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$149+ Cheap flights from Knoxville to Harrisburg (TYS - MDT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MDT
Dec 31 — Jan 71
Wed 12/31
Wed 1/7
1 adult, Economy
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Find flight deals from Knoxville to Harrisburg

Cheapest flights from Knoxville to Harrisburg
Explore the most affordable flight options available from Knoxville to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 1, 2025.

This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amTYS - MDT
1 stop3h 35mAmerican Airlines
Thu 1/19:41 amMDT - TYS
1 stop6h 06mAmerican Airlines
Deal found 12/1$229
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:35 pmTYS - MDT
1 stop6h 32mUnited Airlines
Thu 1/16:15 amMDT - TYS
1 stop4h 41mUnited Airlines
Deal found 12/1$259
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:52 pmTYS - MDT
1 stop7h 05mUnited Airlines
Mon 12/86:15 amMDT - TYS
1 stop4h 33mUnited Airlines
Deal found 11/30$309
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:50 amTYS - MDT
2 stops8h 04mUnited Airlines
Mon 12/86:15 amMDT - TYS
1 stop4h 33mUnited Airlines
Deal found 11/29$314
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:40 amTYS - MDT
1 stop4h 16mAmerican Airlines
Sat 12/611:07 amMDT - TYS
1 stop4h 57mAmerican Airlines
Deal found 11/30$319
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 amTYS - MDT
2 stops7h 09mUnited Airlines
Thu 1/16:15 amMDT - TYS
1 stop4h 41mUnited Airlines
Deal found 12/1$324
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:35 pmTYS - MDT
1 stop6h 32mUnited Airlines
Thu 1/13:00 pmMDT - TYS
2 stops7h 39mUnited Airlines
Deal found 12/1$338
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:40 amTYS - MDT
1 stop4h 12mUnited Airlines
Sat 12/66:15 amMDT - TYS
2 stops7h 02mUnited Airlines
Deal found 11/30$368
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:45 amTYS - MDT
1 stop3h 51mUnited Airlines
Fri 12/2610:30 amMDT - TYS
1 stop13h 29mUnited Airlines
Deal found 11/30$383
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:42 amTYS - MDT
1 stop3h 28mAmerican Airlines
Thu 12/251:58 pmMDT - TYS
1 stop4h 09mAmerican Airlines
Deal found 11/30$417
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:42 amTYS - MDT
1 stop3h 28mAmerican Airlines
Thu 1/11:52 pmMDT - TYS
2 stops5h 49mAmerican Airlines
Deal found 11/30$422

Cheap flight deals from Knoxville to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(American Airlines)

One-way from

$149
(American Airlines)

Popular in

August

Cheapest in

March

Average price

$308
Provider with most accurate pricing for Knoxville McGhee Tyson-Harrisburg flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Harrisburg flights.
Search Deals
From Knoxville McGhee Tyson to Harrisburg
Search Deals
One-way flight from Knoxville McGhee Tyson to Harrisburg
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Knoxville to Harrisburg that are best for you.

Fly from

Knoxville

Fly to

Harrisburg

Route

Depart

Return

Price

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 12/25

7:00 am-10:35 am

1 stop3h 35m

Harrisburg

Thu 1/1

9:41 am-3:47 pm

1 stop6h 06m

$229

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 1/8

8:09 am-12:03 pm

1 stop3h 54m

Harrisburg

Sat 1/10

5:09 pm-10:09 pm

1 stop5h 00m

$229

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 12/26

5:42 am-9:10 am

1 stop3h 28m

Harrisburg

Thu 1/1

9:41 am-3:47 pm

1 stop6h 06m

$229

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Mon 12/22

5:35 pm-12:07 am

1 stop6h 32m

Harrisburg

Thu 1/1

6:15 am-10:56 am

1 stop4h 41m

$259

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 1/8

6:45 am-1:51 pm

2 stops7h 06m

Harrisburg

Sat 1/10

3:10 pm-8:52 pm

1 stop5h 42m

$294

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Sat 1/24

5:14 pm-11:58 pm

1 stop6h 44m

Harrisburg

Wed 1/28

6:25 am-3:20 pm

2 stops8h 55m

$294

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 12/25

6:45 am-1:54 pm

2 stops7h 09m

Harrisburg

Thu 1/1

6:15 am-10:56 am

1 stop4h 41m

$324

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 12/26

5:35 pm-12:07 am

1 stop6h 32m

Harrisburg

Thu 1/1

3:00 pm-10:39 pm

2 stops7h 39m

$338

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 1/2

5:42 am-9:10 am

1 stop3h 28m

$149

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Mon 12/8

11:28 am-3:41 pm

2 stops52h 13m

$203

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

Showing 1-10 of 17 results
1
2

Compare providers for flights from Knoxville to Harrisburg

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Harrisburg in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Harrisburg flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Harrisburg flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Harrisburg flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Harrisburg flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Harrisburg flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Harrisburg

What is the cheapest month to book a flight from Knoxville to Harrisburg?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Harrisburg (average of $125). Flying from Knoxville to Harrisburg in April is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MDT?

Find hourly flight availability from Knoxville to Harrisburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 1, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 23% on flights from Knoxville to Harrisburg by exploring options for tickets in the afternoon.

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated December 1, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Harrisburg. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,010 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,010 reviews
Delta
7.9
Good
8,010 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,065 reviews
Delta
7.9
Good
8,010 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,041 reviews
Delta
7.9
Good
8,010 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Harrisburg?

    A quick flight from Knoxville to Harrisburg can take about 3h 35m. American Airlines provides one of the quickest options available for as low as $229. The distance between Knoxville and Harrisburg is about 496 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Harrisburg round-trip?

    American Airlines, at $228, was found to be the cheapest airline from Knoxville to Harrisburg.Alternate airlines to your destination round-trip include Delta and United Airlines. American Airlines is 47% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Harrisburg.

  • Can I find deals for business class flights from Knoxville to Harrisburg?

    Yes. Cheapflights offers flight deals from Knoxville to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Harrisburg?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Harrisburg (average of $125). Flying from Knoxville to Harrisburg in April is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Mechanicsburg
Hershey
Carlisle
Camp Hill

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Top 3 airlines flying from Knoxville to Harrisburg

Discover the top 3 airlines that operate flights from Knoxville to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$340FlexibilityNo cancel feeOn-time71%
DeltaCheapest$233Average$353FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$328Average$562FlexibilityNo cancel feeOn-time69%

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