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Knoxville

$96+ Cheap flights from Ohio to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — TYS
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Ohio to Knoxville

Cheapest flights from Ohio to Knoxville
Explore the most affordable flight options available from Ohio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This Booking.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:54 am
DTW
-
TYS
1 stop27h 34m
Frontier
Thu 4/164:28 pm
TYS
-
DTW
1 stop18h 30m
Frontier
Deal found 3/11$213
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:36 pm
CAK
-
TYS
1 stop5h 24m
Allegiant Air
Mon 8/312:40 pm
TYS
-
CAK
1 stop8h 51m
Allegiant Air
Deal found 3/11$215
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:29 pm
CLE
-
TYS
1 stop27h 19m
Multiple Airlines
Fri 5/82:06 pm
TYS
-
CLE
1 stop10h 32m
Multiple Airlines
Deal found 3/12$219
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:46 pm
CAK
-
TYS
1 stop7h 04m
Multiple Airlines
Tue 6/235:02 pm
TYS
-
CAK
1 stop21h 53m
Multiple Airlines
Deal found 3/8$221
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:06 pm
CLE
-
TYS
2 stops21h 35m
Multiple Airlines
Wed 4/154:25 pm
TYS
-
CLE
1 stop20h 49m
Multiple Airlines
Deal found 3/11$224
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:40 pm
CAK
-
TYS
1 stop5h 40m
Multiple Airlines
Thu 5/1412:55 pm
TYS
-
CAK
1 stop11h 02m
Multiple Airlines
Deal found 3/10$225
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:59 pm
DTW
-
TYS
1 stop26h 49m
Multiple Airlines
Thu 4/164:28 pm
TYS
-
DTW
1 stop18h 30m
Multiple Airlines
Deal found 3/10$235
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:29 pm
CLE
-
TYS
1 stop27h 19m
Multiple Airlines
Thu 5/79:40 pm
TYS
-
CLE
2 stops14h 10m
Multiple Airlines
Deal found 3/10$237
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:29 pm
CLE
-
TYS
1 stop27h 19m
Multiple Airlines
Sat 5/99:00 am
TYS
-
CLE
2 stops23h 53m
Multiple Airlines
Deal found 3/12$238
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:22 am
CAK
-
TYS
1 stop13h 02m
Allegiant Air
Mon 7/1312:40 pm
TYS
-
CAK
1 stop8h 51m
Allegiant Air
Deal found 3/8$239
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:55 pm
DTW
-
TYS
2 stops21h 46m
Multiple Airlines
Wed 4/154:25 pm
TYS
-
DTW
1 stop7h 21m
Multiple Airlines
Deal found 3/9$240
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:46 pm
CAK
-
TYS
1 stop7h 04m
Multiple Airlines
Tue 6/235:02 pm
TYS
-
CAK
1 stop21h 53m
Multiple Airlines
Deal found 3/8$243

Find flight deals from Ohio to Knoxville

Keep the following information in mind while searching for Ohio to Knoxville flight deals. Data was last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$213
(Booking.com)

One-way from

$96
(Kiwi.com)

Popular in

November

Cheapest in

February

Average price

$351
Provider with most accurate pricing for Cleveland Hopkins Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Knoxville McGhee Tyson flights.
Search Deals
From Ohio to Knoxville McGhee Tyson
Search Deals
One-way flight from Ohio to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Ohio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Sun 5/3

5:30 am-10:33 pm

1 stop17h 03m

Knoxville McGhee Tyson

Fri 5/8

5:39 pm-6:27 pm

2 stops24h 48m

$230

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Tue 4/7

6:10 am-10:50 am

1 stop4h 40m

Knoxville McGhee Tyson

Tue 4/14

7:20 pm-11:20 pm

1 stop4h 00m

$263

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Sat 4/18

7:00 am-1:14 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 4/18

7:20 pm-11:20 pm

1 stop4h 00m

$266

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Tue 4/14

6:25 am-12:00 pm

1 stop5h 35m

Knoxville McGhee Tyson

Sat 4/18

7:45 am-11:30 am

1 stop3h 45m

$267

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Mon 3/30

5:55 pm-10:10 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 4/1

6:35 am-12:15 pm

1 stop5h 40m

$271

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Wed 5/13

5:50 am-5:10 pm

2 stops11h 20m

Knoxville McGhee Tyson

Tue 5/19

12:50 pm-10:15 pm

2 stops9h 25m

$273

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Mon 6/8

7:59 pm-11:46 pm

1 stop3h 47m

Knoxville McGhee Tyson

Wed 6/10

5:30 am-8:52 am

1 stop3h 22m

$275

HuntingtonKnoxville

HTS - TYS

HTSTYS

Huntington Tri State

Thu 3/26

9:20 am-8:18 am

1 stop22h 58m

Knoxville McGhee Tyson

Mon 3/30

3:29 pm-10:29 am

1 stop19h 00m

$275

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Thu 5/28

9:01 pm-2:27 pm

1 stop17h 26m

Knoxville McGhee Tyson

Sun 5/31

6:03 pm-11:28 pm

1 stop5h 25m

$286

AkronKnoxville

CAK - TYS

CAKTYS

Akron/Canton

Sat 8/1

5:57 pm-12:30 am

1 stop6h 33m

Knoxville McGhee Tyson

Tue 8/4

5:55 pm-11:55 pm

1 stop6h 00m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Ohio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Knoxville

What is the cheapest month to book a flight from Ohio to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $190). Flying from Ohio to Knoxville in December is currently the most expensive (average of $242). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Ohio?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Ohio.

  • How long is the flight from Ohio to Knoxville?

    Departing from Ohio to Knoxville will take you 4h 40m. The distance from Ohio to Knoxville is about 382 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Ohio to Knoxville one-way?

    The cheapest airlines for a one-way flight from Ohio to Knoxville are Delta ($99), American Airlines ($125), and United Airlines ($125).

  • What are the most popular routes from Ohio to Knoxville?

    Most travelers choose Detroit Metropolitan Wayne County - Knoxville McGhee Tyson, Pittsburgh - Knoxville McGhee Tyson or Cleveland Hopkins Intl - Knoxville McGhee Tyson when deciding on the best route from Ohio to Knoxville.

  • Can I find deals for flights from Ohio to Knoxville that include hotel bookings?

    Yes. In addition to deals on Ohio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Knoxville.

  • Can I find deals for business class flights from Ohio to Knoxville?

    Yes. Cheapflights offers flight deals from Ohio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $190). Flying from Ohio to Knoxville in December is currently the most expensive (average of $242). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Ohio to Knoxville

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Top 3 airlines flying from Ohio to Knoxville

Discover the top 3 airlines that operate flights from Ohio to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$213Average$372FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$356FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$238Average$357FlexibilityNo cancel feeOn-time69%

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