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La Serena

$863+ Cheap flights from San Francisco (SFO) to La Serena (LSC)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — LSC
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from San Francisco to La Serena

Cheapest flights from San Francisco to La Serena
Explore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:50 pm
SFO
-
LSC
3 stops24h 45m
LATAM Airlines
Wed 4/2210:00 am
LSC
-
SFO
2 stops32h 21m
LATAM Airlines
Deal found 2/9$863

Find flight deals from San Francisco to La Serena

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to La Serena (LSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$863
(LATAM Airlines)
Provider with most accurate pricing for San Francisco-La Serena La Florida flight deals.
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Provider most trusted by Cheapflights users for San Francisco-La Serena La Florida flights.
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From San Francisco to La Serena La Florida
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Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to La Serena that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.

Fly from

San Francisco

Fly to

La Serena

Route

Depart

Return

Price

San FranciscoLa Serena

SFO - LSC

SFOLSC

San Francisco

Sat 4/18

9:25 am-6:23 pm

2 stops29h 58m

La Serena La Florida

Wed 4/22

10:00 am-11:59 am

2 stops28h 59m

$863

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

  • Most accurate provider: When it comes to deals on San Francisco-La Serena flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Francisco-La Serena flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from San Francisco-La Serena flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-La Serena flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-La Serena flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to La Serena

Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to La Serena. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to La Serena?

    For as low as $863, LATAM Airlines can have you in La Serena from San Francisco in 29h 58m. San Francisco and La Serena are separated by a distance of 5714 mi.

  • Can I find deals for flights from San Francisco to La Serena that include hotel bookings?

    Yes. In addition to deals on San Francisco to La Serena flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to La Serena?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to La Serena.

  • Can I find deals for business class flights from San Francisco to La Serena?

    Yes. Cheapflights offers flight deals from San Francisco to La Serena by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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