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$133+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$248
(Kiwi.com)

One-way from

$133
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$283
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Iowa to Knoxville McGhee Tyson
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One-way flight from Iowa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:27 pmMLI - TYS
1 stop4h 28mAmerican Airlines
Mon 12/86:29 pmTYS - MLI
1 stop6h 18mAmerican Airlines
Deal found 11/5$249
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:50 amCID - TYS
1 stop6h 54mDelta
Sat 1/104:45 pmTYS - CID
1 stop6h 06mDelta
Deal found 11/5$249
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:46 pmDSM - TYS
1 stop22h 24mMultiple Airlines
Tue 11/256:30 amTYS - DSM
1 stop15h 46mMultiple Airlines
Deal found 11/6$250
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:50 amCID - TYS
1 stop6h 54mDelta
Thu 1/87:30 amTYS - CID
2 stops9h 05mDelta
Deal found 11/5$254
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/144:25 pmCID - TYS
2 stops6h 03mDelta
Tue 1/67:55 amTYS - CID
2 stops8h 40mDelta
Deal found 11/4$259
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amCID - TYS
2 stops7h 29mAmerican Airlines
Mon 1/55:23 amTYS - CID
1 stop8h 19mAmerican Airlines
Deal found 11/4$269
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:37 pmMLI - TYS
1 stop5h 14mAmerican Airlines
Mon 11/245:10 amTYS - MLI
1 stop6h 19mAmerican Airlines
Deal found 11/5$279
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:26 pmCID - TYS
1 stop4h 29mUnited Airlines
Sun 11/236:45 amTYS - CID
1 stop4h 50mUnited Airlines
Deal found 11/5$279
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:21 pmDSM - TYS
1 stop28h 26mAllegiant Air
Sun 12/2112:21 pmTYS - DSM
1 stop10h 37mAllegiant Air
Deal found 11/5$280
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:00 amDSM - TYS
1 stop28h 01mAllegiant Air
Thu 11/139:00 amTYS - DSM
1 stop6h 01mAllegiant Air
Deal found 11/4$283
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:55 pmCID - TYS
1 stop5h 13mAmerican Airlines
Sat 11/225:05 amTYS - CID
2 stops6h 54mAmerican Airlines
Deal found 11/4$284
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/159:31 amDSM - TYS
2 stops29h 31mAllegiant Air
Thu 12/1812:21 pmTYS - DSM
1 stop6h 59mAllegiant Air
Deal found 11/5$292

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Iowa

Fly to

Knoxville

Route

Depart

Return

Price

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 12/13

5:53 pm-11:59 pm

1 stop5h 06m

Knoxville McGhee Tyson

Mon 1/5

5:23 am-12:42 pm

1 stop8h 19m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Fri 1/23

3:10 pm-9:02 pm

1 stop4h 52m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-10:47 am

1 stop5h 02m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 1/24

2:55 pm-11:09 pm

1 stop7h 14m

Knoxville McGhee Tyson

Wed 1/28

6:19 am-11:31 am

1 stop6h 12m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 12/14

5:50 am-1:44 pm

1 stop6h 54m

Knoxville McGhee Tyson

Thu 1/8

6:19 am-11:31 am

1 stop6h 12m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 1/17

8:00 am-1:24 pm

1 stop4h 24m

Knoxville McGhee Tyson

Tue 1/20

11:10 am-2:20 pm

1 stop4h 10m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 12/14

5:50 am-1:44 pm

1 stop6h 54m

Knoxville McGhee Tyson

Fri 1/9

6:19 am-11:31 am

1 stop6h 12m

$249

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 12/14

5:50 am-1:44 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sat 1/10

4:45 pm-9:51 pm

1 stop6h 06m

$249

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 11/21

7:46 pm-7:10 pm

1 stop22h 24m

Knoxville McGhee Tyson

Tue 11/25

6:30 am-9:16 pm

1 stop15h 46m

$250

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 12/14

5:00 am-11:19 am

1 stop5h 19m

Knoxville McGhee Tyson

Fri 1/9

12:15 pm-6:08 pm

2 stops6h 53m

$254

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 12/14

6:40 am-2:29 pm

1 stop6h 49m

Knoxville McGhee Tyson

Thu 1/8

12:15 pm-6:02 pm

2 stops6h 47m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 44 results
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $118). Flying from Iowa to Knoxville in March is currently the most expensive (average of $282). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to TYS?

Find hourly flight availability from Iowa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s typically best to fly out from Iowa to Knoxville in the afternoon. Doing so could potentially save you 44% on the flight price compared to flying in the evening, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    American Airlines, United Airlines, and Delta can get you from Iowa to Knoxville in just under 4h 52m. Your travel time can differ by up to 2h 22m. The distance from Iowa to Knoxville is about 590 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are Allegiant Air ($133), Delta ($139), and American Airlines ($144).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Cedar Rapids - Knoxville McGhee Tyson, Des Moines - Knoxville McGhee Tyson and Omaha Eppley Airfield - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $118). Flying from Iowa to Knoxville in March is currently the most expensive (average of $282). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$203Average$323FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$352FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$294Average$490FlexibilityNo cancel feeOn-time69%

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