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$105+ Cheap flights from O'Hare Intl (ORD) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — GSP
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheapflights Tip: The best prices from Chicago O'Hare Intl to Greenville are usually found in January or July, booked 69 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from O'Hare Intl to Greenville

Cheapest flights from O'Hare Intl to Greenville
Explore the most affordable flight options available from O'Hare Intl to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:04 pm
ORD
-
GSP
1 stop4h 42m
Delta
Mon 4/207:59 pm
GSP
-
ORD
1 stop5h 00m
Delta
Deal found 3/8$213
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:00 am
ORD
-
GSP
Nonstop1h 56m
American Airlines
Tue 4/77:26 am
GSP
-
ORD
Nonstop2h 13m
American Airlines
Deal found 3/5$219
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:15 am
ORD
-
GSP
1 stop4h 05m
Delta
Thu 4/167:59 pm
GSP
-
ORD
1 stop5h 00m
Delta
Deal found 3/8$224
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:45 pm
ORD
-
GSP
Nonstop2h 02m
United Airlines
Sun 4/56:30 am
GSP
-
ORD
Nonstop2h 24m
United Airlines
Deal found 3/8$229
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:00 am
ORD
-
GSP
Nonstop1h 56m
American Airlines
Thu 4/97:30 am
GSP
-
ORD
Nonstop2h 26m
American Airlines
Deal found 3/5$230
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
ORD
-
GSP
1 stop5h 05m
Delta
Sat 6/67:20 am
GSP
-
ORD
1 stop6h 36m
Delta
Deal found 3/10$233
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:05 am
ORD
-
GSP
1 stop10h 48m
Multiple Airlines
Mon 5/115:43 pm
GSP
-
ORD
1 stop28h 34m
Multiple Airlines
Deal found 3/7$234
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:28 pm
ORD
-
GSP
2 stops15h 15m
Multiple Airlines
Mon 5/115:43 pm
GSP
-
ORD
1 stop16h 53m
Multiple Airlines
Deal found 3/8$238
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:40 am
ORD
-
GSP
Nonstop2h 04m
United Airlines
Tue 4/217:42 pm
GSP
-
ORD
1 stop5h 01m
United Airlines
Deal found 3/7$239
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:50 pm
ORD
-
GSP
Nonstop1h 52m
American Airlines
Wed 4/18:17 pm
GSP
-
ORD
Nonstop2h 19m
American Airlines
Deal found 3/5$240
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:28 pm
ORD
-
GSP
2 stops16h 20m
Multiple Airlines
Mon 4/205:43 pm
GSP
-
ORD
1 stop16h 53m
Multiple Airlines
Deal found 3/9$241
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:45 pm
ORD
-
GSP
Nonstop2h 02m
United Airlines
Mon 4/206:30 am
GSP
-
ORD
Nonstop2h 24m
United Airlines
Deal found 3/5$243

Find flight deals from O'Hare Intl to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$213
(Delta)

One-way from

$105
(American Airlines)

Popular in

October

Cheapest in

January

Average price

$293

Good round-trip deal

$271 or less

Good one-way deal

$143 or less
Provider with most accurate pricing for Chicago O'Hare Intl-Greenville flight deals.
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Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Greenville flights.
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From Chicago O'Hare Intl to Greenville
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One-way flight from Chicago O'Hare Intl to Greenville
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Highest demand for flights based on searches. 6% potential increase in price ($21 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Chicago O'Hare Intl to Greenville.
Search Deals
Price to beat on a one-way flight from Chicago O'Hare Intl to Greenville.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 6/4

6:00 am-12:05 pm

1 stop5h 05m

Greenville

Sat 6/6

7:20 am-12:56 pm

1 stop6h 36m

$213

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 4/18

5:59 pm-11:56 pm

1 stop4h 57m

Greenville

Mon 4/20

7:59 pm-11:59 pm

1 stop5h 00m

$213

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 5/27

1:18 pm-7:04 pm

1 stop4h 46m

Greenville

Sun 5/31

6:00 am-7:20 am

Nonstop2h 20m

$239
Quickest round-trip

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 3/26

7:05 am-10:01 am

Nonstop1h 56m

Greenville

Sun 3/29

6:30 am-7:54 am

Nonstop2h 24m

$269

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Fri 5/15

2:45 pm-10:24 pm

1 stop6h 39m

Greenville

Sun 5/17

7:20 am-10:27 am

1 stop4h 07m

$288

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 4/18

1:55 pm-8:40 pm

1 stop5h 45m

Greenville

Mon 4/20

6:25 am-3:30 pm

2 stops10h 05m

$293

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Tue 3/31

8:45 am-2:12 pm

1 stop4h 27m

Greenville

Mon 4/6

7:42 pm-11:43 pm

1 stop5h 01m

$295

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 4/2

6:50 am-9:46 am

Nonstop1h 56m

Greenville

Sun 4/5

6:30 am-7:54 am

Nonstop2h 24m

$300

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Tue 5/12

6:50 am-9:47 am

Nonstop1h 57m

Greenville

Sat 5/16

10:33 am-4:30 pm

1 stop6h 57m

$309
Cheapest one-way

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 4/15

8:45 am-2:12 pm

1 stop4h 27m

$115

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/5

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from O'Hare Intl to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Greenville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago O'Hare Intl Airport to Greenville

How far ahead should I book a flight from Chicago O'Hare Intl Airport to Greenville?

Use this chart to determine the optimal time to book a round-trip flight from O'Hare Intl to Greenville. Price data was last updated on March 6, 2026.

The price you pay for your flight from Chicago O'Hare Intl Airport to Greenville may vary depending on when you book. For the best chance of a lower fare, look to book 53 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Greenville?

Currently, December is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Greenville (average of $56). Flying from Chicago O'Hare Intl Airport to Greenville in June is currently the most expensive (average of $161). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ORD to GSP?

Find hourly flight availability from O'Hare Intl to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 10, 2026.

One of the essential ways to save on airfare from Chicago O'Hare Intl Airport to Greenville is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the morning could potentially save you up to 9% on airfare.

What is the cheapest day to fly from Chicago O'Hare Intl Airport to Greenville?

Use this chart to determine the cheapest time to fly round-trip from O'Hare Intl to Greenville. Price data was last updated on February 21, 2026.

Travelers seeking maximum savings on their Chicago O'Hare Intl Airport to Greenville flight should consider departing on Saturday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated March 10, 2026.
Read through reviews of airlines operating flights from Chicago O'Hare Intl Airport to Greenville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,409 reviews
Delta
7.9
Good
8,276 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,413 reviews
Delta
7.9
Good
8,276 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Chicago O'Hare Intl?

    Located just 10.4 mi from the city center, Greenville is the airport most travelers will use when flying to Greenville from Chicago O'Hare Intl. Booking flights from Chicago O'Hare Intl to Greenville (GSP) should be relatively easy as there are 13 daily inbound flights from Chicago O'Hare Intl from 3 different airlines.

  • How long is the flight from Chicago O'Hare Intl Airport to Greenville?

    A quick flight from Chicago O'Hare Intl Airport to Greenville can take about 4h 46m. Delta provides one of the quickest options available for as low as $239. There are 577 mi between Chicago O'Hare Intl Airport and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Chicago O'Hare Intl Airport to Greenville round-trip?

    Flying on Delta is currently your cheapest option to Greenville, with prices starting at $146. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $202 and $209, respectively. You may be able to fly from Chicago O'Hare Intl Airport to Greenville for 50% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Chicago O'Hare Intl Airport to Greenville one-way?

    $108 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $118 and $133, respectively.

  • What are the most reliable airlines from Chicago O'Hare Intl Airport to Greenville?

    Before booking your flight to Greenville from Chicago O'Hare Intl Airport, check out the most reliable airlines to get you to your destination on time: PSA Airlines (100%), GoJet (81%), United Airlines( 79%).

  • What are the cheapest flights from Chicago O'Hare Intl Airport to Greenville?

    While on average a flight from Chicago O'Hare Intl Airport to Greenville is generally $249, our data shows the cheapest flight currently is $104. When looking at the most popular route, (Chicago O'Hare Intl - Greenville), you can expect to pay $177 for that flight.

  • Can I find deals for flights from O'Hare Intl to Greenville that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Greenville.

  • Can I find deals for business class flights from O'Hare Intl to Greenville?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Greenville?

    Currently, December is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Greenville (average of $56). Flying from Chicago O'Hare Intl Airport to Greenville in June is currently the most expensive (average of $161). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 3 airlines flying from O'Hare Intl to Greenville

Discover the top 3 airlines that operate flights from O'Hare Intl to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$146Average$214FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$202Average$284FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$209Average$319FlexibilityNo cancel feeOn-time69%

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