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$126+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Oct 23 — Oct 301
Thu 10/23
Thu 10/30
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated September 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$207
(Kiwi.com)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

January

Average price

$380
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Iowa to Knoxville McGhee Tyson
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One-way flight from Iowa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/178:00 amDSM - TYS
1 stop28h 01mAllegiant Air
Thu 11/201:20 pmTYS - DSM
1 stop8h 54mAllegiant Air
Deal found 9/22$207
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/215:00 pmMLI - TYS
1 stop5h 07mDelta
Tue 10/285:16 pmTYS - MLI
1 stop6h 04mDelta
Deal found 9/21$249
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/185:31 pmCID - TYS
1 stop5h 52mAmerican Airlines
Thu 10/238:37 pmTYS - CID
1 stop4h 36mAmerican Airlines
Deal found 9/22$249
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amOMA - TYS
1 stop8h 41mDelta
Tue 11/45:44 amTYS - OMA
1 stop5h 02mDelta
Deal found 9/22$251
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/171:37 pmDSM - TYS
2 stops19h 57mMultiple Airlines
Thu 11/201:20 pmTYS - DSM
1 stop8h 54mMultiple Airlines
Deal found 9/22$253
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:00 amMLI - TYS
1 stop6h 57mAmerican Airlines
Mon 12/86:18 pmTYS - MLI
1 stop5h 41mAmerican Airlines
Deal found 9/22$254
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2112:40 pmCID - TYS
2 stops7h 38mAmerican Airlines
Tue 10/287:43 pmTYS - CID
1 stop4h 27mAmerican Airlines
Deal found 9/21$254
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amOMA - TYS
1 stop6h 35mAmerican Airlines
Tue 11/412:46 pmTYS - OMA
2 stops10h 51mAmerican Airlines
Deal found 9/23$256
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:25 amOMA - TYS
1 stop4h 03mDelta
Mon 10/278:10 pmTYS - OMA
1 stop4h 49mDelta
Deal found 9/22$260
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:48 amMLI - TYS
1 stop6h 32mAmerican Airlines
Sun 11/235:10 amTYS - MLI
1 stop6h 19mAmerican Airlines
Deal found 9/23$279
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amCID - TYS
1 stop3h 50mAmerican Airlines
Sun 1/115:59 amTYS - CID
1 stop6h 45mAmerican Airlines
Deal found 9/21$279
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:05 amOMA - TYS
1 stop5h 40mAmerican Airlines
Sat 10/118:09 amTYS - OMA
1 stop6h 26mAmerican Airlines
Deal found 9/21$279

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 23, 2025.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Iowa

Fly to

Knoxville

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 11/17

8:00 am-1:01 pm

1 stop28h 01m

Knoxville McGhee Tyson

Thu 11/20

1:20 pm-9:14 pm

1 stop8h 54m

$207

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Tue 10/21

5:00 pm-11:07 pm

1 stop5h 07m

Knoxville McGhee Tyson

Tue 10/28

5:16 pm-10:20 pm

1 stop6h 04m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 10/18

5:31 pm-12:23 am

1 stop5h 52m

Knoxville McGhee Tyson

Thu 10/23

8:37 pm-12:13 am

1 stop4h 36m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 10/21

8:24 am-4:51 pm

1 stop7h 27m

Knoxville McGhee Tyson

Tue 10/28

7:43 pm-11:10 pm

1 stop4h 27m

$249

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Sat 10/25

2:07 pm-9:13 pm

1 stop6h 06m

Knoxville McGhee Tyson

Tue 10/28

5:44 am-9:46 am

1 stop5h 02m

$251

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 10/29

7:04 am-1:42 pm

1 stop5h 38m

Knoxville McGhee Tyson

Tue 11/4

6:12 am-12:00 pm

1 stop6h 48m

$251

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 11/17

1:37 pm-10:34 am

2 stops19h 57m

Knoxville McGhee Tyson

Thu 11/20

1:20 pm-9:14 pm

1 stop8h 54m

$253

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 10/29

3:02 pm-11:10 pm

1 stop7h 08m

Knoxville McGhee Tyson

Tue 11/4

12:46 pm-10:37 pm

2 stops10h 51m

$256

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Sat 10/25

5:25 am-10:28 am

1 stop4h 03m

Knoxville McGhee Tyson

Mon 10/27

8:10 pm-11:59 pm

1 stop4h 49m

$260

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Fri 11/21

9:48 am-5:20 pm

1 stop6h 32m

Knoxville McGhee Tyson

Sun 11/23

5:10 am-10:29 am

1 stop6h 19m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/22

Showing 1-10 of 41 results
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $294). Flying from Iowa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to TYS?

Find hourly flight availability from Iowa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 23, 2025.

When flying from Iowa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Iowa to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    Allegiant Air, Delta, and American Airlines can get you from Iowa to Knoxville in just under 5h 07m. Your travel time can differ by up to 22h 54m. The distance from Iowa to Knoxville is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are Delta ($126), Allegiant Air ($139), and United Airlines ($166).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Moline Quad-City - Knoxville McGhee Tyson, Cedar Rapids - Knoxville McGhee Tyson and Omaha Eppley Airfield - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $294). Flying from Iowa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Iowa to Knoxville

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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$350FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$345FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$294Average$485FlexibilityNo cancel feeOn-time69%

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