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Knoxville

$118+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
feb. 6 — feb. 131
vie. 2/6
vie. 2/13
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated enero 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$251
(United Airlines)

One-way from

$118
(United Airlines)

Popular in

March

Cheapest in

November

Average price

$253
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Iowa to Knoxville McGhee Tyson
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One-way flight from Iowa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 16% potential increase in price ($73 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 7, 2026.

This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/43:45 pmMLI - TYS
1 stop4h 07mUnited Airlines
sáb. 2/76:45 amTYS - MLI
1 stop4h 27mUnited Airlines
Deal found 1/7$251
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/47:32 amMLI - TYS
2 stops8h 17mAmerican Airlines
sáb. 2/77:54 amTYS - MLI
1 stop4h 04mAmerican Airlines
Deal found 1/7$256
This United Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/112:45 pmSUX - TYS
1 stop7h 07mUnited Airlines
dom. 2/89:30 amTYS - SUX
2 stops8h 58mUnited Airlines
Deal found 1/4$264
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 1/206:35 amCID - TYS
1 stop5h 49mUnited Airlines
sáb. 1/246:45 amTYS - CID
1 stop5h 02mUnited Airlines
Deal found 1/5$264
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/210:27 amOMA - TYS
1 stop5h 16mDelta
mar. 4/75:30 amTYS - OMA
1 stop6h 05mDelta
Deal found 1/7$264
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/1912:16 pmOMA - TYS
1 stop7h 24mAmerican Airlines
sáb. 2/2112:21 pmTYS - OMA
1 stop6h 22mAmerican Airlines
Deal found 1/6$265
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/1011:00 amMLI - TYS
1 stop6h 17mDelta
vie. 7/175:30 amTYS - MLI
1 stop5h 56mDelta
Deal found 1/7$269
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/63:41 pmCID - TYS
1 stop5h 03mAmerican Airlines
lun. 2/94:41 pmTYS - CID
1 stop5h 50mAmerican Airlines
Deal found 1/6$269
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/216:19 amDSM - TYS
1 stop4h 49mDelta
sáb. 2/286:35 amTYS - DSM
1 stop4h 42mDelta
Deal found 1/7$271
This Southwest deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/21:50 pmOMA - TYS
1 stop6h 25mSouthwest
mar. 4/712:50 pmTYS - OMA
1 stop8h 55mSouthwest
Deal found 1/7$273
This American Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 1/223:41 pmCID - TYS
1 stop5h 03mAmerican Airlines
lun. 1/265:15 pmTYS - CID
1 stop6h 00mAmerican Airlines
Deal found 1/4$274
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 1/2111:28 amMLI - TYS
2 stops10h 26mAmerican Airlines
dom. 1/256:00 amTYS - MLI
1 stop5h 30mAmerican Airlines
Deal found 1/5$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 7, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Iowa

Fly to

Knoxville

Route

Depart

Return

Price

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

mié. 2/4

3:45 pm-8:52 pm

1 stop4h 07m

Knoxville McGhee Tyson

sáb. 2/7

6:45 am-10:12 am

1 stop4h 27m

$251

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

mié. 2/4

7:32 am-4:49 pm

2 stops8h 17m

Knoxville McGhee Tyson

sáb. 2/7

7:54 am-10:58 am

1 stop4h 04m

$256

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

mar. 1/20

6:35 am-1:24 pm

1 stop5h 49m

Knoxville McGhee Tyson

sáb. 1/24

6:45 am-10:47 am

1 stop5h 02m

$264

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

jue. 2/19

12:16 pm-8:40 pm

1 stop7h 24m

Knoxville McGhee Tyson

sáb. 2/21

12:21 pm-5:43 pm

1 stop6h 22m

$265

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

vie. 2/6

3:41 pm-9:44 pm

1 stop5h 03m

Knoxville McGhee Tyson

lun. 2/9

4:41 pm-9:31 pm

1 stop5h 50m

$269

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

sáb. 2/21

6:19 am-12:08 pm

1 stop4h 49m

Knoxville McGhee Tyson

sáb. 2/28

6:35 am-10:17 am

1 stop4h 42m

$271

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

jue. 4/2

1:50 pm-9:15 pm

1 stop6h 25m

Knoxville McGhee Tyson

mar. 4/7

12:50 pm-8:45 pm

1 stop8h 55m

$273

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

jue. 1/22

3:41 pm-9:44 pm

1 stop5h 03m

Knoxville McGhee Tyson

lun. 1/26

5:15 pm-10:15 pm

1 stop6h 00m

$274

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

mar. 1/20

5:35 am-11:08 am

1 stop4h 33m

Knoxville McGhee Tyson

sáb. 1/24

5:40 am-2:12 pm

2 stops9h 32m

$284

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

mié. 1/21

11:28 am-10:54 pm

2 stops10h 26m

Knoxville McGhee Tyson

dom. 1/25

6:00 am-10:30 am

1 stop5h 30m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 39 results
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $118). Flying from Iowa to Knoxville in March is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    United Airlines, American Airlines, and Delta can get you from Iowa to Knoxville in just under 4h 07m. Your travel time can differ by up to 4h 10m. The distance from Iowa to Knoxville is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are American Airlines ($125), United Airlines ($134), and Delta ($154).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Cedar Rapids - Knoxville McGhee Tyson, Des Moines - Knoxville McGhee Tyson and Omaha Eppley Airfield - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $118). Flying from Iowa to Knoxville in March is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$349FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$316FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$468FlexibilityNo cancel feeOn-time69%

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