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Knoxville

$126+ Cheap flights from Syracuse to Knoxville (SYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — TYS
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Syracuse to Knoxville

Cheapest flights from Syracuse to Knoxville
Explore the most affordable flight options available from Syracuse to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:15 am
SYR
-
TYS
1 stop5h 33m
American Airlines
Wed 4/85:06 pm
TYS
-
SYR
1 stop5h 59m
American Airlines
Deal found 2/8$251
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2510:21 am
SYR
-
TYS
1 stop27h 11m
Allegiant Air
Sun 5/316:03 pm
TYS
-
SYR
1 stop15h 28m
Allegiant Air
Deal found 2/10$265
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
SYR
-
TYS
1 stop4h 49m
United Airlines
Tue 3/109:40 am
TYS
-
SYR
1 stop4h 28m
United Airlines
Deal found 2/10$274
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:25 am
SYR
-
TYS
1 stop6h 50m
United Airlines
Sat 2/282:21 pm
TYS
-
SYR
1 stop5h 53m
United Airlines
Deal found 2/9$279
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:19 pm
SYR
-
TYS
2 stops8h 21m
American Airlines
Sat 2/287:02 am
TYS
-
SYR
2 stops7h 57m
American Airlines
Deal found 2/9$289
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:17 pm
SYR
-
TYS
1 stop5h 40m
Delta
Tue 4/76:05 am
TYS
-
SYR
1 stop5h 55m
Delta
Deal found 2/10$300
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:00 am
SYR
-
TYS
1 stop4h 49m
United Airlines
Tue 2/249:40 am
TYS
-
SYR
1 stop4h 32m
United Airlines
Deal found 2/8$309
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:33 pm
SYR
-
TYS
1 stop28h 05m
Allegiant Air
Thu 2/263:25 pm
TYS
-
SYR
1 stop19h 28m
Allegiant Air
Deal found 2/8$324
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:54 pm
SYR
-
TYS
1 stop4h 44m
American Airlines
Mon 3/236:05 am
TYS
-
SYR
1 stop5h 34m
American Airlines
Deal found 2/8$330
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:00 am
SYR
-
TYS
1 stop4h 05m
American Airlines
Sun 8/238:25 pm
TYS
-
SYR
1 stop3h 50m
American Airlines
Deal found 2/8$331

Find flight deals from Syracuse to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(American Airlines)

One-way from

$126
(American Airlines)

Popular in

August

Cheapest in

May

Average price

$368
Provider with most accurate pricing for Syracuse Hancock Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Knoxville McGhee Tyson flights.
Search Deals
From Syracuse Hancock Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Syracuse Hancock Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Syracuse

Fly to

Knoxville

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/1

6:00 am-10:50 am

1 stop4h 50m

Knoxville McGhee Tyson

Wed 4/8

1:52 pm-11:50 pm

2 stops9h 58m

$274

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 3/9

6:17 pm-11:57 pm

1 stop5h 40m

Knoxville McGhee Tyson

Mon 3/16

5:01 pm-10:38 pm

1 stop5h 37m

$274

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 3/2

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Tue 3/10

9:40 am-2:08 pm

1 stop4h 28m

$274

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 2/25

10:23 am-8:37 pm

2 stops10h 14m

Knoxville McGhee Tyson

Sat 2/28

2:21 pm-8:14 pm

1 stop5h 53m

$284

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

10:23 am-8:37 pm

2 stops10h 14m

Knoxville McGhee Tyson

Sat 2/28

2:21 pm-8:14 pm

1 stop5h 53m

$284

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

12:19 pm-8:40 pm

2 stops8h 21m

Knoxville McGhee Tyson

Sat 2/28

7:02 am-2:59 pm

2 stops7h 57m

$289

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 2/25

12:19 pm-8:40 pm

2 stops8h 21m

Knoxville McGhee Tyson

Sat 2/28

8:24 am-2:59 pm

2 stops6h 35m

$289

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 4/3

6:17 pm-11:57 pm

1 stop5h 40m

Knoxville McGhee Tyson

Tue 4/7

6:05 am-12:00 pm

1 stop5h 55m

$300

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 2/20

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Tue 2/24

6:45 am-2:12 pm

2 stops7h 27m

$314

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sun 2/22

7:33 pm-11:38 pm

1 stop28h 05m

Knoxville McGhee Tyson

Thu 2/26

3:25 pm-10:53 am

1 stop19h 28m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 16 results
1
2

Compare providers for flights from Syracuse to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Knoxville

How far ahead should I book a flight from Syracuse to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to Knoxville. Price data was last updated on February 6, 2026.

Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Syracuse to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Syracuse to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $137). Flying from Syracuse to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Syracuse to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 11, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,179 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,179 reviews
Delta
7.9
Good
8,179 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,276 reviews
Delta
7.9
Good
8,179 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,267 reviews
Delta
7.9
Good
8,179 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Knoxville?

    For as low as $274, United Airlines can have you in Knoxville from Syracuse in 4h 50m. Syracuse and Knoxville are separated by a distance of 656 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Knoxville round-trip?

    Our cheapest airline available from Syracuse to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $232 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $248 and $293 round-trip. Delta is currently priced 33% below the average price you’ll pay for this route.

  • Can I find deals for flights from Syracuse to Knoxville that include hotel bookings?

    Yes. In addition to deals on Syracuse to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Knoxville.

  • Can I find deals for business class flights from Syracuse to Knoxville?

    Yes. Cheapflights offers flight deals from Syracuse to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $137). Flying from Syracuse to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Syracuse to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Syracuse to Knoxville

Discover the top 3 airlines that operate flights from Syracuse to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$362FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$293Average$490FlexibilityNo cancel feeOn-time69%

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