$372+ Cheap flights from Missouri to La Crosse (LSE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — LSE
Nov 29 — Dec 61
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to La Crosse
Keep the following information in mind while searching for Missouri to La Crosse flight deals. Data was last updated October 30, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $474 (American Airlines) |
One-way from | $372 (American Airlines) |
Find flight deals from Missouri to La Crosse
Cheapest flights from Missouri to La CrosseExplore the most affordable flight options available from Missouri to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
Explore the most affordable flight options available from Missouri to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:48 amMCI - LSE
1 stop5h 44mAmerican Airlines
Tue 11/186:00 amLSE - MCI
1 stop5h 33mAmerican Airlines
Deal found 10/29![American Airlines logo]()
$474
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to La Crosse that are best for you.
Fly from
Missouri
Fly to
La Crosse
Route
Depart
Return
Price
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sat 11/15
11:48 am-5:32 pm
1 stop5h 44m
La Crosse
Tue 11/18
6:00 am-11:33 am
1 stop5h 33m
$474
SpringfieldLa Crosse
SGF - LSE
SGFLSE
Springfield-Branson
Wed 3/25
6:08 pm-9:40 pm
1 stop3h 32m
La Crosse
Sat 3/28
6:14 am-11:25 am
1 stop5h 11m
$488
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sat 12/20
5:19 pm-11:43 pm
1 stop6h 24m
$372
Best time to book a flight from Missouri to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to La Crosse
What is the cheapest month to book a flight from Missouri to La Crosse?
Currently, October is the cheapest month in which you can book a flight from Missouri to La Crosse (average of $142). Flying from Missouri to La Crosse in December is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsWinona
Decorah
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Alternative routes for Missouri to La Crosse
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from Missouri to La Crosse
Discover the top airline that operate flights from Missouri to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$458 | Average$516 | FlexibilityNo cancel fee | On-time71% |