$119+ Cheap flights from Missouri to Key West (EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Oct 2 — Oct 91
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to Key WestExplore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:30 pm -
1 stop16h 49m
Wed 10/2810:04 am -
2 stops8h 36m
Deal found 8/30![Multiple Airlines logo]()
$233
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:35 am -
1 stop6h 26m
Sat 12/124:49 pm -
1 stop8h 10m
Deal found 8/28![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:58 am -
1 stop6h 03m
Tue 11/176:35 pm -
1 stop6h 24m
Deal found 9/1![American Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:05 pm -
1 stop16h 15m
Sat 12/126:26 pm -
2 stops37h 43m
Deal found 8/31![Multiple Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:36 pm -
1 stop6h 26m
Tue 12/156:06 pm -
1 stop6h 59m
Deal found 9/1![Delta logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:23 pm -
1 stop19h 45m
Wed 12/94:40 pm -
1 stop25h 53m
Deal found 8/30![Allegiant Air logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:32 pm -
1 stop18h 06m
Mon 10/52:53 pm -
1 stop20h 05m
Deal found 9/1![Allegiant Air logo]()
$335
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:01 am -
1 stop7h 53m
Tue 10/275:28 pm -
1 stop6h 31m
Deal found 8/30![American Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop5h 53m
Wed 9/307:40 am -
1 stop6h 43m
Deal found 8/31![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:00 pm -
1 stop4h 57m
Wed 9/92:00 pm -
1 stop7h 02m
Deal found 8/28![Delta logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:05 pm -
1 stop15h 14m
Mon 12/710:59 am -
1 stop14h 42m
Deal found 8/28![Multiple Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:29 pm -
2 stops18h 50m
Sun 10/410:59 am -
1 stop6h 35m
Deal found 9/1![Multiple Airlines logo]()
$357
Best flights from Missouri to Key WestDiscover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
Discover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:05 am -
1 stop6h 18m
Tue 10/62:00 pm -
1 stop5h 15m
Deal found 8/30![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:30 am -
1 stop5h 59m
Sat 10/312:50 pm -
1 stop9h 04m
Deal found 8/27![United Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:37 am -
1 stop6h 34m
Sat 10/175:28 pm -
1 stop5h 31m
Deal found 8/27![American Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/38:26 am -
1 stop4h 54m
Sun 1/1010:59 am -
1 stop22h 54m
Deal found 8/30![Multiple Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/38:26 am -
1 stop4h 54m
Sun 1/104:25 pm -
2 stops25h 54m
Deal found 8/30![Allegiant Air logo]()
$466
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop5h 53m
Wed 9/307:40 am -
1 stop6h 43m
Deal found 8/31![Delta logo]()
$353
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am -
2 stops10h 55m
Tue 9/226:27 pm -
1 stop5h 32m
Deal found 8/31![American Airlines logo]()
$420
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:00 pm -
1 stop4h 57m
Wed 9/96:19 pm -
1 stop6h 32m
Deal found 8/30![Delta logo]()
$399
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:26 pm -
1 stop16h 53m
Sun 11/810:59 am -
1 stop13h 17m
Deal found 8/27![Multiple Airlines logo]()
$460
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am -
1 stop5h 53m
Sat 9/1911:42 am -
1 stop5h 50m
Deal found 8/31![Delta logo]()
$403
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/152:26 pm -
1 stop4h 34m
Sat 9/196:19 pm -
1 stop6h 32m
Deal found 8/31![Delta logo]()
$425
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:36 am -
1 stop6h 53m
Sat 10/312:50 pm -
2 stops31h 05m
Deal found 9/1![United Airlines logo]()
$616
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1711:36 am -
1 stop6h 10m
Mon 12/212:30 pm -
1 stop8h 31m
Deal found 8/31![American Airlines logo]()
$570
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:00 pm -
1 stop7h 00m
Sat 9/267:40 am -
1 stop5h 52m
Deal found 8/30![Delta logo]()
$450
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:13 pm -
1 stop20h 02m
Wed 2/35:51 pm -
1 stop6h 41m
Deal found 8/28![United Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:02 am -
1 stop4h 53m
Sun 12/65:05 pm -
1 stop8h 19m
Deal found 8/30![American Airlines logo]()
$592
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:00 pm -
1 stop7h 00m
Tue 9/296:19 pm -
1 stop6h 23m
Deal found 8/31![Delta logo]()
$450
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:43 am -
1 stop6h 17m
Sat 9/124:35 pm -
1 stop6h 18m
Deal found 8/28![Delta logo]()
$464
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:40 pm -
1 stop5h 20m
Mon 9/146:19 pm -
1 stop6h 23m
Deal found 8/28![Delta logo]()
$470
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 am -
2 stops11h 47m
Mon 10/192:34 pm -
1 stop5h 45m
Deal found 8/28![American Airlines logo]()
$705
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:50 am -
2 stops25h 04m
Thu 10/292:50 pm -
2 stops26h 21m
Deal found 8/29![United Airlines logo]()
$796
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/121:38 pm -
2 stops24h 48m
Wed 12/164:10 pm -
1 stop21h 33m
Deal found 8/29![United Airlines logo]()
$857
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:44 am -
1 stop6h 09m
Sun 10/47:40 am -
1 stop6h 41m
Deal found 8/28![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:32 am -
1 stop5h 38m
Mon 11/307:25 am -
1 stop5h 50m
Deal found 8/29![Delta logo]()
$652
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:06 am -
1 stop5h 47m
Thu 9/246:19 pm -
1 stop4h 49m
Deal found 9/1![Delta logo]()
$654
Last-minute flights from Missouri to Key WestDiscover last-minute flight deals from Missouri to Key West. Data last updated September 2, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Key West. Data last updated September 2, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:00 pm -
1 stop4h 57m
Wed 9/92:00 pm -
1 stop7h 02m
Deal found 8/28![Delta logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:19 pm -
1 stop16h 00m
Thu 9/1710:59 am -
2 stops27h 11m
Deal found 8/29![Multiple Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:26 pm -
1 stop4h 34m
Tue 9/296:19 pm -
1 stop6h 32m
Deal found 8/30![Delta logo]()
$373
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop5h 53m
Wed 9/307:40 am -
1 stop6h 43m
Deal found 8/31![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:05 am -
1 stop6h 18m
Tue 10/62:00 pm -
1 stop5h 15m
Deal found 8/30![Delta logo]()
$303
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:20 pm -
1 stop6h 40m
Wed 10/76:10 pm -
1 stop6h 46m
Deal found 8/31![Delta logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:32 pm -
1 stop18h 06m
Mon 10/52:53 pm -
1 stop20h 05m
Deal found 9/1![Allegiant Air logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:29 pm -
2 stops18h 50m
Sun 10/410:59 am -
1 stop6h 35m
Deal found 9/1![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:32 pm -
2 stops35h 02m
Sat 10/109:52 am -
1 stop25h 29m
Deal found 8/27![Multiple Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:00 pm -
1 stop7h 01m
Tue 10/276:10 pm -
1 stop6h 44m
Deal found 8/31![Delta logo]()
$331
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:01 am -
1 stop7h 53m
Tue 10/275:28 pm -
1 stop6h 31m
Deal found 8/27![American Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:30 pm -
1 stop16h 49m
Wed 10/2810:04 am -
2 stops8h 36m
Deal found 8/30![Multiple Airlines logo]()
$233
One-way flights from Missouri to Key WestSearch for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
Search for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated September 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:44 pm -
2 stops37h 40m
Deal found 8/29![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:59 pm -
2 stops19h 22m
Deal found 9/1![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/14:26 pm -
1 stop20h 21m
Deal found 9/1![Allegiant Air logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:05 pm -
3 stops40h 16m
Deal found 9/1![Multiple Airlines logo]()
$240
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:00 am -
1 stop8h 29m
Deal found 8/29![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/16:14 am -
2 stops8h 50m
Deal found 8/31![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:21 am -
1 stop6h 34m
Deal found 8/31![American Airlines logo]()
$370
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/17:12 am -
2 stops11h 09m
Deal found 9/1![American Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:17 pm -
3 stops46h 04m
Deal found 8/31![Multiple Airlines logo]()
$445
Find flight deals from Missouri to Key West
Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated September 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Kiwi.com) |
One-way from | $119 (Kiwi.com) |
Popular in | October |
Cheapest in | December |
Average price | $551 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Tue 9/29
10:05 am-5:23 pm
1 stop6h 18m
Key West
Tue 10/6
2:00 pm-6:15 pm
1 stop5h 15m
$303
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Wed 10/28
8:30 am-3:29 pm
1 stop5h 59m
Key West
Sat 10/31
2:50 pm-10:54 pm
1 stop9h 04m
$321
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Tue 10/13
8:37 am-4:11 pm
1 stop6h 34m
Key West
Sat 10/17
5:28 pm-9:59 pm
1 stop5h 31m
$353
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Sat 9/26
6:00 am-12:53 pm
1 stop5h 53m
Key West
Wed 9/30
7:40 am-1:23 pm
1 stop6h 43m
$353
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Sat 9/5
2:00 pm-7:57 pm
1 stop4h 57m
Key West
Wed 9/9
6:19 pm-11:51 pm
1 stop6h 32m
$399
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Tue 9/15
6:00 am-12:53 pm
1 stop5h 53m
Key West
Sat 9/19
11:42 am-4:32 pm
1 stop5h 50m
$403
SpringfieldKey West
SGF Springfield-Branson - EYW Key West
SGFEYW
Springfield-Branson
Sun 1/3
8:26 am-2:20 pm
1 stop4h 54m
Key West
Sun 1/10
10:59 am-8:53 am
1 stop22h 54m
$409
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Tue 9/15
6:00 am-5:55 pm
2 stops10h 55m
Key West
Tue 9/22
6:27 pm-10:59 pm
1 stop5h 32m
$420
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Tue 9/15
2:26 pm-8:00 pm
1 stop4h 34m
Key West
Sat 9/19
6:19 pm-11:51 pm
1 stop6h 32m
$425
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Tue 9/22
12:00 pm-8:00 pm
1 stop7h 00m
Key West
Sat 9/26
7:40 am-12:32 pm
1 stop5h 52m
$450
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from Missouri to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Key West
USMO-EYW
STL-EYW
MCI-EYW
SGF-EYW
JLN-EYW
What is the cheapest month to book a flight from Missouri to Key West?
Currently, January is the cheapest month in which you can book a flight from Missouri to Key West (average of $369). Flying from Missouri to Key West in October is currently the most expensive (average of $591). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Key West?
Airfare is below average for this route at the moment.
Missouri to Key West flights typically cost between $457 and $704 in October.The cheapest round-trip price found within the last 5 days was $233 on Multiple Airlines (Oct 24-Oct 28).
How far ahead should I book a flight from Missouri to Key West?
Booking 61 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Key West
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Complete your trip
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Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 2, 2026.
Missouri and Key West flights
Browse other Missouri and Key West flight options. Last updated on September 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Key West flights
Consider these flights traveling from Missouri to Key West.
Top 3 airlines flying from Missouri to Key West
Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$222 | Average$514 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$242 | Average$543 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$400 | FlexibilityNo cancel fee | On-time69% |