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$249+ Cheap flights from Roanoke to Key West (ROA - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — EYW
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Roanoke to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$249
(Delta)

Popular in

October

Cheapest in

November

Average price

$362
From Roanoke to Key West
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High demand for flights, 14% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Roanoke to Key West

Cheapest flights from Roanoke to Key West
Explore the most affordable flight options available from Roanoke to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:47 pmROA - EYW
1 stop7h 02mAmerican Airlines
Sat 11/221:33 pmEYW - ROA
2 stops8h 20mAmerican Airlines
Deal found 9/13$271
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:49 pmROA - EYW
1 stop16h 51mAllegiant Air
Mon 10/203:56 pmEYW - ROA
1 stop16h 27mAllegiant Air
Deal found 9/13$287
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/208:04 amROA - EYW
2 stops10h 55mAmerican Airlines
Wed 9/246:17 pmEYW - ROA
1 stop4h 51mAmerican Airlines
Deal found 9/13$314
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:49 pmROA - EYW
1 stop7h 01mAmerican Airlines
Tue 12/167:30 amEYW - ROA
1 stop4h 47mAmerican Airlines
Deal found 9/13$319

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Roanoke to Key West that are best for you.

Fly from

Roanoke

Fly to

Key West

Route

Depart

Return

Price

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Wed 1/7

6:00 am-11:03 am

1 stop5h 03m

Key West

Tue 1/13

6:00 pm-11:49 pm

1 stop5h 49m

$249

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Wed 1/7

6:00 am-11:03 am

1 stop5h 03m

Key West

Wed 1/14

6:00 pm-11:49 pm

1 stop5h 49m

$249

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Sat 1/10

8:24 am-6:35 pm

2 stops10h 11m

Key West

Thu 1/15

5:24 pm-11:44 pm

1 stop6h 20m

$254

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Sat 11/15

2:47 pm-9:49 pm

1 stop7h 02m

Key West

Sat 11/22

1:33 pm-9:53 pm

2 stops8h 20m

$271

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Sat 1/10

6:00 am-11:03 am

1 stop5h 03m

Key West

Tue 1/13

6:00 pm-11:49 pm

1 stop5h 49m

$294

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Wed 1/7

6:00 am-11:03 am

1 stop5h 03m

Key West

Thu 1/15

6:00 pm-11:49 pm

1 stop5h 49m

$294

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Fri 1/9

3:25 pm-7:44 pm

1 stop4h 19m

Key West

Tue 1/13

6:00 pm-11:49 pm

1 stop5h 49m

$294

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Sun 1/11

3:45 pm-9:37 pm

1 stop5h 52m

Key West

Thu 1/15

3:46 pm-3:18 pm

1 stop23h 32m

$305

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Roanoke to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Key West

What is the cheapest month to book a flight from Roanoke to Key West?

Currently, August is the cheapest month in which you can book a flight from Roanoke to Key West (average of $328). Flying from Roanoke to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Roanoke to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Crew

8.5

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to Key West?

    Airlines like Delta and American Airlines fly from Roanoke to Key West in about 5h 03m. The time it takes to get you to your destination can typically vary by up to 5h 08m. Airlines will cover a distance of 888 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Roanoke to Key West round-trip?

    Delta, at $248, was found to be the cheapest airline from Roanoke to Key West. An alternate airline flying to your destination would be American Airlines. Delta is currently priced 49% below the average price you’ll pay for this route.

  • Can I find deals for flights from Roanoke to Key West that include hotel bookings?

    Yes. In addition to deals on Roanoke to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Key West.

  • Can I find deals for business class flights from Roanoke to Key West?

    Yes. Cheapflights offers flight deals from Roanoke to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Key West?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to Key West (average of $328). Flying from Roanoke to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Key West

Discover the top 2 airlines that operate flights from Roanoke to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$343FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$484FlexibilityNo cancel feeOn-time71%

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