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La Crosse

$472+ Cheap flights from Missouri to La Crosse (LSE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — LSE
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Missouri to La Crosse

Keep the following information in mind while searching for Missouri to La Crosse flight deals. Data was last updated September 16, 2025.

Round-trip from

$472
(American Airlines)
From Missouri to La Crosse
Search Deals

Find flight deals from Missouri to La Crosse

Cheapest flights from Missouri to La Crosse
Explore the most affordable flight options available from Missouri to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/41:03 pmMCI - LSE
1 stop4h 48mAmerican Airlines
Tue 10/76:00 amLSE - MCI
1 stop7h 00mAmerican Airlines
Deal found 9/13$472
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 pmSGF - LSE
1 stop4h 04mAmerican Airlines
Sun 10/56:00 amLSE - SGF
1 stop3h 44mAmerican Airlines
Deal found 9/16$496

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Missouri to La Crosse that are best for you.

Fly from

Missouri

Fly to

La Crosse

Route

Depart

Return

Price

Kansas CityLa Crosse

MCI - LSE

MCILSE

Kansas City

Sat 10/4

1:03 pm-5:51 pm

1 stop4h 48m

La Crosse

Tue 10/7

6:00 am-1:00 pm

1 stop7h 00m

$472

SpringfieldLa Crosse

SGF - LSE

SGFLSE

Springfield-Branson

Wed 10/1

6:00 pm-10:04 pm

1 stop4h 04m

La Crosse

Sun 10/5

6:00 am-9:44 am

1 stop3h 44m

$496

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Missouri to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to La Crosse
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to La Crosse from Missouri?

    Most people fly into La Crosse (LSE) if they book a flight to La Crosse from Missouri. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • How long is the flight from Missouri to La Crosse?

    Airlines like American Airlines fly from Missouri to La Crosse in about 4h 48m. The time it takes to get you to your destination can typically vary by up to . The distance from Missouri to La Crosse is about 363 mi.

  • Can I find deals for flights from Missouri to La Crosse that include hotel bookings?

    Yes. In addition to deals on Missouri to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to La Crosse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to La Crosse.

  • Can I find deals for business class flights from Missouri to La Crosse?

    Yes. Cheapflights offers flight deals from Missouri to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Winona
Decorah

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Alternative routes for Missouri to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Missouri to La Crosse

Discover the top airline that operate flights from Missouri to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$458Average$516FlexibilityNo cancel feeOn-time71%

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