What are the cheapest airlines to fly from Knoxville to Mesa one-way?

$65 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $85 and $138, respectively.

In terms of precipitation, rainfall in Mesa ranges from 0.0 - 1.1 inches per month. July is typically the wettest month, when rainfall can reach 1.1 in. June is typically the driest time to visit Mesa when rainfall is around 0.0 in.

If weather is an important factor for your trip to Mesa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 95.0 F. Travelers looking to avoid the cold should look outside of December, when temperatures are typically at their lowest (around 55.4 F).

What are the cheapest flights from Knoxville to Mesa?

Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $256, our data indicates the cheapest price to be $117. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $212.

What are the most popular airlines that fly from Knoxville to Mesa?

Allegiant Air, American Airlines and Delta are the most popular airlines when flying from Knoxville to Mesa.

What airport do you fly from for flights from Knoxville to Mesa?

For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 6 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Mesa?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

Can I find deals for business class flights from Knoxville to Mesa?

Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Knoxville to Mesa

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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or January, booked 36 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Find flight deals from Knoxville to Mesa

Popular in	June
Cheapest in	August
Average price	$318

Highest demand for flights based on searches. 22% potential increase in price ($104 potential increase over avg. RT price).

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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).

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Average for round-trip flights in October 2026

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Everything you need to know about your flight from Knoxville to Mesa

What is the cheapest time of day to fly from TYS to MS9?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Mesa as you normally would.

Reviews of airlines servicing Mesa

Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Delta

7.8

Good

8,650 reviews

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

United Airlines

7.4

Good

10,360 reviews

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Allegiant Air

7.3

Good

678 reviews

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

American Airlines

7.0

Good

12,164 reviews

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Frontier

5.5

Fair

2,539 reviews

Delta

7.8

Good

8,650 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Related info for your journey

What airport do you fly from for flights from Knoxville to Mesa?
For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 6 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.
What are the cheapest airlines to fly from Knoxville to Mesa one-way?
$65 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $85 and $138, respectively.
What are the cheapest flights from Knoxville to Mesa?
Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $256, our data indicates the cheapest price to be $117. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $212.
Can I find deals for flights from Knoxville to Mesa that include hotel bookings?
Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Mesa?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.
Can I find deals for business class flights from Knoxville to Mesa?
Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 6 airlines flying from Knoxville to Mesa

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$70	Average$324	FlexibilityNo cancel fee	On-time62%
Allegiant Air	Cheapest$127	Average$291	FlexibilityNo cancel fee	On-time88%
Delta	Cheapest$148	Average$398	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$243	Average$516	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$276	Average$386	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$284	Average$431	FlexibilityNo cancel fee	On-time71%

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Cheap flights from Knoxville (TYS) to Mesa, AZ

Find cheap flights from Knoxville to Mesa with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Knoxville to Mesa

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from TYS to MS9?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Mesa as you normally would.

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated October 14, 2026.

Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly from for flights from Knoxville to Mesa?

What are the cheapest airlines to fly from Knoxville to Mesa one-way?

What are the cheapest flights from Knoxville to Mesa?

Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

How can I find direct flights from Knoxville to Mesa?

Can I find deals for business class flights from Knoxville to Mesa?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Mesa

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Knoxville to Mesa by cabin class

Find flights from Knoxville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Knoxville and Mesa flights

Browse other Knoxville and Mesa flight options. Last updated on October 14, 2026.

Other flights from Knoxville

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Top 6 airlines flying from Knoxville to Mesa

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