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Key Largo

$438+ Cheap flights from Florence, SC (FLO) to Key Largo, FL

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MIA
sep. 2 — sep. 91
mar. 9/2
mar. 9/9
1 adult, Economy
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Cheap flight deals from Florence to Key Largo

Keep the following information in mind while searching for Florence to Key Largo flight deals. Data was last updated agosto 28, 2025.

Round-trip from

$438
(American Airlines)
From Florence to Key Largo
Search Deals

Find flight deals from Florence to Key Largo

Cheapest flights from Florence to Key Largo
Explore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 28, 2025.

This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/206:14 amFLO - MIA
2 stops10h 14mAmerican Airlines
lun. 9/225:18 amMIA - FLO
1 stop6h 44mAmerican Airlines
Deal found 8/27$438
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/106:14 amFLO - MIA
1 stop6h 02mAmerican Airlines
dom. 9/147:37 pmMIA - FLO
1 stop4h 36mAmerican Airlines
Deal found 8/25$473
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/255:14 amFLO - MIA
1 stop3h 59mAmerican Airlines
dom. 9/286:10 amMIA - FLO
1 stop4h 43mAmerican Airlines
Deal found 8/27$500
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/54:57 pmFLO - MIA
1 stop6h 13mAmerican Airlines
jue. 10/95:18 amMIA - FLO
1 stop5h 28mAmerican Airlines
Deal found 8/28$507
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/115:14 amFLO - MIA
1 stop5h 52mAmerican Airlines
lun. 9/154:02 pmMIA - FLO
1 stop7h 14mAmerican Airlines
Deal found 8/26$521
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1212:27 pmFLO - MIA
1 stop4h 16mAmerican Airlines
mar. 9/167:06 amMIA - FLO
2 stops10h 06mAmerican Airlines
Deal found 8/27$772

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
Use the filters below to find and compare flights from Florence to Key Largo that are best for you.

Fly from

Florence

Fly to

Key Largo

Route

Depart

Return

Price

FlorenceMiami

FLO - MIA

FLOMIA

Florence

sáb. 9/20

6:14 am-4:28 pm

2 stops10h 14m

Miami

lun. 9/22

5:18 am-12:02 pm

1 stop6h 44m

$438

FlorenceMiami

FLO - MIA

FLOMIA

Florence

mié. 9/10

6:14 am-12:16 pm

1 stop6h 02m

Miami

dom. 9/14

7:37 pm-12:13 am

1 stop4h 36m

$473

FlorenceMiami

FLO - MIA

FLOMIA

Florence

vie. 9/12

6:14 am-12:16 pm

1 stop6h 02m

Miami

mar. 9/16

4:02 pm-11:16 pm

1 stop7h 14m

$473

FlorenceMiami

FLO - MIA

FLOMIA

Florence

jue. 9/25

5:14 am-9:13 am

1 stop3h 59m

Miami

dom. 9/28

6:10 am-10:53 am

1 stop4h 43m

$500

FlorenceMiami

FLO - MIA

FLOMIA

Florence

dom. 10/5

4:57 pm-11:10 pm

1 stop6h 13m

Miami

jue. 10/9

6:20 am-10:46 am

1 stop4h 26m

$507

FlorenceMiami

FLO - MIA

FLOMIA

Florence

jue. 9/11

5:14 am-11:06 am

1 stop5h 52m

Miami

lun. 9/15

4:02 pm-11:16 pm

1 stop7h 14m

$521

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/27

Best time to book a flight from Florence to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Key Largo

What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $232). Flying from Florence, South Carolina to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated agosto 28, 2025.
Get a feel of what it's like to fly with American Airlines from Florence to Key Largo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.5

Boarding

7.5

Overall

7.2

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.5

Boarding

7.5

Overall

7.2

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Florence to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Key Largo?

    Most people fly from Florence (FLO) if they book a flight from Florence to Key Largo. On average, Florence has 0 outbound flights to Key Largo per day from 1 airline. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Key Largo?

    For as low as $438, American Airlines can have you in Key Largo from Florence, South Carolina in 10h 14m. There are 580 mi between Florence, South Carolina and Key Largo.

  • Can I find deals for flights from Florence to Key Largo that include hotel bookings?

    Yes. In addition to deals on Florence to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Key Largo.

  • Can I find deals for business class flights from Florence to Key Largo?

    Yes. Cheapflights offers flight deals from Florence to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $232). Flying from Florence, South Carolina to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Florence to Key Largo

Discover the top airline that operate flights from Florence to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$424Average$520FlexibilityNo cancel feeOn-time71%

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