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$147+ Cheap flights from Key West to Knoxville (EYW - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Dec 15 — Dec 221
Mon 12/15
Mon 12/22
1 adult, Economy
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Cheap flight deals from Key West to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$147
(FlightHub)

Popular in

September

Cheapest in

October

Average price

$328

Good one-way deal

$96 or less
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
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From Key West to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 18% potential increase in price ($84 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a one-way flight from Key West to Knoxville McGhee Tyson.
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Find flight deals from Key West to Knoxville

Cheapest flights from Key West to Knoxville
Explore the most affordable flight options available from Key West to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 15, 2025.

This FlightHub deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:33 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Sun 12/2812:31 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Deal found 11/12$147
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:56 pmEYW - TYS
3 stops46h 19mMultiple Airlines
Sun 12/2812:31 pmTYS - EYW
Nonstop2h 11mMultiple Airlines
Deal found 11/12$368
This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:33 pmEYW - TYS
1 stop4h 18mAmerican Airlines
Fri 11/284:15 pmTYS - EYW
1 stop5h 32mAmerican Airlines
Deal found 11/13$381
This Delta deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:18 pmEYW - TYS
1 stop5h 23mDelta
Fri 11/283:53 pmTYS - EYW
1 stop4h 00mDelta
Deal found 11/13$419
This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:30 pmEYW - TYS
1 stop4h 08mAmerican Airlines
Sun 12/285:40 pmTYS - EYW
1 stop5h 04mAmerican Airlines
Deal found 11/13$498

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 15, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Key West

Fly to

Knoxville

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/22

2:33 pm-4:48 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Sun 12/28

12:31 pm-2:42 pm

Nonstop2h 11m

$147

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 3/6

11:01 am-1:16 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Thu 3/12

6:50 am-9:43 pm

1 stop14h 53m

$270

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 3/7

11:55 am-10:39 pm

1 stop10h 44m

Knoxville McGhee Tyson

Thu 3/12

6:50 am-9:43 pm

1 stop14h 53m

$338

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/22

5:56 pm-4:15 pm

3 stops46h 19m

Knoxville McGhee Tyson

Sun 12/28

12:31 pm-2:42 pm

Nonstop2h 11m

$368

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 3/7

11:55 am-10:39 pm

1 stop10h 44m

Knoxville McGhee Tyson

Thu 3/12

7:30 am-12:26 pm

2 stops28h 56m

$448

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 12/22

8:30 pm-12:38 am

1 stop4h 08m

Knoxville McGhee Tyson

Sun 12/28

5:40 pm-10:44 pm

1 stop5h 04m

$498

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 3/6

4:02 pm-11:52 pm

2 stops7h 50m

Knoxville McGhee Tyson

Thu 3/12

4:16 pm-11:59 pm

2 stops7h 43m

$622

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 12/24

7:52 pm-12:38 am

1 stop4h 46m

Knoxville McGhee Tyson

Fri 12/26

5:40 pm-10:44 pm

1 stop5h 04m

$630

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 3/7

4:02 pm-11:52 pm

2 stops7h 50m

Knoxville McGhee Tyson

Thu 3/12

4:16 pm-11:59 pm

2 stops7h 43m

$639

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 12/17

3:02 pm-6:58 pm

1 stop3h 56m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 11 results
1
2

Compare providers for flights from Key West to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to Knoxville

What is the cheapest month to book a flight from Key West to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Key West to Knoxville (average of $83). Flying from Key West to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to TYS?

Find hourly flight availability from Key West to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 15, 2025.

It’s optimal to fly from Key West to Knoxville at noon. By choosing this option you can save up to 66% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 15, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,012 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,012 reviews
Delta
7.9
Good
8,012 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,012 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key West to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Knoxville?

    Departing from Key West to Knoxville will take you 2h 15m. Key West and Knoxville are separated by a distance of 788 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Key West to Knoxville round-trip?

    Delta, at $253, was found to be the cheapest airline from Key West to Knoxville. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Key West to Knoxville for 32% less than the average price by searching for these airlines.

  • What are the cheapest flights from Key West to Knoxville?

    While on average a flight from Key West to Knoxville is generally $96, our data shows the cheapest flight currently is $96. When looking at the most popular route, (Key West - Knoxville McGhee Tyson), you can expect to pay $270 for that flight.

  • Can I find deals for flights from Key West to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key West to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Knoxville.

  • Can I find deals for business class flights from Key West to Knoxville?

    Yes. Cheapflights offers flight deals from Key West to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Key West to Knoxville (average of $83). Flying from Key West to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Key West to Knoxville

Discover the top 2 airlines that operate flights from Key West to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$353FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$398FlexibilityNo cancel feeOn-time71%

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