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Italy

$348+ Cheap flights from Des Moines (DSM) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — NAP
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Italy

Cheapest flights from Des Moines to Italy
Explore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:00 am
DSM
-
MXP
3 stops19h 20m
United Airlines
Fri 8/2112:20 pm
MXP
-
DSM
2 stops34h 54m
United Airlines
Deal found 1/27$475
This Air Canada deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/83:15 pm
DSM
-
MXP
3 stops36h 05m
Air Canada
Thu 8/2012:20 pm
MXP
-
DSM
2 stops30h 40m
Air Canada
Deal found 1/27$480
This Cheapflightsfares deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:55 pm
DSM
-
FLR
2 stops14h 35m
Lufthansa
Thu 3/126:30 am
FLR
-
DSM
2 stops17h 38m
Lufthansa
Deal found 1/26$482
This oojo deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:18 pm
DSM
-
FLR
2 stops25h 02m
British Airways
Wed 4/227:05 am
FLR
-
DSM
2 stops23h 24m
British Airways
Deal found 1/26$489
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:30 am
DSM
-
MXP
1 stop18h 50m
United Airlines
Thu 8/203:20 pm
MXP
-
DSM
1 stop29h 51m
United Airlines
Deal found 1/27$492
This oojo deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:22 pm
DSM
-
MXP
2 stops21h 28m
British Airways
Fri 8/216:30 pm
MXP
-
DSM
2 stops35h 56m
British Airways
Deal found 1/27$493
This oojo deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:22 pm
DSM
-
LIN
2 stops16h 08m
British Airways
Sat 8/225:40 pm
LIN
-
DSM
2 stops36h 46m
British Airways
Deal found 1/26$495
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:24 pm
DSM
-
FCO
2 stops34h 31m
United Airlines
Tue 3/1012:10 pm
FCO
-
DSM
2 stops32h 14m
United Airlines
Deal found 1/26$496
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:28 pm
DSM
-
MXP
2 stops35h 27m
United Airlines
Tue 3/179:45 am
MXP
-
DSM
2 stops17h 55m
United Airlines
Deal found 1/25$499
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:45 pm
DSM
-
MXP
2 stops14h 55m
United Airlines
Sat 8/223:20 pm
MXP
-
DSM
1 stop12h 36m
United Airlines
Deal found 1/27$500
This Flysmarter deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:20 pm
DSM
-
LIN
2 stops16h 35m
KLM
Tue 3/176:30 am
LIN
-
DSM
2 stops16h 24m
KLM
Deal found 1/26$503
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:10 pm
DSM
-
MXP
2 stops20h 30m
United Airlines
Sat 8/2212:20 pm
MXP
-
DSM
2 stops29h 00m
United Airlines
Deal found 1/27$503

Find flight deals from Des Moines to Italy

Keep the following information in mind while searching for Des Moines to Italy flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$482
(Cheapflightsfares)

One-way from

$348
(American Airlines)

Popular in

June

Cheapest in

November

Average price

$1,176
Provider with most accurate pricing for Des Moines-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Rome (ROM) flights.
Search Deals
From Des Moines to Italy
Search Deals
One-way flight from Des Moines to Italy
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($216 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Des Moines

Fly to

Italy

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 3/3

6:55 pm-4:30 pm

2 stops14h 35m

Florence Peretola

Thu 3/12

6:30 am-6:08 pm

2 stops17h 38m

$482

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 3/3

8:00 am-8:55 am

2 stops41h 55m

Rome Fiumicino

Tue 3/10

12:10 pm-9:40 pm

2 stops39h 30m

$496

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 3/10

3:28 pm-8:55 am

2 stops35h 27m

Milan Malpensa

Tue 3/17

9:45 am-10:44 pm

2 stops18h 59m

$499

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Tue 3/10

5:20 pm-3:55 pm

2 stops16h 35m

Milan Linate

Tue 3/17

6:30 am-4:54 pm

2 stops16h 24m

$503

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Tue 3/10

3:28 pm-11:55 am

2 stops14h 27m

Milan Linate

Tue 3/17

6:15 am-9:40 pm

2 stops21h 25m

$507

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 3/3

10:57 am-3:15 pm

2 stops21h 18m

Rome Fiumicino

Tue 3/10

9:05 am-8:45 pm

1 stop17h 40m

$512

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/16

6:49 pm-12:35 pm

2 stops35h 46m

Florence Peretola

Mon 3/23

2:15 pm-9:41 pm

2 stops37h 26m

$522

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Sun 4/26

5:00 pm-5:15 pm

2 stops17h 15m

Milan Linate

Wed 5/13

7:25 am-11:29 pm

2 stops23h 04m

$530

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Thu 2/19

3:24 pm-4:40 pm

2 stops18h 16m

Milan Malpensa

Mon 3/2

10:40 am-9:41 pm

2 stops18h 01m

$539

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Thu 2/19

3:24 pm-4:55 pm

2 stops18h 31m

Milan Linate

Mon 3/2

6:10 am-2:27 pm

2 stops15h 17m

$553

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Italy

What is the cheapest month to book a flight from Des Moines to Italy?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $465). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,013). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated January 28, 2026.
Peruse reviews from past customers who have flown with Delta, KLM, and United Airlines from Des Moines to Italy to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,120 reviews
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
KLM
7.7
Good
1,443 reviews
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,205 reviews
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,199 reviews
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,704 reviews
Delta
7.9
Good
8,120 reviews

Crew

8.5

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Italy?

    For a flight from Des Moines to Italy, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Italy?

    For as low as $482, Lufthansa can have you in Italy from Des Moines in 14h 35m. The distance between Des Moines and Italy is about 4923 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to Italy?

    While some choose either Des Moines - Florence Peretola or Des Moines - Milan Malpensa, Des Moines - Rome Fiumicino is the most popular route from Des Moines to Italy.

  • Can I find deals for flights from Des Moines to Italy that include hotel bookings?

    Yes. In addition to deals on Des Moines to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Italy.

  • Can I find deals for business class flights from Des Moines to Italy?

    Yes. Cheapflights offers flight deals from Des Moines to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Italy?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $465). Flying from Des Moines to Italy in June is currently the most expensive (average of $1,013). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to Italy

Discover the top 4 airlines that operate flights from Des Moines to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$457Average$1,013FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$502Average$1,029FlexibilityNo cancel feeOn-time69%
DeltaCheapest$505Average$1,271FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$623Average$1,078FlexibilityNo cancel feeOn-time71%

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