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$100+ Cheap flights from Syracuse to Knoxville (SYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — TYS
oct. 25 — nov. 11
sáb. 10/25
sáb. 11/1
1 adult, Economy
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Cheapflights Tip: The best prices from Syracuse Hancock Intl to Knoxville McGhee Tyson are usually found in May or January, booked 90 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday

Cheap flight deals from Syracuse to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$100
(American Airlines)

Popular in

August

Cheapest in

May

Average price

$343
Provider with most accurate pricing for Syracuse Hancock Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Knoxville McGhee Tyson flights.
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From Syracuse Hancock Intl to Knoxville McGhee Tyson
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One-way flight from Syracuse Hancock Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 5% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Syracuse to Knoxville

Cheapest flights from Syracuse to Knoxville
Explore the most affordable flight options available from Syracuse to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 25, 2025.

This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/255:29 pmSYR - TYS
1 stop6h 21mAmerican Airlines
vie. 10/3110:57 amTYS - SYR
1 stop3h 52mAmerican Airlines
Deal found 9/23$225
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/116:08 amSYR - TYS
1 stop6h 01mDelta
sáb. 11/157:39 amTYS - SYR
1 stop4h 29mDelta
Deal found 9/24$249
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/115:30 amSYR - TYS
2 stops6h 16mAmerican Airlines
sáb. 11/151:13 pmTYS - SYR
1 stop6h 23mAmerican Airlines
Deal found 9/24$254
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:00 amSYR - TYS
1 stop6h 23mAmerican Airlines
jue. 10/98:37 pmTYS - SYR
1 stop3h 43mAmerican Airlines
Deal found 9/23$304
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/85:28 pmSYR - TYS
2 stops6h 23mAmerican Airlines
mar. 11/117:20 pmTYS - SYR
1 stop4h 03mAmerican Airlines
Deal found 9/23$314
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/211:03 amSYR - TYS
2 stops11h 47mUnited Airlines
jue. 10/97:26 pmTYS - SYR
1 stop4h 16mUnited Airlines
Deal found 9/23$332
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/256:00 amSYR - TYS
2 stops11h 18mUnited Airlines
vie. 10/312:25 pmTYS - SYR
2 stops8h 48mUnited Airlines
Deal found 9/23$348
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/81:05 pmSYR - TYS
2 stops10h 54mUnited Airlines
mar. 11/111:52 pmTYS - SYR
2 stops9h 21mUnited Airlines
Deal found 9/23$354
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/96:00 amSYR - TYS
1 stop5h 45mDelta
mié. 11/125:35 amTYS - SYR
1 stop5h 33mDelta
Deal found 9/23$364
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/97:58 pmSYR - TYS
2 stops16h 58mMultiple Airlines
mié. 11/129:54 pmTYS - SYR
1 stop12h 18mMultiple Airlines
Deal found 9/24$381

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 25, 2025.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Syracuse

Fly to

Knoxville

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

sáb. 10/25

5:29 pm-11:50 pm

1 stop6h 21m

Knoxville McGhee Tyson

vie. 10/31

10:57 am-2:49 pm

1 stop3h 52m

$225

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

mar. 11/11

6:08 am-12:09 pm

1 stop6h 01m

Knoxville McGhee Tyson

sáb. 11/15

7:39 am-12:08 pm

1 stop4h 29m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

mar. 2/24

6:00 am-11:07 am

1 stop5h 07m

Knoxville McGhee Tyson

sáb. 2/28

7:30 am-12:04 pm

1 stop4h 34m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

mar. 2/24

1:38 pm-9:31 pm

2 stops7h 53m

Knoxville McGhee Tyson

sáb. 2/28

7:52 pm-11:23 pm

1 stop3h 31m

$324

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

sáb. 11/8

3:23 pm-9:03 pm

1 stop5h 40m

Knoxville McGhee Tyson

mar. 11/11

7:20 pm-11:23 pm

1 stop4h 03m

$334

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

sáb. 11/8

1:05 pm-11:59 pm

2 stops10h 54m

Knoxville McGhee Tyson

mar. 11/11

1:52 pm-11:13 pm

2 stops9h 21m

$354

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

dom. 11/9

5:45 am-10:48 am

1 stop5h 03m

Knoxville McGhee Tyson

mié. 11/12

5:45 am-9:43 am

1 stop3h 58m

$364

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

dom. 11/9

6:00 am-11:45 am

1 stop5h 45m

Knoxville McGhee Tyson

mié. 11/12

5:35 am-11:08 am

1 stop5h 33m

$364

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

dom. 11/9

7:58 pm-12:56 pm

2 stops16h 58m

Knoxville McGhee Tyson

mié. 11/12

9:54 pm-10:12 am

1 stop12h 18m

$381

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

lun. 11/24

5:30 am-10:52 am

1 stop5h 22m

$100

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 18 results
1
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Compare providers for flights from Syracuse to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Knoxville in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Knoxville

How far ahead should I book a flight from Syracuse to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to Knoxville. Price data was last updated on September 19, 2025.

Booking 89 days in advance of your planned departure date is, on average, the best time to get cheap flights from Syracuse to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Syracuse to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $294). Flying from Syracuse to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to TYS?

Find hourly flight availability from Syracuse to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 25, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 23% on flights from Syracuse to Knoxville by exploring options for tickets at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 25, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Knoxville?

    For as low as $249, American Airlines can have you in Knoxville from Syracuse in 6h 01m. Syracuse and Knoxville are separated by a distance of 656 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Knoxville round-trip?

    Our cheapest airline available from Syracuse to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $223 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $232 and $318 round-trip. American Airlines is currently priced 37% below the average price you’ll pay for this route.

  • Can I find deals for flights from Syracuse to Knoxville that include hotel bookings?

    Yes. In addition to deals on Syracuse to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Knoxville.

  • Can I find deals for business class flights from Syracuse to Knoxville?

    Yes. Cheapflights offers flight deals from Syracuse to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $294). Flying from Syracuse to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Syracuse to Knoxville

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Top 3 airlines flying from Syracuse to Knoxville

Discover the top 3 airlines that operate flights from Syracuse to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$223Average$358FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$287FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$318Average$491FlexibilityNo cancel feeOn-time69%

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