$220+ Cheap flights from Des Moines to Knoxville (DSM - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Des Moines to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or November, booked 37 days in advance, depart on a Saturday or Tuesday and return on a Thursday
Cheap flight deals from Des Moines to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junho 12, 2025.
Round-trip from | $249 (Delta) |
|---|---|
One-way from | $220 (Delta) |
Popular in | March |
Cheapest in | January |
Average price | $383 |
Find flight deals from Des Moines to Knoxville
Cheapest flights from Des Moines to KnoxvilleExplore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junho 12, 2025.
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junho 12, 2025.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junho 12, 2025.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
sex 7/18
5:23 pm-11:44 pm
1 stop5h 21m
Knoxville McGhee Tyson
ter 7/22
5:30 am-10:39 am
1 stop6h 09m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
ter 7/8
7:00 am-5:59 pm
1 stop9h 59m
Knoxville McGhee Tyson
qui 7/10
12:39 pm-7:04 pm
1 stop7h 25m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
qua 6/25
8:09 am-4:08 pm
1 stop6h 59m
Knoxville McGhee Tyson
sáb 6/28
5:12 pm-9:43 pm
1 stop5h 31m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
sex 6/27
3:38 pm-10:35 pm
1 stop5h 57m
Knoxville McGhee Tyson
seg 6/30
5:45 am-2:41 pm
2 stops9h 56m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
ter 7/8
7:00 am-5:59 pm
1 stop9h 59m
Knoxville McGhee Tyson
qui 7/10
8:54 pm-6:06 pm
2 stops22h 12m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
sáb 7/26
3:00 pm-10:26 pm
1 stop6h 26m
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
sáb 7/26
6:50 pm-11:27 pm
2 stops27h 37m
Best time to book a flight from Des Moines to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Knoxville
How far ahead should I book a flight from Des Moines to Knoxville?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Knoxville. Price data was last updated on June 9, 2025.
Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $296). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Rainfall in Knoxville by month
Plan your trip to Knoxville by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.
Temperature in Knoxville by month
Plan your trip to Knoxville by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated junho 12, 2025.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta, United Airlines and Allegiant Air. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
Boarding
Entertainment
Overall
Comfort
Crew
Reviews
Kim,May 2025
PIH - SLC
Food
Boarding
Entertainment
Overall
Comfort
Crew
Reviews
Kim,May 2025
PIH - SLC
Food
Boarding
Entertainment
Overall
Comfort
Crew
Reviews
Kim,May 2025
PIH - SLC
Food
Boarding
Entertainment
Overall
Comfort
Crew
Reviews
Kim,May 2025
PIH - SLC
Food
Boarding
Entertainment
Overall
Comfort
Crew
Reviews
Kim,May 2025
PIH - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
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Alternative routes for Des Moines to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Des Moines to Knoxville
Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junho 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$320 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$497 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$348 | FlexibilityNo cancel fee | On-time71% |