$841+ Cheap flights from San Francisco (SFO) to La Serena (LSC)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — LSC
Jan 27 — Feb 31
1 adult, Economy
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1. Tell us where you want to go
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Best flights from San Francisco to La SerenaDiscover carefully curated flight deals from San Francisco to La Serena that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.
Discover carefully curated flight deals from San Francisco to La Serena that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.
This LATAM Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:00 amSFO - LSC
2 stops26h 32mLATAM Airlines
Wed 4/2210:00 amLSC - SFO
2 stops32h 18mLATAM Airlines
Deal found 12/25![LATAM Airlines logo]()
$841
Find flight deals from San Francisco to La Serena
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to La Serena (LSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.
Most accurate provider | Expedia 2 stars |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $841 (LATAM Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to La Serena that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.
Fly from
San Francisco
Fly to
La Serena
Route
Depart
Return
Price
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Sat 4/18
6:00 am-11:32 am
2 stops26h 32m
La Serena La Florida
Wed 4/22
10:00 am-3:18 pm
2 stops32h 18m
$841
- Most accurate provider: When it comes to deals on San Francisco-La Serena flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Francisco-La Serena flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from San Francisco-La Serena flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-La Serena flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-La Serena flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to La Serena
Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.