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$213+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheap flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 16, 2025.

Round-trip from

$255
(Kiwi.com)

One-way from

$213
(Kiwi.com)

Popular in

August

Cheapest in

October

Average price

$572
From Key West to Knoxville McGhee Tyson
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One-way flight from Key West to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 22% potential increase in price ($103 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/69:50 amEYW - TYS
Nonstop2h 15mMultiple Airlines
Mon 10/1312:08 pmTYS - EYW
2 stops45h 04mMultiple Airlines
Deal found 8/13$255
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/69:50 amEYW - TYS
Nonstop2h 15mAllegiant Air
Mon 10/1312:55 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 8/13$258
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/294:49 pmEYW - TYS
1 stop5h 17mAmerican Airlines
Tue 9/212:03 pmTYS - EYW
1 stop4h 43mAmerican Airlines
Deal found 8/14$259
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/611:22 amEYW - TYS
2 stops8h 34mAmerican Airlines
Mon 10/136:15 amTYS - EYW
1 stop4h 37mAmerican Airlines
Deal found 8/13$279
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2812:50 pmEYW - TYS
1 stop4h 50mAmerican Airlines
Mon 9/17:00 amTYS - EYW
1 stop3h 53mAmerican Airlines
Deal found 8/13$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Key West

Fly to

Knoxville

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 10/6

9:50 am-12:05 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 10/13

12:08 pm-9:12 am

2 stops45h 04m

$255

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 10/6

9:50 am-12:05 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 10/13

12:55 pm-3:06 pm

Nonstop2h 11m

$258

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 8/29

4:49 pm-10:06 pm

1 stop5h 17m

Knoxville McGhee Tyson

Tue 9/2

12:03 pm-4:46 pm

1 stop4h 43m

$259

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 10/6

11:22 am-7:56 pm

2 stops8h 34m

Knoxville McGhee Tyson

Mon 10/13

6:15 am-10:52 am

1 stop4h 37m

$279

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/28

12:50 pm-5:40 pm

1 stop4h 50m

Knoxville McGhee Tyson

Mon 9/1

7:00 am-10:53 am

1 stop3h 53m

$284

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 10/10

3:08 pm-9:04 pm

1 stop5h 56m

$213

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 9/1

5:41 pm-11:01 am

1 stop17h 20m

$364

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 9/1

1:29 pm-10:01 pm

2 stops8h 32m

$619

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest month to book a flight from Key West to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $294). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

It’s optimal to fly from Key West to Knoxville in the morning. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Key West to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 16, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,985 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Key West to Knoxville round-trip?

    Delta, at $253, was found to be the cheapest airline from Key West to Knoxville. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Key West to Knoxville for 31% less than the average price by searching for these airlines.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $294). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Key West to Knoxville

Discover the top 2 airlines that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$389FlexibilityNo cancel feeOn-time71%

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