$147+ Cheap flights from Key West to Knoxville (EYW - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Dec 5 — Dec 121
Round-trip
1 adult, Economy
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Find cheap flights from Key West to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to Knoxville
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Cheapest flights from Key West to KnoxvilleExplore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
This CheapOair deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:54 am -
Nonstop2h 13m
Fri 11/207:00 am -
Nonstop2h 05m
Deal found 11/1![Allegiant Air logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:40 pm -
1 stop27h 35m
Wed 12/911:02 am -
1 stop4h 48m
Deal found 11/4![Allegiant Air logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:20 pm -
1 stop4h 26m
Thu 12/246:33 pm -
1 stop22h 09m
Deal found 11/3![Allegiant Air logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:59 pm -
3 stops28h 19m
Fri 11/207:00 am -
Nonstop2h 05m
Deal found 11/1![Multiple Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 pm -
1 stop4h 05m
Mon 12/146:00 am -
1 stop4h 56m
Deal found 11/1![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:06 pm -
1 stop4h 11m
Wed 12/95:40 am -
1 stop5h 08m
Deal found 11/4![Delta logo]()
$404
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:41 pm -
1 stop7h 12m
Wed 12/98:09 am -
2 stops9h 10m
Deal found 11/4![American Airlines logo]()
$533
Best flights from Key West to KnoxvilleDiscover carefully curated flight deals from Key West to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
Discover carefully curated flight deals from Key West to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
This CheapOair deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:54 am -
Nonstop2h 13m
Fri 11/207:00 am -
Nonstop2h 05m
Deal found 11/1![Allegiant Air logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/82:04 pm -
Nonstop2h 13m
Mon 2/19:00 am -
2 stops27h 36m
Deal found 11/2![Multiple Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 pm -
1 stop4h 05m
Mon 12/146:00 am -
1 stop4h 56m
Deal found 11/1![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:06 pm -
1 stop4h 11m
Wed 12/95:40 am -
1 stop5h 08m
Deal found 11/4![Delta logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/112:59 pm -
1 stop19h 46m
Fri 1/89:26 pm -
1 stop17h 51m
Deal found 11/2![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/15:32 pm -
1 stop15h 13m
Fri 1/81:57 pm -
2 stops25h 20m
Deal found 11/2![Allegiant Air logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:20 pm -
1 stop4h 26m
Thu 12/249:08 pm -
2 stops15h 11m
Deal found 11/3![Multiple Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:26 am -
2 stops11h 27m
Wed 12/98:09 am -
2 stops9h 10m
Deal found 11/4![American Airlines logo]()
$617
Last-minute flights from Key West to KnoxvilleDiscover last-minute flight deals from Key West to Knoxville. Data last updated November 5, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to Knoxville. Data last updated November 5, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:54 am -
Nonstop2h 13m
Fri 11/207:00 am -
Nonstop2h 05m
Deal found 11/1![Allegiant Air logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:59 pm -
3 stops28h 19m
Fri 11/207:00 am -
Nonstop2h 05m
Deal found 11/1![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:40 pm -
1 stop27h 35m
Wed 12/911:02 am -
1 stop4h 48m
Deal found 11/4![Allegiant Air logo]()
$278
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:06 pm -
1 stop4h 11m
Wed 12/95:40 am -
1 stop5h 08m
Deal found 11/4![Delta logo]()
$404
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:41 pm -
1 stop7h 12m
Wed 12/98:09 am -
2 stops9h 10m
Deal found 11/4![American Airlines logo]()
$533
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 pm -
1 stop4h 05m
Mon 12/146:00 am -
1 stop4h 56m
Deal found 11/1![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:20 pm -
1 stop4h 26m
Thu 12/246:33 pm -
1 stop22h 09m
Deal found 11/3![Allegiant Air logo]()
$291
Find flight deals from Key West to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $80 (Kiwi.com) |
Popular in | September |
Cheapest in | October |
Average price | $144 |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Mon 11/16
11:54 am-2:07 pm
Nonstop2h 13m
Knoxville McGhee Tyson
Fri 11/20
7:00 am-9:05 am
Nonstop2h 05m
$147
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 1/8
2:04 pm-4:17 pm
Nonstop2h 13m
Knoxville McGhee Tyson
Mon 2/1
9:00 am-12:36 pm
2 stops27h 36m
$189
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 1/1
12:59 pm-8:45 am
1 stop19h 46m
Knoxville McGhee Tyson
Fri 1/8
9:26 pm-3:17 pm
1 stop17h 51m
$323
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Sun 12/20
6:20 pm-10:46 pm
1 stop4h 26m
Knoxville McGhee Tyson
Thu 12/24
9:08 pm-12:19 pm
2 stops15h 11m
$335
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Thu 12/10
8:00 pm-12:05 am
1 stop4h 05m
Knoxville McGhee Tyson
Mon 12/14
6:00 am-10:56 am
1 stop4h 56m
$339
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Fri 1/1
5:32 pm-8:45 am
1 stop15h 13m
Knoxville McGhee Tyson
Fri 1/8
1:57 pm-3:17 pm
2 stops25h 20m
$357
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Wed 12/2
6:06 pm-10:17 pm
1 stop4h 11m
Knoxville McGhee Tyson
Wed 12/9
5:40 am-10:48 am
1 stop5h 08m
$404
Key WestKnoxville
EYW Key West - TYS Knoxville McGhee Tyson
EYWTYS
Key West
Wed 12/2
11:26 am-10:53 pm
2 stops11h 27m
Knoxville McGhee Tyson
Wed 12/9
8:09 am-5:19 pm
2 stops9h 10m
$617
Sorted by cheapest first
Compare providers for flights from Key West to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
EYW-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Key West to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 5, 2026.
Read reviews from past customers who have flown Allegiant Air from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
5.9
Boarding
7.7
Overall
7.3
Entertainment
5.5
Crew
8.1
Comfort
6.9
Reviews
1 / 20
2.0
MediocreNic,Aug 2026
SRQ - ALB
Food
5.9
Boarding
7.7
Overall
7.3
Entertainment
5.5
Crew
8.1
Comfort
6.9
Reviews
1 / 20
2.0
MediocreNic,Aug 2026
SRQ - ALB
Related info for your journey
Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Morristown
Newport
Bryson City
Crossville
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 5, 2026.
Key West and Knoxville flights
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Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Key West to Knoxville
Discover the top airline that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$145 | FlexibilityNo cancel fee | On-time88% |