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Knoxville

$126+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Apr 6 — Apr 131
Mon 4/6
Mon 4/13
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/279:49 am
CID
-
TYS
1 stop11h 35m
Allegiant Air
Thu 5/79:40 pm
TYS
-
CID
1 stop21h 15m
Allegiant Air
Deal found 3/5$242
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:27 am
CID
-
TYS
1 stop26h 31m
Allegiant Air
Thu 4/169:32 pm
TYS
-
CID
1 stop21h 23m
Allegiant Air
Deal found 3/5$247
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:29 pm
CID
-
TYS
1 stop4h 14m
United Airlines
Sat 4/187:00 am
TYS
-
CID
1 stop6h 47m
United Airlines
Deal found 3/2$251
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:25 am
CID
-
TYS
1 stop4h 20m
American Airlines
Sat 4/185:00 am
TYS
-
CID
2 stops8h 18m
American Airlines
Deal found 3/2$256
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:06 pm
CID
-
TYS
1 stop26h 42m
Allegiant Air
Thu 5/79:40 pm
TYS
-
CID
1 stop21h 15m
Allegiant Air
Deal found 3/5$258
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:11 pm
CID
-
TYS
1 stop21h 04m
Allegiant Air
Tue 6/94:45 pm
TYS
-
CID
1 stop17h 37m
Allegiant Air
Deal found 3/6$261
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:11 pm
CID
-
TYS
1 stop21h 04m
Allegiant Air
Fri 6/512:19 pm
TYS
-
CID
1 stop21h 39m
Allegiant Air
Deal found 3/6$264
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:03 pm
DSM
-
TYS
1 stop23h 55m
Allegiant Air
Sun 5/243:46 pm
TYS
-
DSM
1 stop7h 45m
Allegiant Air
Deal found 3/6$265
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:11 pm
CID
-
TYS
1 stop21h 04m
Allegiant Air
Sun 6/75:53 pm
TYS
-
CID
1 stop15h 19m
Allegiant Air
Deal found 3/6$265
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:20 pm
MLI
-
TYS
1 stop6h 14m
United Airlines
Wed 4/227:00 am
TYS
-
MLI
1 stop6h 27m
United Airlines
Deal found 3/2$269
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:29 pm
CID
-
TYS
1 stop4h 05m
United Airlines
Wed 4/227:00 am
TYS
-
CID
1 stop6h 47m
United Airlines
Deal found 3/2$269
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:21 pm
DSM
-
TYS
1 stop6h 47m
United Airlines
Tue 4/74:30 pm
TYS
-
DSM
1 stop8h 12m
United Airlines
Deal found 3/5$271

Find flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated March 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$242
(Kiwi.com)

One-way from

$126
(United Airlines)

Popular in

October

Cheapest in

November

Average price

$326
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Iowa to Knoxville McGhee Tyson
Search Deals
One-way flight from Iowa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 4/14

5:29 pm-10:43 pm

1 stop4h 14m

Knoxville McGhee Tyson

Sat 4/18

7:00 am-12:47 pm

1 stop6h 47m

$251

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 3/31

2:39 pm-10:29 pm

1 stop6h 50m

Knoxville McGhee Tyson

Wed 4/1

7:00 am-10:35 am

1 stop4h 35m

$251

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Mon 4/13

3:20 pm-10:34 pm

1 stop6h 14m

Knoxville McGhee Tyson

Wed 4/22

7:00 am-12:27 pm

1 stop6h 27m

$269
Quickest round-trip

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Mon 4/13

5:29 pm-10:34 pm

1 stop4h 05m

Knoxville McGhee Tyson

Wed 4/22

7:00 am-10:35 am

1 stop4h 35m

$269

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

4:23 pm-10:59 pm

1 stop5h 36m

Knoxville McGhee Tyson

Tue 5/5

12:30 pm-7:28 pm

1 stop7h 58m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/1

5:35 am-11:17 am

1 stop4h 42m

Knoxville McGhee Tyson

Tue 4/7

5:40 am-10:48 am

1 stop6h 08m

$271

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Mon 4/13

12:51 pm-8:18 pm

1 stop6h 27m

Knoxville McGhee Tyson

Wed 4/22

5:00 am-12:21 pm

2 stops8h 21m

$274

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 3/25

2:59 pm-11:44 pm

1 stop7h 45m

Knoxville McGhee Tyson

Sat 3/28

7:00 am-10:28 am

1 stop4h 28m

$281

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Fri 3/20

5:15 pm-11:57 pm

1 stop5h 42m

Knoxville McGhee Tyson

Wed 4/8

5:10 pm-10:30 pm

1 stop6h 20m

$285

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/1

6:20 am-3:09 pm

2 stops7h 49m

Knoxville McGhee Tyson

Tue 4/7

4:30 pm-11:42 pm

1 stop8h 12m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/4

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $163). Flying from Iowa to Knoxville in January is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    United Airlines, Allegiant Air, and American Airlines can get you from Iowa to Knoxville in just under 4h 14m. Your travel time can differ by up to 19h 41m. The distance from Iowa to Knoxville is about 590 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are American Airlines ($125), United Airlines ($134), and Delta ($154).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Omaha Eppley Airfield - Knoxville McGhee Tyson, Des Moines - Knoxville McGhee Tyson and Cedar Rapids - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $163). Flying from Iowa to Knoxville in January is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Iowa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$336FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$384FlexibilityNo cancel feeOn-time69%

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