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Knoxville

$81+ Cheap flights from Ohio to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Ohio to Knoxville

Cheapest flights from Ohio to Knoxville
Explore the most affordable flight options available from Ohio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:28 pmDTW - TYS
1 stop14h 32mMultiple Airlines
Tue 1/67:22 pmTYS - DTW
2 stops12h 45mMultiple Airlines
Deal found 12/17$272
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:02 pmCLE - TYS
1 stop3h 58mDelta
Tue 1/207:30 amTYS - CLE
1 stop6h 27mDelta
Deal found 12/16$297
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:00 amCAK - TYS
1 stop4h 40mAmerican Airlines
Sun 12/283:01 pmTYS - CAK
1 stop6h 21mAmerican Airlines
Deal found 12/17$299
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:26 pmCLE - TYS
1 stop5h 10mAmerican Airlines
Tue 1/204:00 pmTYS - CLE
2 stops7h 57mAmerican Airlines
Deal found 12/16$302
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:57 amCAK - TYS
1 stop6h 03mAmerican Airlines
Fri 12/265:08 pmTYS - CAK
1 stop4h 14mAmerican Airlines
Deal found 12/17$309
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:51 pmCMH - TYS
1 stop4h 52mAmerican Airlines
Sun 1/45:42 amTYS - CMH
1 stop6h 27mAmerican Airlines
Deal found 12/16$315
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:04 pmCAK - TYS
1 stop4h 17mAmerican Airlines
Mon 12/297:00 amTYS - CAK
1 stop4h 24mAmerican Airlines
Deal found 12/17$319
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:20 amCLE - TYS
1 stop6h 47mAmerican Airlines
Tue 12/305:42 amTYS - CLE
1 stop5h 04mAmerican Airlines
Deal found 12/15$319
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amPIT - TYS
1 stop9h 54mAllegiant Air
Sun 12/2812:31 pmTYS - PIT
1 stop24h 33mAllegiant Air
Deal found 12/16$331
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:40 amPIT - TYS
2 stops8h 35mMultiple Airlines
Sun 12/2812:31 pmTYS - PIT
1 stop24h 33mMultiple Airlines
Deal found 12/16$337
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:20 pmPIT - TYS
2 stops25h 17mMultiple Airlines
Mon 12/299:20 pmTYS - PIT
1 stop12h 38mMultiple Airlines
Deal found 12/16$358
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/174:48 pmCLE - TYS
1 stop19h 44mMultiple Airlines
Wed 12/245:05 pmTYS - CLE
1 stop14h 38mMultiple Airlines
Deal found 12/16$365

Find flight deals from Ohio to Knoxville

Keep the following information in mind while searching for Ohio to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$199
(Kiwi.com)

One-way from

$81
(Frontier)

Popular in

November

Cheapest in

February

Average price

$356
Provider with most accurate pricing for Cleveland Hopkins Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Knoxville McGhee Tyson flights.
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From Ohio to Knoxville McGhee Tyson
Search Deals
One-way flight from Ohio to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Ohio to Knoxville that are best for you.

Fly from

Ohio

Fly to

Knoxville

Route

Depart

Return

Price

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Fri 1/9

5:32 am-10:28 pm

1 stop16h 56m

Knoxville McGhee Tyson

Mon 1/12

6:18 pm-11:44 pm

2 stops29h 26m

$215

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Thu 1/8

11:00 am-11:05 pm

1 stop12h 05m

Knoxville McGhee Tyson

Mon 1/12

6:18 pm-4:45 pm

1 stop22h 27m

$219

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Fri 1/23

5:50 pm-11:09 am

1 stop17h 19m

Knoxville McGhee Tyson

Sun 1/25

1:39 pm-9:28 pm

2 stops7h 49m

$228

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Wed 1/7

10:53 am-8:39 am

1 stop21h 46m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-9:40 am

1 stop24h 11m

$229

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Tue 1/13

4:00 pm-3:03 pm

1 stop23h 03m

Knoxville McGhee Tyson

Tue 1/20

1:00 pm-2:39 pm

1 stop25h 39m

$236

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 1/13

3:00 pm-9:21 pm

1 stop6h 21m

Knoxville McGhee Tyson

Tue 1/20

2:17 pm-9:30 pm

1 stop7h 13m

$237

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 1/13

4:34 pm-8:43 pm

1 stop4h 09m

Knoxville McGhee Tyson

Tue 1/20

7:30 am-1:28 pm

1 stop5h 58m

$237

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Sat 1/10

5:50 pm-8:39 am

1 stop14h 49m

Knoxville McGhee Tyson

Mon 1/12

8:30 am-11:44 pm

1 stop15h 14m

$240

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 1/26

6:06 am-5:28 pm

1 stop11h 22m

Knoxville McGhee Tyson

Thu 1/29

1:39 pm-10:47 am

2 stops21h 08m

$241

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Tue 1/20

1:15 pm-8:22 pm

1 stop7h 07m

Knoxville McGhee Tyson

Sat 1/31

7:30 am-1:57 pm

1 stop6h 27m

$245

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 57 results
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Best time to book a flight from Ohio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Knoxville

What is the cheapest month to book a flight from Ohio to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $152). Flying from Ohio to Knoxville in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from OH to TYS?

Find hourly flight availability from Ohio to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Ohio to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 17% versus a flight in the evening.

What is the cheapest day to fly from Ohio to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Ohio to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Ohio to Knoxville flight should consider departing on Saturday evenings when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Ohio?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Ohio.

  • How long is the flight from Ohio to Knoxville?

    Departing from Ohio to Knoxville will take you 4h 09m. The distance from Ohio to Knoxville is about 296 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Ohio to Knoxville one-way?

    The cheapest airlines for a one-way flight from Ohio to Knoxville are Delta ($99), American Airlines ($125), and United Airlines ($125).

  • What are the most popular routes from Ohio to Knoxville?

    Most travelers choose Detroit Metropolitan Wayne County - Knoxville McGhee Tyson, Pittsburgh - Knoxville McGhee Tyson or Columbus - Knoxville McGhee Tyson when deciding on the best route from Ohio to Knoxville.

  • Can I find deals for flights from Ohio to Knoxville that include hotel bookings?

    Yes. In addition to deals on Ohio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Knoxville.

  • Can I find deals for business class flights from Ohio to Knoxville?

    Yes. Cheapflights offers flight deals from Ohio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $152). Flying from Ohio to Knoxville in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Ohio to Knoxville

Discover the top 3 airlines that operate flights from Ohio to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$320FlexibilityNo cancel feeOn-time69%
DeltaCheapest$213Average$360FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$326FlexibilityNo cancel feeOn-time71%

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