$166+ Cheap flights from Missouri to Key West (EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Nov 22 — Nov 291
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Key West
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Cheapest flights from Missouri to Key WestExplore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2026.
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:02 pm -
2 stops21h 17m
Tue 12/1510:59 am -
1 stop14h 13m
Deal found 10/21![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:02 pm -
2 stops21h 17m
Tue 12/1510:59 am -
1 stop14h 13m
Deal found 10/20![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:02 pm -
2 stops21h 17m
Mon 12/1410:59 am -
1 stop14h 13m
Deal found 10/20![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:23 pm -
1 stop19h 45m
Sat 12/194:01 pm -
1 stop28h 02m
Deal found 10/18![Allegiant Air logo]()
$339
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:36 pm -
1 stop6h 25m
Sat 12/56:06 pm -
1 stop6h 59m
Deal found 10/21![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:01 am -
1 stop26h 00m
Fri 11/2012:59 pm -
2 stops31h 35m
Deal found 10/21![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:29 pm -
2 stops12h 50m
Sun 12/67:22 pm -
1 stop15h 13m
Deal found 10/22![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
2 stops36h 01m
Wed 11/412:54 pm -
1 stop21h 37m
Deal found 10/22![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:26 pm -
1 stop15h 04m
Sun 11/227:20 pm -
1 stop18h 05m
Deal found 10/18![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/207:53 pm -
1 stop18h 14m
Fri 12/2510:59 am -
1 stop7h 07m
Deal found 10/22![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:26 pm -
1 stop15h 04m
Tue 11/101:16 pm -
2 stops29h 26m
Deal found 10/21![Multiple Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:58 am -
1 stop6h 03m
Mon 12/711:26 am -
1 stop6h 31m
Deal found 10/19![American Airlines logo]()
$380
Best flights from Missouri to Key WestDiscover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2026.
Discover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/16:00 am -
2 stops9h 22m
Sat 3/64:45 pm -
1 stop6h 40m
Deal found 10/22![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:39 am -
1 stop8h 49m
Sat 2/62:36 pm -
1 stop5h 33m
Deal found 10/18![American Airlines logo]()
$400
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am -
1 stop6h 55m
Mon 12/286:20 pm -
1 stop4h 44m
Deal found 10/22![Delta logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:03 am -
1 stop4h 28m
Sun 1/36:20 pm -
1 stop15h 28m
Deal found 10/18![Allegiant Air logo]()
$534
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:05 pm -
1 stop15h 14m
Sat 11/289:58 am -
2 stops15h 01m
Deal found 10/22![Multiple Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/176:10 am -
1 stop8h 45m
Mon 3/224:45 pm -
1 stop6h 40m
Deal found 10/18![United Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/317:36 am -
2 stops10h 32m
Tue 4/68:05 am -
1 stop7h 38m
Deal found 10/21![American Airlines logo]()
$476
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/293:48 pm -
1 stop4h 10m
Tue 1/56:00 pm -
1 stop6h 39m
Deal found 10/22![Delta logo]()
$491
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/166:00 am -
2 stops9h 22m
Mon 3/224:45 pm -
1 stop6h 40m
Deal found 10/18![United Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:46 am -
2 stops8h 44m
Thu 2/254:45 pm -
1 stop6h 58m
Deal found 10/23![American Airlines logo]()
$481
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1711:42 am -
1 stop7h 19m
Mon 12/216:20 pm -
1 stop5h 22m
Deal found 10/18![Delta logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/254:26 pm -
1 stop20h 21m
Sat 1/22:37 pm -
1 stop17h 59m
Deal found 10/21![Allegiant Air logo]()
$565
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:40 am -
1 stop6h 19m
Thu 11/267:30 am -
1 stop7h 01m
Deal found 10/18![Delta logo]()
$505
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/157:12 am -
1 stop7h 28m
Thu 4/224:20 pm -
1 stop7h 22m
Deal found 10/18![American Airlines logo]()
$507
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:36 am -
1 stop6h 50m
Wed 12/1612:05 pm -
1 stop6h 37m
Deal found 10/21![United Airlines logo]()
$549
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:00 am -
1 stop6h 20m
Sat 11/77:40 am -
1 stop6h 40m
Deal found 10/20![Delta logo]()
$512
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/287:36 am -
1 stop9h 02m
Sat 3/64:45 pm -
1 stop6h 26m
Deal found 10/21![American Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:35 am -
1 stop6h 54m
Wed 11/114:10 pm -
1 stop8h 00m
Deal found 10/23![United Airlines logo]()
$562
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:09 pm -
1 stop15h 10m
Sun 11/2912:01 pm -
2 stops30h 39m
Deal found 10/18![Multiple Airlines logo]()
$749
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/101:20 pm -
1 stop5h 41m
Mon 12/146:06 pm -
1 stop6h 50m
Deal found 10/20![Delta logo]()
$579
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:00 am -
1 stop6h 29m
Tue 11/104:10 pm -
1 stop7h 48m
Deal found 10/21![United Airlines logo]()
$593
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:38 am -
2 stops7h 52m
Tue 12/82:36 pm -
1 stop8h 44m
Deal found 10/18![American Airlines logo]()
$622
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/169:00 am -
1 stop7h 11m
Tue 1/196:00 pm -
1 stop6h 39m
Deal found 10/19![Delta logo]()
$581
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:45 am -
1 stop6h 37m
Tue 1/124:09 pm -
1 stop8h 21m
Deal found 10/21![United Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/138:14 am -
2 stops8h 12m
Sat 1/1612:55 pm -
2 stops9h 55m
Deal found 10/18![American Airlines logo]()
$623
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:36 pm -
1 stop6h 25m
Tue 12/86:06 pm -
1 stop6h 59m
Deal found 10/18![Delta logo]()
$595
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/257:12 am -
1 stop7h 41m
Wed 3/3111:30 am -
2 stops12h 13m
Deal found 10/22![American Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:45 am -
1 stop6h 37m
Thu 1/143:15 pm -
2 stops20h 31m
Deal found 10/21![United Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:12 am -
1 stop5h 54m
Thu 11/124:45 pm -
1 stop6h 57m
Deal found 10/19![American Airlines logo]()
$626
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 am -
1 stop5h 59m
Fri 11/132:51 pm -
1 stop8h 09m
Deal found 10/18![United Airlines logo]()
$657
Last-minute flights from Missouri to Key WestDiscover last-minute flight deals from Missouri to Key West. Data last updated October 23, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Key West. Data last updated October 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:56 am -
1 stop27h 17m
Thu 11/58:54 am -
2 stops24h 52m
Deal found 10/22![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
2 stops36h 01m
Wed 11/412:54 pm -
1 stop21h 37m
Deal found 10/22![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:48 am -
1 stop24h 16m
Sun 11/88:54 pm -
1 stop22h 28m
Deal found 10/21![Allegiant Air logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:28 pm -
2 stops19h 51m
Mon 11/99:20 am -
1 stop14h 56m
Deal found 10/22![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:26 pm -
1 stop15h 04m
Tue 11/101:16 pm -
2 stops29h 26m
Deal found 10/21![Multiple Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:34 pm -
2 stops14h 45m
Sun 11/1510:59 am -
1 stop13h 17m
Deal found 10/21![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:26 pm -
1 stop16h 53m
Tue 11/171:16 pm -
2 stops29h 26m
Deal found 10/19![Multiple Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:29 pm -
1 stop5h 33m
Tue 11/176:35 pm -
1 stop6h 24m
Deal found 10/20![American Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:01 am -
1 stop26h 00m
Fri 11/2012:59 pm -
2 stops31h 35m
Deal found 10/21![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:26 pm -
1 stop15h 04m
Sun 11/227:20 pm -
1 stop18h 05m
Deal found 10/18![Multiple Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:58 am -
1 stop6h 03m
Mon 12/711:26 am -
1 stop6h 31m
Deal found 10/19![American Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:11 am -
1 stop22h 13m
Mon 11/303:06 pm -
2 stops29h 27m
Deal found 10/20![Multiple Airlines logo]()
$398
One-way flights from Missouri to Key WestSearch for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated October 23, 2026.
Search for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated October 23, 2026.
This WAYA deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:02 pm -
1 stop21h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:34 pm -
2 stops39h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:18 pm -
2 stops14h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:29 pm -
2 stops40h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/89:49 pm -
3 stops36h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:15 pm -
1 stop20h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
2 stops35h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:44 pm -
2 stops14h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:29 pm -
3 stops43h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Allegiant Air logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:37 pm -
3 stops24h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/89:30 am -
1 stop6h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:30 am -
1 stop6h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![United Airlines logo]()
$329
Find flight deals from Missouri to Key West
Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated October 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $219 (Kiwi.com) |
One-way from | $166 (WAYA) |
Popular in | October |
Cheapest in | January |
Average price | $656 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 23, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Thu 12/10
5:02 pm-3:08 pm
1 stop21h 06m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$166
SpringfieldKey West
SGF Springfield-Branson - EYW Key West
SGFEYW
Springfield-Branson
Mon 2/8
9:49 pm-11:39 am
3 stops36h 50m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$234
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Wed 11/18
6:34 pm-10:46 am
3 stops39h 12m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$237
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Fri 10/30
8:43 pm-9:22 am
2 stops35h 39m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$244
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Wed 11/4
4:18 pm-11:19 am
3 stops42h 01m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$268
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Fri 11/20
3:30 pm-11:18 am
3 stops42h 48m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$271
St. LouisKey West
STL Lambert-St Louis - EYW Key West
STLEYW
Lambert-St Louis
Wed 10/28
6:44 pm-10:19 am
2 stops14h 35m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$289
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Fri 10/30
5:29 pm-1:38 pm
3 stops43h 09m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$291
Kansas CityKey West
MCI Kansas City - EYW Key West
MCIEYW
Kansas City
Thu 11/19
1:37 pm-3:16 pm
3 stops24h 39m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$316
SpringfieldKey West
SGF Springfield-Branson - EYW Key West
SGFEYW
Springfield-Branson
Wed 11/18
7:49 am-5:15 pm
2 stops8h 26m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$378
Showing 1-10 of 55 resultsSorted by cheapest first
Best time to book a flight from Missouri to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
MCI-EYW
SGF-EYW
STL-EYW
COU-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Key West
USMO-EYW
MCI-EYW
SGF-EYW
STL-EYW
COU-EYW
What is the cheapest month to book a flight from Missouri to Key West?
Currently, January is the cheapest month in which you can book a flight from Missouri to Key West (average of $377). Flying from Missouri to Key West in October is currently the most expensive (average of $613). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Key West?
Airfare is below average for this route at the moment.
Missouri to Key West flights typically cost between $460 and $698 in December.The cheapest round-trip price found within the last 5 days was $259 on Multiple Airlines (Dec 7-Dec 15).
How far ahead should I book a flight from Missouri to Key West?
Booking 29 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Key West
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Key West by cabin class
Find flights from Missouri to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 23, 2026.
Missouri and Key West flights
Browse other Missouri and Key West flight options. Last updated on October 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Key West flights
Consider these flights traveling from Missouri to Key West.
Top 3 airlines flying from Missouri to Key West
Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$223 | Average$527 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$230 | Average$550 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$401 | FlexibilityNo cancel fee | On-time69% |