HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$221+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Aug 1 — Aug 81
Sat 8/1
Sat 8/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:37 am
EYW
-
TYS
1 stop11h 44m
Allegiant Air
Mon 10/268:15 am
TYS
-
EYW
Nonstop2h 04m
Allegiant Air
Deal found 6/28$221
This WAYA deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:53 am
EYW
-
TYS
1 stop8h 21m
Allegiant Air
Mon 10/129:00 am
TYS
-
EYW
Nonstop2h 04m
Allegiant Air
Deal found 7/1$281
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:00 am
EYW
-
TYS
1 stop6h 23m
Delta
Mon 12/142:30 pm
TYS
-
EYW
1 stop5h 13m
Delta
Deal found 6/30$309
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:37 am
EYW
-
TYS
1 stop11h 44m
Multiple Airlines
Mon 10/268:14 pm
TYS
-
EYW
2 stops37h 10m
Multiple Airlines
Deal found 6/28$335
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:59 am
EYW
-
TYS
1 stop12h 22m
Multiple Airlines
Fri 10/99:35 pm
TYS
-
EYW
2 stops11h 49m
Multiple Airlines
Deal found 7/1$387
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2112:59 pm
EYW
-
TYS
1 stop20h 40m
Multiple Airlines
Mon 10/129:33 pm
TYS
-
EYW
2 stops35h 51m
Multiple Airlines
Deal found 7/1$400
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:50 am
EYW
-
TYS
1 stop6h 59m
Delta
Sun 7/55:40 am
TYS
-
EYW
1 stop6h 43m
Delta
Deal found 6/27$414
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:31 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Sun 7/58:15 am
TYS
-
EYW
1 stop7h 12m
Allegiant Air
Deal found 6/27$426
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:07 pm
EYW
-
TYS
1 stop11h 26m
Multiple Airlines
Sun 7/53:38 pm
TYS
-
EYW
2 stops19h 49m
Multiple Airlines
Deal found 6/27$565
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:00 pm
EYW
-
TYS
2 stops7h 43m
American Airlines
Mon 12/142:55 pm
TYS
-
EYW
1 stop6h 50m
American Airlines
Deal found 6/30$568
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:00 pm
EYW
-
TYS
1 stop17h 43m
United Airlines
Mon 8/35:45 am
TYS
-
EYW
2 stops31h 45m
United Airlines
Deal found 6/27$696

Find flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$221
(Kiwi.com)

Popular in

September

Cheapest in

March

Average price

$526
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
Search Deals
From Key West to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($124 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/7

7:00 am-1:23 pm

1 stop6h 23m

Knoxville McGhee Tyson

Mon 12/14

7:00 am-1:08 pm

1 stop6h 08m

$309

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 9/21

12:59 pm-9:39 am

1 stop20h 40m

Knoxville McGhee Tyson

Mon 10/12

9:33 pm-9:24 am

2 stops35h 51m

$400

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 9/25

10:59 am-11:21 pm

1 stop12h 22m

Knoxville McGhee Tyson

Fri 10/9

6:10 am-9:30 pm

1 stop15h 20m

$414

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 7/31

4:00 pm-10:19 pm

2 stops30h 19m

Knoxville McGhee Tyson

Mon 8/3

5:45 am-1:30 pm

2 stops31h 45m

$731

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/7

4:05 pm-2:42 pm

2 stops22h 37m

Knoxville McGhee Tyson

Mon 12/14

7:35 pm-1:02 pm

2 stops17h 27m

$768
Cheapest one-way
Quickest one-way

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/14

7:00 am-11:06 am

1 stop4h 06m

$269

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 11/6

6:11 pm-11:59 pm

1 stop5h 48m

$269

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/14

4:10 pm-11:57 pm

2 stops7h 47m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Sorted by cheapest first

Compare providers for flights from Key West to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 2, 2026.
Read reviews from past customers who have flown Allegiant Air from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Allegiant Air
7.3
Good
689 reviews

Food

5.8

Comfort

6.9

Boarding

7.6

Overall

7.3

Entertainment

5.4

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Jeff,Jun 2026

DEN - TYS

Everything about the flight timing was perfect. The plane was clean and comfortable. The only aggravation is no access to phone charging or complementary food/drink on a cross-country trip. There were no entertainment options, so I'm not sure how I'm supposed to evaluate that on a survey. It's a discount carrier, I get it, but other options are flying the same route with better depart/arrival times that offer these options.
Allegiant Air
7.3
Good
689 reviews
Allegiant Air
7.3
Good
689 reviews

Food

5.8

Comfort

6.9

Boarding

7.6

Overall

7.3

Entertainment

5.4

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Jeff,Jun 2026

DEN - TYS

Everything about the flight timing was perfect. The plane was clean and comfortable. The only aggravation is no access to phone charging or complementary food/drink on a cross-country trip. There were no entertainment options, so I'm not sure how I'm supposed to evaluate that on a survey. It's a discount carrier, I get it, but other options are flying the same route with better depart/arrival times that offer these options.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 6h 23m. Key West and Knoxville are separated by a distance of 788 mi.

  • What is the cheapest airline to fly from Key West to Knoxville round-trip?

    Allegiant Air, at $92, was found to be the cheapest airline from Key West to Knoxville.. You may be able to fly from Key West to Knoxville for 72% less than the average price by searching for this airline.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Tampa to Nashville flights
Orlando to Nashville flights
Fort Lauderdale to Nashville flights
Miami to Nashville flights
West Palm Beach to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Orlando to Knoxville flights
Fort Myers to Nashville flights
Orlando to Chattanooga flights
Jacksonville to Nashville flights
Miami to Knoxville flights
Orlando to Memphis flights
Tampa to Knoxville flights
Pensacola to Nashville flights
Sarasota to Nashville flights
West Palm Beach to Knoxville flights
Panama City to Nashville flights
St Petersburg to Knoxville flights
Tampa to Chattanooga flights
Miami to Memphis flights
Fort Myers to Knoxville flights
Fort Lauderdale to Memphis flights
Jacksonville to Knoxville flights
Miami to Chattanooga flights
West Palm Beach to Chattanooga flights
West Palm Beach to Memphis flights
Fort Lauderdale to Chattanooga flights
Sarasota to Chattanooga flights
Orlando to Blountville flights
Fort Myers to Chattanooga flights
Tallahassee to Nashville flights
Pensacola to Knoxville flights
Daytona Beach to Nashville flights
Sarasota to Knoxville flights
Jacksonville to Chattanooga flights
Valparaiso to Nashville flights
Jacksonville to Memphis flights
Punta Gorda to Nashville flights
Pensacola to Memphis flights
Gainesville to Nashville flights
Melbourne to Nashville flights
Fort Myers to Memphis flights
Tampa to Memphis flights
Tampa to Blountville flights
Sarasota to Memphis flights
Panama City to Knoxville flights
Key West to Nashville flights
West Palm Beach to Blountville flights
Melbourne to Chattanooga flights

Top airline flying from Key West to Knoxville

Discover the top airline that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$92Average$148FlexibilityNo cancel feeOn-time88%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights