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$156+ Cheap flights from Syracuse to Louisville (SYR - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — SDF
Mar 26 — Apr 21
Thu 3/26
Thu 4/2
1 adult, Economy
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Cheap flight deals from Syracuse to Louisville

Cheapest flights from Syracuse to Louisville
Explore the most affordable flight options available from Syracuse to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 24, 2026.

This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:50 am
SYR
-
SDF
1 stop4h 16m
Delta
Sat 5/95:50 pm
SDF
-
SYR
1 stop6h 02m
Delta
Deal found 2/20$269
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:00 am
SYR
-
SDF
2 stops8h 07m
United Airlines
Sat 5/97:15 am
SDF
-
SYR
1 stop6h 10m
United Airlines
Deal found 2/23$274
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:30 am
SYR
-
SDF
1 stop5h 43m
American Airlines
Tue 3/106:00 am
SDF
-
SYR
1 stop5h 39m
American Airlines
Deal found 2/20$291
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1511:31 am
SYR
-
SDF
1 stop7h 27m
Multiple Airlines
Sun 5/173:33 pm
SDF
-
SYR
1 stop19h 08m
Multiple Airlines
Deal found 2/21$295
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:11 pm
SYR
-
SDF
1 stop5h 41m
Delta
Mon 9/285:45 pm
SDF
-
SYR
1 stop6h 13m
Delta
Deal found 2/20$314
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2311:37 am
SYR
-
SDF
1 stop24h 10m
Multiple Airlines
Sun 3/299:42 pm
SDF
-
SYR
1 stop21h 07m
Multiple Airlines
Deal found 2/20$333
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
SYR
-
SDF
2 stops8h 07m
United Airlines
Sat 5/93:36 pm
SDF
-
SYR
1 stop5h 10m
United Airlines
Deal found 2/20$344
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:03 pm
SYR
-
SDF
1 stop26h 25m
Allegiant Air
Sun 3/299:42 pm
SDF
-
SYR
1 stop21h 07m
Allegiant Air
Deal found 2/20$351
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:01 pm
SYR
-
SDF
1 stop6h 19m
American Airlines
Sat 4/114:30 pm
SDF
-
SYR
1 stop6h 41m
American Airlines
Deal found 2/23$352
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:50 am
SYR
-
SDF
1 stop4h 14m
Delta
Tue 3/37:50 am
SDF
-
SYR
1 stop4h 15m
Delta
Deal found 2/21$354

Find flight deals from Syracuse to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(Delta)

One-way from

$156
(Kiwi.com)

Popular in

September

Cheapest in

August

Average price

$348
Provider with most accurate pricing for Syracuse Hancock Intl-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Louisville Intl flights.
Search Deals
From Syracuse Hancock Intl to Louisville Intl
Search Deals
One-way flight from Syracuse Hancock Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($5 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
Use the filters below to find and compare flights from Syracuse to Louisville that are best for you.

Fly from

Syracuse

Fly to

Louisville

Route

Depart

Return

Price

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Tue 5/5

5:50 am-10:06 am

1 stop4h 16m

Louisville Intl

Sat 5/9

5:50 pm-11:52 pm

1 stop6h 02m

$269

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Tue 5/5

3:23 pm-10:31 pm

1 stop7h 08m

Louisville Intl

Sat 5/9

7:31 am-2:27 pm

1 stop6h 56m

$269

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Thu 5/21

6:00 am-1:41 pm

1 stop7h 41m

Louisville Intl

Wed 5/27

5:50 pm-11:52 pm

1 stop6h 02m

$269

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Thu 3/12

6:15 am-1:06 pm

1 stop6h 51m

Louisville Intl

Tue 3/17

7:05 am-2:08 pm

2 stops7h 03m

$279

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Fri 3/6

5:30 am-11:13 am

1 stop5h 43m

Louisville Intl

Tue 3/10

6:00 am-11:39 am

1 stop5h 39m

$291

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Tue 5/5

10:35 am-6:36 pm

2 stops8h 01m

Louisville Intl

Sat 5/9

5:50 am-2:16 pm

2 stops8h 26m

$349

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Tue 5/5

6:00 am-2:54 pm

2 stops8h 54m

Louisville Intl

Tue 5/12

7:15 am-2:14 pm

2 stops6h 59m

$349

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Fri 2/27

6:10 am-1:06 pm

1 stop6h 56m

Louisville Intl

Tue 3/3

9:00 am-8:14 pm

2 stops11h 14m

$368

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Fri 2/27

6:37 pm-11:58 pm

1 stop5h 21m

Louisville Intl

Sat 2/28

8:55 am-1:36 pm

1 stop4h 41m

$369

SyracuseLouisville

SYR - SDF

SYRSDF

Syracuse Hancock Intl

Tue 4/7

2:45 pm-11:12 pm

2 stops8h 27m

Louisville Intl

Sat 4/11

5:00 am-9:53 am

1 stop4h 53m

$421

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 16 results
1
2

Compare providers for flights from Syracuse to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Louisville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Louisville

What is the cheapest month to book a flight from Syracuse to Louisville?

Currently, April is the cheapest month in which you can book a flight from Syracuse to Louisville (average of $108). Flying from Syracuse to Louisville in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated February 24, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Louisville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,239 reviews

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,239 reviews
Delta
7.9
Good
8,239 reviews

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,344 reviews
Delta
7.9
Good
8,239 reviews

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,344 reviews
Delta
7.9
Good
8,239 reviews

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Louisville?

    A quick flight from Syracuse to Louisville can take about 4h 16m. Delta provides one of the quickest options available for as low as $269. The distance between Syracuse and Louisville is about 608 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Louisville round-trip?

    According to our current data, Delta ($200), American Airlines ($244), and United Airlines ($271) offers the cheapest pricing from Syracuse to Louisville. Users have found that Delta is 45% cheaper than the other options available to this destination.

  • Can I find deals for flights from Syracuse to Louisville that include hotel bookings?

    Yes. In addition to deals on Syracuse to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Louisville.

  • Can I find deals for business class flights from Syracuse to Louisville?

    Yes. Cheapflights offers flight deals from Syracuse to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Louisville?

    Currently, April is the cheapest month in which you can book a flight from Syracuse to Louisville (average of $108). Flying from Syracuse to Louisville in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 3 airlines flying from Syracuse to Louisville

Discover the top 3 airlines that operate flights from Syracuse to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$200Average$339FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$244Average$303FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$271Average$344FlexibilityNo cancel feeOn-time69%

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