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$199+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or November, booked 51 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$248
(Kiwi.com)

One-way from

$199
(Delta)

Popular in

March

Cheapest in

January

Average price

$449
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Des Moines to Knoxville McGhee Tyson
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One-way flight from Des Moines to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:00 amDSM - TYS
1 stop28h 01mAllegiant Air
Sun 11/169:00 amTYS - DSM
1 stop6h 01mAllegiant Air
Deal found 10/25$248
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:51 pmDSM - TYS
1 stop5h 08mAmerican Airlines
Wed 12/175:24 amTYS - DSM
1 stop6h 04mAmerican Airlines
Deal found 10/26$270
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - TYS
1 stop16h 37mAllegiant Air
Fri 12/512:45 pmTYS - DSM
1 stop11h 27mAllegiant Air
Deal found 10/27$271
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/162:51 pmDSM - TYS
1 stop17h 34mAllegiant Air
Tue 11/184:04 pmTYS - DSM
1 stop25h 27mAllegiant Air
Deal found 10/25$276
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - TYS
1 stop16h 37mAllegiant Air
Thu 12/1812:21 pmTYS - DSM
1 stop6h 59mAllegiant Air
Deal found 10/27$280
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:23 amDSM - TYS
1 stop6h 29mDelta
Sat 12/68:35 amTYS - DSM
1 stop6h 37mDelta
Deal found 10/27$300
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:00 amDSM - TYS
1 stop28h 01mAllegiant Air
Fri 11/147:20 amTYS - DSM
1 stop8h 35mAllegiant Air
Deal found 10/25$306
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/214:03 pmDSM - TYS
1 stop5h 51mAmerican Airlines
Mon 11/245:07 pmTYS - DSM
1 stop7h 31mAmerican Airlines
Deal found 10/27$329

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Des Moines

Fly to

Knoxville

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 11/14

8:00 am-1:01 pm

1 stop28h 01m

Knoxville McGhee Tyson

Sun 11/16

9:00 am-2:01 pm

1 stop6h 01m

$248

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/4

2:56 pm-8:33 am

1 stop16h 37m

Knoxville McGhee Tyson

Fri 12/5

12:45 pm-11:12 pm

1 stop11h 27m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 11/16

2:51 pm-9:25 am

1 stop17h 34m

Knoxville McGhee Tyson

Tue 11/18

4:04 pm-4:31 pm

1 stop25h 27m

$276

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/4

11:23 am-6:52 pm

1 stop6h 29m

Knoxville McGhee Tyson

Sat 12/6

8:35 am-2:12 pm

1 stop6h 37m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 12/5

7:05 am-2:27 pm

1 stop6h 22m

Knoxville McGhee Tyson

Sat 12/13

8:13 pm-12:25 am

1 stop5h 12m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/4

2:08 pm-7:43 pm

1 stop4h 35m

Knoxville McGhee Tyson

Sat 12/6

5:45 pm-10:29 pm

1 stop5h 44m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 11/10

8:00 am-1:01 pm

1 stop28h 01m

Knoxville McGhee Tyson

Fri 11/14

7:20 am-2:55 pm

1 stop8h 35m

$306

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 11/23

3:15 pm-10:55 pm

1 stop6h 40m

Knoxville McGhee Tyson

Thu 11/27

8:26 am-2:19 pm

1 stop6h 53m

$329

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 11/15

3:15 pm-8:33 pm

1 stop4h 18m

Knoxville McGhee Tyson

Tue 11/18

1:52 pm-5:25 pm

1 stop4h 33m

$334

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 12/3

2:16 pm-6:58 pm

1 stop3h 42m

Knoxville McGhee Tyson

Thu 12/4

12:50 pm-4:16 pm

1 stop4h 26m

$337

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 14 results
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Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How far ahead should I book a flight from Des Moines to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Knoxville. Price data was last updated on October 24, 2025.

Booking 44 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $163). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Knoxville?

    A quick flight from Des Moines to Knoxville can take about 6h 22m. Allegiant Air provides one of the quickest options available for as low as $300. Des Moines and Knoxville are separated by a distance of 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, Delta ($203), American Airlines ($248), and United Airlines ($354) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 44% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Knoxville one-way?

    The cheapest airlines for a one-way flight from Des Moines to Knoxville are American Airlines ($199), Delta ($199), and United Airlines ($239).

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $163). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$203Average$313FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$342FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$331Average$498FlexibilityNo cancel feeOn-time69%

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