HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$56+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$231
(American Airlines)

One-way from

$56
(Kiwi.com)

Popular in

September

Cheapest in

October

Average price

$203

Good one-way deal

$96 or less
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
Search Deals
From Key West to Knoxville McGhee Tyson
Search Deals
One-way flight from Key West to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a one-way flight from Key West to Knoxville McGhee Tyson.
Search Deals

Find flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This Gotogate deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/243:39 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Fri 10/316:44 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 10/18$105
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/263:30 pmEYW - TYS
1 stop25h 06mMultiple Airlines
Sun 11/21:16 pmTYS - EYW
2 stops18h 59mMultiple Airlines
Deal found 10/19$519
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/263:30 pmEYW - TYS
1 stop25h 06mAllegiant Air
Sun 11/212:28 pmTYS - EYW
1 stop25h 47mAllegiant Air
Deal found 10/19$675

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Key West

Fly to

Knoxville

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 1/14

7:08 am-11:47 am

1 stop4h 39m

Knoxville McGhee Tyson

Sun 1/18

2:57 pm-9:47 pm

1 stop6h 50m

$231

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 2/20

7:00 am-1:26 pm

1 stop6h 26m

Knoxville McGhee Tyson

Tue 2/24

6:10 am-12:44 pm

1 stop6h 34m

$266

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 2/20

1:59 pm-9:31 pm

2 stops7h 32m

Knoxville McGhee Tyson

Tue 2/24

12:37 pm-6:23 pm

1 stop5h 46m

$306

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 1/14

2:25 pm-10:57 am

2 stops20h 32m

Knoxville McGhee Tyson

Sun 1/18

6:45 am-4:22 pm

2 stops9h 37m

$515

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 12/24

7:52 pm-12:38 am

1 stop4h 46m

Knoxville McGhee Tyson

Fri 12/26

4:12 pm-10:44 pm

1 stop6h 32m

$836

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 12/24

3:09 pm-2:48 pm

2 stops23h 39m

Knoxville McGhee Tyson

Fri 12/26

9:50 am-11:41 am

1 stop25h 51m

$905

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 11/3

3:05 pm-5:20 pm

Nonstop2h 15m

$56

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 11/3

8:55 am-10:33 am

2 stops25h 38m

$171

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 1/19

5:41 pm-7:56 pm

Nonstop2h 15m

$177

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 11/3

6:17 pm-11:46 pm

1 stop5h 29m

$322

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/18

Showing 1-10 of 13 results
1
2

Compare providers for flights from Key West to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest month to book a flight from Key West to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Key West to Knoxville (average of $81). Flying from Key West to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 20, 2025.

It’s optimal to fly from Key West to Knoxville at noon. By choosing this option you can save up to 76% on the cost of your flight, compared to a flight in the evening.

How much does it cost to fly round-trip from Key West to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 20, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,976 reviews

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,976 reviews
Delta
7.9
Good
7,976 reviews

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,026 reviews
Delta
7.9
Good
7,976 reviews

Comfort

7.9

Overall

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 4h 39m. Key West and Knoxville are separated by a distance of 788 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Key West to Knoxville round-trip?

    Delta, at $253, was found to be the cheapest airline from Key West to Knoxville. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Key West to Knoxville for 33% less than the average price by searching for these airlines.

  • What are the cheapest flights from Key West to Knoxville?

    While on average a flight from Key West to Knoxville is generally $96, our data shows the cheapest flight currently is $41. When looking at the most popular route, (Key West - Knoxville McGhee Tyson), you can expect to pay $109 for that flight.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Key West to Knoxville (average of $81). Flying from Key West to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Tampa to Nashville flights
Miami to Nashville flights
Jacksonville to Nashville flights
West Palm Beach to Nashville flights
Fort Lauderdale to Knoxville flights
Sarasota to Nashville flights
Orlando to Memphis flights
Tampa to Memphis flights
Fort Myers to Nashville flights
Miami to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Tampa to Knoxville flights
Orlando to Knoxville flights
St Petersburg to Knoxville flights
Tampa to Chattanooga flights
Pensacola to Nashville flights
Panama City to Nashville flights
Pensacola to Memphis flights
Jacksonville to Memphis flights
Orlando to Chattanooga flights
Fort Lauderdale to Chattanooga flights
Fort Myers to Knoxville flights
Jacksonville to Knoxville flights
West Palm Beach to Chattanooga flights
Gainesville to Memphis flights
West Palm Beach to Knoxville flights
Pensacola to Knoxville flights
Sarasota to Knoxville flights
Miami to Chattanooga flights
Tampa to Blountville flights
Miami to Memphis flights
West Palm Beach to Memphis flights
Fort Myers to Memphis flights
Valparaiso to Nashville flights
Orlando to Blountville flights
Fort Myers to Chattanooga flights
Panama City to Knoxville flights
Tallahassee to Nashville flights
Sarasota to Memphis flights
Sarasota to Chattanooga flights
Daytona Beach to Nashville flights
Melbourne to Nashville flights
Fort Myers to Blountville flights
Gainesville to Nashville flights
Melbourne to Chattanooga flights
Fort Lauderdale to Blountville flights
Fort Lauderdale to Memphis flights
Melbourne to Knoxville flights

Top 2 airlines flying from Key West to Knoxville

Discover the top 2 airlines that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$408FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$398FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.