Mesa

$85+ Cheap flights from Knoxville (TYS) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PHX
Jun 22 — Jun 291
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Mesa are usually found in August or September, booked 36 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Knoxville to Mesa

Cheapest flights from Knoxville to Mesa
Explore the most affordable flight options available from Knoxville to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
TYS
-
PHX
Nonstop4h 10m
Allegiant Air
Sun 8/94:51 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/18$160
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:34 pm
TYS
-
PHX
Nonstop3h 58m
Allegiant Air
Sun 9/134:22 pm
PHX
-
TYS
Nonstop3h 31m
Allegiant Air
Deal found 5/18$165
This Cheapflightsfares deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/20$174
This Cheapflightsfares deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:01 pm
TYS
-
PHX
Nonstop4h 10m
Allegiant Air
Sun 8/164:51 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/18$181
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Thu 10/223:43 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19$219
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Sun 10/253:43 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19$226
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
-
PHX
Nonstop4h 01m
Multiple Airlines
Sat 10/246:36 pm
PHX
-
TYS
1 stop17h 53m
Multiple Airlines
Deal found 5/19$232
This Cheapflightsfares deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:41 pm
TYS
-
PHX
Nonstop3h 49m
Allegiant Air
Sun 7/194:20 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Deal found 5/21$236
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am
TYS
-
PHX
Nonstop4h 01m
Multiple Airlines
Tue 10/273:14 pm
PHX
-
TYS
2 stops42h 57m
Multiple Airlines
Deal found 5/19$237
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 am
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Thu 10/223:43 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Deal found 5/19$244
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm
TYS
-
PHX
1 stop15h 14m
Multiple Airlines
Sat 10/246:36 pm
PHX
-
TYS
1 stop15h 35m
Multiple Airlines
Deal found 5/19$246

Find flight deals from Knoxville to Mesa

Keep the following information in mind while searching for Knoxville to Mesa flight deals. Data was last updated May 23, 2026.

Round-trip from

$160
(Cheapflightsfares)

One-way from

$85
(Cheapflightsfares)

Popular in

June

Cheapest in

August

Average price

$401
From Knoxville McGhee Tyson to Mesa
One-way flight from Knoxville McGhee Tyson to Mesa
Highest demand for flights based on searches. 17% potential increase in price ($68 potential increase over avg. RT price).
Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Knoxville to Mesa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 8/3

8:19 pm-11:32 pm

1 stop6h 13m

Phoenix Sky Harbor Intl

Fri 8/7

8:40 am-7:24 pm

1 stop7h 44m

$359

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 8/13

5:45 pm-9:55 pm

2 stops7h 10m

Phoenix Sky Harbor Intl

Sun 8/16

5:55 am-8:45 pm

1 stop11h 50m

$409

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Fri 7/31

6:40 am-1:15 pm

2 stops9h 35m

Phoenix Sky Harbor Intl

Fri 8/7

7:55 am-6:35 pm

2 stops7h 40m

$424

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 7/2

6:40 am-12:05 pm

2 stops8h 25m

Phoenix Sky Harbor Intl

Thu 7/9

11:35 am-9:10 pm

2 stops6h 35m

$468

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 8/17

6:02 pm-10:52 pm

1 stop7h 50m

Phoenix Sky Harbor Intl

Fri 8/21

6:55 pm-10:37 am

2 stops12h 42m

$488

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Sat 7/11

7:00 am-12:20 pm

2 stops8h 20m

Phoenix Sky Harbor Intl

Wed 7/15

7:30 am-8:20 pm

2 stops9h 50m

$497

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Wed 6/17

12:45 pm-8:45 pm

2 stops11h 00m

Phoenix Sky Harbor Intl

Wed 6/24

5:05 am-2:05 pm

1 stop6h 00m

$558

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 6/25

6:40 am-12:40 pm

2 stops9h 00m

Phoenix Sky Harbor Intl

Sun 6/28

8:20 am-9:15 pm

2 stops9h 55m

$567

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Thu 6/4

7:51 am-1:49 pm

1 stop8h 58m

Phoenix Sky Harbor Intl

Sun 6/7

11:59 pm-9:38 am

1 stop6h 39m

$577

KnoxvillePhoenix

TYS - PHX

TYSPHX

Knoxville McGhee Tyson

Mon 6/8

1:54 pm-7:54 pm

1 stop9h 00m

Phoenix Sky Harbor Intl

Thu 6/11

12:52 pm-11:59 pm

1 stop8h 07m

$582

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/18

Showing 1-10 of 23 resultsSorted by cheapest first
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2
3

Best time to book a flight from Knoxville to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mesa

How much does it cost to fly round-trip from Knoxville to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 23, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Boarding

8.1

Comfort

7.8

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Mesa?

    For a flight from Knoxville to Mesa, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 outbound flights to Mesa per day. 5 airlines have flights to Mesa from Knoxville McGhee Tyson on a regular basis.

  • How long is the flight from Knoxville to Mesa?

    Airlines like Frontier, Southwest, and United Airlines fly from Knoxville to Mesa in about 6h 13m. The time it takes to get you to your destination can typically vary by up to 1h 37m. The distance from Knoxville to Mesa is about 1594 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Knoxville to Mesa one-way?

    $65 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $71 and $125, respectively.

  • What are the cheapest flights from Knoxville to Mesa?

    Looking for the cheapest flight from Knoxville to Mesa? While on average our users pay $230, our data indicates the cheapest price to be $110. The most popular route (Knoxville McGhee Tyson - Phoenix Sky Harbor Intl), is priced around $174.

  • Can I find deals for flights from Knoxville to Mesa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mesa.

  • Can I find deals for business class flights from Knoxville to Mesa?

    Yes. Cheapflights offers flight deals from Knoxville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 5 airlines flying from Knoxville to Mesa

Discover the top 5 airlines that operate flights from Knoxville to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$115Average$250FlexibilityNo cancel feeOn-time88%
FrontierCheapest$125Average$327FlexibilityNo cancel feeOn-time62%
DeltaCheapest$128Average$366FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$229Average$437FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$260Average$402FlexibilityNo cancel feeOn-time71%

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