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Mesa

$360+ Cheap flights from Columbia, MO (COU) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
COU — PHX
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Columbia to Mesa

Keep the following information in mind while searching for Columbia to Mesa flight deals. Data was last updated September 15, 2025.

Round-trip from

$420
(American Airlines)

One-way from

$360
(American Airlines)

Popular in

August

Cheapest in

June

Average price

$489
From Columbia Regional to Mesa
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One-way flight from Columbia Regional to Mesa
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Highest demand for flights based on searches. 15% potential increase in price ($98 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Columbia to Mesa

Cheapest flights from Columbia to Mesa
Explore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:58 pmCOU - PHX
1 stop6h 41mAmerican Airlines
Tue 11/115:00 amPHX - COU
1 stop5h 40mAmerican Airlines
Deal found 9/14$420
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:13 pmCOU - PHX
1 stop6h 04mAmerican Airlines
Sat 10/1812:18 amPHX - COU
1 stop8h 49mAmerican Airlines
Deal found 9/13$470
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:28 pmCOU - PHX
1 stop6h 47mAmerican Airlines
Wed 10/81:27 pmPHX - COU
1 stop6h 04mAmerican Airlines
Deal found 9/14$488
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:00 amCOU - PHX
2 stops17h 14mUnited Airlines
Tue 11/114:35 pmPHX - COU
1 stop27h 16mUnited Airlines
Deal found 9/14$506
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/201:36 pmCOU - PHX
1 stop9h 21mAmerican Airlines
Sun 9/218:40 amPHX - COU
1 stop7h 02mAmerican Airlines
Deal found 9/14$519
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/19:01 amCOU - PHX
1 stop13h 11mUnited Airlines
Wed 10/86:00 amPHX - COU
2 stops13h 27mUnited Airlines
Deal found 9/14$546
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:05 pmCOU - PHX
1 stop6h 24mAmerican Airlines
Fri 1/212:58 amPHX - COU
1 stop7h 41mAmerican Airlines
Deal found 9/13$552
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/299:01 amCOU - PHX
1 stop25h 42mUnited Airlines
Fri 10/36:45 pmPHX - COU
1 stop23h 40mUnited Airlines
Deal found 9/14$581

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Columbia to Mesa that are best for you.

Fly from

Columbia

Fly to

Mesa

Route

Depart

Return

Price

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Thu 10/16

7:13 pm-11:17 pm

1 stop6h 04m

Phoenix Sky Harbor Intl

Sat 10/18

12:18 am-11:07 am

1 stop8h 49m

$470

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Wed 10/1

12:28 pm-5:15 pm

1 stop6h 47m

Phoenix Sky Harbor Intl

Wed 10/8

1:27 pm-9:31 pm

1 stop6h 04m

$488

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Thu 11/6

9:00 am-1:14 am

2 stops17h 14m

Phoenix Sky Harbor Intl

Tue 11/11

4:35 pm-8:51 pm

1 stop27h 16m

$506

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Wed 10/1

9:01 am-8:12 pm

1 stop13h 11m

Phoenix Sky Harbor Intl

Wed 10/8

6:00 am-9:27 pm

2 stops13h 27m

$546

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 3/14

4:37 pm-8:58 pm

1 stop6h 21m

Phoenix Sky Harbor Intl

Wed 3/18

5:00 am-2:36 pm

1 stop7h 36m

$547

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Thu 12/18

6:05 pm-11:29 pm

1 stop6h 24m

Phoenix Sky Harbor Intl

Fri 1/2

12:58 am-9:39 am

1 stop7h 41m

$552

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 3/14

4:37 pm-10:30 pm

1 stop7h 53m

Phoenix Sky Harbor Intl

Thu 3/19

6:45 am-2:36 pm

1 stop5h 51m

$557

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Mon 9/29

9:01 am-8:43 am

1 stop25h 42m

Phoenix Sky Harbor Intl

Fri 10/3

6:45 pm-8:25 pm

1 stop23h 40m

$581

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sun 9/28

6:24 am-11:46 am

1 stop7h 22m

$360

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Best time to book a flight from Columbia to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Mesa

What is the cheapest month to book a flight from Columbia, Missouri to Mesa?

Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to Mesa (average of $258). Flying from Columbia, Missouri to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from COU to MS9?

Find hourly flight availability from Columbia to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Columbia, Missouri to Mesa as you normally would.

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with American Airlines from Columbia to Mesa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Entertainment

6.9

Overall

7.2

Food

6.4

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Columbia to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Mesa?

    For a flight from Columbia to Mesa, you will be flying from Columbia Regional. Columbia Regional (COU) is just 11.1 mi from the center of the city. Columbia Regional is the only Columbia airport and it handles 0 outbound flights to Mesa per day. 1 airline has flights to Mesa from Columbia Regional on a regular basis.

  • How long is the flight from Columbia, Missouri to Mesa?

    For as low as $470, American Airlines can have you in Mesa from Columbia, Missouri in 6h 04m. There are 1161 mi between Columbia, Missouri and Mesa. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Columbia to Mesa that include hotel bookings?

    Yes. In addition to deals on Columbia to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Mesa.

  • Can I find deals for business class flights from Columbia to Mesa?

    Yes. Cheapflights offers flight deals from Columbia to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to Mesa (average of $258). Flying from Columbia, Missouri to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Columbia to Mesa

Discover the top airline that operate flights from Columbia to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$370Average$523FlexibilityNo cancel feeOn-time71%

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