$236+ Cheap flights from Missouri to Key West (EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — EYW
Aug 14 — Aug 211
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Key West with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to Key WestExplore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:09 pm
MCI
- EYW
1 stop19h 33m
Multiple Airlines
Tue 8/181:14 pm
EYW
- MCI
2 stops22h 27m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:11 pm
MCI
- EYW
2 stops41h 08m
Multiple Airlines
Sat 10/33:58 pm
EYW
- MCI
1 stop18h 48m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:34 pm
STL
- EYW
1 stop12h 45m
Multiple Airlines
Thu 10/1512:01 pm
EYW
- STL
2 stops22h 39m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:09 pm
MCI
- EYW
1 stop19h 33m
Multiple Airlines
Mon 8/1712:07 pm
EYW
- MCI
2 stops47h 34m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:09 pm
STL
- EYW
1 stop18h 18m
Multiple Airlines
Thu 8/2011:04 am
EYW
- STL
2 stops31h 18m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:09 pm
STL
- EYW
1 stop18h 18m
Multiple Airlines
Thu 8/1311:04 am
EYW
- STL
2 stops22h 53m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:09 pm
STL
- EYW
1 stop21h 28m
Multiple Airlines
Mon 8/103:27 pm
EYW
- STL
2 stops27h 10m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:35 am
STL
- EYW
2 stops24h 27m
Multiple Airlines
Fri 10/308:29 am
EYW
- STL
1 stop12h 10m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2511:16 am
MCI
- EYW
1 stop24h 03m
Multiple Airlines
Fri 10/3010:59 am
EYW
- MCI
2 stops29h 18m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:35 am
STL
- EYW
2 stops23h 46m
Multiple Airlines
Sun 9/206:11 pm
EYW
- STL
1 stop26h 28m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:00 pm
STL
- EYW
1 stop4h 24m
Delta
Sat 9/266:19 pm
EYW
- STL
1 stop6h 23m
Delta
Deal found 7/13![Delta logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/89:18 am
SGF
- EYW
1 stop27h 43m
Allegiant Air
Fri 11/138:25 am
EYW
- SGF
1 stop12h 05m
Allegiant Air
Deal found 7/11![Allegiant Air logo]()
$296
Best flights from Missouri to Key WestDiscover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
Discover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:00 pm
MCI
- EYW
1 stop4h 57m
Delta
Wed 9/96:19 pm
EYW
- MCI
1 stop6h 32m
Delta
Deal found 7/11![Delta logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:04 pm
SGF
- EYW
1 stop18h 38m
Allegiant Air
Sun 8/169:42 pm
EYW
- SGF
1 stop12h 56m
Allegiant Air
Deal found 7/11![Allegiant Air logo]()
$320
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:25 am
SGF
- EYW
1 stop5h 30m
American Airlines
Tue 8/251:50 pm
EYW
- SGF
1 stop7h 52m
American Airlines
Deal found 7/13![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
STL
- EYW
1 stop7h 18m
United Airlines
Wed 10/284:00 pm
EYW
- STL
1 stop6h 13m
United Airlines
Deal found 7/14![United Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:51 pm
SGF
- EYW
2 stops43h 36m
Multiple Airlines
Sun 8/99:31 pm
EYW
- SGF
1 stop13h 07m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:20 am
MCI
- EYW
1 stop7h 37m
Delta
Tue 9/17:40 am
EYW
- MCI
1 stop7h 12m
Delta
Deal found 7/10![Delta logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/811:51 am
SGF
- EYW
2 stops22h 13m
Allegiant Air
Fri 11/138:25 am
EYW
- SGF
1 stop12h 05m
Allegiant Air
Deal found 7/11![Allegiant Air logo]()
$368
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:06 am
SGF
- EYW
1 stop5h 54m
Delta
Tue 8/256:15 pm
EYW
- SGF
1 stop5h 06m
Delta
Deal found 7/10![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:27 pm
SGF
- EYW
1 stop5h 17m
American Airlines
Mon 12/218:00 am
EYW
- SGF
1 stop7h 54m
American Airlines
Deal found 7/12![American Airlines logo]()
$414
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:11 am
MCI
- EYW
1 stop6h 41m
Delta
Thu 8/137:40 am
EYW
- MCI
1 stop5h 46m
Delta
Deal found 7/10![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:00 am
STL
- EYW
1 stop8h 19m
United Airlines
Wed 8/52:26 pm
EYW
- STL
2 stops10h 03m
United Airlines
Deal found 7/13![United Airlines logo]()
$455
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:08 am
SGF
- EYW
1 stop7h 49m
American Airlines
Sat 1/94:04 pm
EYW
- SGF
1 stop5h 56m
American Airlines
Deal found 7/12![American Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:00 am
STL
- EYW
1 stop7h 17m
American Airlines
Mon 9/287:47 pm
EYW
- STL
1 stop5h 12m
American Airlines
Deal found 7/15![American Airlines logo]()
$431
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2211:51 am
STL
- EYW
1 stop6h 52m
Delta
Mon 12/286:00 pm
EYW
- STL
1 stop6h 39m
Delta
Deal found 7/13![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:15 am
SGF
- EYW
1 stop7h 28m
American Airlines
Tue 8/111:40 pm
EYW
- SGF
2 stops8h 49m
American Airlines
Deal found 7/14![American Airlines logo]()
$451
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:13 pm
MCI
- EYW
1 stop5h 38m
Delta
Mon 10/127:40 am
EYW
- MCI
1 stop7h 58m
Delta
Deal found 7/12![Delta logo]()
$422
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/168:00 am
SGF
- EYW
1 stop7h 22m
American Airlines
Sun 12/201:15 pm
EYW
- SGF
1 stop7h 03m
American Airlines
Deal found 7/13![American Airlines logo]()
$460
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:02 am
JLN
- EYW
1 stop7h 04m
United Airlines
Tue 12/154:05 pm
EYW
- JLN
1 stop21h 14m
United Airlines
Deal found 7/11![United Airlines logo]()
$621
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:02 am
STL
- EYW
1 stop6h 14m
Delta
Sun 10/116:11 pm
EYW
- STL
1 stop6h 37m
Delta
Deal found 7/10![Delta logo]()
$466
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:51 am
STL
- EYW
1 stop6h 52m
Delta
Thu 11/266:00 pm
EYW
- STL
1 stop6h 39m
Delta
Deal found 7/11![Delta logo]()
$485
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:20 pm
JLN
- EYW
2 stops25h 56m
United Airlines
Wed 11/42:55 pm
EYW
- JLN
2 stops22h 27m
United Airlines
Deal found 7/14![United Airlines logo]()
$854
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:51 am
STL
- EYW
1 stop6h 52m
Delta
Sun 12/67:00 am
EYW
- STL
1 stop4h 48m
Delta
Deal found 7/11![Delta logo]()
$535
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:30 am
JLN
- EYW
2 stops27h 59m
United Airlines
Tue 9/12:15 pm
EYW
- JLN
2 stops24h 03m
United Airlines
Deal found 7/12![United Airlines logo]()
$967
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:51 am
STL
- EYW
1 stop6h 52m
Delta
Sun 11/156:00 pm
EYW
- STL
1 stop6h 39m
Delta
Deal found 7/10![Delta logo]()
$650
Last-minute flights from Missouri to Key WestDiscover last-minute flight deals from Missouri to Key West. Data last updated July 15, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Key West. Data last updated July 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/24:09 pm
STL
- EYW
1 stop21h 28m
Multiple Airlines
Sat 8/84:35 pm
EYW
- STL
2 stops41h 22m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:09 pm
STL
- EYW
1 stop18h 18m
Multiple Airlines
Thu 8/1311:04 am
EYW
- STL
2 stops22h 53m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:09 pm
STL
- EYW
1 stop21h 28m
Multiple Airlines
Mon 8/103:27 pm
EYW
- STL
2 stops27h 10m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/104:57 pm
STL
- EYW
2 stops41h 09m
Multiple Airlines
Mon 8/1712:07 pm
EYW
- STL
1 stop12h 52m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:09 pm
MCI
- EYW
1 stop19h 33m
Multiple Airlines
Tue 8/181:14 pm
EYW
- MCI
2 stops22h 27m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:09 pm
MCI
- EYW
1 stop19h 33m
Multiple Airlines
Mon 8/1712:07 pm
EYW
- MCI
2 stops47h 34m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:09 pm
STL
- EYW
1 stop18h 18m
Multiple Airlines
Thu 8/2011:04 am
EYW
- STL
2 stops31h 18m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:04 pm
SGF
- EYW
1 stop18h 38m
Allegiant Air
Sun 8/169:42 pm
EYW
- SGF
1 stop12h 56m
Allegiant Air
Deal found 7/11![Allegiant Air logo]()
$320
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:22 pm
MCI
- EYW
1 stop6h 35m
Delta
Tue 8/186:15 pm
EYW
- MCI
1 stop6h 43m
Delta
Deal found 7/15![Delta logo]()
$323
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:20 am
MCI
- EYW
1 stop7h 37m
Delta
Tue 9/17:40 am
EYW
- MCI
1 stop7h 12m
Delta
Deal found 7/15![Delta logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:17 pm
STL
- EYW
2 stops17h 14m
Multiple Airlines
Thu 8/2712:05 pm
EYW
- STL
1 stop28h 23m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:52 pm
STL
- EYW
1 stop6h 05m
Delta
Wed 9/21:59 pm
EYW
- STL
1 stop5h 28m
Delta
Deal found 7/12![Delta logo]()
$293
One-way flights from Missouri to Key WestSearch for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
Search for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:57 pm
STL
- EYW
2 stops41h 09m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:32 pm
MCI
- EYW
2 stops17h 55m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$313
This deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
STL
- EYW
1 stop6h 19m
United Airlines
Deal found 7/10![United Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:57 pm
MCI
- EYW
1 stop19h 54m
Allegiant Air
Deal found 7/10![Allegiant Air logo]()
$360
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:00 am
STL
- EYW
1 stop6h 19m
United Airlines
Deal found 7/11![United Airlines logo]()
$379
Find flight deals from Missouri to Key West
Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated July 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $236 (Kiwi.com) |
Popular in | October |
Cheapest in | December |
Average price | $462 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sat 9/5
2:00 pm-7:57 pm
1 stop4h 57m
Key West
Wed 9/9
6:19 pm-11:51 pm
1 stop6h 32m
$297
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sat 8/22
11:20 am-7:57 pm
1 stop7h 37m
Key West
Tue 9/1
7:40 am-1:52 pm
1 stop7h 12m
$297
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Thu 8/13
8:04 pm-3:42 pm
1 stop18h 38m
Key West
Sun 8/16
9:42 pm-9:38 am
1 stop12h 56m
$320
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Tue 8/18
6:25 am-12:55 pm
1 stop5h 30m
Key West
Tue 8/25
1:50 pm-8:42 pm
1 stop7h 52m
$349
Quickest round-trip
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Tue 8/18
6:06 am-1:00 pm
1 stop5h 54m
Key West
Tue 8/25
6:15 pm-10:21 pm
1 stop5h 06m
$349
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Sun 11/8
11:51 am-11:04 am
2 stops22h 13m
Key West
Fri 11/13
8:25 am-7:30 pm
1 stop12h 05m
$368
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sat 8/8
7:11 am-2:52 pm
1 stop6h 41m
Key West
Thu 8/13
7:40 am-12:26 pm
1 stop5h 46m
$369
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 10/24
6:00 am-2:18 pm
1 stop7h 18m
Key West
Wed 10/28
4:00 pm-9:13 pm
1 stop6h 13m
$383
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 12/22
11:51 am-7:43 pm
1 stop6h 52m
Key West
Mon 12/28
6:00 pm-11:39 pm
1 stop6h 39m
$395
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Thu 12/17
4:27 pm-10:44 pm
1 stop5h 17m
Key West
Mon 12/21
8:00 am-2:54 pm
1 stop7h 54m
$414
Showing 1-10 of 29 resultsSorted by cheapest first
Best time to book a flight from Missouri to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Key West
USMO-EYW
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
What is the cheapest month to book a flight from Missouri to Key West?
Currently, November is the cheapest month in which you can book a flight from Missouri to Key West (average of $121). Flying from Missouri to Key West in April is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Key West?
How far ahead should I book a flight from Missouri to Key West?
Booking 73 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Key West
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Key West by cabin class
Find flights from Missouri to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 15, 2026.
Missouri and Key West flights
Browse other Missouri and Key West flight options. Last updated on July 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Key West flights
Consider these flights traveling from Missouri to Key West.
Top 3 airlines flying from Missouri to Key West
Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$222 | Average$495 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$230 | Average$520 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$406 | FlexibilityNo cancel fee | On-time69% |