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$147+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:30 am
DSM
-
TYS
1 stop7h 42m
Delta
Sat 3/145:13 pm
TYS
-
DSM
1 stop6h 25m
Delta
Deal found 1/26$271
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
DSM
-
TYS
2 stops8h 30m
American Airlines
Tue 3/177:02 am
TYS
-
DSM
1 stop7h 05m
American Airlines
Deal found 1/25$276
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:04 pm
DSM
-
TYS
1 stop7h 37m
United Airlines
Sat 4/257:00 am
TYS
-
DSM
1 stop4h 44m
United Airlines
Deal found 1/25$282
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:24 pm
DSM
-
TYS
1 stop4h 13m
United Airlines
Sun 3/87:00 am
TYS
-
DSM
1 stop4h 30m
United Airlines
Deal found 1/25$300
This Southwest deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 am
DSM
-
TYS
2 stops13h 35m
Southwest
Wed 4/88:15 am
TYS
-
DSM
2 stops14h 55m
Southwest
Deal found 1/26$304
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
DSM
-
TYS
2 stops8h 30m
American Airlines
Sat 3/146:05 am
TYS
-
DSM
1 stop6h 49m
American Airlines
Deal found 1/25$305
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:24 pm
DSM
-
TYS
1 stop4h 13m
United Airlines
Sun 3/87:00 am
TYS
-
DSM
1 stop4h 30m
United Airlines
Deal found 1/25$324
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:04 pm
DSM
-
TYS
1 stop7h 37m
United Airlines
Fri 4/244:30 pm
TYS
-
DSM
1 stop8h 12m
United Airlines
Deal found 1/25$329
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:00 am
DSM
-
TYS
2 stops8h 24m
American Airlines
Wed 4/86:54 pm
TYS
-
DSM
1 stop6h 17m
American Airlines
Deal found 1/25$332
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:00 am
DSM
-
TYS
1 stop4h 18m
United Airlines
Fri 8/284:25 pm
TYS
-
DSM
1 stop8h 14m
United Airlines
Deal found 1/25$337

Find flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$271
(Delta)

One-way from

$147
(Delta)

Popular in

March

Cheapest in

November

Average price

$253
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Des Moines to Knoxville McGhee Tyson
Search Deals
One-way flight from Des Moines to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($67 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Des Moines

Fly to

Knoxville

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:20 pm-11:57 pm

1 stop5h 37m

Knoxville McGhee Tyson

Sat 3/14

5:40 am-10:48 am

1 stop6h 08m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/1

3:21 pm-11:03 pm

1 stop6h 42m

Knoxville McGhee Tyson

Wed 4/8

7:00 am-12:29 pm

1 stop6h 29m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:20 pm-11:57 pm

1 stop5h 37m

Knoxville McGhee Tyson

Tue 3/17

11:18 am-4:54 pm

1 stop6h 36m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 4/20

3:04 pm-11:41 pm

1 stop7h 37m

Knoxville McGhee Tyson

Sat 4/25

7:00 am-10:44 am

1 stop4h 44m

$282

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:30 am-5:40 pm

2 stops11h 10m

Knoxville McGhee Tyson

Tue 3/17

7:50 am-10:05 pm

2 stops15h 15m

$304

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/1

5:30 am-8:05 pm

2 stops13h 35m

Knoxville McGhee Tyson

Wed 4/8

8:15 am-10:10 pm

2 stops14h 55m

$304

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:20 pm-11:57 pm

1 stop5h 37m

$147

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 3/27

3:28 pm-8:47 pm

1 stop4h 19m

$169

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 3/26

10:28 am-4:43 pm

1 stop5h 15m

$209

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 3/26

5:35 am-6:45 pm

2 stops12h 10m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 18 results
1
2

Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

What is the cheapest month to book a flight from Des Moines to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $163). Flying from Des Moines to Knoxville in December is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 26, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,111 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,199 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Knoxville?

    A quick flight from Des Moines to Knoxville can take about 5h 37m. Delta provides one of the quickest options available for as low as $271. Des Moines and Knoxville are separated by a distance of 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, American Airlines ($203), Delta ($203), and United Airlines ($331) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 44% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $163). Flying from Des Moines to Knoxville in December is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$347FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$308FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$331Average$498FlexibilityNo cancel feeOn-time69%

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