HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$115+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Jun 18 — Jun 251
Wed 6/18
Wed 6/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2025.

Round-trip from

$169
(Mytrip)

One-way from

$115
(Mytrip)

Popular in

December

Cheapest in

August

Average price

$313
From Key West to Knoxville McGhee Tyson
Search Deals
One-way flight from Key West to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2025.

This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:12 amEYW - TYS
Nonstop2h 15mAllegiant Air
Sun 10/59:25 pmTYS - EYW
1 stop11h 35mAllegiant Air
Deal found 6/11$169
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:33 pmEYW - TYS
1 stop3h 48mAmerican Airlines
Wed 11/262:23 pmTYS - EYW
1 stop4h 04mAmerican Airlines
Deal found 6/11$299
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:32 pmEYW - TYS
3 stops23h 23mMultiple Airlines
Sun 10/59:25 pmTYS - EYW
1 stop11h 35mMultiple Airlines
Deal found 6/11$356

Cheapflights Fare Finder

Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Key West

Fly to

Knoxville

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 10/3

8:12 am-10:27 am

Nonstop2h 15m

Knoxville McGhee Tyson

Sun 10/5

9:25 pm-9:00 am

1 stop11h 35m

$169

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 11/22

7:33 pm-11:21 pm

1 stop3h 48m

Knoxville McGhee Tyson

Wed 11/26

2:23 pm-6:27 pm

1 stop4h 04m

$299

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 10/3

12:32 pm-11:55 am

3 stops23h 23m

Knoxville McGhee Tyson

Sun 10/5

9:25 pm-9:00 am

1 stop11h 35m

$356

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 6/26

5:32 pm-11:33 pm

1 stop6h 01m

$115

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 8/30

7:00 am-1:08 pm

1 stop6h 08m

$239

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 6/27

10:12 am-8:17 am

2 stops22h 05m

$267

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 8/30

6:45 pm-8:56 pm

2 stops26h 11m

$313

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 10/18

7:36 pm-11:12 pm

1 stop3h 36m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest month to book a flight from Key West to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $296). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 13, 2025.

It’s optimal to fly from Key West to Knoxville in the morning. By choosing this option you can save up to 17% on the cost of your flight, compared to a flight in the afternoon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 13, 2025.
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,787 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.3
Good
724 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Key West to Knoxville round-trip?

    Allegiant Air, at $169, was found to be the cheapest airline from Key West to Knoxville. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Key West to Knoxville for 52% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Key West to Knoxville one-way?

    One-way options have recently been found by users for as low as $115 on Allegiant Air. Other airlines that offer cheap prices include Delta from $239 and United Airlines from $313 one-way.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key West to Knoxville (average of $296). Flying from Key West to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Miami to Nashville flights
West Palm Beach to Nashville flights
Tampa to Nashville flights
Fort Myers to Nashville flights
Jacksonville to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando to Memphis flights
Sarasota to Nashville flights
Tampa to Knoxville flights
Miami to Knoxville flights
West Palm Beach to Knoxville flights
Orlando to Knoxville flights
St Petersburg to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Fort Lauderdale to Memphis flights
Panama City to Nashville flights
Pensacola to Knoxville flights
Tampa to Memphis flights
Miami to Memphis flights
Fort Myers to Knoxville flights
Miami to Chattanooga flights
Tampa to Chattanooga flights
Pensacola to Nashville flights
Tallahassee to Nashville flights
Jacksonville to Memphis flights
Orlando to Chattanooga flights
Fort Myers to Chattanooga flights
West Palm Beach to Memphis flights
Pensacola to Memphis flights
West Palm Beach to Chattanooga flights
Jacksonville to Knoxville flights
Punta Gorda to Nashville flights
Key West to Nashville flights
Fort Lauderdale to Chattanooga flights
Sarasota to Memphis flights
Fort Myers to Memphis flights
Gainesville to Nashville flights
Tampa to Blountville flights
Sarasota to Knoxville flights
Valparaiso to Nashville flights
Jacksonville to Blountville flights
Daytona Beach to Nashville flights
Jacksonville to Chattanooga flights
Sarasota to Chattanooga flights
Orlando to Blountville flights
Tallahassee to Knoxville flights
Melbourne to Nashville flights
Daytona Beach to Knoxville flights

Top 2 airlines flying from Key West to Knoxville

Discover the top 2 airlines that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$389FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Privacy Preferences©2025 Cheapflights