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$127+ Cheap flights from Syracuse to Knoxville (SYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — TYS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Syracuse Hancock Intl to Knoxville McGhee Tyson are usually found in May or January, booked 37 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday

Cheap flight deals from Syracuse to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$233
(Delta)

One-way from

$127
(Kiwi.com)

Popular in

August

Cheapest in

May

Average price

$453
From Syracuse Hancock Intl to Knoxville McGhee Tyson
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One-way flight from Syracuse Hancock Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Syracuse to Knoxville

Cheapest flights from Syracuse to Knoxville
Explore the most affordable flight options available from Syracuse to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:51 pmSYR - TYS
1 stop4h 57mDelta
Fri 9/56:14 pmTYS - SYR
1 stop5h 37mDelta
Deal found 8/13$233
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:10 amSYR - TYS
1 stop5h 53mDelta
Tue 9/25:19 pmTYS - SYR
1 stop5h 49mDelta
Deal found 8/13$238
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:20 amSYR - TYS
1 stop4h 25mDelta
Wed 9/175:40 pmTYS - SYR
1 stop5h 23mDelta
Deal found 8/12$249
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:00 amSYR - TYS
2 stops8h 40mUnited Airlines
Wed 9/175:45 amTYS - SYR
1 stop3h 58mUnited Airlines
Deal found 8/12$254
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/266:15 amSYR - TYS
2 stops6h 48mAmerican Airlines
Sun 9/78:36 pmTYS - SYR
1 stop3h 53mAmerican Airlines
Deal found 8/11$259
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/11:55 pmSYR - TYS
1 stop4h 55mAmerican Airlines
Thu 10/97:00 amTYS - SYR
1 stop3h 48mAmerican Airlines
Deal found 8/13$274
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:38 pmSYR - TYS
1 stop4h 29mAmerican Airlines
Sun 9/148:36 pmTYS - SYR
1 stop3h 53mAmerican Airlines
Deal found 8/12$279
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2612:10 pmSYR - TYS
1 stop5h 09mDelta
Tue 9/26:14 pmTYS - SYR
1 stop5h 37mDelta
Deal found 8/13$284
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:10 amSYR - TYS
1 stop5h 53mDelta
Mon 9/15:45 amTYS - SYR
1 stop5h 20mDelta
Deal found 8/13$288
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/303:01 pmSYR - TYS
2 stops7h 36mUnited Airlines
Tue 9/25:45 amTYS - SYR
1 stop3h 59mUnited Airlines
Deal found 8/13$304
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/215:34 amSYR - TYS
1 stop6h 43mAmerican Airlines
Sun 8/248:25 pmTYS - SYR
1 stop3h 50mAmerican Airlines
Deal found 8/12$309
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/295:35 pmSYR - TYS
1 stop4h 26mAmerican Airlines
Tue 9/26:13 amTYS - SYR
2 stops8h 00mAmerican Airlines
Deal found 8/14$314

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Syracuse

Fly to

Knoxville

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 8/30

6:51 pm-11:48 pm

1 stop4h 57m

Knoxville McGhee Tyson

Fri 9/5

6:14 pm-11:51 pm

1 stop5h 37m

$233

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 8/30

6:10 am-12:03 pm

1 stop5h 53m

Knoxville McGhee Tyson

Tue 9/2

5:19 pm-11:08 pm

1 stop5h 49m

$238

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 9/10

1:55 pm-6:50 pm

1 stop4h 55m

Knoxville McGhee Tyson

Wed 9/17

7:18 am-12:28 pm

1 stop5h 10m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 11/17

5:33 pm-9:31 pm

1 stop3h 58m

Knoxville McGhee Tyson

Mon 11/24

7:38 am-11:38 am

1 stop4h 00m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 9/10

6:20 am-10:45 am

1 stop4h 25m

Knoxville McGhee Tyson

Wed 9/17

5:40 pm-11:03 pm

1 stop5h 23m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 9/11

7:38 pm-12:07 am

1 stop4h 29m

Knoxville McGhee Tyson

Thu 9/18

10:57 am-4:06 pm

1 stop5h 09m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 10/7

6:39 pm-11:07 pm

1 stop4h 28m

Knoxville McGhee Tyson

Tue 11/4

6:12 am-11:37 am

1 stop5h 25m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 9/5

1:43 pm-8:50 pm

1 stop7h 07m

Knoxville McGhee Tyson

Sun 9/7

8:36 pm-12:29 am

1 stop3h 53m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 9/26

1:43 pm-7:05 pm

1 stop5h 22m

Knoxville McGhee Tyson

Sun 9/28

8:36 pm-12:29 am

1 stop3h 53m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 8/25

6:06 pm-7:24 pm

1 stop25h 18m

$127

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 17 results
1
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Best time to book a flight from Syracuse to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Knoxville

How far ahead should I book a flight from Syracuse to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to Knoxville. Price data was last updated on August 8, 2025.

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Syracuse to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Syracuse to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $294). Flying from Syracuse to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to TYS?

Find hourly flight availability from Syracuse to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 23% on flights from Syracuse to Knoxville by exploring options for tickets at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 14, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Syracuse to Knoxville round-trip?

    Our cheapest airline available from Syracuse to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $214 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $232 and $318 round-trip. American Airlines is currently priced 38% below the average price you’ll pay for this route.

  • Can I find deals for flights from Syracuse to Knoxville that include hotel bookings?

    Yes. In addition to deals on Syracuse to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Knoxville.

  • Can I find deals for business class flights from Syracuse to Knoxville?

    Yes. Cheapflights offers flight deals from Syracuse to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $294). Flying from Syracuse to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Syracuse to Knoxville

Discover the top 3 airlines that operate flights from Syracuse to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$214Average$359FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$291FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$318Average$491FlexibilityNo cancel feeOn-time69%

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