$306+ Cheap flights from Des Moines (DSM) to Italy
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — NAP
Apr 11 — Apr 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Italy with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Italy
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to ItalyExplore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
Explore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
This Air Canada deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/278:15 pm
DSM
- MXP
2 stops30h 40m
Air Canada
Tue 1/121:05 pm
MXP
- DSM
2 stops40h 56m
Air Canada
Deal found 3/8![Air Canada logo]()
$578
This Air Canada deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:15 am
DSM
- MXP
3 stops20h 40m
Air Canada
Tue 1/121:05 pm
MXP
- DSM
2 stops39h 12m
Air Canada
Deal found 3/8![Air Canada logo]()
$584
This Air Canada deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:15 am
DSM
- MXP
3 stops20h 40m
Air Canada
Tue 1/121:05 pm
MXP
- DSM
3 stops32h 06m
Air Canada
Deal found 3/8![Air Canada logo]()
$588
This Flysmarter deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:16 pm
DSM
- MXP
2 stops14h 24m
Multiple Airlines
Wed 4/2212:20 pm
MXP
- DSM
2 stops17h 57m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$600
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am
DSM
- MXP
2 stops21h 05m
United Airlines
Wed 10/2112:20 pm
MXP
- DSM
2 stops39h 12m
United Airlines
Deal found 3/8![United Airlines logo]()
$601
This FlightHub deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:15 am
DSM
- MXP
2 stops20h 40m
Multiple Airlines
Sat 1/96:55 am
MXP
- DSM
2 stops21h 22m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$602
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:00 am
DSM
- MXP
2 stops18h 55m
United Airlines
Wed 1/139:45 am
MXP
- DSM
2 stops16h 40m
United Airlines
Deal found 3/8![United Airlines logo]()
$603
This Flighttix deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:16 pm
DSM
- MXP
2 stops14h 24m
Lufthansa
Wed 4/223:20 pm
MXP
- DSM
1 stop13h 12m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$604
This Air Canada deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:30 am
DSM
- MXP
3 stops15h 50m
Multiple Airlines
Wed 10/2112:20 pm
MXP
- DSM
3 stops29h 00m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$606
This KAYAK deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:45 pm
DSM
- MXP
2 stops14h 55m
Lufthansa
Sat 1/92:40 pm
MXP
- DSM
2 stops15h 21m
Lufthansa
Deal found 3/8![Lufthansa logo]()
$607
This FlightHub deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:45 pm
DSM
- LIN
2 stops17h 05m
Lufthansa
Sun 1/102:50 pm
LIN
- DSM
2 stops15h 11m
Lufthansa
Deal found 3/8![Lufthansa logo]()
$608
This KAYAK deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:45 pm
DSM
- LIN
2 stops17h 05m
Lufthansa
Fri 1/86:10 am
LIN
- DSM
2 stops23h 51m
Lufthansa
Deal found 3/8![Lufthansa logo]()
$609
Best flights from Des Moines to ItalyDiscover carefully curated flight deals from Des Moines to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
Discover carefully curated flight deals from Des Moines to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
DSM
- MXP
3 stops19h 20m
United Airlines
Fri 5/2212:20 pm
MXP
- DSM
2 stops31h 10m
United Airlines
Deal found 3/12![United Airlines logo]()
$664
This Booking.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:16 pm
DSM
- FLR
2 stops25h 04m
British Airways
Wed 4/297:05 am
FLR
- DSM
2 stops19h 28m
British Airways
Deal found 3/10![British Airways logo]()
$702
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:16 pm
DSM
- LIN
2 stops15h 14m
American Airlines
Sun 5/310:50 am
LIN
- DSM
2 stops15h 43m
American Airlines
Deal found 3/11![American Airlines logo]()
$714
This Lufthansa deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:16 pm
DSM
- LIN
2 stops15h 29m
Lufthansa
Sat 5/21:40 pm
LIN
- DSM
2 stops16h 44m
Lufthansa
Deal found 3/11![Lufthansa logo]()
$722
This KLM deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:51 am
DSM
- VCE
1 stop14h 04m
KLM
Wed 4/296:00 am
VCE
- DSM
2 stops18h 02m
KLM
Deal found 3/7![KLM logo]()
$815
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:00 am
DSM
- VCE
2 stops18h 55m
Delta
Tue 4/2811:05 am
VCE
- DSM
2 stops29h 49m
Delta
Deal found 3/8![Delta logo]()
$822
This KLM deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:47 pm
DSM
- FCO
2 stops15h 28m
Multiple Airlines
Mon 3/301:10 pm
FCO
- DSM
1 stop16h 28m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$830
This oojo deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:16 pm
DSM
- LIN
2 stops37h 24m
Aer Lingus
Fri 5/2211:20 am
LIN
- DSM
2 stops28h 06m
Aer Lingus
Deal found 3/10![Aer Lingus logo]()
$830
This Iberia deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:16 pm
DSM
- FLR
2 stops22h 19m
Iberia
Wed 4/296:45 am
FLR
- DSM
2 stops24h 04m
Iberia
Deal found 3/7![Iberia logo]()
$832
This Air Canada deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:10 pm
DSM
- TRN
3 stops17h 40m
Air Canada
Sat 5/26:00 am
TRN
- DSM
3 stops19h 05m
Air Canada
Deal found 3/10![Air Canada logo]()
$1,143
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:12 pm
DSM
- MXP
2 stops16h 28m
United Airlines
Fri 4/243:20 pm
MXP
- DSM
1 stop13h 12m
United Airlines
Deal found 3/12![United Airlines logo]()
$688
This Lufthansa deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:16 pm
DSM
- LIN
2 stops15h 29m
Lufthansa
Sun 5/31:40 pm
LIN
- DSM
2 stops16h 37m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$722
This British Airways deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:16 pm
DSM
- FLR
2 stops14h 19m
British Airways
Wed 4/227:05 am
FLR
- DSM
2 stops19h 28m
British Airways
Deal found 3/12![British Airways logo]()
$723
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:20 pm
DSM
- LIN
2 stops14h 00m
United Airlines
Fri 5/226:20 am
LIN
- DSM
2 stops16h 28m
United Airlines
Deal found 3/12![United Airlines logo]()
$696
This British Airways deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:16 pm
DSM
- MXP
2 stops16h 04m
British Airways
Sun 5/37:05 am
MXP
- DSM
2 stops19h 28m
British Airways
Deal found 3/11![British Airways logo]()
$726
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:34 am
DSM
- LIN
2 stops16h 31m
Delta
Wed 4/226:40 am
LIN
- DSM
2 stops20h 59m
Delta
Deal found 3/10![Delta logo]()
$827
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:16 pm
DSM
- MXP
1 stop11h 04m
United Airlines
Sun 5/33:20 pm
MXP
- DSM
1 stop14h 57m
United Airlines
Deal found 3/12![United Airlines logo]()
$697
This KLM deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:45 pm
DSM
- MXP
2 stops14h 00m
Multiple Airlines
Wed 4/2211:40 am
MXP
- DSM
1 stop17h 54m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$866
This KLM deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:44 pm
DSM
- VCE
1 stop35h 11m
KLM
Mon 4/276:00 am
VCE
- DSM
2 stops16h 41m
KLM
Deal found 3/8![KLM logo]()
$868
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:56 am
DSM
- LIN
2 stops25h 04m
Delta
Tue 6/166:40 am
LIN
- DSM
2 stops14h 27m
Delta
Deal found 3/8![Delta logo]()
$871
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:25 am
DSM
- LIN
2 stops15h 35m
United Airlines
Sun 5/36:50 am
LIN
- DSM
2 stops18h 15m
United Airlines
Deal found 3/12![United Airlines logo]()
$734
This Cheapflightsfares deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:05 pm
DSM
- TRN
2 stops21h 10m
Lufthansa
Sat 6/66:15 am
TRN
- DSM
2 stops22h 25m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$915
This KLM deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:51 am
DSM
- VCE
1 stop14h 04m
KLM
Thu 4/3011:45 am
VCE
- DSM
2 stops15h 54m
KLM
Deal found 3/10![KLM logo]()
$925
This British Airways deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:01 pm
DSM
- VCE
2 stops16h 09m
Multiple Airlines
Fri 5/19:50 am
VCE
- DSM
2 stops20h 59m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$938
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:45 am
DSM
- VCE
1 stop20h 10m
Delta
Thu 4/3011:05 am
VCE
- DSM
1 stop31h 00m
Delta
Deal found 3/9![Delta logo]()
$873
This KLM deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:31 pm
DSM
- VCE
2 stops14h 39m
KLM
Sun 5/311:05 am
VCE
- DSM
1 stop18h 29m
KLM
Deal found 3/11![KLM logo]()
$925
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:20 am
DSM
- FLR
2 stops27h 15m
United Airlines
Wed 4/226:30 am
FLR
- DSM
2 stops23h 47m
United Airlines
Deal found 3/8![United Airlines logo]()
$769
This Air Canada deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/268:04 am
DSM
- FLR
3 stops18h 36m
Air Canada
Sun 5/32:20 pm
FLR
- DSM
3 stops17h 19m
Air Canada
Deal found 3/11![Air Canada logo]()
$1,178
This Iberia deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:03 pm
DSM
- FLR
2 stops19h 17m
Multiple Airlines
Fri 5/16:45 am
FLR
- DSM
2 stops19h 48m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$984
This British Airways deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:16 pm
DSM
- FCO
2 stops17h 59m
British Airways
Sun 5/39:00 am
FCO
- DSM
2 stops17h 33m
British Airways
Deal found 3/9![British Airways logo]()
$1,023
Last-minute flights from Des Moines to ItalyDiscover last-minute flight deals from Des Moines to Italy. Data last updated March 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Italy. Data last updated March 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:49 pm
DSM
- MXP
2 stops32h 06m
United Airlines
Sun 3/2211:40 am
MXP
- DSM
2 stops56h 42m
United Airlines
Deal found 3/12![United Airlines logo]()
$678
This Cheapflightsfares deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:59 pm
DSM
- MXP
2 stops14h 41m
Lufthansa
Fri 4/242:40 pm
MXP
- DSM
2 stops15h 37m
Lufthansa
Deal found 3/11![Lufthansa logo]()
$656
This Cheapflightsfares deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:59 pm
DSM
- LIN
2 stops15h 46m
Lufthansa
Fri 4/2412:40 pm
LIN
- DSM
2 stops17h 37m
Lufthansa
Deal found 3/11![Lufthansa logo]()
$660
This Flysmarter deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:16 pm
DSM
- MXP
2 stops14h 24m
Multiple Airlines
Wed 4/2212:20 pm
MXP
- DSM
2 stops17h 57m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$600
This Flighttix deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:16 pm
DSM
- MXP
2 stops14h 24m
Lufthansa
Wed 4/223:20 pm
MXP
- DSM
1 stop13h 12m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$604
This Gotogate deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:21 pm
DSM
- MXP
2 stops35h 59m
Air Canada
Wed 4/2212:20 pm
MXP
- DSM
2 stops17h 57m
Air Canada
Deal found 3/11![Air Canada logo]()
$613
This Flighttix deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:10 pm
DSM
- LIN
2 stops13h 50m
Lufthansa
Wed 4/2212:40 pm
LIN
- DSM
2 stops17h 37m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$618
This Cheapflightsfares deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:10 pm
DSM
- MXP
2 stops14h 25m
Lufthansa
Wed 4/2911:20 am
MXP
- DSM
2 stops18h 57m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$637
This Cheapflightsfares deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:10 pm
DSM
- LIN
2 stops21h 20m
Lufthansa
Wed 4/296:50 am
LIN
- DSM
2 stops23h 27m
Lufthansa
Deal found 3/12![Lufthansa logo]()
$640
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:45 am
DSM
- MXP
2 stops18h 00m
Delta
Wed 4/2911:40 am
MXP
- DSM
1 stop17h 54m
Delta
Deal found 3/12![Delta logo]()
$651
This Air Canada deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:10 pm
DSM
- MXP
2 stops14h 10m
Multiple Airlines
Wed 4/2912:20 pm
MXP
- DSM
3 stops28h 03m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$659
This Booking.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:10 pm
DSM
- LIN
2 stops13h 50m
Multiple Airlines
Wed 4/296:50 am
LIN
- DSM
3 stops23h 27m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$677
One-way flights from Des Moines to ItalySearch for one-way flight options from Des Moines to Italy. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
Search for one-way flight options from Des Moines to Italy. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
This EaseMyTrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure EaseMyTrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:16 pm
DSM
- LIN
2 stops15h 29m
Lufthansa
Deal found 3/11![Lufthansa logo]()
$306
This EaseMyTrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure EaseMyTrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:16 pm
DSM
- MXP
2 stops14h 24m
Lufthansa
Deal found 3/11![Lufthansa logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- FLR
3 stops30h 55m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$335
This Flightnetwork deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:16 pm
DSM
- MXP
3 stops56h 04m
Air Canada
Deal found 3/11![Air Canada logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2110:26 am
DSM
- FLR
3 stops54h 04m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
DSM
- FCO
3 stops41h 55m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 am
DSM
- FCO
2 stops34h 50m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:10 pm
DSM
- FCO
3 stops36h 30m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2710:26 am
DSM
- FLR
2 stops30h 39m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$490
This oojo deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:46 pm
DSM
- MXP
2 stops24h 49m
Aer Lingus
Deal found 3/9![Aer Lingus logo]()
$498
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:23 pm
DSM
- FLR
3 stops47h 07m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$517
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- FLR
3 stops43h 15m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$528
Find flight deals from Des Moines to Italy
Keep the following information in mind while searching for Des Moines to Italy flight deals. Data was last updated March 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $600 (Flysmarter) |
One-way from | $306 (EaseMyTrip) |
Popular in | June |
Cheapest in | November |
Average price | $858 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Tue 5/12
8:00 am-10:20 am
3 stops19h 20m
Milan Malpensa
Fri 5/22
12:20 pm-12:30 pm
2 stops31h 10m
$664
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Tue 3/31
5:12 pm-4:40 pm
2 stops16h 28m
Milan Malpensa
Fri 4/24
3:20 pm-9:32 pm
1 stop13h 12m
$688
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Tue 5/12
3:20 pm-12:20 pm
2 stops14h 00m
Milan Linate
Fri 5/22
6:20 am-3:48 pm
2 stops16h 28m
$696
Quickest round-trip
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Sun 4/26
7:16 pm-1:20 pm
1 stop11h 04m
Milan Malpensa
Sun 5/3
3:20 pm-11:17 pm
1 stop14h 57m
$697
Des MoinesFlorence
DSM - FLR
DSMFLR
Des Moines
Wed 4/22
2:16 pm-10:20 pm
2 stops25h 04m
Florence Peretola
Wed 4/29
7:05 am-7:33 pm
2 stops19h 28m
$702
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Sun 4/26
2:16 pm-12:30 pm
2 stops15h 14m
Milan Linate
Sun 5/3
10:50 am-7:33 pm
2 stops15h 43m
$714
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Sat 4/25
7:16 pm-5:45 pm
2 stops15h 29m
Milan Linate
Sat 5/2
1:40 pm-11:24 pm
2 stops16h 44m
$722
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Sun 4/26
7:16 pm-5:45 pm
2 stops15h 29m
Milan Linate
Sun 5/3
1:40 pm-11:17 pm
2 stops16h 37m
$722
Des MoinesFlorence
DSM - FLR
DSMFLR
Des Moines
Wed 4/15
2:16 pm-11:35 am
2 stops14h 19m
Florence Peretola
Wed 4/22
7:05 am-7:33 pm
2 stops19h 28m
$723
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Sun 4/26
2:16 pm-1:20 pm
2 stops16h 04m
Milan Malpensa
Sun 5/3
7:05 am-7:33 pm
2 stops19h 28m
$726
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Italy
Have a flexible travel schedule? Discover the best time to fly to Italy from Des Moines with our price prediction graph.
DSM-MXP
DSM-LIN
DSM-FLR
DSM-FCO
DSM-VCE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Italy
DSM-IT0
DSM-MXP
DSM-LIN
DSM-FLR
DSM-FCO
What is the cheapest month to book a flight from Des Moines to Italy?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $464). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,013). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Italy
Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated March 12, 2026.
Peruse reviews from past customers who have flown with Delta,KLM, andUnited Airlines from Des Moines to Italy to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top regions
Alternative routes for Des Moines to Italy
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Italy by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Italy by cabin class
Find flights from Des Moines to Italy, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Italy flights
Browse other Des Moines and Italy flight options. Last updated on March 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Italy regions
Consider these flights traveling to Italy regions.
Top 2 airlines flying from Des Moines to Italy
Discover the top 2 airlines that operate flights from Des Moines to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$491 | Average$884 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$505 | Average$1,175 | FlexibilityNo cancel fee | On-timeN/A |