HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Louisville

$184+ Cheap flights from Panama City, FL to Louisville (ECP - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SDF
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Louisville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$377
(Delta)

One-way from

$184
(American Airlines)

Popular in

January

Cheapest in

August

Average price

$308
Provider with most accurate pricing for Panama City NW Florida Beaches-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Louisville Intl flights.
Search Deals
From Panama City NW Florida Beaches to Louisville Intl
Search Deals
One-way flight from Panama City NW Florida Beaches to Louisville Intl
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($154 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($38 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:06 amECP - SDF
1 stop6h 00mDelta
Sat 1/34:44 pmSDF - ECP
1 stop4h 12mDelta
Deal found 10/28$377
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:55 pmECP - SDF
1 stop5h 04mAmerican Airlines
Tue 11/1811:19 amSDF - ECP
1 stop6h 25mAmerican Airlines
Deal found 10/27$387
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1812:00 pmECP - SDF
2 stops9h 55mAmerican Airlines
Wed 11/196:15 amSDF - ECP
1 stop6h 14mAmerican Airlines
Deal found 10/27$392
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1810:00 amECP - SDF
2 stops12h 05mSouthwest
Wed 11/196:45 amSDF - ECP
2 stops8h 55mSouthwest
Deal found 10/27$397
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:40 pmECP - SDF
1 stop4h 26mDelta
Tue 11/1810:37 amSDF - ECP
1 stop3h 10mDelta
Deal found 10/28$407
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/274:09 pmECP - SDF
1 stop7h 12mAmerican Airlines
Sat 1/32:00 pmSDF - ECP
2 stops10h 58mAmerican Airlines
Deal found 10/28$427
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:15 amECP - SDF
2 stops8h 35mAmerican Airlines
Mon 11/1712:43 pmSDF - ECP
2 stops11h 32mAmerican Airlines
Deal found 10/28$457

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Panama City

Fly to

Louisville

Route

Depart

Return

Price

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Sun 3/15

5:25 am-1:40 pm

1 stop7h 15m

Louisville Intl

Thu 3/19

11:15 am-4:15 pm

1 stop6h 00m

$397

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Fri 11/14

4:26 pm-11:00 pm

1 stop5h 34m

Louisville Intl

Tue 11/18

7:05 am-10:26 am

1 stop4h 21m

$447

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 11/13

6:00 am-12:07 pm

1 stop5h 07m

Louisville Intl

Mon 11/17

6:16 pm-11:07 pm

1 stop5h 51m

$447

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 11/18

11:11 am-5:16 pm

1 stop5h 05m

Louisville Intl

Wed 11/19

6:00 am-8:35 am

1 stop3h 35m

$447

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 11/17

7:02 am-2:04 pm

1 stop6h 02m

Louisville Intl

Tue 11/18

8:35 am-12:47 pm

1 stop5h 12m

$447

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 11/13

2:37 pm-9:47 pm

1 stop6h 10m

Louisville Intl

Mon 11/17

4:59 pm-11:15 pm

2 stops7h 16m

$452

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 11/18

8:21 am-8:19 pm

2 stops10h 58m

Louisville Intl

Wed 11/19

7:13 am-2:49 pm

1 stop8h 36m

$452

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 11/17

6:47 am-1:12 pm

1 stop5h 25m

Louisville Intl

Tue 11/18

11:09 am-4:44 pm

2 stops6h 35m

$452

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 12/29

11:11 am-6:21 pm

1 stop6h 10m

$184

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Wed 11/26

3:00 pm-9:57 pm

1 stop5h 57m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 13 results
1
2

Compare providers for flights from Panama City to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Louisville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Louisville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Louisville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City, Florida to Louisville?

Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to Louisville (average of $66). Flying from Panama City, Florida to Louisville in February is currently the most expensive (average of $116). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SDF?

Find hourly flight availability from Panama City to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Louisville at noon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Panama City to Louisville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Louisville?

    Southwest and Delta can get you from Panama City, Florida to Louisville in just under 5h 34m. Your travel time can differ by up to 1h 41m. The distance from Panama City, Florida to Louisville is about 540 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Panama City, Florida to Louisville round-trip?

    American Airlines, at $236, was found to be the cheapest airline from Panama City, Florida to Louisville. An alternate airline flying to your destination would be Delta. These flights start at 42% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Panama City, Florida to Louisville one-way?

    The cheapest airlines for a one-way flight from Panama City, Florida to Louisville are American Airlines ($184), United Airlines ($194), and Delta ($214).

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Louisville?

    Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to Louisville (average of $66). Flying from Panama City, Florida to Louisville in February is currently the most expensive (average of $116). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Nashville flights
Fort Lauderdale to Nashville flights
Tampa to Nashville flights
Tampa to Cincinnati flights
Miami to Nashville flights
Jacksonville to Nashville flights
Orlando to Cincinnati flights
Fort Lauderdale to Knoxville flights
Miami to Cincinnati flights
Fort Myers to Cincinnati flights
Melbourne to Cincinnati flights
West Palm Beach to Nashville flights
Fort Myers to Nashville flights
Sarasota to Nashville flights
Fort Lauderdale to Cincinnati flights
Orlando to Louisville flights
Sarasota to Knoxville flights
Miami to Knoxville flights
Orlando to Knoxville flights
Valparaiso to Cincinnati flights
Tampa to Knoxville flights
St Petersburg to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Tampa to Louisville flights
Sarasota to Lexington flights
Panama City to Nashville flights
Pensacola to Nashville flights
Miami to Louisville flights
St Petersburg to Cincinnati flights
Orlando Sanford Intl to Cincinnati flights
Jacksonville to Louisville flights
Jacksonville to Cincinnati flights
Orlando to Lexington flights
Fort Lauderdale to Louisville flights
West Palm Beach to Cincinnati flights
Tampa to Lexington flights
Fort Myers to Lexington flights
Sarasota to Cincinnati flights
West Palm Beach to Knoxville flights
Jacksonville to Lexington flights
Pensacola to Knoxville flights
West Palm Beach to Lexington flights
Fort Myers to Knoxville flights
Miami to Lexington flights
Gainesville to Nashville flights
West Palm Beach to Louisville flights
Pensacola to Lexington flights
Fort Myers to Louisville flights
Pensacola to Cincinnati flights
Tallahassee to Nashville flights

Top 2 airlines flying from Panama City to Louisville

Discover the top 2 airlines that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$517FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$383FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.