HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$141+ Cheap flights from San Diego to Greenville (SAN - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — GSP
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Diego to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Diego to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$370
(American Airlines)

One-way from

$141
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$397
From San Diego to Greenville
Search Deals
One-way flight from San Diego to Greenville
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from San Diego to Greenville

Cheapest flights from San Diego to Greenville
Explore the most affordable flight options available from San Diego to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:46 amSAN - GSP
1 stop6h 25mAmerican Airlines
Mon 11/36:01 amGSP - SAN
1 stop8h 17mAmerican Airlines
Deal found 9/14$370
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:15 amSAN - GSP
1 stop12h 39mAmerican Airlines
Tue 10/711:26 amGSP - SAN
1 stop10h 57mAmerican Airlines
Deal found 9/15$390
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/99:45 pmSAN - GSP
1 stop9h 00mSouthwest
Wed 11/123:05 pmGSP - SAN
1 stop6h 50mSouthwest
Deal found 9/14$392
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/169:27 pmSAN - GSP
1 stop7h 57mAmerican Airlines
Tue 10/2111:26 amGSP - SAN
1 stop10h 57mAmerican Airlines
Deal found 9/16$405
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:25 amSAN - GSP
2 stops8h 50mSouthwest
Mon 11/34:45 pmGSP - SAN
1 stop7h 50mSouthwest
Deal found 9/14$418
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/72:05 pmSAN - GSP
1 stop6h 50mDelta
Sun 10/127:52 amGSP - SAN
1 stop15h 27mDelta
Deal found 9/14$421
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/169:27 pmSAN - GSP
1 stop7h 57mAmerican Airlines
Mon 10/204:46 pmGSP - SAN
1 stop8h 36mAmerican Airlines
Deal found 9/16$425
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:25 amSAN - GSP
1 stop7h 16mDelta
Sun 10/126:35 amGSP - SAN
1 stop19h 39mDelta
Deal found 9/14$432
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:15 amSAN - GSP
1 stop7h 41mAmerican Airlines
Wed 10/2211:26 amGSP - SAN
1 stop10h 57mAmerican Airlines
Deal found 9/16$433

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.

Fly from

San Diego

Fly to

Greenville

Route

Depart

Return

Price

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sun 11/9

6:35 am-3:40 pm

1 stop6h 05m

Greenville

Wed 11/12

3:05 pm-9:10 pm

2 stops9h 05m

$397

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 10/16

9:27 pm-8:24 am

1 stop7h 57m

Greenville

Tue 10/21

6:00 am-10:45 am

1 stop7h 45m

$414

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 10/25

6:25 am-6:15 pm

2 stops8h 50m

Greenville

Mon 11/3

4:45 pm-9:35 pm

1 stop7h 50m

$418

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 10/16

9:27 pm-8:24 am

1 stop7h 57m

Greenville

Mon 10/20

4:46 pm-10:22 pm

1 stop8h 36m

$425

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Mon 10/6

7:15 am-5:56 pm

1 stop7h 41m

Greenville

Wed 10/22

11:26 am-7:23 pm

1 stop10h 57m

$433

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 10/16

9:48 pm-8:59 am

1 stop8h 11m

Greenville

Tue 10/21

6:35 am-9:48 am

1 stop6h 13m

$438

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Mon 10/6

6:15 am-3:42 pm

1 stop6h 27m

Greenville

Wed 10/22

4:29 pm-11:41 pm

2 stops10h 12m

$442

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 10/3

12:07 pm-10:27 pm

1 stop7h 20m

Greenville

Tue 10/7

5:16 pm-11:14 pm

1 stop8h 58m

$442

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 10/10

9:48 pm-8:59 am

1 stop8h 11m

Greenville

Sun 10/12

5:30 am-8:19 pm

1 stop17h 49m

$442

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Mon 11/24

12:11 pm-11:55 pm

1 stop8h 44m

Greenville

Mon 12/1

7:59 pm-9:58 am

1 stop16h 59m

$442

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 19 results
1
2

Best time to book a flight from San Diego to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Greenville

What is the cheapest month to book a flight from San Diego to Greenville?

Currently, August is the cheapest month in which you can book a flight from San Diego to Greenville (average of $321). Flying from San Diego to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to GSP?

Find hourly flight availability from San Diego to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

It’s typically best to fly out from San Diego to Greenville in the morning. Doing so could potentially save you 7% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 16, 2025.
Read through reviews of airlines operating flights from San Diego to Greenville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Diego to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Greenville?

    Departing from San Diego to Greenville will take you 6h 05m. There are 2002 mi between San Diego and Greenville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from San Diego to Greenville round-trip?

    Currently priced at $286, American Airlines will fly you from San Diego to Greenville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and Delta - these airlines can fly you to your destination from $306 and $312, respectively. Users have found that American Airlines is 32% cheaper than the other options available to this destination.

  • Can I find deals for flights from San Diego to Greenville that include hotel bookings?

    Yes. In addition to deals on San Diego to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Greenville.

  • Can I find deals for business class flights from San Diego to Greenville?

    Yes. Cheapflights offers flight deals from San Diego to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Greenville?

    Currently, August is the cheapest month in which you can book a flight from San Diego to Greenville (average of $321). Flying from San Diego to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Charlotte flights
San Francisco to Charlotte flights
Ontario to Charlotte flights
Santa Ana to Charlotte flights
San Diego to Charlotte flights
Los Angeles to Charleston flights
Las Vegas to Charlotte flights
San Francisco to Charleston flights
San Francisco to Savannah flights
Ontario to Charleston flights
Los Angeles to Savannah flights
Sacramento to Charlotte flights
Burbank to Charlotte flights
San Diego to Charleston flights
Los Angeles to Columbia flights
Los Angeles to Myrtle Beach flights
Santa Ana to Charleston flights
Ontario to Columbia flights
Ontario to Savannah flights
Las Vegas to Charleston flights
San Diego to Myrtle Beach flights
Fresno to Charlotte flights
San Francisco to Columbia flights
San Jose to Savannah flights
Sacramento to Charleston flights
Ontario to Myrtle Beach flights
San Francisco to Greenville flights
San Jose to Charlotte flights
San Diego to Savannah flights
Oakland to Charlotte flights
Sacramento to Greenville flights
Reno to Charlotte flights
Sacramento to Myrtle Beach flights
Santa Ana to Savannah flights
San Francisco to Myrtle Beach flights
Los Angeles to Greenville flights
Sacramento to Savannah flights
Santa Ana to Greenville flights
Sacramento to Columbia flights
San Jose to Columbia flights
Ontario to Greenville flights
Las Vegas to Myrtle Beach flights
San Jose to Myrtle Beach flights
Burbank to Charleston flights
San Diego to Columbia flights
San Luis Obispo to Savannah flights
Burbank to Greenville flights
Long Beach to Charlotte flights
Santa Ana to Myrtle Beach flights

Top 3 airlines flying from San Diego to Greenville

Discover the top 3 airlines that operate flights from San Diego to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$286Average$428FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$306Average$486FlexibilityNo cancel feeOn-time69%
DeltaCheapest$312Average$452FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.