HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Jacksonville

$81+ Cheap flights from Missouri to Jacksonville (JAX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — JAX
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Jacksonville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Jacksonville

Cheapest flights from Missouri to Jacksonville
Explore the most affordable flight options available from Missouri to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amMCI - JAX
1 stop6h 51mDelta
Wed 12/311:44 pmJAX - MCI
1 stop6h 54mDelta
Deal found 12/14$269
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amMCI - JAX
1 stop6h 51mDelta
Tue 12/305:01 pmJAX - MCI
1 stop5h 07mDelta
Deal found 12/14$344
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:53 pmSTL - JAX
1 stop4h 59mAmerican Airlines
Fri 1/26:00 amJAX - STL
1 stop5h 50mAmerican Airlines
Deal found 12/12$344
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:13 pmSTL - JAX
1 stop5h 19mUnited Airlines
Sat 12/204:55 pmJAX - STL
1 stop6h 00mUnited Airlines
Deal found 12/13$351
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:33 amSGF - JAX
1 stop4h 42mAmerican Airlines
Sat 12/204:55 pmJAX - SGF
1 stop8h 01mAmerican Airlines
Deal found 12/14$359
This Delta deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:00 amMCI - JAX
1 stop6h 51mDelta
Thu 1/16:00 amJAX - MCI
1 stop6h 32mDelta
Deal found 12/12$368
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:10 pmSTL - JAX
1 stop5h 32mUnited Airlines
Mon 12/297:40 amJAX - STL
1 stop5h 47mUnited Airlines
Deal found 12/13$374
This Southwest deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:15 amSTL - JAX
Nonstop2h 00mSouthwest
Fri 1/27:35 pmJAX - STL
1 stop5h 30mSouthwest
Deal found 12/12$377
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amMCI - JAX
1 stop6h 51mDelta
Sun 12/287:59 pmJAX - MCI
1 stop4h 57mDelta
Deal found 12/14$379
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:35 pmMCI - JAX
1 stop6h 08mDelta
Wed 12/311:44 pmJAX - MCI
1 stop6h 54mDelta
Deal found 12/14$394
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:14 amMCI - JAX
1 stop8h 07mAmerican Airlines
Sun 12/286:05 pmJAX - MCI
1 stop6h 48mAmerican Airlines
Deal found 12/13$399
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:00 amMCI - JAX
2 stops7h 53mAmerican Airlines
Tue 12/309:33 amJAX - MCI
1 stop6h 19mAmerican Airlines
Deal found 12/15$405

Find flight deals from Missouri to Jacksonville

Keep the following information in mind while searching for Missouri to Jacksonville flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$224
(Kiwi.com)

One-way from

$81
(Priceline)

Popular in

December

Cheapest in

October

Average price

$367

Good round-trip deal

$377 or less
Provider with most accurate pricing for Lambert-St Louis-Jacksonville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Jacksonville flights.
Search Deals
From Missouri to Jacksonville
Search Deals
One-way flight from Missouri to Jacksonville
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($21 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Missouri to Jacksonville.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Missouri to Jacksonville that are best for you.

Fly from

Missouri

Fly to

Jacksonville

Route

Depart

Return

Price

SpringfieldJacksonville

SGF - JAX

SGFJAX

Springfield-Branson

Fri 1/9

5:00 pm-11:58 pm

1 stop5h 58m

Jacksonville

Fri 1/16

5:30 am-11:20 am

1 stop6h 50m

$269

SpringfieldJacksonville

SGF - JAX

SGFJAX

Springfield-Branson

Fri 1/30

12:26 pm-8:58 pm

1 stop7h 32m

Jacksonville

Thu 2/12

6:13 pm-10:13 pm

1 stop5h 00m

$269

Kansas CityJacksonville

MCI - JAX

MCIJAX

Kansas City

Wed 12/24

8:00 am-3:51 pm

1 stop6h 51m

Jacksonville

Wed 12/31

1:44 pm-7:38 pm

1 stop6h 54m

$269

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Thu 2/26

8:55 pm-11:50 pm

Nonstop1h 55m

Jacksonville

Mon 3/2

7:35 am-8:55 am

Nonstop2h 20m

$291

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Sat 1/17

8:45 am-11:45 am

Nonstop2h 00m

Jacksonville

Mon 1/19

7:35 am-8:55 am

Nonstop2h 20m

$291

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Wed 1/14

7:10 am-2:18 pm

1 stop6h 08m

Jacksonville

Wed 1/21

6:30 am-11:54 am

1 stop6h 24m

$301

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Sat 1/31

5:04 pm-11:59 pm

1 stop5h 55m

Jacksonville

Thu 2/5

7:30 am-11:04 am

1 stop4h 34m

$301

SpringfieldJacksonville

SGF - JAX

SGFJAX

Springfield-Branson

Fri 1/16

12:45 pm-6:00 pm

1 stop4h 15m

Jacksonville

Sun 1/18

4:31 pm-9:00 pm

1 stop5h 29m

$303

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Sat 1/24

1:15 pm-9:44 pm

1 stop7h 29m

Jacksonville

Sun 1/25

4:38 pm-10:58 pm

1 stop7h 20m

$309

St. LouisJacksonville

STL - JAX

STLJAX

Lambert-St Louis

Sat 1/17

7:00 am-3:42 pm

1 stop7h 42m

Jacksonville

Sun 1/18

8:00 am-12:29 pm

1 stop5h 29m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Missouri to Jacksonville

Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Jacksonville

What is the cheapest month to book a flight from Missouri to Jacksonville?

Currently, October is the cheapest month in which you can book a flight from Missouri to Jacksonville (average of $163). Flying from Missouri to Jacksonville in December is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to JAX?

Find hourly flight availability from Missouri to Jacksonville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

It’s optimal to fly from Missouri to Jacksonville in the evening. By choosing this option you can save up to 41% on the cost of your flight, compared to a flight in the morning.

What is the cheapest day to fly from Missouri to Jacksonville?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Jacksonville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Jacksonville flight should consider departing on Monday evenings when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Jacksonville from Missouri?

    Most people fly into Jacksonville (JAX) if they book a flight to Jacksonville from Missouri. Jacksonville is conveniently located just 11.2 mi from Jacksonville’s city center.

  • How long is the flight from Missouri to Jacksonville?

    Departing from Missouri to Jacksonville will take you 1h 55m. The distance between Missouri and Jacksonville is about 753 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Jacksonville one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $91. Southwest flights start at $94 while deals on Delta start at $96 one-way.

  • What are the most popular routes from Missouri to Jacksonville?

    When deciding which route to take from Missouri to Jacksonville consider Lambert-St Louis - Jacksonville, Kansas City - Jacksonville or Springfield-Branson - Jacksonville as they are the most popular.

  • What are the most reliable airlines from Missouri to Jacksonville?

    Before booking your flight to Jacksonville from Missouri, check out the most reliable airlines to get you to your destination on time: American Airlines (100%), Southwest (100%), Delta( 100%).

  • Can I find deals for flights from Missouri to Jacksonville that include hotel bookings?

    Yes. In addition to deals on Missouri to Jacksonville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Jacksonville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Jacksonville.

  • Can I find deals for business class flights from Missouri to Jacksonville?

    Yes. Cheapflights offers flight deals from Missouri to Jacksonville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Jacksonville?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Jacksonville (average of $163). Flying from Missouri to Jacksonville in December is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Jacksonville?

Book flights to Jacksonville if you plan to visit one of these locations
Jacksonville Beach
Orange Park
Fernandina Beach
Kingsland
Waycross

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Jacksonville

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Miami flights
Newark to Miami flights
Newark to Fort Lauderdale flights
LaGuardia to Miami flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
Newark to West Palm Beach flights
Newark to Orlando flights
John F Kennedy Intl to West Palm Beach flights
Boston to Fort Lauderdale flights
John F Kennedy Intl to Tampa flights
O'Hare Intl to Orlando flights
Boston to Miami flights
Baltimore to Fort Lauderdale flights
Dulles Intl to Miami flights
LaGuardia to Orlando flights
LaGuardia to West Palm Beach flights
Dallas/Fort Worth to Orlando flights
Dulles Intl to Orlando flights
Detroit to Fort Lauderdale flights
Philadelphia to Orlando flights
Reagan-National to Miami flights
Boston to Tampa flights
Detroit to Orlando flights
Newark to Tampa flights
Dulles Intl to Fort Lauderdale flights
O'Hare Intl to Miami flights
Boston to Orlando flights
O'Hare Intl to Fort Lauderdale flights
Minneapolis to Orlando flights
LaGuardia to Tampa flights
Reagan-National to Orlando flights
Baltimore to Miami flights
Philadelphia to Miami flights
Dallas/Fort Worth to Miami flights
Dallas/Fort Worth to Fort Lauderdale flights
Los Angeles to Orlando flights
Philadelphia to Fort Lauderdale flights
Detroit to Miami flights
Los Angeles to Miami flights
Newark to Fort Myers flights
Baltimore to Orlando flights
Reagan-National to Fort Lauderdale flights
Cleveland to Orlando flights
Los Angeles to Fort Lauderdale flights
John F Kennedy Intl to Fort Myers flights
Minneapolis to Miami flights
Boston to Fort Myers flights
Hartford to Orlando flights

Top 4 airlines flying from Missouri to Jacksonville

Discover the top 4 airlines that operate flights from Missouri to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$182Average$355FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$342FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$214Average$349FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$248Average$351FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.