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$57+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 15, 2025.

Round-trip from

$199
(Kiwi.com)

One-way from

$57
(FlightHub)

Popular in

August

Cheapest in

October
From Key West to Knoxville McGhee Tyson
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One-way flight from Key West to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 21% potential increase in price ($102 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Find flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/318:45 pmEYW - TYS
Nonstop2h 15mAllegiant Air
dom. 1/41:01 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 9/14$199
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/119:52 amEYW - TYS
1 stop11h 16mAllegiant Air
vie. 10/1712:07 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 9/15$255
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/119:52 amEYW - TYS
1 stop11h 16mAllegiant Air
sáb. 10/189:58 pmTYS - EYW
1 stop18h 06mAllegiant Air
Deal found 9/15$296
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/119:52 amEYW - TYS
1 stop11h 16mMultiple Airlines
jue. 10/169:25 pmTYS - EYW
1 stop11h 52mMultiple Airlines
Deal found 9/15$306
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/128:55 amEYW - TYS
3 stops38h 21mMultiple Airlines
vie. 10/1712:07 pmTYS - EYW
Nonstop2h 11mMultiple Airlines
Deal found 9/15$323
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/1110:47 amEYW - TYS
3 stops34h 30mMultiple Airlines
vie. 10/1712:07 pmTYS - EYW
Nonstop2h 11mMultiple Airlines
Deal found 9/15$331
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/103:08 pmEYW - TYS
1 stop5h 56mAllegiant Air
vie. 10/1712:07 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 9/15$350
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/119:52 amEYW - TYS
1 stop11h 16mMultiple Airlines
sáb. 10/184:26 pmTYS - EYW
2 stops15h 49mMultiple Airlines
Deal found 9/15$363

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Key West

Fly to

Knoxville

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

mié. 12/31

8:45 pm-11:00 pm

Nonstop2h 15m

Knoxville McGhee Tyson

dom. 1/4

1:01 pm-3:12 pm

Nonstop2h 11m

$199

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 10/11

9:52 am-9:08 pm

1 stop11h 16m

Knoxville McGhee Tyson

vie. 10/17

12:07 pm-2:18 pm

Nonstop2h 11m

$255

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 10/11

9:52 am-9:08 pm

1 stop11h 16m

Knoxville McGhee Tyson

sáb. 10/18

9:58 pm-4:04 pm

1 stop18h 06m

$296

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 10/11

9:52 am-9:08 pm

1 stop11h 16m

Knoxville McGhee Tyson

jue. 10/16

9:25 pm-9:17 am

1 stop11h 52m

$306

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

dom. 10/12

8:55 am-11:16 pm

3 stops38h 21m

Knoxville McGhee Tyson

vie. 10/17

12:07 pm-2:18 pm

Nonstop2h 11m

$323

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 10/11

10:47 am-9:17 pm

3 stops34h 30m

Knoxville McGhee Tyson

vie. 10/17

12:07 pm-2:18 pm

Nonstop2h 11m

$331

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

vie. 10/10

3:08 pm-9:04 pm

1 stop5h 56m

Knoxville McGhee Tyson

vie. 10/17

12:07 pm-2:18 pm

Nonstop2h 11m

$350

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 10/11

9:52 am-9:08 pm

1 stop11h 16m

Knoxville McGhee Tyson

sáb. 10/18

4:26 pm-8:15 am

2 stops15h 49m

$363

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

lun. 10/27

2:57 pm-5:12 pm

Nonstop2h 15m

$57

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

lun. 10/27

7:52 pm-11:39 pm

1 stop3h 47m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 11 results
1
2

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest month to book a flight from Key West to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $295). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

It’s optimal to fly from Key West to Knoxville in the morning. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 15, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 2h 15m. Key West and Knoxville are separated by a distance of 788 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Key West to Knoxville round-trip?

    Delta, at $253, was found to be the cheapest airline from Key West to Knoxville. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Key West to Knoxville for 31% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Key West to Knoxville one-way?

    One-way options have recently been found by users for as low as $57 on Allegiant Air. Other airlines that offer cheap prices include American Airlines from $239 and United Airlines from $344 one-way.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $295). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Key West to Knoxville

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Top 2 airlines flying from Key West to Knoxville

Discover the top 2 airlines that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$398FlexibilityNo cancel feeOn-time71%

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