Knoxville

$117+ Cheap flights from North Carolina to Knoxville (TYS)

CLT — TYS
Dec 10 — Dec 171
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Cheap flight deals from North Carolina to Knoxville

Cheapest flights from North Carolina to Knoxville

Mon 12/76:44 pm -
1 stop18h 23m
Mon 12/141:58 pm -
1 stop27h 51m
Deal found 11/7$203
Sat 11/1410:06 am -
2 stops25h 17m
Wed 11/186:17 pm -
1 stop19h 41m
Deal found 11/6$220
Fri 12/46:44 pm -
1 stop15h 53m
Sun 12/611:00 am -
1 stop11h 40m
Deal found 11/7$232
Mon 11/165:38 pm -
1 stop23h 40m
Thu 11/1911:36 am -
1 stop8h 23m
Deal found 11/7$242
Thu 12/179:46 pm -
1 stop16h 44m
Mon 12/216:00 am -
1 stop14h 56m
Deal found 11/7$250
Tue 12/812:21 pm -
2 stops25h 47m
Tue 12/151:57 pm -
1 stop7h 05m
Deal found 11/8$253
Thu 12/36:44 pm -
1 stop13h 43m
Thu 12/1011:00 am -
2 stops10h 02m
Deal found 11/5$263
Sat 12/197:56 am -
1 stop12h 46m
Mon 12/218:32 pm -
1 stop17h 02m
Deal found 11/8$270
Thu 12/35:00 am -
1 stop3h 54m
Thu 12/106:50 am -
1 stop5h 11m
Deal found 11/5$273
Thu 12/36:44 pm -
1 stop13h 43m
Sun 12/611:00 am -
1 stop11h 40m
Deal found 11/5$278
Sat 11/1410:06 am -
2 stops25h 17m
Mon 11/162:21 pm -
1 stop20h 41m
Deal found 11/7$287
Sun 11/221:23 pm -
1 stop8h 41m
Thu 11/2612:56 pm -
1 stop20h 03m
Deal found 11/7$288

Find flight deals from North Carolina to Knoxville

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$117
(Kiwi.com)

Popular in

September

Cheapest in

April

Average price

$550
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
From North Carolina to Knoxville McGhee Tyson
One-way flight from North Carolina to Knoxville McGhee Tyson
Highest demand for flights based on searches. 12% potential increase in price ($86 potential increase over avg. RT price).
Cheapest flight prices on average. 3% potential price decrease ($20 potential savings vs. average RT price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from North Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Fri 12/18

5:07 am-10:01 am

1 stop4h 54m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$137

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Sat 12/5

3:06 pm-8:14 pm

1 stop5h 08m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$148

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Sat 12/19

3:25 pm-9:40 pm

1 stop6h 15m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$154

CharlotteKnoxville

CLT Charlotte Douglas - TYS Knoxville McGhee Tyson

CLTTYS

Charlotte Douglas

Thu 2/18

8:54 am-5:20 pm

1 stop8h 26m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$155

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Sat 11/14

10:06 am-11:23 am

2 stops25h 17m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$157

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Thu 11/12

2:45 pm-12:49 pm

1 stop22h 04m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$158

CharlotteKnoxville

CLT Charlotte Douglas - TYS Knoxville McGhee Tyson

CLTTYS

Charlotte Douglas

Sat 11/14

8:08 pm-8:05 am

1 stop11h 57m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$165

CharlotteKnoxville

CLT Charlotte Douglas - TYS Knoxville McGhee Tyson

CLTTYS

Charlotte Douglas

Mon 12/21

7:56 am-3:34 pm

2 stops31h 38m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$172

RaleighKnoxville

RDU Raleigh-Durham - TYS Knoxville McGhee Tyson

RDUTYS

Raleigh-Durham

Sun 11/15

9:30 pm-1:31 pm

1 stop16h 01m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$182

CharlotteKnoxville

CLT Charlotte Douglas - TYS Knoxville McGhee Tyson

CLTTYS

Charlotte Douglas

Fri 2/12

3:15 pm-10:20 pm

1 stop7h 05m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$188

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 58 resultsSorted by cheapest first
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Best time to book a flight from North Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from North Carolina with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Knoxville

What is the cheapest month to book a flight from North Carolina to Knoxville?

Currently, April is the cheapest month in which you can book a flight from North Carolina to Knoxville (average of $308). Flying from North Carolina to Knoxville in February is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to TYS?

It’s typically best to fly out from North Carolina to Knoxville in the morning. Doing so could potentially save you 28% on the flight price compared to flying in the evening, which is usually more expensive.

Weekly flight availability from North Carolina to Knoxville

The most flights from USNC to TYS are scheduled on a Thursday (12 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (9 on average).

Related info for your journey

  • What airport do you fly into for flights to Knoxville from North Carolina?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from North Carolina. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from North Carolina to Knoxville?

    For as low as $273, Delta can have you in Knoxville from North Carolina in 3h 52m. There are 291 mi between North Carolina and Knoxville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from North Carolina to Knoxville?

  • What are the most reliable airlines from North Carolina to Knoxville?

    Consider Piedmont Airlines (86%), American Airlines (77%) or SkyWest Airlines (73%) when booking your flight. These represent the most reliable airlines when flying from North Carolina to Knoxville.

  • Can I find deals for flights from North Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on North Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Knoxville.

  • Can I find deals for business class flights from North Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from North Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from North Carolina to Knoxville (average of $308). Flying from North Carolina to Knoxville in February is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Newport
Bryson City
Crossville
Morristown
Murphy

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for North Carolina to Knoxville

Top 2 airlines flying from North Carolina to Knoxville

AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$382FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$262Average$496FlexibilityNo cancel feeOn-time71%

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