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$224+ Cheap flights from Santa Ana, CA to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Nov 24 — Dec 11
Mon 11/24
Mon 12/1
1 adult, Economy
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Cheap flight deals from Santa Ana to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$387
(American Airlines)

One-way from

$224
(Delta)

Popular in

December

Cheapest in

July

Average price

$544
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.
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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.
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From Santa Ana J. Wayne/Orange Cnty to Greenville
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville
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Highest demand for flights based on searches. 9% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2025.

This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:20 pmSNA - GSP
1 stop8h 42mDelta
Wed 12/35:35 amGSP - SNA
2 stops10h 25mDelta
Deal found 10/22$377
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:45 amSNA - GSP
1 stop7h 00mDelta
Mon 11/175:16 pmGSP - SNA
1 stop8h 03mDelta
Deal found 10/22$389
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:45 amSNA - GSP
1 stop9h 15mAmerican Airlines
Mon 11/176:00 amGSP - SNA
1 stop8h 37mAmerican Airlines
Deal found 10/22$439
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:25 pmSNA - GSP
2 stops11h 20mSouthwest
Mon 11/177:40 amGSP - SNA
2 stops10h 55mSouthwest
Deal found 10/22$449
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:47 pmSNA - GSP
1 stop6h 05mAmerican Airlines
Tue 1/63:44 pmGSP - SNA
1 stop7h 18mAmerican Airlines
Deal found 10/22$507
This Mytrip deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:46 pmSNA - GSP
3 stops23h 58mMultiple Airlines
Mon 11/243:09 pmGSP - SNA
2 stops21h 08mMultiple Airlines
Deal found 10/22$509
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2312:27 pmSNA - GSP
2 stops8h 31mAmerican Airlines
Wed 12/36:01 amGSP - SNA
2 stops9h 37mAmerican Airlines
Deal found 10/22$512
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:55 pmSNA - GSP
2 stops11h 10mSouthwest
Tue 1/611:15 amGSP - SNA
2 stops9h 40mSouthwest
Deal found 10/22$529
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:20 pmSNA - GSP
1 stop8h 42mDelta
Wed 11/265:16 pmGSP - SNA
1 stop8h 03mDelta
Deal found 10/22$533

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 25, 2025.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Santa Ana

Fly to

Greenville

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

12:10 pm-11:36 pm

1 stop8h 26m

Greenville

Sat 2/28

6:45 am-11:34 am

1 stop7h 49m

$352

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 11/23

9:20 pm-9:02 am

1 stop8h 42m

Greenville

Wed 12/3

5:35 am-1:00 pm

2 stops10h 25m

$377

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 3/3

8:28 am-8:08 pm

1 stop8h 40m

Greenville

Wed 3/4

8:05 am-12:36 pm

1 stop7h 31m

$387

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 11/12

11:45 am-9:45 pm

1 stop7h 00m

Greenville

Mon 11/17

5:16 pm-10:19 pm

1 stop8h 03m

$389

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

7:05 pm-9:27 am

2 stops11h 22m

Greenville

Sun 3/1

12:00 pm-6:50 pm

1 stop9h 50m

$453

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

12:10 pm-11:36 pm

1 stop8h 26m

Greenville

Thu 3/5

12:00 pm-6:50 pm

1 stop9h 50m

$458

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

9:20 pm-9:27 am

1 stop9h 07m

Greenville

Thu 3/5

12:00 pm-6:50 pm

1 stop9h 50m

$473

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

12:15 pm-10:05 pm

1 stop6h 50m

Greenville

Wed 3/4

5:45 am-6:50 pm

1 stop16h 05m

$492

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 12/1

9:20 pm-9:02 am

1 stop8h 42m

$224

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 11/1

8:09 pm-8:23 pm

2 stops21h 14m

$323

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 13 results
1
2

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to GSP?

Find hourly flight availability from Santa Ana to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 25, 2025.

When flying from Santa Ana, California to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 4% versus a flight in the evening.

How much does it cost to fly round-trip from Santa Ana, California to Greenville?

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 25, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,982 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
7,982 reviews
Delta
7.9
Good
7,982 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,996 reviews
Delta
7.9
Good
7,982 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
7,982 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Greenville?

    A quick flight from Santa Ana, California to Greenville can take about 8h 26m. Delta provides one of the quickest options available for as low as $352. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

    According to our current data, American Airlines ($336), Delta ($337), and United Airlines ($426) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

  • Can I find deals for business class flights from Santa Ana to Greenville?

    Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 3 airlines flying from Santa Ana to Greenville

Discover the top 3 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$336Average$456FlexibilityNo cancel feeOn-time71%
DeltaCheapest$337Average$460FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$426Average$559FlexibilityNo cancel feeOn-time69%

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