from Knoxville to Mesa?

    Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $252, our data indicates the cheapest price to be $64. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $144.

  • Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

  • Can I find deals for business class flights from Knoxville to Mesa?

    Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mesa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mesa (average of $106). Flying from Knoxville to Mesa in December is currently the most expensive (average of $156). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Mesa

Discover the top 4 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$115Average$233FlexibilityNo cancel feeOn-time88%
DeltaCheapest$128Average$355FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$220Average$487FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$250Average$463FlexibilityNo cancel feeOn-time71%

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