$117+ Cheap flights from San Diego to Greenville (SAN - GSP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — GSP
May 15 — May 221
Round-trip
1 adult, Economy
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Find cheap flights from San Diego to Greenville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Diego to Greenville
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Best
Last-minute
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Cheapest flights from San Diego to GreenvilleExplore the most affordable flight options available from San Diego to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
Explore the most affordable flight options available from San Diego to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:24 pm
SAN
- GSP
1 stop20h 02m
Breeze Airways
Sun 8/2310:35 am
GSP
- SAN
1 stop28h 13m
Breeze Airways
Deal found 4/15![Breeze Airways logo]()
$364
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:30 pm
SAN
- GSP
1 stop8h 50m
Delta
Tue 5/1211:43 am
GSP
- SAN
1 stop9h 18m
Delta
Deal found 4/11![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:31 pm
SAN
- GSP
1 stop7h 26m
American Airlines
Sat 5/165:20 am
GSP
- SAN
1 stop8h 49m
American Airlines
Deal found 4/15![American Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:40 pm
SAN
- GSP
1 stop10h 30m
Southwest
Tue 5/126:45 am
GSP
- SAN
2 stops9h 10m
Southwest
Deal found 4/11![Southwest logo]()
$402
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:31 pm
SAN
- GSP
1 stop7h 26m
American Airlines
Tue 5/196:00 am
GSP
- SAN
1 stop8h 16m
American Airlines
Deal found 4/14![American Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/229:25 pm
SAN
- GSP
1 stop7h 53m
American Airlines
Tue 5/265:25 pm
GSP
- SAN
1 stop9h 34m
American Airlines
Deal found 4/15![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:40 pm
SAN
- GSP
1 stop9h 30m
Southwest
Thu 6/46:50 pm
GSP
- SAN
1 stop7h 35m
Southwest
Deal found 4/10![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:20 am
SAN
- GSP
2 stops9h 15m
Southwest
Tue 5/265:05 pm
GSP
- SAN
1 stop7h 15m
Southwest
Deal found 4/11![Southwest logo]()
$440
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:45 pm
SAN
- GSP
2 stops10h 02m
United Airlines
Tue 5/195:00 pm
GSP
- SAN
1 stop7h 25m
United Airlines
Deal found 4/14![United Airlines logo]()
$445
Best flights from San Diego to GreenvilleDiscover carefully curated flight deals from San Diego to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
Discover carefully curated flight deals from San Diego to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:30 pm
SAN
- GSP
1 stop8h 50m
Delta
Tue 5/1211:43 am
GSP
- SAN
1 stop9h 18m
Delta
Deal found 4/11![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:40 pm
SAN
- GSP
1 stop10h 30m
Southwest
Tue 5/126:45 am
GSP
- SAN
2 stops9h 10m
Southwest
Deal found 4/11![Southwest logo]()
$402
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:30 pm
SAN
- GSP
1 stop9h 07m
United Airlines
Wed 6/34:15 pm
GSP
- SAN
1 stop9h 10m
United Airlines
Deal found 4/12![United Airlines logo]()
$493
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:20 am
SAN
- GSP
2 stops9h 15m
Southwest
Thu 6/412:55 pm
GSP
- SAN
2 stops9h 10m
Southwest
Deal found 4/10![Southwest logo]()
$443
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:45 pm
SAN
- GSP
1 stop8h 19m
Delta
Fri 5/85:40 am
GSP
- SAN
1 stop6h 59m
Delta
Deal found 4/12![Delta logo]()
$461
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1310:40 pm
SAN
- GSP
1 stop10h 30m
Southwest
Sat 6/206:55 am
GSP
- SAN
2 stops9h 50m
Southwest
Deal found 4/14![Southwest logo]()
$478
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:20 am
SAN
- GSP
1 stop8h 55m
Southwest
Wed 5/65:05 pm
GSP
- SAN
1 stop7h 15m
Southwest
Deal found 4/15![Southwest logo]()
$485
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:05 pm
SAN
- GSP
1 stop6h 35m
Southwest
Wed 5/2012:50 pm
GSP
- SAN
2 stops8h 35m
Southwest
Deal found 4/10![Southwest logo]()
$490
Last-minute flights from San Diego to GreenvilleDiscover last-minute flight deals from San Diego to Greenville. Data last updated April 15, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to Greenville. Data last updated April 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:30 pm
SAN
- GSP
1 stop8h 50m
Delta
Tue 5/1211:43 am
GSP
- SAN
1 stop9h 18m
Delta
Deal found 4/11![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:40 pm
SAN
- GSP
1 stop10h 30m
Southwest
Tue 5/126:45 am
GSP
- SAN
2 stops9h 10m
Southwest
Deal found 4/11![Southwest logo]()
$402
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:45 pm
SAN
- GSP
1 stop8h 19m
Delta
Fri 5/87:42 pm
GSP
- SAN
1 stop6h 45m
Delta
Deal found 4/13![Delta logo]()
$461
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:31 pm
SAN
- GSP
1 stop7h 26m
American Airlines
Sat 5/165:20 am
GSP
- SAN
1 stop8h 49m
American Airlines
Deal found 4/15![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:45 pm
SAN
- GSP
2 stops10h 02m
United Airlines
Sat 5/164:35 pm
GSP
- SAN
1 stop7h 37m
United Airlines
Deal found 4/15![United Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:31 pm
SAN
- GSP
1 stop7h 26m
American Airlines
Tue 5/196:00 am
GSP
- SAN
1 stop8h 16m
American Airlines
Deal found 4/14![American Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:45 pm
SAN
- GSP
2 stops10h 02m
United Airlines
Tue 5/195:00 pm
GSP
- SAN
1 stop7h 25m
United Airlines
Deal found 4/14![United Airlines logo]()
$445
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/229:25 pm
SAN
- GSP
1 stop7h 53m
American Airlines
Tue 5/265:25 pm
GSP
- SAN
1 stop9h 34m
American Airlines
Deal found 4/15![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:20 am
SAN
- GSP
2 stops9h 15m
Southwest
Tue 5/265:05 pm
GSP
- SAN
1 stop7h 15m
Southwest
Deal found 4/11![Southwest logo]()
$440
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:40 pm
SAN
- GSP
1 stop9h 30m
Southwest
Thu 6/46:50 pm
GSP
- SAN
1 stop7h 35m
Southwest
Deal found 4/10![Southwest logo]()
$433
One-way flights from San Diego to GreenvilleSearch for one-way flight options from San Diego to Greenville. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
Search for one-way flight options from San Diego to Greenville. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:37 am
SAN
- GSP
2 stops26h 16m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:25 am
SAN
- GSP
2 stops29h 28m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:07 pm
SAN
- GSP
3 stops37h 46m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:44 pm
SAN
- GSP
3 stops43h 09m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/269:25 pm
SAN
- GSP
1 stop9h 43m
American Airlines
Deal found 4/14![American Airlines logo]()
$192
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:32 pm
SAN
- GSP
2 stops10h 39m
United Airlines
Deal found 4/13![United Airlines logo]()
$197
Find flight deals from San Diego to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $391 (Delta) |
One-way from | $139 (Kiwi.com) |
Popular in | February |
Cheapest in | August |
Average price | $553 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Mon 5/4
10:30 pm-10:20 am
1 stop8h 50m
Greenville
Tue 5/12
11:43 am-6:01 pm
1 stop9h 18m
$391
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Mon 5/4
10:40 pm-12:10 pm
1 stop10h 30m
Greenville
Tue 5/12
6:45 am-12:55 pm
2 stops9h 10m
$402
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Fri 5/29
10:20 am-10:35 pm
2 stops9h 15m
Greenville
Thu 6/4
12:55 pm-7:05 pm
2 stops9h 10m
$443
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Wed 5/6
9:45 pm-9:04 am
1 stop8h 19m
Greenville
Fri 5/8
5:40 am-9:39 am
1 stop6h 59m
$461
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Sat 6/13
10:40 pm-12:10 pm
1 stop10h 30m
Greenville
Sat 6/20
6:55 am-1:45 pm
2 stops9h 50m
$478
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Mon 5/4
10:20 am-10:15 pm
1 stop8h 55m
Greenville
Wed 5/6
5:05 pm-9:20 pm
1 stop7h 15m
$485
Quickest round-trip
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Wed 4/29
12:05 pm-9:40 pm
1 stop6h 35m
Greenville
Wed 5/20
12:50 pm-6:25 pm
2 stops8h 35m
$490
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Tue 6/2
10:30 pm-10:37 am
1 stop9h 07m
Greenville
Wed 6/3
4:15 pm-10:25 pm
1 stop9h 10m
$493
Cheapest one-way
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Sat 5/23
6:25 am-2:53 pm
2 stops29h 28m
$139
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Tue 5/26
10:07 pm-7:39 pm
3 stops42h 32m
$177
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from San Diego to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Greenville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Diego-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from San Diego with our price prediction graph.
SAN-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Greenville
What is the cheapest month to book a flight from San Diego to Greenville?
Currently, May is the cheapest month in which you can book a flight from San Diego to Greenville (average of $153). Flying from San Diego to Greenville in March is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Diego to Greenville?
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated April 15, 2026.
Read through reviews of airlines operating flights from San Diego to Greenville, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Diego to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Duncan
Seneca
Anderson
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Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 15, 2026.
San Diego and Greenville flights
Browse other San Diego and Greenville flight options. Last updated on April 15, 2026.
Other flights from San Diego
Browse through other flights departing from San Diego. Flights are based on user searches made on Cheapflights and were last updated on April 15, 2026.
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Top 4 airlines flying from San Diego to Greenville
Discover the top 4 airlines that operate flights from San Diego to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$286 | Average$417 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$312 | Average$502 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$358 | Average$518 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$398 | Average$550 | FlexibilityNo cancel fee | On-time63% |