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$121+ Cheap flights from San Diego to Greenville (SAN - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — GSP
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
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Find flight deals from San Diego to Greenville

Cheapest flights from San Diego to Greenville
Explore the most affordable flight options available from San Diego to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2212:01 pmSAN - GSP
1 stop8h 58mAmerican Airlines
Wed 11/262:31 pmGSP - SAN
1 stop9h 29mAmerican Airlines
Deal found 10/27$408
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:35 amSAN - GSP
1 stop6h 05mSouthwest
Wed 12/314:45 pmGSP - SAN
1 stop7h 50mSouthwest
Deal found 10/26$417
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:19 amSAN - GSP
1 stop10h 41mAmerican Airlines
Sat 11/156:12 amGSP - SAN
1 stop11h 03mAmerican Airlines
Deal found 10/26$441
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:35 pmSAN - GSP
2 stops12h 10mSouthwest
Wed 11/264:20 pmGSP - SAN
1 stop7h 15mSouthwest
Deal found 10/27$464
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:03 pmSAN - GSP
1 stop8h 44mAmerican Airlines
Mon 12/224:00 pmGSP - SAN
1 stop8h 02mAmerican Airlines
Deal found 10/26$469
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:30 amSAN - GSP
2 stops10h 10mSouthwest
Mon 12/224:20 pmGSP - SAN
2 stops10h 05mSouthwest
Deal found 10/26$501
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:40 amSAN - GSP
1 stop6h 25mSouthwest
Sat 11/810:25 amGSP - SAN
1 stop9h 45mSouthwest
Deal found 10/27$511
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2210:30 pmSAN - GSP
1 stop7h 32mDelta
Wed 11/2610:07 amGSP - SAN
1 stop8h 24mDelta
Deal found 10/27$519

Cheap flight deals from San Diego to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$403
(American Airlines)

One-way from

$121
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$441
Provider with most accurate pricing for San Diego-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Greenville flights.
Search Deals
From San Diego to Greenville
Search Deals
One-way flight from San Diego to Greenville
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.

Fly from

San Diego

Fly to

Greenville

Route

Depart

Return

Price

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 1/6

6:20 am-4:42 pm

1 stop7h 22m

Greenville

Sun 1/11

7:45 am-1:08 pm

1 stop8h 23m

$403

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 11/22

12:01 pm-11:59 pm

1 stop8h 58m

Greenville

Wed 11/26

2:31 pm-9:00 pm

1 stop9h 29m

$408

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 12/26

6:35 am-3:40 pm

1 stop6h 05m

Greenville

Wed 12/31

4:45 pm-9:35 pm

1 stop7h 50m

$417

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 11/11

6:19 am-8:00 pm

1 stop10h 41m

Greenville

Sat 11/15

6:12 am-2:15 pm

1 stop11h 03m

$441

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 12/19

3:03 pm-2:47 am

1 stop8h 44m

Greenville

Mon 12/22

4:00 pm-9:02 pm

1 stop8h 02m

$469

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 11/22

6:35 pm-9:45 am

2 stops12h 10m

Greenville

Wed 11/26

4:20 pm-11:25 pm

2 stops10h 05m

$483

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 12/19

6:30 am-7:40 pm

2 stops10h 10m

Greenville

Mon 12/22

4:20 pm-11:25 pm

2 stops10h 05m

$501

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 11/4

6:40 am-4:05 pm

1 stop6h 25m

Greenville

Sat 11/8

10:25 am-5:10 pm

1 stop9h 45m

$511

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Wed 1/7

1:18 pm-4:19 pm

2 stops24h 01m

$124

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Wed 1/21

6:25 am-4:19 pm

2 stops30h 54m

$132

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 18 results
1
2

Compare providers for flights from San Diego to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Diego-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Diego-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Diego-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Greenville

What is the cheapest month to book a flight from San Diego to Greenville?

Currently, January is the cheapest month in which you can book a flight from San Diego to Greenville (average of $42). Flying from San Diego to Greenville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to GSP?

Find hourly flight availability from San Diego to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

It’s typically best to fly out from San Diego to Greenville in the morning. Doing so could potentially save you 88% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 27, 2025.
Read through reviews of airlines operating flights from San Diego to Greenville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,997 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
7,997 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,030 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Diego to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Greenville?

    Departing from San Diego to Greenville will take you 6h 05m. There are 2002 mi between San Diego and Greenville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from San Diego to Greenville round-trip?

    Currently priced at $249, Delta will fly you from San Diego to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $286 and $306, respectively. Users have found that Delta is 42% cheaper than the other options available to this destination.

  • Can I find deals for flights from San Diego to Greenville that include hotel bookings?

    Yes. In addition to deals on San Diego to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Greenville.

  • Can I find deals for business class flights from San Diego to Greenville?

    Yes. Cheapflights offers flight deals from San Diego to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Greenville?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Greenville (average of $42). Flying from San Diego to Greenville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 3 airlines flying from San Diego to Greenville

Discover the top 3 airlines that operate flights from San Diego to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$249Average$459FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$286Average$408FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$306Average$518FlexibilityNo cancel feeOn-time69%

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