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Key Largo

$466+ Cheap flights from Florence, SC (FLO) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MIA
May 10 — May 171
Sun 5/10
Sun 5/17
1 adult, Economy
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Cheap flight deals from Florence to Key Largo

Cheapest flights from Florence to Key Largo
Explore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.

This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:35 pm
FLO
-
MIA
1 stop4h 22m
American Airlines
Sat 7/115:23 pm
MIA
-
FLO
1 stop4h 21m
American Airlines
Deal found 4/7$531
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:35 pm
FLO
-
MIA
1 stop7h 09m
American Airlines
Mon 7/135:23 pm
MIA
-
FLO
1 stop4h 21m
American Airlines
Deal found 4/5$539
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:35 pm
FLO
-
MIA
1 stop7h 09m
American Airlines
Sun 7/267:50 am
MIA
-
FLO
1 stop6h 20m
American Airlines
Deal found 4/5$559
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:16 pm
FLO
-
MIA
1 stop4h 31m
American Airlines
Tue 4/2811:26 am
MIA
-
FLO
1 stop4h 06m
American Airlines
Deal found 4/9$590
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:20 am
FLO
-
MIA
1 stop3h 55m
American Airlines
Mon 4/2011:26 am
MIA
-
FLO
1 stop4h 24m
American Airlines
Deal found 4/10$591
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:16 pm
FLO
-
MIA
1 stop4h 31m
American Airlines
Sun 4/195:30 pm
MIA
-
FLO
1 stop4h 17m
American Airlines
Deal found 4/8$621
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:34 pm
FLO
-
MIA
2 stops7h 29m
American Airlines
Fri 9/116:10 am
MIA
-
FLO
1 stop4h 11m
American Airlines
Deal found 4/6$867
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:16 pm
FLO
-
MIA
1 stop14h 58m
American Airlines
Sat 5/28:35 am
MIA
-
FLO
2 stops7h 15m
American Airlines
Deal found 4/7$911

Find flight deals from Florence to Key Largo

Keep the following information in mind while searching for Florence to Key Largo flight deals. Data was last updated April 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$531
(American Airlines)

One-way from

$466
(American Airlines)
Provider with most accurate pricing for Florence-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Miami flights.
Search Deals
From Florence to Key Largo
Search Deals
One-way flight from Florence to Key Largo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Florence to Key Largo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Mon 7/6

2:35 pm-6:57 pm

1 stop4h 22m

Miami

Sat 7/11

5:23 pm-9:44 pm

1 stop4h 21m

$531

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Thu 7/9

2:35 pm-9:44 pm

1 stop7h 09m

Miami

Mon 7/13

5:23 pm-9:44 pm

1 stop4h 21m

$539

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 9/4

5:14 am-9:07 am

1 stop3h 53m

Miami

Fri 9/11

5:30 pm-12:13 am

1 stop6h 43m

$539

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Thu 7/23

2:35 pm-9:44 pm

1 stop7h 09m

Miami

Sun 7/26

7:50 am-2:10 pm

1 stop6h 20m

$559
Quickest round-trip

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 4/24

4:16 pm-8:47 pm

1 stop4h 31m

Miami

Tue 4/28

11:26 am-3:32 pm

1 stop4h 06m

$590

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 5/1

4:16 pm-8:47 pm

1 stop4h 31m

Miami

Sat 5/2

3:40 pm-9:47 pm

1 stop6h 07m

$590

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 5/1

4:16 pm-8:47 pm

1 stop4h 31m

Miami

Mon 5/4

5:30 pm-9:47 pm

1 stop4h 17m

$621
Cheapest one-way

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Thu 5/14

4:16 pm-10:51 pm

1 stop6h 35m

$466
Quickest one-way

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 5/29

5:05 am-9:17 am

1 stop4h 12m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/7

Sorted by cheapest first

Best time to book a flight from Florence to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Key Largo

What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

Currently, December is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $33). Flying from Florence, South Carolina to Key Largo in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Key Largo?

    Most people fly from Florence (FLO) if they book a flight from Florence to Key Largo. On average, Florence has 0 outbound flights to Key Largo per day from 0 airlines. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Key Largo?

    For as low as $531, American Airlines can have you in Key Largo from Florence, South Carolina in 4h 22m. There are 580 mi between Florence, South Carolina and Key Largo.

  • Can I find deals for flights from Florence to Key Largo that include hotel bookings?

    Yes. In addition to deals on Florence to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Key Largo.

  • Can I find deals for business class flights from Florence to Key Largo?

    Yes. Cheapflights offers flight deals from Florence to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

    Currently, December is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $33). Flying from Florence, South Carolina to Key Largo in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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