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Knoxville

$58+ Cheap flights from Maine to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — TYS
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Cheap flight deals from Maine to Knoxville

Keep the following information in mind while searching for Maine to Knoxville flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$140
(Booking.com)

One-way from

$58
(Cheapflightsfares)

Popular in

May

Cheapest in

December

Average price

$383
Provider with most accurate pricing for Portland-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Portland-Knoxville McGhee Tyson flights.
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From Maine to Knoxville McGhee Tyson
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One-way flight from Maine to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 12% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Maine to Knoxville

Cheapest flights from Maine to Knoxville
Explore the most affordable flight options available from Maine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This Booking.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1611:33 amBOS - TYS
Nonstop2h 32mAllegiant Air
Thu 11/206:00 amTYS - BOS
Nonstop2h 12mAllegiant Air
Deal found 11/1$140
This Cheapflightsfares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:33 amBOS - TYS
Nonstop2h 28mAllegiant Air
Thu 11/138:30 amTYS - BOS
Nonstop2h 13mAllegiant Air
Deal found 11/2$148
This Cheapflightsfares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/810:33 amBOS - TYS
Nonstop2h 28mAllegiant Air
Tue 11/117:30 amTYS - BOS
Nonstop2h 13mAllegiant Air
Deal found 11/2$166
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:28 amBOS - TYS
2 stops10h 09mMultiple Airlines
Sun 12/76:00 amTYS - BOS
Nonstop2h 10mMultiple Airlines
Deal found 11/2$179
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:16 amBOS - TYS
2 stops31h 41mMultiple Airlines
Thu 11/206:00 amTYS - BOS
Nonstop2h 12mMultiple Airlines
Deal found 11/1$180
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:33 amBOS - TYS
Nonstop2h 28mMultiple Airlines
Thu 11/136:58 pmTYS - BOS
1 stop13h 30mMultiple Airlines
Deal found 11/2$184
This Cheapflightsfares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/911:33 amBOS - TYS
Nonstop2h 32mAllegiant Air
Thu 11/138:30 amTYS - BOS
Nonstop2h 13mAllegiant Air
Deal found 11/2$187
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:33 amBOS - TYS
Nonstop2h 28mAllegiant Air
Tue 11/117:30 amTYS - BOS
Nonstop2h 13mAllegiant Air
Deal found 10/31$188
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:45 pmBOS - TYS
Nonstop2h 31mMultiple Airlines
Wed 12/315:05 pmTYS - BOS
1 stop16h 56mMultiple Airlines
Deal found 10/30$189
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1510:33 amBOS - TYS
Nonstop2h 28mMultiple Airlines
Mon 11/172:22 pmTYS - BOS
3 stops33h 37mMultiple Airlines
Deal found 10/30$196
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/108:11 pmBOS - TYS
1 stop25h 33mMultiple Airlines
Mon 12/151:05 pmTYS - BOS
1 stop20h 56mMultiple Airlines
Deal found 11/2$198
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:24 pmBGR - TYS
1 stop12h 52mAllegiant Air
Wed 11/1912:44 pmTYS - BGR
1 stop21h 04mAllegiant Air
Deal found 11/1$239

Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Maine to Knoxville that are best for you.

Fly from

Maine

Fly to

Knoxville

Route

Depart

Return

Price

BostonKnoxville

BOS - TYS

BOSTYS

Boston Logan Intl

Sun 11/16

6:16 am-1:57 pm

2 stops31h 41m

Knoxville McGhee Tyson

Thu 11/20

6:00 am-8:12 am

Nonstop2h 12m

$180

BostonKnoxville

BOS - TYS

BOSTYS

Boston Logan Intl

Thu 11/20

9:02 am-11:34 am

Nonstop2h 32m

Knoxville McGhee Tyson

Tue 11/25

9:53 am-7:29 am

2 stops21h 36m

$236

BangorKnoxville

BGR - TYS

BGRTYS

Bangor

Tue 12/9

4:56 pm-9:36 pm

1 stop4h 40m

Knoxville McGhee Tyson

Wed 12/17

7:38 am-12:24 pm

1 stop4h 46m

$259

BangorKnoxville

BGR - TYS

BGRTYS

Bangor

Tue 12/9

11:55 am-4:44 pm

1 stop4h 49m

Knoxville McGhee Tyson

Wed 12/17

5:25 pm-11:27 pm

1 stop6h 02m

$259

BangorKnoxville

BGR - TYS

BGRTYS

Bangor

Tue 12/9

4:56 pm-9:36 pm

1 stop4h 40m

Knoxville McGhee Tyson

Sun 12/14

7:00 am-12:24 pm

1 stop5h 24m

$259

BangorKnoxville

BGR - TYS

BGRTYS

Bangor

Thu 11/13

7:43 pm-1:12 pm

1 stop17h 29m

Knoxville McGhee Tyson

Mon 11/17

9:29 pm-9:02 am

1 stop11h 33m

$263

BangorKnoxville

BGR - TYS

BGRTYS

Bangor

Tue 12/9

5:14 am-2:52 pm

2 stops9h 38m

Knoxville McGhee Tyson

Sun 12/14

6:10 am-11:15 am

1 stop5h 05m

$264

BostonKnoxville

BOS - TYS

BOSTYS

Boston Logan Intl

Wed 12/17

5:20 pm-9:36 pm

1 stop4h 16m

Knoxville McGhee Tyson

Wed 12/31

7:35 am-12:23 pm

1 stop4h 48m

$279

BostonKnoxville

BOS - TYS

BOSTYS

Boston Logan Intl

Tue 12/2

9:15 am-2:52 pm

1 stop5h 37m

Knoxville McGhee Tyson

Tue 12/9

5:40 am-12:30 pm

1 stop6h 50m

$279

BostonKnoxville

BOS - TYS

BOSTYS

Boston Logan Intl

Tue 12/2

5:29 am-11:47 am

1 stop6h 18m

Knoxville McGhee Tyson

Sat 12/6

7:30 am-11:59 am

1 stop4h 29m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/31

Showing 1-10 of 47 results
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Best time to book a flight from Maine to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Knoxville

What is the cheapest month to book a flight from Maine to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Maine to Knoxville (average of $165). Flying from Maine to Knoxville in April is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ME to TYS?

Find hourly flight availability from Maine to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

A simple way to save on the total cost of your ticket is to fly from Maine to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from Maine to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Maine?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Maine.

  • How long is the flight from Maine to Knoxville?

    For as low as $259, American Airlines can have you in Knoxville from Maine in 4h 40m. Airlines will cover a distance of 1009 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Maine to Knoxville one-way?

    The cheapest airlines for a one-way flight from Maine to Knoxville are Allegiant Air ($58), American Airlines ($116), and Delta ($140).

  • What are the most popular routes from Maine to Knoxville?

    When deciding which route to take from Maine to Knoxville consider Boston Logan Intl - Knoxville McGhee Tyson, Portland - Knoxville McGhee Tyson or Bangor - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Maine to Knoxville that include hotel bookings?

    Yes. In addition to deals on Maine to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Knoxville.

  • Can I find deals for business class flights from Maine to Knoxville?

    Yes. Cheapflights offers flight deals from Maine to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Maine to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Maine to Knoxville (average of $165). Flying from Maine to Knoxville in April is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Maine to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Maine to Knoxville

Discover the top 3 airlines that operate flights from Maine to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$476FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$373FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$416FlexibilityNo cancel feeOn-timeN/A

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