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$179+ Cheap flights from La Crosse to Greenville (LSE - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — GSP
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from La Crosse to Greenville

Cheapest flights from La Crosse to Greenville
Explore the most affordable flight options available from La Crosse to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:32 pm
LSE
-
GSP
1 stop4h 26m
American Airlines
Fri 4/1011:31 am
GSP
-
LSE
1 stop7h 31m
American Airlines
Deal found 1/31$510
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:20 am
LSE
-
GSP
1 stop4h 36m
American Airlines
Sun 2/157:20 am
GSP
-
LSE
1 stop4h 35m
American Airlines
Deal found 1/31$568
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:20 am
LSE
-
GSP
2 stops12h 36m
American Airlines
Sun 2/157:20 am
GSP
-
LSE
1 stop4h 35m
American Airlines
Deal found 1/31$574
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1811:31 am
LSE
-
GSP
2 stops9h 37m
American Airlines
Sun 2/227:20 am
GSP
-
LSE
2 stops11h 39m
American Airlines
Deal found 2/3$599
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:15 am
LSE
-
GSP
1 stop9h 45m
United Airlines
Tue 9/226:46 am
GSP
-
LSE
1 stop12h 24m
United Airlines
Deal found 2/1$641

Find flight deals from La Crosse to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$510
(American Airlines)

One-way from

$179
(Kiwi.com)
Provider with most accurate pricing for La Crosse-Greenville flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Greenville flights.
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From La Crosse to Greenville
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One-way flight from La Crosse to Greenville
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from La Crosse to Greenville that are best for you.

Fly from

La Crosse

Fly to

Greenville

Route

Depart

Return

Price

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Tue 4/7

6:32 pm-11:58 pm

1 stop4h 26m

Greenville

Fri 4/10

11:31 am-6:02 pm

1 stop7h 31m

$510

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Wed 2/18

6:29 pm-11:42 pm

1 stop4h 13m

Greenville

Sun 2/22

7:20 am-10:55 am

1 stop4h 35m

$568

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Fri 2/13

5:20 am-10:56 am

1 stop4h 36m

Greenville

Sun 2/15

7:20 am-10:55 am

1 stop4h 35m

$568

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Sat 2/14

5:20 am-6:56 pm

2 stops12h 36m

Greenville

Sun 2/15

7:20 am-10:55 am

1 stop4h 35m

$574

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Tue 3/10

6:29 pm-11:39 pm

1 stop4h 10m

Greenville

Fri 3/13

8:17 pm-11:02 am

1 stop15h 45m

$670

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Sun 7/19

5:30 pm-7:30 am

1 stop13h 00m

$179

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Mon 7/20

8:15 pm-5:00 pm

1 stop19h 45m

$407

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Mon 7/20

11:31 am-9:18 pm

2 stops8h 47m

$448

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Sun 7/19

11:31 am-11:57 pm

2 stops11h 26m

$503

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

  • Most accurate provider: When it comes to deals on La Crosse-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on La Crosse-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from La Crosse to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from La Crosse to Greenville?

    American Airlines can get you from La Crosse to Greenville in just under 4h 26m. Your travel time can differ by up to . The distance from La Crosse to Greenville is about 785 mi.

  • Can I find deals for flights from La Crosse to Greenville that include hotel bookings?

    Yes. In addition to deals on La Crosse to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Greenville.

  • Can I find deals for business class flights from La Crosse to Greenville?

    Yes. Cheapflights offers flight deals from La Crosse to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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