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Guayaquil

$158+ Cheap flights from Missouri to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GYE
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Missouri to Guayaquil

Keep the following information in mind while searching for Missouri to Guayaquil flight deals. Data was last updated September 17, 2025.

Round-trip from

$577
(KAYAK)

One-way from

$160
(Kiwi.com)
From Missouri to Guayaquil Jose Joaquin de Olmedo
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One-way flight from Missouri to Guayaquil Jose Joaquin de Olmedo
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Find flight deals from Missouri to Guayaquil

Cheapest flights from Missouri to Guayaquil
Explore the most affordable flight options available from Missouri to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:09 amMCI - GYE
2 stops14h 32mUnited Airlines
Wed 1/288:34 amGYE - MCI
2 stops33h 19mUnited Airlines
Deal found 9/15$587
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:15 amSTL - GYE
2 stops28h 03mUnited Airlines
Fri 2/202:35 pmGYE - STL
2 stops21h 11mUnited Airlines
Deal found 9/15$597
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:13 pmMCI - GYE
1 stop10h 32mSpirit Airlines
Tue 1/2712:59 amGYE - MCI
2 stops12h 40mSpirit Airlines
Deal found 9/15$614
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:10 amMCI - GYE
2 stops50h 08mUnited Airlines
Sun 11/168:30 amGYE - MCI
2 stops30h 43mUnited Airlines
Deal found 9/15$625
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:12 amMCI - GYE
2 stops17h 38mAmerican Airlines
Wed 1/287:30 amGYE - MCI
1 stop9h 46mAmerican Airlines
Deal found 9/15$626
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:20 pmMCI - GYE
2 stops28h 46mAmerican Airlines
Sun 11/166:00 amGYE - MCI
1 stop18h 59mAmerican Airlines
Deal found 9/17$665
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:34 pmMCI - GYE
2 stops17h 46mMultiple Airlines
Tue 1/2712:59 amGYE - MCI
2 stops12h 40mMultiple Airlines
Deal found 9/15$793
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:15 amSTL - GYE
2 stops31h 31mUnited Airlines
Thu 10/22:54 pmGYE - STL
2 stops31h 06mUnited Airlines
Deal found 9/15$841
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:10 amSTL - GYE
1 stop16h 56mAmerican Airlines
Fri 2/202:33 pmGYE - STL
1 stop10h 13mAmerican Airlines
Deal found 9/15$902
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/295:28 amSTL - GYE
1 stop14h 20mAmerican Airlines
Thu 10/28:20 amGYE - STL
1 stop15h 39mAmerican Airlines
Deal found 9/15$952
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:30 pmSTL - GYE
3 stops33h 10mMultiple Airlines
Wed 10/13:15 amGYE - STL
3 stops32h 14mMultiple Airlines
Deal found 9/15$1,119

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Missouri to Guayaquil that are best for you.

Fly from

Missouri

Fly to

Guayaquil

Route

Depart

Return

Price

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 2/19

12:20 pm-11:45 pm

1 stop10h 25m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

12:59 am-11:01 am

1 stop11h 02m

$577

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 12/4

6:15 am-11:18 am

2 stops28h 03m

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

2:35 pm-10:46 am

2 stops21h 11m

$597

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 2/19

4:17 pm-11:18 am

2 stops42h 01m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:20 pm-10:14 pm

2 stops34h 54m

$615

Kansas CityGuayaquil

MCI - GYE

MCIGYE

Kansas City

Wed 11/12

8:10 am-11:18 am

2 stops50h 08m

Guayaquil Jose Joaquin de Olmedo

Sun 11/16

8:30 am-2:13 pm

2 stops30h 43m

$625

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 2/19

5:11 pm-11:45 pm

2 stops53h 34m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

12:59 am-11:01 am

1 stop11h 02m

$643

Kansas CityGuayaquil

MCI - GYE

MCIGYE

Kansas City

Wed 11/12

5:20 pm-11:06 pm

2 stops28h 46m

Guayaquil Jose Joaquin de Olmedo

Sun 11/16

6:00 am-11:59 pm

1 stop18h 59m

$668

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 2/19

5:19 am-1:33 pm

1 stop7h 14m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

2:33 pm-11:46 pm

1 stop10h 13m

$753

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Mon 9/29

6:15 am-11:15 am

2 stops29h 00m

Guayaquil Jose Joaquin de Olmedo

Wed 10/1

3:15 am-10:00 pm

2 stops18h 45m

$851

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Thu 12/4

5:10 am-11:06 pm

1 stop16h 56m

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

2:33 pm-11:46 pm

1 stop10h 13m

$902

St. LouisGuayaquil

STL - GYE

STLGYE

Lambert-St Louis

Mon 9/29

5:28 am-7:48 pm

1 stop14h 20m

Guayaquil Jose Joaquin de Olmedo

Thu 10/2

8:20 am-11:59 pm

1 stop15h 39m

$952

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 26 results
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Best time to book a flight from Missouri to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Guayaquil
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from Missouri?

    Most people fly into Guayaquil Jose Joaquin de Olmedo (GYE) if they book a flight to Guayaquil from Missouri. Jose Joaquin de Olmedo is conveniently located just 2.5 mi from Guayaquil’s city center.

  • How long is the flight from Missouri to Guayaquil?

    A quick flight from Missouri to Guayaquil can take about 10h 25m. Spirit Airlines provides one of the quickest options available for as low as $577. Missouri and Guayaquil are separated by a distance of 2902 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Missouri to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Guayaquil.

  • Can I find deals for business class flights from Missouri to Guayaquil?

    Yes. Cheapflights offers flight deals from Missouri to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Guayaquil (average of $440). Flying from Missouri to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Missouri to Guayaquil

Discover the top airline that operate flights from Missouri to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$516Average$1,124FlexibilityNo cancel feeOn-time71%

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