What are the cheapest airlines flying from Panama City, Florida to Indianapolis round-trip?

Cheapflights users have booked flights from Panama City, Florida to Indianapolis round-trip from $226. Other airlines that can offer you cheap pricing are American Airlines, from $286, and Southwest, from $333. Delta is currently priced 43% below the average price you’ll pay for this route.

What is the cheapest day to fly from Panama City, Florida to Indianapolis?

Travelers seeking maximum savings on their Panama City, Florida to Indianapolis flight should consider departing on Monday afternoons when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Indianapolis ranges from 2.3 - 5.1 inches per month. May is typically the wettest month, when rainfall can reach 5.1 in. February is typically the driest time to visit Indianapolis when rainfall is around 2.3 in.

If weather is an important factor for your trip to Indianapolis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

What are the most popular airlines that fly from Panama City, Florida to Indianapolis?

American Airlines, Delta and Southwest are the most popular airlines when flying from Panama City, Florida to Indianapolis.

What is the cheapest day to fly round-trip from Panama City, Florida to Indianapolis?

Users have found that leaving on a Monday can be a cost-effective option. It’s possible to save up to 123% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City, Florida to Indianapolis?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, September can be a great choice for travel to Indianapolis. Flights to Indianapolis from Panama City, Florida in September are about $404 on average during September, but can be found for as low as $226.

Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Indianapolis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.

Can I find deals for business class flights from Panama City to Indianapolis?

Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$121+ Flights from Panama City, FL to Indianapolis

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Indianapolis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Indianapolis

Round-trip from	$241 (American Airlines)
One-way from	$121 (American Airlines)
Popular in	March
Cheapest in	September
Average price	$393

From Panama City NW Florida Beaches to Indianapolis

Search Deals

One-way flight from Panama City NW Florida Beaches to Indianapolis

Search Deals

Highest demand for flights based on searches. 18% potential increase in price ($93 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in August 2025

Search Deals

Find flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 16, 2025.

mer. 9/33:29 pmECP - IND

1 stop5h 01mAmerican Airlines

mer. 9/107:39 amIND - ECP

1 stop7h 41mAmerican Airlines

Deal found 8/14

$241

sam. 9/66:06 pmECP - IND

1 stop4h 04mAmerican Airlines

sam. 9/132:30 pmIND - ECP

1 stop7h 42mAmerican Airlines

Deal found 8/14

$275

ven. 9/197:25 amECP - IND

2 stops7h 55mSouthwest

lun. 9/225:25 amIND - ECP

1 stop6h 25mSouthwest

Deal found 8/14

$292

ven. 10/3110:30 amECP - IND

1 stop7h 50mSouthwest

dim. 11/95:50 amIND - ECP

1 stop8h 05mSouthwest

Deal found 8/14

$294

jeu. 10/95:30 amECP - IND

1 stop6h 40mAmerican Airlines

lun. 10/136:56 pmIND - ECP

1 stop5h 48mAmerican Airlines

Deal found 8/14

$299

sam. 9/206:32 amECP - IND

1 stop6h 06mAmerican Airlines

jeu. 9/256:10 amIND - ECP

1 stop4h 32mAmerican Airlines

Deal found 8/14

$317

ven. 10/316:00 amECP - IND

1 stop3h 33mDelta

dim. 11/98:00 pmIND - ECP

1 stop3h 43mDelta

Deal found 8/15

$324

Best flights from Panama City to Indianapolis
Discover carefully curated flight deals from Panama City to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated août 16, 2025.

sam. 9/66:06 pmECP - IND

1 stop4h 04mAmerican Airlines

sam. 9/132:30 pmIND - ECP

1 stop7h 42mAmerican Airlines

Deal found 8/14

$275

ven. 10/3110:30 amECP - IND

1 stop7h 50mSouthwest

dim. 11/95:50 amIND - ECP

1 stop8h 05mSouthwest

Deal found 8/14

$294

ven. 10/316:00 amECP - IND

1 stop3h 33mDelta

dim. 11/98:00 pmIND - ECP

1 stop3h 43mDelta

Deal found 8/15

$324

ven. 9/193:53 pmECP - IND

1 stop7h 21mAmerican Airlines

lun. 9/226:00 amIND - ECP

1 stop6h 07mAmerican Airlines

Deal found 8/14

$287

ven. 9/197:25 amECP - IND

2 stops7h 55mSouthwest

lun. 9/225:25 amIND - ECP

2 stops8h 35mSouthwest

Deal found 8/14

$297

jeu. 10/95:30 amECP - IND

1 stop6h 40mAmerican Airlines

lun. 10/136:56 pmIND - ECP

1 stop5h 48mAmerican Airlines

Deal found 8/14

$299

ven. 9/265:40 pmECP - IND

1 stop5h 05mSouthwest

lun. 9/296:35 amIND - ECP

1 stop4h 20mSouthwest

Deal found 8/16

$322

sam. 9/206:32 amECP - IND

1 stop6h 06mAmerican Airlines

jeu. 9/256:27 amIND - ECP

2 stops8h 32mAmerican Airlines

Deal found 8/14

$322

ven. 9/263:29 pmECP - IND

1 stop5h 01mAmerican Airlines

lun. 9/2911:00 amIND - ECP

2 stops7h 36mAmerican Airlines

Deal found 8/16

$327

Last-minute flights from Panama City to Indianapolis
Discover last-minute flight deals from Panama City to Indianapolis. Data last updated août 16, 2025 and is based on user searches.

mer. 9/33:29 pmECP - IND

1 stop5h 01mAmerican Airlines

mer. 9/107:39 amIND - ECP

1 stop7h 41mAmerican Airlines

Deal found 8/14

$241

sam. 9/66:06 pmECP - IND

1 stop4h 04mAmerican Airlines

sam. 9/132:30 pmIND - ECP

1 stop7h 42mAmerican Airlines

Deal found 8/14

$275

sam. 9/611:09 amECP - IND

2 stops11h 50mUnited Airlines

sam. 9/139:05 amIND - ECP

2 stops12h 11mUnited Airlines

Deal found 8/14

$355

ven. 9/197:25 amECP - IND

2 stops7h 55mSouthwest

lun. 9/225:25 amIND - ECP

1 stop6h 25mSouthwest

Deal found 8/14

$292

sam. 9/206:32 amECP - IND

1 stop6h 06mAmerican Airlines

jeu. 9/256:10 amIND - ECP

1 stop4h 32mAmerican Airlines

Deal found 8/14

$317

ven. 9/263:29 pmECP - IND

1 stop5h 01mAmerican Airlines

lun. 9/2911:00 amIND - ECP

2 stops7h 36mAmerican Airlines

Deal found 8/16

$327

One-way flights from Panama City to Indianapolis
Search for one-way flight options from Panama City to Indianapolis. Find affordable one-way fares based on user searches. Data last updated août 16, 2025.

mar. 9/166:06 pmECP - IND

1 stop4h 04mAmerican Airlines

Deal found 8/15

$121

mar. 11/181:11 pmECP - IND

1 stop7h 54mAmerican Airlines

Deal found 8/14

$122

mar. 9/236:30 amECP - IND

2 stops9h 02mUnited Airlines

Deal found 8/14

$126

mar. 9/161:44 pmECP - IND

1 stop7h 07mUnited Airlines

Deal found 8/15

$129

mar. 9/167:40 amECP - IND

2 stops8h 30mSouthwest

Deal found 8/15

$134

jeu. 9/186:59 pmECP - IND

1 stop4h 00mAmerican Airlines

Deal found 8/15

$138

sam. 11/151:21 pmECP - IND

1 stop4h 40mAmerican Airlines

Deal found 8/15

$142

jeu. 9/187:25 amECP - IND

2 stops7h 55mSouthwest

Deal found 8/15

$143

mer. 11/127:45 amECP - IND

1 stop6h 25mDelta

Deal found 8/15

$145

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

sam. 9/6

6:06 pm-11:10 pm

1 stop4h 04m

Indianapolis

sam. 9/13

2:30 pm-9:12 pm

1 stop7h 42m

$275

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 9/19

3:53 pm-12:14 am

1 stop7h 21m

Indianapolis

lun. 9/22

6:00 am-11:07 am

1 stop6h 07m

$287

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 10/31

10:30 am-7:20 pm

1 stop7h 50m

Indianapolis

dim. 11/9

5:50 am-12:55 pm

1 stop8h 05m

$294

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 9/19

7:25 am-4:20 pm

2 stops7h 55m

Indianapolis

lun. 9/22

5:25 am-1:00 pm

2 stops8h 35m

$297

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

jeu. 10/9

5:30 am-1:10 pm

1 stop6h 40m

Indianapolis

lun. 10/13

6:56 pm-11:44 pm

1 stop5h 48m

$299

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 9/26

5:40 pm-11:45 pm

1 stop5h 05m

Indianapolis

lun. 9/29

6:35 am-9:55 am

1 stop4h 20m

$322

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

sam. 9/20

6:32 am-1:38 pm

1 stop6h 06m

Indianapolis

jeu. 9/25

6:27 am-1:59 pm

2 stops8h 32m

$322

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 10/31

6:00 am-10:33 am

1 stop3h 33m

Indianapolis

dim. 11/9

8:00 pm-10:43 pm

1 stop3h 43m

$324

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

ven. 9/26

3:29 pm-9:30 pm

1 stop5h 01m

Indianapolis

lun. 9/29

11:00 am-5:36 pm

2 stops7h 36m

$327

Panama CityIndianapolis

ECP - IND

ECPIND

Panama City NW Florida Beaches

mar. 10/28

3:38 pm-12:15 am

1 stop7h 37m

$121

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 19 results

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City, Florida to Indianapolis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Indianapolis (average of $297). Flying from Panama City, Florida to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to IND?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Indianapolis in the evening. If you’re flexible enough to do this you can expect to save up to 37% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Indianapolis

Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Panama City to Indianapolis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,246 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Delta

8.0

Very good

7,985 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to Indianapolis round-trip?
Cheapflights users have booked flights from Panama City, Florida to Indianapolis round-trip from $226. Other airlines that can offer you cheap pricing are American Airlines, from $286, and Southwest, from $333. Delta is currently priced 43% below the average price you’ll pay for this route.
Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?
Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Indianapolis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.
Can I find deals for business class flights from Panama City to Indianapolis?
Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to Indianapolis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Indianapolis (average of $297). Flying from Panama City, Florida to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Greenwood

Bloomington

Muncie

Noblesville

Fishers

Terre Haute

Anderson

Kokomo

Franklin

Plainfield

Carmel

Crawfordsville

Shelbyville

Speedway

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to Indianapolis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$226	Average$333	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$286	Average$418	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$333	Average$402	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$121+ Cheap flights from Panama City, FL to Indianapolis (ECP - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Indianapolis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to Indianapolis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to IndianapolisExplore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 16, 2025.

Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City, Florida to Indianapolis?

What is the cheapest time of day to fly from ECP to IND?

Find hourly flight availability from Panama City to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated août 16, 2025.

Reviews of airlines servicing Indianapolis

Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Panama City to Indianapolis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to Indianapolis round-trip?

Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

How can I find direct flights from Panama City to Indianapolis?

Can I find deals for business class flights from Panama City to Indianapolis?

What is the cheapest month to book a flight from Panama City, Florida to Indianapolis?

Traveling to a place near Indianapolis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Panama City to Indianapolis

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 16, 2025.