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$109+ Cheap flights from Ohio to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — TYS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Ohio to Knoxville

Keep the following information in mind while searching for Ohio to Knoxville flight deals. Data was last updated September 15, 2025.

Round-trip from

$183
(American Airlines)

One-way from

$109
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$298
From Ohio to Knoxville McGhee Tyson
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One-way flight from Ohio to Knoxville McGhee Tyson
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Ohio to Knoxville

Cheapest flights from Ohio to Knoxville
Explore the most affordable flight options available from Ohio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:00 amCMH - TYS
1 stop6h 09mAmerican Airlines
Tue 10/77:00 amTYS - CMH
1 stop5h 05mAmerican Airlines
Deal found 9/12$183
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/216:10 amDTW - TYS
1 stop10h 08mFrontier
Sun 9/285:08 pmTYS - DTW
1 stop7h 38mFrontier
Deal found 9/14$188
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:55 pmDTW - TYS
1 stop20h 06mMultiple Airlines
Fri 11/76:12 pmTYS - DTW
1 stop14h 10mMultiple Airlines
Deal found 9/14$209
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:00 amCMH - TYS
1 stop6h 09mAmerican Airlines
Tue 10/76:14 pmTYS - CMH
1 stop4h 37mAmerican Airlines
Deal found 9/12$211
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:00 amCVG - TYS
1 stop28h 33mMultiple Airlines
Fri 10/248:40 amTYS - CVG
1 stop8h 15mMultiple Airlines
Deal found 9/15$213
This Mytrip deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:40 amPIT - TYS
2 stops14h 33mMultiple Airlines
Mon 10/2711:00 amTYS - PIT
2 stops10h 28mMultiple Airlines
Deal found 9/12$225
This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:40 amPIT - TYS
2 stops14h 46mMultiple Airlines
Fri 11/146:42 pmTYS - PIT
2 stops19h 40mMultiple Airlines
Deal found 9/13$228
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:36 pmCAK - TYS
1 stop4h 27mAmerican Airlines
Tue 10/75:37 pmTYS - CAK
1 stop4h 03mAmerican Airlines
Deal found 9/13$229
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:45 pmCAK - TYS
1 stop5h 05mUnited Airlines
Tue 10/78:50 amTYS - CAK
1 stop4h 38mUnited Airlines
Deal found 9/14$234
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/269:11 pmDTW - TYS
1 stop12h 12mMultiple Airlines
Sat 9/279:05 pmTYS - DTW
1 stop11h 39mMultiple Airlines
Deal found 9/12$234
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/26:21 pmCMH - TYS
1 stop18h 12mMultiple Airlines
Fri 11/79:09 pmTYS - CMH
1 stop24h 03mMultiple Airlines
Deal found 9/14$235
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/207:59 pmCMH - TYS
1 stop3h 47mDelta
Sat 11/82:41 pmTYS - CMH
1 stop5h 56mDelta
Deal found 9/15$239

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Ohio to Knoxville that are best for you.

Fly from

Ohio

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 9/30

8:00 am-2:09 pm

1 stop6h 09m

Knoxville McGhee Tyson

Tue 10/7

7:00 am-12:05 pm

1 stop5h 05m

$183

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 2/21

5:45 pm-9:43 pm

1 stop3h 58m

Knoxville McGhee Tyson

Wed 2/25

7:30 am-1:30 pm

1 stop6h 00m

$197

ClevelandKnoxville

CLE - TYS

CLETYS

Cleveland Hopkins Intl

Sat 2/21

6:15 am-10:17 am

1 stop4h 02m

Knoxville McGhee Tyson

Wed 2/25

11:30 am-3:16 pm

1 stop3h 46m

$197

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 10/3

8:00 am-2:09 pm

1 stop6h 09m

Knoxville McGhee Tyson

Tue 10/7

6:14 pm-10:51 pm

1 stop4h 37m

$211

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Mon 10/20

6:00 am-10:33 am

1 stop28h 33m

Knoxville McGhee Tyson

Fri 10/24

8:40 am-4:55 pm

1 stop8h 15m

$213

AkronKnoxville

CAK - TYS

CAKTYS

Akron/Canton

Sat 10/4

6:36 pm-11:03 pm

1 stop4h 27m

Knoxville McGhee Tyson

Tue 10/7

5:37 pm-9:40 pm

1 stop4h 03m

$229

PittsburghKnoxville

PIT - TYS

PITTYS

Pittsburgh

Fri 11/7

6:24 pm-9:27 am

1 stop15h 03m

Knoxville McGhee Tyson

Fri 11/14

6:42 pm-2:22 pm

2 stops19h 40m

$233

AkronKnoxville

CAK - TYS

CAKTYS

Akron/Canton

Thu 10/2

5:45 pm-10:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Tue 10/7

8:50 am-1:28 pm

1 stop4h 38m

$234

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 10/20

7:59 pm-11:46 pm

1 stop3h 47m

Knoxville McGhee Tyson

Sat 11/8

2:41 pm-8:37 pm

1 stop5h 56m

$239

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Fri 9/26

8:30 am-10:18 am

1 stop25h 48m

Knoxville McGhee Tyson

Sun 9/28

3:19 pm-10:22 am

1 stop19h 03m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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Best time to book a flight from Ohio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Knoxville

What is the cheapest month to book a flight from Ohio to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $295). Flying from Ohio to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from OH to TYS?

Find hourly flight availability from Ohio to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Ohio to Knoxville as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Ohio?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Ohio.

  • How long is the flight from Ohio to Knoxville?

    Departing from Ohio to Knoxville will take you 3h 58m. The distance from Ohio to Knoxville is about 296 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Ohio to Knoxville one-way?

    The cheapest airlines for a one-way flight from Ohio to Knoxville are Allegiant Air ($109), United Airlines ($126), and Delta ($126).

  • What are the most popular routes from Ohio to Knoxville?

    Most travelers choose Detroit Metropolitan Wayne County - Knoxville McGhee Tyson, Pittsburgh - Knoxville McGhee Tyson or Cleveland Hopkins Intl - Knoxville McGhee Tyson when deciding on the best route from Ohio to Knoxville.

  • Can I find deals for flights from Ohio to Knoxville that include hotel bookings?

    Yes. In addition to deals on Ohio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Knoxville.

  • Can I find deals for business class flights from Ohio to Knoxville?

    Yes. Cheapflights offers flight deals from Ohio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Ohio to Knoxville (average of $295). Flying from Ohio to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Ohio to Knoxville

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Top 3 airlines flying from Ohio to Knoxville

Discover the top 3 airlines that operate flights from Ohio to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$205Average$337FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$318FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$292FlexibilityNo cancel feeOn-timeN/A

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