$46+ Cheap flights from Key West to Knoxville (EYW - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Oct 24 — Oct 311
Round-trip
1 adult, Economy
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Find cheap flights from Key West to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to Knoxville
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Cheapest flights from Key West to KnoxvilleExplore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This CheapOair deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:54 am -
Nonstop2h 13m
Fri 10/96:20 am -
Nonstop2h 04m
Deal found 9/20![Allegiant Air logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop23h 44m
Sun 11/2911:38 am -
Nonstop2h 05m
Deal found 9/22![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:54 am -
Nonstop2h 13m
Tue 10/66:04 pm -
2 stops15h 20m
Deal found 9/21![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:54 am -
Nonstop2h 13m
Fri 10/99:35 pm -
2 stops11h 49m
Deal found 9/20![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:11 pm -
1 stop22h 27m
Wed 10/710:28 am -
1 stop23h 51m
Deal found 9/20![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:54 am -
Nonstop2h 13m
Tue 10/64:04 pm -
1 stop19h 58m
Deal found 9/21![Allegiant Air logo]()
$290
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:06 pm -
1 stop5h 51m
Mon 12/144:01 pm -
1 stop4h 00m
Deal found 9/24![Delta logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:04 am -
2 stops25h 25m
Wed 10/282:43 pm -
1 stop21h 55m
Deal found 9/23![Multiple Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:28 pm -
1 stop5h 31m
Sun 10/116:00 am -
1 stop7h 03m
Deal found 9/22![American Airlines logo]()
$369
Best flights from Key West to KnoxvilleDiscover carefully curated flight deals from Key West to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Key West to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:54 am -
Nonstop2h 13m
Fri 10/99:35 pm -
2 stops11h 49m
Deal found 9/20![Multiple Airlines logo]()
$254
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:06 pm -
1 stop5h 51m
Mon 12/144:01 pm -
1 stop4h 00m
Deal found 9/24![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:19 pm -
1 stop4h 36m
Wed 10/286:00 am -
1 stop3h 54m
Deal found 9/23![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:04 am -
2 stops25h 25m
Wed 10/282:43 pm -
1 stop21h 55m
Deal found 9/23![Multiple Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:11 pm -
1 stop22h 27m
Wed 10/74:14 pm -
2 stops19h 07m
Deal found 9/20![Multiple Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:24 am -
2 stops9h 08m
Sun 10/116:56 am -
2 stops6h 07m
Deal found 9/22![American Airlines logo]()
$682
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/41:47 pm -
2 stops8h 06m
Wed 10/710:00 am -
2 stops9h 33m
Deal found 9/20![American Airlines logo]()
$906
Last-minute flights from Key West to KnoxvilleDiscover last-minute flight deals from Key West to Knoxville. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to Knoxville. Data last updated September 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:54 am -
Nonstop2h 13m
Tue 10/66:04 pm -
2 stops15h 20m
Deal found 9/21![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:54 am -
Nonstop2h 13m
Tue 10/64:04 pm -
1 stop19h 58m
Deal found 9/21![Allegiant Air logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:11 pm -
1 stop22h 27m
Wed 10/710:28 am -
1 stop23h 51m
Deal found 9/20![Multiple Airlines logo]()
$282
This CheapOair deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:54 am -
Nonstop2h 13m
Fri 10/96:20 am -
Nonstop2h 04m
Deal found 9/20![Allegiant Air logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:54 am -
Nonstop2h 13m
Fri 10/99:35 pm -
2 stops11h 49m
Deal found 9/20![Multiple Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:28 pm -
1 stop5h 31m
Sun 10/116:00 am -
1 stop7h 03m
Deal found 9/22![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:19 pm -
1 stop4h 36m
Wed 10/286:00 am -
1 stop3h 54m
Deal found 9/23![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:04 am -
2 stops25h 25m
Wed 10/282:43 pm -
1 stop21h 55m
Deal found 9/23![Multiple Airlines logo]()
$340
One-way flights from Key West to KnoxvilleSearch for one-way flight options from Key West to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Key West to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This CheapOair deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:14 am -
Nonstop2h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Allegiant Air logo]()
$46
This Super.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:14 am -
Nonstop2h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Allegiant Air logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:59 pm -
3 stops52h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:59 am -
1 stop24h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:16 pm -
1 stop20h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/189:02 am -
2 stops36h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Allegiant Air logo]()
$212
Find flight deals from Key West to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $147 (CheapOair) |
One-way from | $46 (CheapOair) |
Popular in | September |
Cheapest in | March |
Average price | $577 |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 11/6
10:14 am-12:27 pm
Nonstop2h 13m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$46
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Sun 10/18
10:59 am-11:14 am
1 stop24h 15m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$171
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Tue 10/6
1:16 pm-9:38 am
1 stop20h 22m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$208
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Mon 10/5
10:54 am-1:07 pm
Nonstop2h 13m
Knoxville McGhee Tyson
Fri 10/9
9:35 pm-9:24 am
2 stops11h 49m
$254
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 10/16
12:59 pm-11:06 pm
2 stops10h 07m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$270
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 11/6
7:18 pm-11:58 pm
1 stop4h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Thu 10/8
10:59 am-11:36 pm
1 stop12h 37m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$286
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Sun 10/25
7:40 am-1:40 pm
1 stop6h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$310
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Thu 12/10
6:06 pm-11:57 pm
1 stop5h 51m
Knoxville McGhee Tyson
Mon 12/14
4:01 pm-8:01 pm
1 stop4h 00m
$339
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Wed 10/21
7:19 pm-11:55 pm
1 stop4h 36m
Knoxville McGhee Tyson
Wed 10/28
6:00 am-9:54 am
1 stop3h 54m
$339
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Key West to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
EYW-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 24, 2026.
Read reviews from past customers who have flown Allegiant Air from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
5.5
Boarding
7.7
Comfort
6.9
Crew
8.1
Food
5.8
Overall
7.3
Reviews
1 / 20
2.0
MediocreNic,Aug 2026
SRQ - ALB
Entertainment
5.5
Boarding
7.7
Comfort
6.9
Crew
8.1
Food
5.8
Overall
7.3
Reviews
1 / 20
2.0
MediocreNic,Aug 2026
SRQ - ALB
Related info for your journey
Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Key West and Knoxville flights
Browse other Key West and Knoxville flight options. Last updated on September 24, 2026.
Other flights from Key West
Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Key West to Knoxville
Discover the top airline that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$148 | FlexibilityNo cancel fee | On-time88% |