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Key Largo

$350+ Cheap flights from Florence, SC (FLO) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MIA
Feb 11 — Feb 181
Wed 2/11
Wed 2/18
1 adult, Economy
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Cheap flight deals from Florence to Key Largo

Keep the following information in mind while searching for Florence to Key Largo flight deals. Data was last updated January 12, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$479
(American Airlines)

One-way from

$426
(American Airlines)
Provider with most accurate pricing for Florence-Miami flight deals.
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Provider most trusted by Cheapflights users for Florence-Miami flights.
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From Florence to Key Largo
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One-way flight from Florence to Key Largo
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Find flight deals from Florence to Key Largo

Cheapest flights from Florence to Key Largo
Explore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 12, 2026.

This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:25 pm
FLO
-
MIA
1 stop5h 18m
American Airlines
Sun 3/295:30 pm
MIA
-
FLO
1 stop6h 27m
American Airlines
Deal found 1/11$481
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:16 am
FLO
-
MIA
1 stop5h 57m
American Airlines
Mon 3/25:30 pm
MIA
-
FLO
1 stop6h 27m
American Airlines
Deal found 1/12$499
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/236:15 am
FLO
-
MIA
1 stop4h 43m
American Airlines
Tue 1/275:36 pm
MIA
-
FLO
1 stop5h 07m
American Airlines
Deal found 1/11$548
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:25 pm
FLO
-
MIA
1 stop5h 18m
American Airlines
Sat 2/215:29 pm
MIA
-
FLO
2 stops6h 28m
American Airlines
Deal found 1/11$801
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/185:36 pm
FLO
-
MIA
1 stop4h 46m
American Airlines
Tue 1/205:36 pm
MIA
-
FLO
1 stop5h 07m
American Airlines
Deal found 1/11$957

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Florence to Key Largo that are best for you.

Fly from

Florence

Fly to

Key Largo

Route

Depart

Return

Price

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 3/21

6:25 pm-11:43 pm

1 stop5h 18m

Miami

Sun 3/29

5:30 pm-11:57 pm

1 stop6h 27m

$481

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Thu 2/26

5:16 am-11:13 am

1 stop5h 57m

Miami

Mon 3/2

5:30 pm-11:57 pm

1 stop6h 27m

$499

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 1/23

6:15 am-10:58 am

1 stop4h 43m

Miami

Tue 1/27

5:36 pm-10:43 pm

1 stop5h 07m

$548

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 2/14

6:25 pm-11:43 pm

1 stop5h 18m

Miami

Sat 2/21

6:56 pm-11:57 pm

1 stop5h 01m

$548

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 2/14

5:16 am-8:23 pm

2 stops15h 07m

$350

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 2/8

5:36 pm-10:22 pm

1 stop4h 46m

$426

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 2/15

5:16 am-4:23 pm

2 stops11h 07m

$428

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Mon 2/16

5:16 am-4:23 pm

2 stops11h 07m

$428

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Best time to book a flight from Florence to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Key Largo

What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

Currently, March is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $33). Flying from Florence, South Carolina to Key Largo in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Key Largo?

    Most people fly from Florence (FLO) if they book a flight from Florence to Key Largo. On average, Florence has 0 outbound flights to Key Largo per day from 0 airlines. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Key Largo?

    For as low as $481, American Airlines can have you in Key Largo from Florence, South Carolina in 5h 18m. There are 580 mi between Florence, South Carolina and Key Largo.

  • Can I find deals for flights from Florence to Key Largo that include hotel bookings?

    Yes. In addition to deals on Florence to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Key Largo.

  • Can I find deals for business class flights from Florence to Key Largo?

    Yes. Cheapflights offers flight deals from Florence to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Key Largo?

    Currently, March is the cheapest month in which you can book a flight from Florence, South Carolina to Key Largo (average of $33). Flying from Florence, South Carolina to Key Largo in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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