$217+ Cheap flights from Missouri to Key West (EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — EYW
Jun 22 — Jun 291
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to Key WestExplore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:10 pm
STL
- EYW
1 stop18h 17m
Multiple Airlines
Tue 8/251:14 pm
EYW
- STL
2 stops20h 38m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:42 am
SGF
- EYW
1 stop6h 00m
Allegiant Air
Thu 8/203:51 pm
EYW
- SGF
1 stop18h 42m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$255
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:51 am
STL
- EYW
1 stop5h 32m
Delta
Tue 7/146:18 pm
EYW
- STL
1 stop4h 57m
Delta
Deal found 5/19![Delta logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:09 pm
STL
- EYW
1 stop20h 22m
Multiple Airlines
Thu 8/1312:05 pm
EYW
- STL
1 stop12h 54m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:53 pm
MCI
- EYW
1 stop5h 01m
Delta
Tue 9/16:00 pm
EYW
- MCI
1 stop6h 52m
Delta
Deal found 5/18![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:40 pm
STL
- EYW
1 stop5h 08m
American Airlines
Tue 7/141:47 pm
EYW
- STL
2 stops8h 08m
American Airlines
Deal found 5/22![American Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/229:13 am
MCI
- EYW
2 stops8h 32m
American Airlines
Tue 9/14:57 pm
EYW
- MCI
1 stop8h 39m
American Airlines
Deal found 5/22![American Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:09 pm
STL
- EYW
1 stop18h 16m
Multiple Airlines
Mon 7/1312:07 pm
EYW
- STL
2 stops30h 30m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:17 pm
STL
- EYW
1 stop18h 10m
Multiple Airlines
Wed 6/2411:46 am
EYW
- STL
2 stops30h 44m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/510:40 am
MCI
- EYW
1 stop26h 18m
Multiple Airlines
Tue 6/91:14 pm
EYW
- MCI
2 stops29h 07m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:17 pm
STL
- EYW
1 stop21h 18m
Multiple Airlines
Mon 6/153:25 pm
EYW
- STL
2 stops27h 05m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:04 pm
STL
- EYW
1 stop5h 50m
Delta
Wed 8/127:40 am
EYW
- STL
1 stop5h 06m
Delta
Deal found 5/19![Delta logo]()
$326
Best flights from Missouri to Key WestDiscover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
Discover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/79:24 am
STL
- EYW
1 stop6h 59m
Delta
Tue 7/146:18 pm
EYW
- STL
1 stop4h 57m
Delta
Deal found 5/18![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:40 pm
STL
- EYW
1 stop5h 08m
American Airlines
Tue 7/141:47 pm
EYW
- STL
2 stops8h 08m
American Airlines
Deal found 5/22![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:42 am
SGF
- EYW
1 stop6h 00m
Allegiant Air
Thu 8/2010:00 am
EYW
- SGF
2 stops24h 33m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$319
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- EYW
1 stop8h 07m
United Airlines
Fri 6/53:55 pm
EYW
- STL
1 stop6h 35m
United Airlines
Deal found 5/22![United Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:17 pm
STL
- EYW
1 stop21h 18m
Multiple Airlines
Mon 6/153:25 pm
EYW
- STL
1 stop9h 24m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:53 pm
MCI
- EYW
1 stop5h 01m
Delta
Tue 9/16:00 pm
EYW
- MCI
1 stop6h 52m
Delta
Deal found 5/18![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
MCI
- EYW
1 stop9h 42m
American Airlines
Tue 7/1411:28 am
EYW
- MCI
1 stop6h 55m
American Airlines
Deal found 5/18![American Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:56 am
SGF
- EYW
1 stop28h 02m
Allegiant Air
Thu 6/254:12 pm
EYW
- SGF
1 stop16h 54m
Allegiant Air
Deal found 5/19![Allegiant Air logo]()
$357
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:04 pm
STL
- EYW
1 stop5h 50m
Delta
Wed 8/127:40 am
EYW
- STL
1 stop5h 06m
Delta
Deal found 5/19![Delta logo]()
$326
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:10 am
SGF
- EYW
1 stop5h 35m
American Airlines
Tue 8/251:50 pm
EYW
- SGF
2 stops9h 55m
American Airlines
Deal found 5/18![American Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:04 pm
MCI
- EYW
1 stop6h 39m
Delta
Mon 10/196:00 pm
EYW
- MCI
1 stop6h 58m
Delta
Deal found 5/21![Delta logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:51 am
SGF
- EYW
1 stop6h 00m
Allegiant Air
Fri 7/104:41 pm
EYW
- SGF
1 stop16h 10m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$397
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:38 am
SGF
- EYW
1 stop4h 42m
Delta
Tue 8/256:15 pm
EYW
- SGF
1 stop5h 06m
Delta
Deal found 5/21![Delta logo]()
$333
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:13 pm
MCI
- EYW
1 stop5h 30m
Delta
Sun 10/187:00 am
EYW
- MCI
1 stop6h 27m
Delta
Deal found 5/18![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:20 pm
MCI
- EYW
1 stop5h 33m
Delta
Thu 6/257:50 am
EYW
- MCI
1 stop5h 25m
Delta
Deal found 5/19![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:00 am
STL
- EYW
1 stop5h 00m
Delta
Tue 8/251:57 pm
EYW
- STL
1 stop4h 56m
Delta
Deal found 5/18![Delta logo]()
$362
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:53 pm
JLN
- EYW
3 stops31h 18m
United Airlines
Wed 10/284:05 pm
EYW
- JLN
1 stop8h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$644
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:40 am
SGF
- EYW
1 stop7h 03m
Delta
Fri 10/307:00 am
EYW
- SGF
1 stop5h 11m
Delta
Deal found 5/22![Delta logo]()
$386
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:53 pm
JLN
- EYW
2 stops48h 13m
United Airlines
Thu 10/294:05 pm
EYW
- JLN
1 stop8h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$728
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:39 pm
STL
- EYW
1 stop5h 14m
Delta
Mon 7/66:24 pm
EYW
- STL
1 stop6h 32m
Delta
Deal found 5/21![Delta logo]()
$416
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:13 pm
MCI
- EYW
1 stop5h 30m
Delta
Tue 10/207:00 am
EYW
- MCI
1 stop5h 09m
Delta
Deal found 5/22![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:40 am
JLN
- EYW
2 stops28h 54m
United Airlines
Mon 10/264:05 pm
EYW
- JLN
1 stop8h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$859
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:40 am
SGF
- EYW
1 stop7h 03m
Delta
Tue 10/277:00 am
EYW
- SGF
1 stop5h 11m
Delta
Deal found 5/22![Delta logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:53 pm
JLN
- EYW
2 stops48h 13m
United Airlines
Mon 10/264:05 pm
EYW
- JLN
1 stop8h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$872
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:40 am
SGF
- EYW
1 stop7h 03m
Delta
Tue 10/277:00 am
EYW
- SGF
1 stop5h 11m
Delta
Deal found 5/22![Delta logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:40 am
JLN
- EYW
2 stops28h 54m
United Airlines
Thu 10/294:05 pm
EYW
- JLN
2 stops26h 06m
United Airlines
Deal found 5/22![United Airlines logo]()
$884
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:38 am
MCI
- EYW
1 stop6h 50m
Delta
Mon 6/227:50 am
EYW
- MCI
1 stop5h 25m
Delta
Deal found 5/21![Delta logo]()
$438
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/119:21 am
STL
- EYW
1 stop7h 06m
Delta
Tue 6/166:24 pm
EYW
- STL
1 stop6h 32m
Delta
Deal found 5/18![Delta logo]()
$440
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:54 am
JLN
- EYW
1 stop29h 15m
United Airlines
Sat 6/62:26 pm
EYW
- JLN
2 stops23h 56m
United Airlines
Deal found 5/18![United Airlines logo]()
$949
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:59 pm
STL
- EYW
1 stop5h 50m
Delta
Thu 6/46:19 pm
EYW
- STL
1 stop6h 40m
Delta
Deal found 5/18![Delta logo]()
$462
Last-minute flights from Missouri to Key WestDiscover last-minute flight deals from Missouri to Key West. Data last updated May 23, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Key West. Data last updated May 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:08 am
STL
- EYW
2 stops8h 41m
American Airlines
Tue 6/25:37 pm
EYW
- STL
1 stop7h 22m
American Airlines
Deal found 5/18![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- EYW
1 stop8h 07m
United Airlines
Fri 6/53:55 pm
EYW
- STL
1 stop6h 35m
United Airlines
Deal found 5/22![United Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/510:40 am
MCI
- EYW
1 stop26h 18m
Multiple Airlines
Tue 6/91:14 pm
EYW
- MCI
2 stops29h 07m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:17 pm
STL
- EYW
1 stop21h 18m
Multiple Airlines
Mon 6/153:25 pm
EYW
- STL
2 stops27h 05m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:00 am
MCI
- EYW
1 stop27h 45m
Multiple Airlines
Fri 6/191:11 pm
EYW
- MCI
2 stops29h 10m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:00 am
MCI
- EYW
1 stop27h 45m
Multiple Airlines
Tue 6/231:14 pm
EYW
- MCI
2 stops29h 07m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:20 pm
MCI
- EYW
1 stop5h 33m
Delta
Thu 6/257:50 am
EYW
- MCI
1 stop5h 25m
Delta
Deal found 5/19![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:20 pm
MCI
- EYW
1 stop5h 33m
Delta
Wed 6/247:50 am
EYW
- MCI
2 stops12h 27m
Delta
Deal found 5/21![Delta logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:17 pm
STL
- EYW
1 stop18h 10m
Multiple Airlines
Wed 6/2411:46 am
EYW
- STL
2 stops30h 44m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:16 pm
MCI
- EYW
2 stops39h 08m
Multiple Airlines
Thu 6/254:12 pm
EYW
- MCI
1 stop18h 38m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:17 pm
MCI
- EYW
1 stop5h 32m
American Airlines
Thu 6/257:40 pm
EYW
- MCI
1 stop5h 10m
American Airlines
Deal found 5/21![American Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:16 pm
MCI
- EYW
2 stops39h 48m
Multiple Airlines
Thu 6/254:12 pm
EYW
- MCI
1 stop18h 38m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$348
One-way flights from Missouri to Key WestSearch for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
Search for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:24 pm
MCI
- EYW
2 stops39h 42m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:08 pm
STL
- EYW
2 stops14h 17m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:05 pm
MCI
- EYW
3 stops41h 19m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$313
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:51 am
STL
- EYW
1 stop5h 32m
Delta
Deal found 5/19![Delta logo]()
$348
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:55 am
STL
- EYW
2 stops10h 53m
American Airlines
Deal found 5/19![American Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:34 pm
MCI
- EYW
3 stops45h 50m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:22 am
STL
- EYW
1 stop6h 45m
United Airlines
Deal found 5/21![United Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:53 am
MCI
- EYW
1 stop6h 14m
United Airlines
Deal found 5/18![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:30 am
MCI
- EYW
2 stops12h 40m
American Airlines
Deal found 5/18![American Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
MCI
- EYW
1 stop8h 09m
United Airlines
Deal found 5/20![United Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:53 am
MCI
- EYW
1 stop6h 14m
United Airlines
Deal found 5/18![United Airlines logo]()
$448
Find flight deals from Missouri to Key West
Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated May 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $231 (Kiwi.com) |
One-way from | $217 (Kiwi.com) |
Popular in | October |
Cheapest in | December |
Average price | $449 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 7/7
9:24 am-5:23 pm
1 stop6h 59m
Key West
Tue 7/14
6:18 pm-10:15 pm
1 stop4h 57m
$293
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sat 8/22
1:53 pm-7:54 pm
1 stop5h 01m
Key West
Tue 9/1
6:00 pm-11:52 pm
1 stop6h 52m
$297
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 7/7
12:40 pm-6:48 pm
1 stop5h 08m
Key West
Tue 7/14
1:47 pm-8:55 pm
2 stops8h 08m
$298
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Mon 8/17
8:42 am-3:42 pm
1 stop6h 00m
Key West
Thu 8/20
10:00 am-9:33 am
2 stops24h 33m
$319
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 8/8
1:04 pm-7:54 pm
1 stop5h 50m
Key West
Wed 8/12
7:40 am-11:46 am
1 stop5h 06m
$326
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sat 7/11
6:00 am-4:42 pm
1 stop9h 42m
Key West
Tue 7/14
11:28 am-5:23 pm
1 stop6h 55m
$328
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Wed 10/14
12:04 pm-7:43 pm
1 stop6h 39m
Key West
Mon 10/19
6:00 pm-11:58 pm
1 stop6h 58m
$329
Quickest round-trip
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Tue 8/18
11:38 am-5:20 pm
1 stop4h 42m
Key West
Tue 8/25
6:15 pm-10:21 pm
1 stop5h 06m
$333
SpringfieldKey West
SGF - EYW
SGFEYW
Springfield-Branson
Tue 8/18
6:10 am-12:45 pm
1 stop5h 35m
Key West
Tue 8/25
1:50 pm-10:45 pm
2 stops9h 55m
$338
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Sun 10/11
1:13 pm-7:43 pm
1 stop5h 30m
Key West
Sun 10/18
7:00 am-12:27 pm
1 stop6h 27m
$349
Showing 1-10 of 40 resultsSorted by cheapest first
Best time to book a flight from Missouri to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Key West
USMO-EYW
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
What is the cheapest month to book a flight from Missouri to Key West?
Currently, November is the cheapest month in which you can book a flight from Missouri to Key West (average of $121). Flying from Missouri to Key West in April is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Key West?
How far ahead should I book a flight from Missouri to Key West?
Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Key West flight routes
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Alternative routes for Missouri to Key West
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Key West by cabin class
Find flights from Missouri to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 23, 2026.
Missouri and Key West flights
Browse other Missouri and Key West flight options. Last updated on May 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Key West flights
Consider these flights traveling from Missouri to Key West.
Top 3 airlines flying from Missouri to Key West
Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$164 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$502 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$262 | Average$406 | FlexibilityNo cancel fee | On-time69% |