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$65+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Aug 28 — Sep 41
Fri 8/28
Fri 9/4
1 adult, Economy
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Cheap flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.

This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:35 am
EYW
-
TYS
1 stop3h 54m
Delta
Mon 12/146:00 am
TYS
-
EYW
1 stop4h 48m
Delta
Deal found 7/25$319
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:10 pm
EYW
-
TYS
2 stops7h 47m
American Airlines
Mon 12/142:55 pm
TYS
-
EYW
1 stop6h 50m
American Airlines
Deal found 7/25$572
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:30 pm
EYW
-
TYS
2 stops19h 29m
United Airlines
Mon 12/147:35 pm
TYS
-
EYW
2 stops17h 27m
United Airlines
Deal found 7/25$769
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:15 pm
EYW
-
TYS
2 stops26h 43m
United Airlines
Mon 8/177:20 pm
TYS
-
EYW
2 stops18h 09m
United Airlines
Deal found 7/26$1,266

Find flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Delta)

One-way from

$65
(FlightHub)

Popular in

September

Cheapest in

March

Average price

$228

Good one-way deal

$107 or less
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
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From Key West to Knoxville McGhee Tyson
Search Deals
One-way flight from Key West to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($152 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in July 2026
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Price to beat on a one-way flight from Key West to Knoxville McGhee Tyson.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

7:35 am-11:29 am

1 stop3h 54m

Knoxville McGhee Tyson

Mon 12/14

6:00 am-10:48 am

1 stop4h 48m

$319

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

2:30 pm-9:59 am

2 stops19h 29m

Knoxville McGhee Tyson

Mon 12/14

7:35 pm-1:02 pm

2 stops17h 27m

$769

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 8/14

2:15 pm-4:58 pm

2 stops26h 43m

Knoxville McGhee Tyson

Mon 8/17

7:20 pm-1:29 pm

2 stops18h 09m

$1,266
Cheapest one-way
Quickest one-way

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 11/6

10:14 am-12:27 pm

Nonstop2h 13m

$65

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 9/12

9:53 am-6:05 pm

1 stop8h 12m

$131

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 9/12

10:04 am-10:04 am

2 stops24h 00m

$149

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 11/26

4:59 pm-9:39 am

1 stop16h 40m

$185

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 12/26

2:37 pm-8:38 pm

1 stop6h 01m

$239

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 11/6

2:00 pm-7:42 pm

1 stop5h 42m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Sorted by cheapest first

Compare providers for flights from Key West to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 29, 2026.
Read reviews from past customers who have flown Allegiant Air from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Allegiant Air
7.3
Good
678 reviews

Crew

8.1

Overall

7.3

Entertainment

5.5

Comfort

6.9

Boarding

7.6

Food

5.8

Reviews

1 / 20
10.0
Excellent

Jeff,Jun 2026

DEN - TYS

Everything about the flight timing was perfect. The plane was clean and comfortable. The only aggravation is no access to phone charging or complementary food/drink on a cross-country trip. There were no entertainment options, so I'm not sure how I'm supposed to evaluate that on a survey. It's a discount carrier, I get it, but other options are flying the same route with better depart/arrival times that offer these options.
Allegiant Air
7.3
Good
678 reviews
Allegiant Air
7.3
Good
678 reviews

Crew

8.1

Overall

7.3

Entertainment

5.5

Comfort

6.9

Boarding

7.6

Food

5.8

Reviews

1 / 20
10.0
Excellent

Jeff,Jun 2026

DEN - TYS

Everything about the flight timing was perfect. The plane was clean and comfortable. The only aggravation is no access to phone charging or complementary food/drink on a cross-country trip. There were no entertainment options, so I'm not sure how I'm supposed to evaluate that on a survey. It's a discount carrier, I get it, but other options are flying the same route with better depart/arrival times that offer these options.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 3h 54m. Key West and Knoxville are separated by a distance of 788 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Key West to Knoxville round-trip?

    Allegiant Air, at $92, was found to be the cheapest airline from Key West to Knoxville.. You may be able to fly from Key West to Knoxville for 70% less than the average price by searching for this airline.

  • What are the cheapest flights from Key West to Knoxville?

    While on average a flight from Key West to Knoxville is generally $131, our data shows the cheapest flight currently is $46. When looking at the most popular route, (Key West - Knoxville McGhee Tyson), you can expect to pay $1,266 for that flight.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top airline flying from Key West to Knoxville

Discover the top airline that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$92Average$162FlexibilityNo cancel feeOn-time88%

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