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Italy

$286+ Cheap flights from Des Moines (DSM) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — NAP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Italy

Keep the following information in mind while searching for Des Moines to Italy flight deals. Data was last updated September 11, 2025.

Round-trip from

$512
(United Airlines)

One-way from

$286
(KLM)

Popular in

June

Cheapest in

November

Average price

$1,139
From Des Moines to Italy
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One-way flight from Des Moines to Italy
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Highest demand for flights based on searches. 19% potential increase in price ($258 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($54 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Italy

Cheapest flights from Des Moines to Italy
Explore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/209:00 amDSM - MXP
2 stops17h 10mAmerican Airlines
Sat 2/2810:15 amMXP - DSM
2 stops19h 41mAmerican Airlines
Deal found 9/10$554
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1212:49 pmDSM - MXP
1 stop15h 31mAmerican Airlines
Tue 10/211:20 pmMXP - DSM
1 stop14h 53mAmerican Airlines
Deal found 9/9$560
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:15 pmDSM - FCO
2 stops17h 15mAmerican Airlines
Fri 12/51:00 pmFCO - DSM
1 stop16h 59mAmerican Airlines
Deal found 9/10$579
This KLM deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/242:13 pmDSM - MXP
1 stop12h 12mMultiple Airlines
Fri 10/317:50 pmMXP - DSM
2 stops27h 02mMultiple Airlines
Deal found 9/9$582
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:07 pmDSM - LIN
2 stops16h 08mAmerican Airlines
Sat 2/287:50 amLIN - DSM
2 stops21h 06mAmerican Airlines
Deal found 9/10$584
This Iberia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:07 pmDSM - MXP
2 stops17h 23mMultiple Airlines
Tue 10/212:25 pmMXP - DSM
2 stops34h 12mMultiple Airlines
Deal found 9/10$587
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:39 pmDSM - MXP
1 stop31h 26mDelta
Sun 11/212:00 pmMXP - DSM
2 stops35h 52mDelta
Deal found 9/11$588
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:00 amDSM - MXP
1 stop22h 20mAmerican Airlines
Thu 11/2010:25 amMXP - DSM
2 stops20h 30mAmerican Airlines
Deal found 9/10$594
This lol.travel deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:52 pmDSM - MXP
2 stops36h 38mUnited Airlines
Sat 11/111:30 amMXP - DSM
2 stops33h 49mUnited Airlines
Deal found 9/10$598
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:09 pmDSM - LIN
2 stops16h 06mAmerican Airlines
Sat 11/227:55 amLIN - DSM
2 stops22h 46mAmerican Airlines
Deal found 9/10$600
This Air France deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:56 pmDSM - MXP
2 stops12h 59mAir France
Fri 10/317:50 pmMXP - DSM
2 stops27h 02mAir France
Deal found 9/9$601
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/123:25 pmDSM - MXP
2 stops35h 35mUnited Airlines
Tue 10/2112:15 pmMXP - DSM
3 stops40h 35mUnited Airlines
Deal found 9/11$607

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Des Moines

Fly to

Italy

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Mon 10/20

12:49 pm-11:20 am

1 stop15h 31m

Milan Malpensa

Sat 2/28

10:15 am-10:56 pm

2 stops19h 41m

$554

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

2:15 pm-2:30 pm

2 stops17h 15m

Rome Fiumicino

Fri 12/5

1:00 pm-10:59 pm

1 stop16h 59m

$579

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Mon 10/20

6:07 pm-3:00 pm

2 stops13h 53m

Milan Linate

Sat 2/28

7:50 am-9:56 pm

2 stops21h 06m

$584

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/12

6:07 pm-6:30 pm

2 stops17h 23m

Milan Malpensa

Tue 10/21

7:05 pm-5:37 pm

2 stops29h 32m

$587

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/26

6:39 pm-8:05 am

1 stop31h 26m

Milan Malpensa

Sun 11/2

12:00 pm-4:52 pm

2 stops35h 52m

$588

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sat 9/27

6:00 am-11:20 am

1 stop22h 20m

Milan Malpensa

Thu 11/20

10:25 am-11:55 pm

2 stops20h 30m

$594

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Sun 9/28

6:09 pm-5:15 pm

2 stops16h 06m

Milan Linate

Sat 11/22

7:55 am-11:41 pm

2 stops22h 46m

$600

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sat 9/27

3:25 pm-10:00 am

2 stops35h 35m

Milan Malpensa

Fri 11/21

1:05 pm-9:32 pm

2 stops39h 27m

$607

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/12

11:31 am-10:00 am

2 stops39h 29m

Milan Malpensa

Tue 10/21

12:15 pm-9:50 pm

2 stops40h 35m

$607

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/12

6:00 am-11:20 am

1 stop22h 20m

Milan Malpensa

Tue 10/21

1:20 pm-9:13 pm

1 stop14h 53m

$610

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 46 results
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Best time to book a flight from Des Moines to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Italy

What is the cheapest month to book a flight from Des Moines to Italy?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $703). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to IT?

Find hourly flight availability from Des Moines to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Italy as you normally would.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Delta, KLM, and United Airlines from Des Moines to Italy to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
KLM
7.8
Good
1,385 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,361 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Italy?

    For a flight from Des Moines to Italy, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Italy?

    For as low as $554, American Airlines can have you in Italy from Des Moines in 15h 31m. The distance between Des Moines and Italy is about 4750 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Italy one-way?

    The cheapest airline one-way is KLM, with whom users have recently found tickets for as low as $286. However, be on the lookout for offers from Air France and Delta, as they are both options that can get you from Des Moines to Italy for a low price.

  • What are the most popular routes from Des Moines to Italy?

    While some choose either Des Moines - Milan Malpensa or Des Moines - Milan Linate, Des Moines - Rome Fiumicino is the most popular route from Des Moines to Italy.

  • Can I find deals for flights from Des Moines to Italy that include hotel bookings?

    Yes. In addition to deals on Des Moines to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Italy.

  • Can I find deals for business class flights from Des Moines to Italy?

    Yes. Cheapflights offers flight deals from Des Moines to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Italy?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $703). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to Italy

Discover the top 4 airlines that operate flights from Des Moines to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$647Average$1,279FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$680Average$1,090FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$703Average$1,122FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$811Average$1,367FlexibilityNo cancel feeOn-time76%

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