$896+ Cheap flights from San Francisco (SFO) to La Serena (LSC)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — LSC
Nov 27 — Dec 41
1 adult, Economy
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Find cheap flights from San Francisco to La Serena with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to La Serena
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to La Serena (LSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.
Most accurate provider | Expedia 2 stars |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $896 (LATAM Airlines) |
Find flight deals from San Francisco to La Serena
Cheapest flights from San Francisco to La SerenaExplore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.
Explore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.
This SmartFares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1210:40 amSFO - LSC
2 stops17h 15mLATAM Airlines
Fri 12/199:25 pmLSC - SFO
2 stops18h 09mLATAM Airlines
Deal found 10/28![LATAM Airlines logo]()
$1,446
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/122:30 pmSFO - LSC
2 stops20h 05mMultiple Airlines
Fri 12/196:15 pmLSC - SFO
3 stops22h 45mMultiple Airlines
Deal found 10/28![Multiple Airlines logo]()
$3,463
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to La Serena that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.
Fly from
San Francisco
Fly to
La Serena
Route
Depart
Return
Price
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Tue 3/17
6:00 am-8:55 am
2 stops22h 55m
La Serena La Florida
Thu 3/19
3:10 pm-3:13 pm
2 stops28h 03m
$896
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Mon 3/16
6:00 am-8:55 am
2 stops22h 55m
La Serena La Florida
Thu 3/19
3:10 pm-12:01 pm
2 stops24h 51m
$1,031
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Fri 12/12
10:40 am-8:55 am
2 stops17h 15m
La Serena La Florida
Fri 12/19
9:25 pm-10:34 am
2 stops18h 09m
$1,446
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Fri 12/12
2:30 pm-3:35 pm
2 stops20h 05m
La Serena La Florida
Fri 12/19
6:15 pm-12:00 pm
3 stops22h 45m
$3,463
- Most accurate provider: When it comes to deals on San Francisco-La Serena flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Francisco-La Serena flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from San Francisco-La Serena flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-La Serena flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-La Serena flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to La Serena
Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.