How long is the flight from Des Moines to Knoxville?

A quick flight from Des Moines to Knoxville can take about 4h 28m. American Airlines provides one of the quickest options available for as low as $193. Des Moines and Knoxville are separated by a distance of 654 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

According to our current data, American Airlines ($248), Delta ($248), and United Airlines ($331) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 30% lower than the current average price 3 months from now.

What is the cheapest day to fly from Des Moines to Knoxville?

Travelers seeking maximum savings on their Des Moines to Knoxville flight should consider departing on Saturday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular airlines that fly from Des Moines to Knoxville?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Des Moines to Knoxville.

What is the cheapest day to fly round-trip from Des Moines to Knoxville?

Travelers have found that booking a Friday departure is the best way to save up to 61% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Des Moines to Knoxville?

Find a great deal and save up to 103% by booking at least 38 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Knoxville within the next two weeks, with the cheapest ticket starting at $308.

What is the cheapest month to fly from Des Moines to Knoxville?

January can be a great time to fly to Knoxville from Des Moines with a flight ticket averaging about $356. Cheapflights users have found deals in the month of January for as cheap as $249. The most expensive prices can be found in the month of March.

What is the cheapest time of day to fly from DSM to TYS?

When flying from Des Moines to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 13% versus a flight in the morning.

Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

Can I find deals for business class flights from Des Moines to Knoxville?

Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$97+ Flights from Des Moines to Knoxville

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Cheapflights Tip: The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or July, booked 37 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Des Moines to Knoxville

Round-trip from	$193 (United Airlines)
One-way from	$97 (American Airlines)
Popular in	March
Cheapest in	January
Average price	$313

From Des Moines to Knoxville McGhee Tyson

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One-way flight from Des Moines to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 14% potential increase in price ($58 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Sat 10/256:22 pmDSM - TYS

1 stop4h 28mAmerican Airlines

Sat 11/16:47 pmTYS - DSM

1 stop5h 29mAmerican Airlines

Deal found 9/10

$193

Wed 11/51:05 pmDSM - TYS

2 stops9h 54mUnited Airlines

Sat 11/88:26 amTYS - DSM

1 stop6h 53mUnited Airlines

Deal found 9/10

$198

Thu 10/26:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Deal found 9/11

$218

Thu 11/202:43 pmDSM - TYS

1 stop6h 43mAllegiant Air

Sun 11/231:20 pmTYS - DSM

1 stop8h 54mAllegiant Air

Deal found 9/9

$222

Wed 11/53:39 pmDSM - TYS

1 stop7h 29mAmerican Airlines

Sat 11/86:18 pmTYS - DSM

1 stop5h 41mAmerican Airlines

Deal found 9/11

$232

Thu 11/202:43 pmDSM - TYS

1 stop6h 43mAllegiant Air

Sat 11/222:28 pmTYS - DSM

1 stop8h 20mAllegiant Air

Deal found 9/9

$256

Thu 9/256:30 amDSM - TYS

1 stop11h 15mMultiple Airlines

Mon 9/298:35 pmTYS - DSM

2 stops42h 52mMultiple Airlines

Deal found 9/10

$293

Wed 11/196:00 amDSM - TYS

2 stops6h 52mAmerican Airlines

Sat 11/225:10 amTYS - DSM

1 stop6h 30mAmerican Airlines

Deal found 9/9

$312

Best flights from Des Moines to Knoxville
Discover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Sat 10/256:22 pmDSM - TYS

1 stop4h 28mAmerican Airlines

Sat 11/16:47 pmTYS - DSM

1 stop5h 29mAmerican Airlines

Deal found 9/10

$193

Wed 11/51:05 pmDSM - TYS

2 stops9h 54mUnited Airlines

Sat 11/88:26 amTYS - DSM

1 stop6h 53mUnited Airlines

Deal found 9/10

$198

Thu 10/26:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Deal found 9/11

$218

Thu 9/256:30 amDSM - TYS

1 stop11h 15mMultiple Airlines

Mon 9/298:35 pmTYS - DSM

2 stops42h 52mMultiple Airlines

Deal found 9/10

$293

Mon 11/172:17 pmDSM - TYS

1 stop4h 49mDelta

Fri 11/216:29 amTYS - DSM

1 stop4h 51mDelta

Deal found 9/10

$322

Wed 11/53:39 pmDSM - TYS

1 stop7h 29mAmerican Airlines

Sat 11/86:18 pmTYS - DSM

1 stop5h 41mAmerican Airlines

Deal found 9/11

$232

Wed 11/196:01 pmDSM - TYS

1 stop5h 07mAmerican Airlines

Sat 11/2212:09 pmTYS - DSM

1 stop5h 32mAmerican Airlines

Deal found 9/9

$232

Thu 11/202:43 pmDSM - TYS

1 stop6h 43mAllegiant Air

Sat 11/222:28 pmTYS - DSM

1 stop8h 20mAllegiant Air

Deal found 9/9

$256

Thu 11/205:00 amDSM - TYS

1 stop5h 24mAmerican Airlines

Sun 11/236:30 amTYS - DSM

2 stops7h 46mAmerican Airlines

Deal found 9/9

$312

Last-minute flights from Des Moines to Knoxville
Discover last-minute flight deals from Des Moines to Knoxville. Data last updated September 11, 2025 and is based on user searches.

Thu 9/186:30 amDSM - TYS

1 stop11h 15mMultiple Airlines

Sun 9/217:00 amTYS - DSM

1 stop7h 40mMultiple Airlines

Deal found 9/9

$359

Sat 9/202:49 pmDSM - TYS

1 stop6h 46mDelta

Sun 9/285:45 amTYS - DSM

1 stop5h 59mDelta

Deal found 9/11

$341

Sat 9/207:08 amDSM - TYS

2 stops8h 41mAmerican Airlines

Sun 9/288:36 pmTYS - DSM

1 stop4h 39mAmerican Airlines

Deal found 9/10

$346

Thu 9/256:30 amDSM - TYS

1 stop11h 15mMultiple Airlines

Mon 9/298:35 pmTYS - DSM

2 stops42h 52mMultiple Airlines

Deal found 9/10

$293

Thu 9/256:30 amDSM - TYS

1 stop11h 15mAllegiant Air

Mon 9/298:30 amTYS - DSM

1 stop14h 59mAllegiant Air

Deal found 9/10

$337

Thu 10/26:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Deal found 9/11

$218

Sat 10/113:25 pmDSM - TYS

1 stop6h 25mUnited Airlines

Sat 10/1810:51 amTYS - DSM

1 stop4h 32mUnited Airlines

Deal found 9/11

$331

Thu 10/166:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Sun 10/199:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Deal found 9/10

$342

Sat 10/256:22 pmDSM - TYS

1 stop4h 28mAmerican Airlines

Sat 11/16:47 pmTYS - DSM

1 stop5h 29mAmerican Airlines

Deal found 9/10

$193

One-way flights from Des Moines to Knoxville
Search for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Sat 10/256:00 amDSM - TYS

1 stop6h 48mAmerican Airlines

Deal found 9/10

$97

Fri 9/1910:37 amDSM - TYS

1 stop22h 30mAllegiant Air

Deal found 9/10

$198

Sat 10/256:50 pmDSM - TYS

2 stops45h 22mAllegiant Air

Deal found 9/10

$253

Fri 9/192:25 pmDSM - TYS

2 stops55h 25mMultiple Airlines

Deal found 9/10

$295

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 10/25

6:22 pm-11:50 pm

1 stop4h 28m

Knoxville McGhee Tyson

Sat 11/1

6:47 pm-11:16 pm

1 stop5h 29m

$193

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 11/5

1:05 pm-11:59 pm

2 stops9h 54m

Knoxville McGhee Tyson

Sat 11/8

8:26 am-2:19 pm

1 stop6h 53m

$198

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 10/2

6:30 am-4:44 pm

1 stop9h 14m

Knoxville McGhee Tyson

Thu 10/9

9:50 pm-8:30 am

1 stop11h 40m

$218

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 11/5

3:39 pm-12:08 am

1 stop7h 29m

Knoxville McGhee Tyson

Sat 11/8

6:18 pm-10:59 pm

1 stop5h 41m

$232

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 11/19

6:01 pm-12:08 am

1 stop5h 07m

Knoxville McGhee Tyson

Sat 11/22

12:09 pm-4:41 pm

1 stop5h 32m

$232

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 11/20

2:43 pm-10:26 pm

1 stop6h 43m

Knoxville McGhee Tyson

Sat 11/22

2:28 pm-9:48 pm

1 stop8h 20m

$256

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 9/25

6:30 am-6:45 pm

1 stop11h 15m

Knoxville McGhee Tyson

Mon 9/29

8:35 pm-2:27 pm

2 stops42h 52m

$293

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 11/20

5:00 am-11:24 am

1 stop5h 24m

Knoxville McGhee Tyson

Sun 11/23

6:30 am-1:16 pm

2 stops7h 46m

$312

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 11/17

2:17 pm-8:06 pm

1 stop4h 49m

Knoxville McGhee Tyson

Fri 11/21

6:29 am-10:20 am

1 stop4h 51m

$322

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 10/25

6:00 am-1:48 pm

1 stop6h 48m

$97

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 13 results

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How far ahead should I book a flight from Des Moines to Knoxville?

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $294). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,960 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,937 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Des Moines to Knoxville?
A quick flight from Des Moines to Knoxville can take about 4h 28m. American Airlines provides one of the quickest options available for as low as $193. Des Moines and Knoxville are separated by a distance of 654 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Des Moines to Knoxville round-trip?
According to our current data, American Airlines ($248), Delta ($248), and United Airlines ($331) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 30% lower than the current average price 3 months from now.
Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?
Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.
Can I find deals for business class flights from Des Moines to Knoxville?
Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $294). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Alcoa

Oak Ridge

Murphy

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Alternative routes for Des Moines to Knoxville

Complete your trip

Knoxville car rentals

Knoxville McGhee Tyson Airport car rentals

Asheville Regional Airport car rentals

Chattanooga Lovell Field Airport car rentals

Blountville Tri Cities TN/VA Airport car rentals

Nashville car rentals

Memphis car rentals

Chattanooga car rentals

Kingsport car rentals

Jackson car rentals

Other flights to Knoxville

Top 3 airlines flying from Des Moines to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$248	Average$345	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$248	Average$311	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$331	Average$498	FlexibilityNo cancel fee	On-time69%

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$97+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or July, booked 37 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Des Moines to Knoxville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to KnoxvilleExplore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How far ahead should I book a flight from Des Moines to Knoxville?

What is the cheapest month to book a flight from Des Moines to Knoxville?

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Knoxville?

What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

How can I find direct flights from Des Moines to Knoxville?

Can I find deals for business class flights from Des Moines to Knoxville?

What is the cheapest month to book a flight from Des Moines to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Knoxville

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Top 3 airlines flying from Des Moines to Knoxville

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Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.