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$237+ Cheap flights from Des Moines (DSM) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — NAP
nov. 28 — déc. 51
ven. 11/28
ven. 12/5
1 adult, Economy
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Cheap flight deals from Des Moines to Italy

Keep the following information in mind while searching for Des Moines to Italy flight deals. Data was last updated octobre 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$460
(Ticket)

One-way from

$242

Popular in

June

Cheapest in

November

Average price

$813
Provider with most accurate pricing for Des Moines-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Rome (ROM) flights.
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From Des Moines to Italy
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One-way flight from Des Moines to Italy
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Highest demand for flights based on searches. 23% potential increase in price ($311 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($56 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Italy

Cheapest flights from Des Moines to Italy
Explore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octobre 29, 2025.

This Ticket deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/96:50 pmDSM - FLR
2 stops20h 10mLufthansa
mar. 12/161:15 pmFLR - DSM
2 stops15h 35mLufthansa
Deal found 10/27$460
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 11/96:33 pmDSM - MXP
2 stops32h 12mDelta
mar. 11/2511:05 amMXP - DSM
1 stop18h 28mDelta
Deal found 10/27$492
This Billigflug deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/108:00 amDSM - MXP
2 stops18h 55mMultiple Airlines
mer. 12/171:20 pmMXP - DSM
2 stops15h 17mMultiple Airlines
Deal found 10/27$499
This Expedia deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 11/96:33 pmDSM - MXP
2 stops37h 22mAir France
mar. 11/256:55 amMXP - DSM
2 stops16h 24mAir France
Deal found 10/27$506
This Gotogate deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 11/911:26 amDSM - MXP
3 stops39h 29mAir Canada
mar. 11/251:05 pmMXP - DSM
2 stops39h 27mAir Canada
Deal found 10/27$510
This Billigflug deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/103:17 pmDSM - LIN
2 stops13h 38mMultiple Airlines
mer. 12/176:10 amLIN - DSM
2 stops15h 10mMultiple Airlines
Deal found 10/27$511
This Billigflug deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/98:00 amDSM - VCE
2 stops17h 55mAir Canada
mar. 12/1611:05 amVCE - DSM
2 stops30h 48mAir Canada
Deal found 10/29$512
This Travelocity deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 11/263:15 pmDSM - MXP
2 stops35h 40mMultiple Airlines
mer. 12/36:55 amMXP - DSM
2 stops21h 42mMultiple Airlines
Deal found 10/27$514
This Billigflug deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/98:00 amDSM - FCO
2 stops16h 55mMultiple Airlines
mar. 12/169:45 amFCO - DSM
2 stops19h 05mMultiple Airlines
Deal found 10/27$523
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/108:00 amDSM - FCO
1 stop16h 45mUnited Airlines
mer. 12/171:10 pmFCO - DSM
2 stops39h 30mUnited Airlines
Deal found 10/28$532
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/103:17 pmDSM - FLR
2 stops14h 18mUnited Airlines
mer. 12/176:30 amFLR - DSM
2 stops22h 07mUnited Airlines
Deal found 10/27$535
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/279:01 amDSM - FCO
2 stops15h 44mUnited Airlines
ven. 12/51:10 pmFCO - DSM
2 stops35h 14mUnited Airlines
Deal found 10/29$537

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 29, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Des Moines

Fly to

Italy

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

mar. 12/9

6:50 pm-10:00 pm

2 stops20h 10m

Florence Peretola

mar. 12/16

1:15 pm-9:50 pm

2 stops15h 35m

$460

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

dim. 11/9

6:33 pm-9:45 am

2 stops32h 12m

Milan Malpensa

mar. 11/25

11:05 am-10:33 pm

1 stop18h 28m

$492

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

mer. 12/10

8:00 am-9:55 am

2 stops18h 55m

Milan Malpensa

mer. 12/17

1:20 pm-9:37 pm

2 stops15h 17m

$499

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

mer. 12/10

3:17 pm-11:55 am

2 stops13h 38m

Milan Linate

mer. 12/17

6:10 am-2:20 pm

2 stops15h 10m

$511

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

mar. 12/9

8:00 am-8:55 am

2 stops17h 55m

Venice Marco Polo

mar. 12/16

11:05 am-10:53 am

2 stops30h 48m

$512

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

mer. 11/26

1:05 pm-9:55 am

3 stops37h 50m

Milan Malpensa

mer. 12/3

6:55 am-9:37 pm

2 stops21h 42m

$520

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

mar. 12/9

8:00 am-7:55 am

2 stops16h 55m

Rome Fiumicino

mar. 12/16

9:45 am-9:50 pm

2 stops19h 05m

$523

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

mer. 12/10

5:45 am-9:25 am

2 stops20h 40m

Rome Fiumicino

mer. 12/17

1:10 pm-9:40 pm

2 stops39h 30m

$532

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

mar. 12/9

8:00 am-7:45 am

1 stop16h 45m

Rome Fiumicino

mar. 12/16

9:45 am-9:50 pm

1 stop19h 05m

$532

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

jeu. 11/27

8:02 am-7:45 am

1 stop16h 43m

Rome Fiumicino

ven. 12/5

1:10 pm-9:37 pm

2 stops39h 27m

$532

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 54 results
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Best time to book a flight from Des Moines to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Italy

What is the cheapest month to book a flight from Des Moines to Italy?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Italy (average of $590). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,013). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to IT?

Find hourly flight availability from Des Moines to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octobre 29, 2025.

It’s optimal to fly from Des Moines to Italy in the evening. By choosing this option you can save up to 27% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated octobre 29, 2025.
Peruse reviews from past customers who have flown with Delta, KLM, and United Airlines from Des Moines to Italy to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
KLM
7.7
Good
1,406 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
British Airways
6.7
Okay
7,483 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Italy?

    For a flight from Des Moines to Italy, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Italy?

    For as low as $512, Lufthansa can have you in Italy from Des Moines in 17h 55m. The distance between Des Moines and Italy is about 4890 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Italy one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $237. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Des Moines to Italy for a low price.

  • What are the most popular routes from Des Moines to Italy?

    While some choose either Des Moines - Milan Malpensa or Des Moines - Milan Linate, Des Moines - Rome Fiumicino is the most popular route from Des Moines to Italy.

  • Can I find deals for flights from Des Moines to Italy that include hotel bookings?

    Yes. In addition to deals on Des Moines to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Italy.

  • Can I find deals for business class flights from Des Moines to Italy?

    Yes. Cheapflights offers flight deals from Des Moines to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Italy?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Italy (average of $590). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,013). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Des Moines to Italy

Discover the top 5 airlines that operate flights from Des Moines to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$623Average$1,097FlexibilityNo cancel feeOn-time71%
DeltaCheapest$641Average$1,302FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$655Average$1,140FlexibilityNo cancel feeOn-time69%
KLMCheapest$680Average$1,091FlexibilityNo cancel feeOn-time75%
LufthansaCheapest$811Average$1,367FlexibilityNo cancel feeOn-time76%

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