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McAllen

$253+ Cheap flights from Knoxville to McAllen (TYS - MFE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MFE
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to McAllen

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to McAllen (MFE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$253
(American Airlines)
From Knoxville McGhee Tyson to McAllen Miller Intl
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Find flight deals from Knoxville to McAllen

Cheapest flights from Knoxville to McAllen
Explore the most affordable flight options available from Knoxville to McAllen. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:00 amTYS - MFE
1 stop5h 08mAmerican Airlines
Tue 9/306:23 pmMFE - TYS
1 stop4h 58mAmerican Airlines
Deal found 9/11$253
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:00 amTYS - MFE
1 stop5h 08mAmerican Airlines
Sun 9/286:45 amMFE - TYS
1 stop5h 24mAmerican Airlines
Deal found 9/9$289
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:28 amTYS - MFE
1 stop5h 39mAmerican Airlines
Sun 9/216:45 amMFE - TYS
1 stop5h 24mAmerican Airlines
Deal found 9/10$369
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/195:10 pmTYS - MFE
1 stop5h 37mUnited Airlines
Sun 9/215:00 amMFE - TYS
2 stops11h 00mUnited Airlines
Deal found 9/10$454
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:45 amTYS - MFE
2 stops7h 04mDelta
Tue 9/305:25 amMFE - TYS
2 stops6h 42mDelta
Deal found 9/11$498

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to McAllen that are best for you.

Fly from

Knoxville

Fly to

McAllen

Route

Depart

Return

Price

KnoxvilleMcAllen

TYS - MFE

TYSMFE

Knoxville McGhee Tyson

Fri 9/26

6:00 am-10:08 am

1 stop5h 08m

McAllen Miller Intl

Tue 9/30

6:23 pm-12:21 am

1 stop4h 58m

$253

KnoxvilleMcAllen

TYS - MFE

TYSMFE

Knoxville McGhee Tyson

Wed 9/24

6:00 am-10:08 am

1 stop5h 08m

McAllen Miller Intl

Sun 9/28

6:45 am-1:09 pm

1 stop5h 24m

$289

KnoxvilleMcAllen

TYS - MFE

TYSMFE

Knoxville McGhee Tyson

Sat 2/21

6:26 pm-10:26 pm

1 stop5h 00m

McAllen Miller Intl

Wed 2/25

4:11 pm-11:40 pm

1 stop6h 29m

$297

KnoxvilleMcAllen

TYS - MFE

TYSMFE

Knoxville McGhee Tyson

Sat 2/21

10:05 am-4:55 pm

2 stops7h 50m

McAllen Miller Intl

Wed 2/25

1:00 pm-11:44 pm

2 stops9h 44m

$308

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Knoxville to McAllen

Have a flexible travel schedule? Discover the best time to fly to McAllen from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to McAllen

What is the cheapest time of day to fly from TYS to MFE?

Find hourly flight availability from Knoxville to McAllen. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Knoxville to McAllen in the afternoon. By choosing this option you can save up to 25% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing McAllen

Get insights into the airlines that provide service to McAllen. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to McAllen. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with American Airlines from Knoxville to McAllen by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.4

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2025

PIT - DFW

Due to gate changes,we nearly missed our flight. The gate agent reassigned our seats and would NOT give us our assigned seats,but she did honor that same request to the man who arrived after us. Her rudeness and difficulty was not appropriate.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.4

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2025

PIT - DFW

Due to gate changes,we nearly missed our flight. The gate agent reassigned our seats and would NOT give us our assigned seats,but she did honor that same request to the man who arrived after us. Her rudeness and difficulty was not appropriate.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to McAllen. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to McAllen?

    For as low as $253, American Airlines can have you in McAllen from Knoxville in 5h 08m. There are 1072 mi between Knoxville and McAllen.

  • What is the cheapest airline to fly from Knoxville to McAllen round-trip?

    Our cheapest airline available from Knoxville to McAllen is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline.

  • Can I find deals for flights from Knoxville to McAllen that include hotel bookings?

    Yes. In addition to deals on Knoxville to McAllen flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to McAllen?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to McAllen.

  • Can I find deals for business class flights from Knoxville to McAllen?

    Yes. Cheapflights offers flight deals from Knoxville to McAllen by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to McAllen?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to McAllen (average of $281). Flying from Knoxville to McAllen in December is currently the most expensive (average of $416). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near McAllen?

Book flights to McAllen if you plan to visit one of these locations
Mission
Weslaco
Pharr
Edinburg

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Top airline flying from Knoxville to McAllen

Discover the top airline that operate flights from Knoxville to McAllen. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$376FlexibilityNo cancel feeOn-time71%

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