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Knoxville

$170+ Cheap flights from Key West to Knoxville (EYW - TYS)

EYW — TYS
Dec 10 — Dec 171
Thu 12/10
Thu 12/17
1 adult, Economy
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Cheap flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville

Thu 12/108:00 pm -
1 stop4h 05m
Mon 12/146:00 am -
1 stop7h 06m
Deal found 11/7$349
Sun 11/227:20 pm -
1 stop13h 19m
Thu 11/2612:56 pm -
2 stops44h 12m
Deal found 11/7$371
Sun 11/227:20 pm -
1 stop13h 19m
Thu 11/2612:56 pm -
1 stop20h 04m
Deal found 11/7$503
Thu 12/1012:05 pm -
2 stops26h 48m
Mon 12/147:45 pm -
3 stops18h 51m
Deal found 11/9$959
Sun 11/226:30 am -
2 stops8h 51m
Thu 11/268:50 am -
2 stops25h 02m
Deal found 11/7$1,230
Sun 11/222:52 pm -
2 stops23h 56m
Thu 11/266:00 am -
3 stops31h 52m
Deal found 11/7$1,287

Find flight deals from Key West to Knoxville

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$119
(Kiwi.com)

Popular in

September

Cheapest in

October

Average price

$498
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
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From Key West to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($5 potential increase over avg. RT price).
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Cheapest flight prices on average. 13% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in November 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestKnoxville

EYW Key West - TYS Knoxville McGhee Tyson

EYWTYS

Key West

Thu 1/28

3:25 pm-8:16 pm

1 stop4h 51m

Knoxville McGhee Tyson

Mon 2/1

2:34 pm-4:46 pm

Nonstop2h 12m

$170

Key WestKnoxville

EYW Key West - TYS Knoxville McGhee Tyson

EYWTYS

Key West

Thu 1/28

12:06 pm-12:08 pm

3 stops24h 02m

Knoxville McGhee Tyson

Mon 2/1

2:34 pm-4:46 pm

Nonstop2h 12m

$253

Key WestKnoxville

EYW Key West - TYS Knoxville McGhee Tyson

EYWTYS

Key West

Thu 12/10

8:00 pm-12:05 am

1 stop4h 05m

Knoxville McGhee Tyson

Mon 12/14

6:00 am-1:06 pm

1 stop7h 06m

$349

Key WestKnoxville

EYW Key West - TYS Knoxville McGhee Tyson

EYWTYS

Key West

Thu 1/28

3:15 pm-10:10 am

2 stops18h 55m

Knoxville McGhee Tyson

Mon 2/1

5:55 pm-3:22 pm

1 stop21h 27m

$750

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/9

Sorted by cheapest first

Compare providers for flights from Key West to Knoxville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest time of day to fly from EYW to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key West to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Read reviews from past customers who have flown Allegiant Air from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Allegiant Air
7.3
Good
676 reviews

Boarding

7.7

Comfort

6.9

Crew

8.1

Entertainment

5.5

Overall

7.3

Food

5.9

Reviews

1 / 20
2.0
Mediocre

Nic,Aug 2026

SRQ - ALB

Worker at gate refused to let me measure my personal item and insisted it needed to be a carryon and to pay 75$. I understand if it’s too big but she wouldn’t even let me go measure it. She eventually let me measure my own luggage after back n forth. It is a few inches too big and she comes over and attempts to grab my suitcase out my hands and I pull it away from her. She then shuts the door of the gate and says to call the police. I then just offer to pay for the carryon and she says ok. Then refuses to use let me use my tap to pay, luckily I had my physical card on me. As soon as I walked out the door I respectfully asked for her name. She began screaming at me and threatening me. This worker was just so hostile I understand if my stuffs too big I will pay the difference I’m not trying to get over on the rules. I was confused because I was allowed to board my destination flight with this item as a personal item. So I was confused by this whole situation from the go. It also caused a massive scene at the airport and I was extremely embarrassed. It genuinely seemed like this worker was out to get me for some reason. I had literally just arrived to the gate as it was already boarding so I hadn’t done anything prior. Super weird situation and it really spooked me.
Allegiant Air
7.3
Good
676 reviews
Allegiant Air
7.3
Good
676 reviews

Boarding

7.7

Comfort

6.9

Crew

8.1

Entertainment

5.5

Overall

7.3

Food

5.9

Reviews

1 / 20
2.0
Mediocre

Nic,Aug 2026

SRQ - ALB

Worker at gate refused to let me measure my personal item and insisted it needed to be a carryon and to pay 75$. I understand if it’s too big but she wouldn’t even let me go measure it. She eventually let me measure my own luggage after back n forth. It is a few inches too big and she comes over and attempts to grab my suitcase out my hands and I pull it away from her. She then shuts the door of the gate and says to call the police. I then just offer to pay for the carryon and she says ok. Then refuses to use let me use my tap to pay, luckily I had my physical card on me. As soon as I walked out the door I respectfully asked for her name. She began screaming at me and threatening me. This worker was just so hostile I understand if my stuffs too big I will pay the difference I’m not trying to get over on the rules. I was confused because I was allowed to board my destination flight with this item as a personal item. So I was confused by this whole situation from the go. It also caused a massive scene at the airport and I was extremely embarrassed. It genuinely seemed like this worker was out to get me for some reason. I had literally just arrived to the gate as it was already boarding so I hadn’t done anything prior. Super weird situation and it really spooked me.

Related info for your journey

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 4h 05m. Key West and Knoxville are separated by a distance of 788 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Key West to Knoxville round-trip?

    Allegiant Air, at $91, was found to be the cheapest airline from Key West to Knoxville.. You may be able to fly from Key West to Knoxville for 67% less than the average price by searching for this airline.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Newport
Bryson City
Crossville
Morristown
Murphy

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Top airline flying from Key West to Knoxville

AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$91Average$145FlexibilityNo cancel feeOn-time88%

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