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$133+ Cheap flights from Knoxville to Harrisburg (TYS - MDT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MDT
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$229
(American Airlines)

One-way from

$133
(Kiwi.com)

Popular in

August

Cheapest in

March

Average price

$305
From Knoxville McGhee Tyson to Harrisburg
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One-way flight from Knoxville McGhee Tyson to Harrisburg
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Highest demand for flights based on searches. 15% potential increase in price ($76 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Harrisburg

Cheapest flights from Knoxville to Harrisburg
Explore the most affordable flight options available from Knoxville to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:24 pmTYS - MDT
1 stop6h 25mAmerican Airlines
Thu 1/19:41 amMDT - TYS
1 stop6h 06mAmerican Airlines
Deal found 9/14$229
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:00 amTYS - MDT
2 stops6h 54mUnited Airlines
Wed 10/226:15 amMDT - TYS
1 stop4h 14mUnited Airlines
Deal found 9/15$257
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:44 amTYS - MDT
1 stop5h 15mDelta
Wed 10/226:00 amMDT - TYS
1 stop4h 45mDelta
Deal found 9/15$268
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/208:23 amTYS - MDT
1 stop6h 03mAmerican Airlines
Mon 9/228:31 amMDT - TYS
1 stop5h 12mAmerican Airlines
Deal found 9/14$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/234:23 pmTYS - MDT
1 stop27h 44mAllegiant Air
Fri 11/78:55 pmMDT - TYS
1 stop12h 32mAllegiant Air
Deal found 9/15$296
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3010:51 amTYS - MDT
1 stop6h 01mUnited Airlines
Sat 10/46:15 amMDT - TYS
1 stop4h 14mUnited Airlines
Deal found 9/15$299
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/195:45 amTYS - MDT
1 stop3h 48mUnited Airlines
Sat 9/202:24 pmMDT - TYS
2 stops8h 21mUnited Airlines
Deal found 9/15$310

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Harrisburg that are best for you.

Fly from

Knoxville

Fly to

Harrisburg

Route

Depart

Return

Price

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 12/25

1:24 pm-7:49 pm

1 stop6h 25m

Harrisburg

Thu 1/1

9:41 am-3:47 pm

1 stop6h 06m

$229

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 10/15

7:00 am-1:54 pm

2 stops6h 54m

Harrisburg

Wed 10/22

6:15 am-10:29 am

1 stop4h 14m

$257

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 2/18

11:44 am-4:03 pm

1 stop4h 19m

Harrisburg

Sat 2/21

12:05 pm-3:40 pm

1 stop3h 35m

$289

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 10/23

4:23 pm-8:07 pm

1 stop27h 44m

Harrisburg

Fri 11/7

8:55 pm-9:27 am

1 stop12h 32m

$296

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Tue 9/30

10:51 am-4:52 pm

1 stop6h 01m

Harrisburg

Sat 10/4

6:15 am-10:29 am

1 stop4h 14m

$299

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 10/16

9:25 pm-8:22 pm

1 stop22h 57m

$133

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 10/15

7:00 am-1:54 pm

2 stops6h 54m

$157

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 10/15

5:44 am-10:59 am

1 stop5h 15m

$159

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 10/15

5:37 pm-11:48 pm

1 stop6h 11m

$169

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 10/2

9:25 pm-8:17 pm

1 stop22h 52m

$208

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 16 results
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Best time to book a flight from Knoxville to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Harrisburg

What is the cheapest month to book a flight from Knoxville to Harrisburg?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Harrisburg (average of $347). Flying from Knoxville to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MDT?

Find hourly flight availability from Knoxville to Harrisburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 24% on flights from Knoxville to Harrisburg by exploring options for tickets in the afternoon.

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Harrisburg. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Harrisburg?

    A quick flight from Knoxville to Harrisburg can take about 6h 25m. American Airlines provides one of the quickest options available for as low as $229. The distance between Knoxville and Harrisburg is about 496 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Harrisburg round-trip?

    American Airlines, at $228, was found to be the cheapest airline from Knoxville to Harrisburg.Alternate airlines to your destination round-trip include Delta and United Airlines. American Airlines is 46% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Knoxville to Harrisburg one-way?

    The cheapest airlines for a one-way flight from Knoxville to Harrisburg are Allegiant Air ($133), United Airlines ($157), and Delta ($159).

  • Can I find deals for flights from Knoxville to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Harrisburg.

  • Can I find deals for business class flights from Knoxville to Harrisburg?

    Yes. Cheapflights offers flight deals from Knoxville to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Harrisburg?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Harrisburg (average of $347). Flying from Knoxville to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Carlisle
Mechanicsburg
Hershey
Camp Hill

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Top 3 airlines flying from Knoxville to Harrisburg

Discover the top 3 airlines that operate flights from Knoxville to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$331FlexibilityNo cancel feeOn-time71%
DeltaCheapest$273Average$353FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$306Average$500FlexibilityNo cancel feeOn-time69%

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