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$143+ Cheap flights from Santa Ana to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Apr 6 — Apr 131
Mon 4/6
Mon 4/13
1 adult, Economy
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Cheap flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 7, 2026.

This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:52 pm
SNA
-
GSP
1 stop6h 53m
American Airlines
Tue 4/147:00 am
GSP
-
SNA
1 stop9h 49m
American Airlines
Deal found 3/4$367
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
SNA
-
GSP
2 stops10h 47m
United Airlines
Tue 4/144:41 pm
GSP
-
SNA
1 stop8h 04m
United Airlines
Deal found 3/4$372
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:35 am
SNA
-
GSP
2 stops9h 05m
Southwest
Tue 4/712:50 pm
GSP
-
SNA
2 stops9h 15m
Southwest
Deal found 3/3$377
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:28 pm
SNA
-
GSP
2 stops12h 27m
United Airlines
Tue 4/144:10 pm
GSP
-
SNA
1 stop7h 37m
United Airlines
Deal found 3/5$378
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3010:45 am
SNA
-
GSP
2 stops9h 00m
Southwest
Tue 4/1412:50 pm
GSP
-
SNA
2 stops9h 15m
Southwest
Deal found 3/5$383
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:45 am
SNA
-
GSP
2 stops10h 55m
Southwest
Sat 4/2512:25 pm
GSP
-
SNA
2 stops11h 25m
Southwest
Deal found 3/3$387
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/169:05 pm
SNA
-
GSP
1 stop11h 09m
United Airlines
Wed 5/204:35 pm
GSP
-
SNA
1 stop8h 22m
United Airlines
Deal found 3/5$388
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3011:40 am
SNA
-
GSP
2 stops8h 05m
Southwest
Mon 4/61:55 pm
GSP
-
SNA
2 stops11h 00m
Southwest
Deal found 3/2$389
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:23 pm
SNA
-
GSP
1 stop6h 17m
American Airlines
Sat 4/256:31 am
GSP
-
SNA
1 stop8h 34m
American Airlines
Deal found 3/3$396
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:50 am
SNA
-
GSP
1 stop6h 57m
United Airlines
Tue 4/712:34 pm
GSP
-
SNA
2 stops11h 13m
United Airlines
Deal found 3/3$400
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:52 pm
SNA
-
GSP
1 stop6h 53m
American Airlines
Tue 4/77:00 am
GSP
-
SNA
1 stop9h 49m
American Airlines
Deal found 3/3$406

Find flight deals from Santa Ana to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$367
(American Airlines)

One-way from

$143
(Kiwi.com)

Popular in

February

Cheapest in

July

Average price

$418
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Greenville
Search Deals
One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 3/31

7:00 am-8:47 pm

2 stops10h 47m

Greenville

Tue 4/14

4:41 pm-9:45 pm

1 stop8h 04m

$372

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 3/30

6:28 pm-9:55 am

2 stops12h 27m

Greenville

Tue 4/14

4:10 pm-8:47 pm

1 stop7h 37m

$378

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 3/30

11:40 am-10:45 pm

2 stops8h 05m

Greenville

Tue 4/14

12:50 pm-7:05 pm

2 stops9h 15m

$383

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 4/18

6:45 am-8:40 pm

2 stops10h 55m

Greenville

Sat 4/25

12:25 pm-8:50 pm

2 stops11h 25m

$387

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

9:45 am-9:40 pm

2 stops8h 55m

Greenville

Mon 4/13

6:25 am-11:55 am

2 stops8h 30m

$417

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/2

11:40 am-10:45 pm

2 stops8h 05m

Greenville

Mon 4/6

1:55 pm-9:55 pm

2 stops11h 00m

$420
Quickest round-trip

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 4/14

10:50 am-8:47 pm

1 stop6h 57m

Greenville

Sat 4/18

7:00 am-11:13 am

1 stop7h 13m

$473

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

6:39 pm-9:46 am

2 stops12h 07m

Greenville

Mon 4/13

5:41 pm-10:35 pm

1 stop7h 54m

$516

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/2

7:48 pm-8:38 am

2 stops9h 50m

Greenville

Mon 4/6

4:30 pm-10:45 pm

1 stop9h 15m

$520
Cheapest one-way

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 5/9

3:23 pm-4:53 pm

3 stops46h 30m

$181

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $117). Flying from Santa Ana, California to Greenville in January is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated March 7, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,271 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
8,271 reviews
Delta
7.9
Good
8,271 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
9,404 reviews
Delta
7.9
Good
8,271 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.1
Good
11,398 reviews
Delta
7.9
Good
8,271 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Greenville?

    A quick flight from Santa Ana, California to Greenville can take about 8h 05m. United Airlines provides one of the quickest options available for as low as $383. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

    According to our current data, American Airlines ($324), Delta ($337), and United Airlines ($434) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

  • Can I find deals for business class flights from Santa Ana to Greenville?

    Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Greenville?

    Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $117). Flying from Santa Ana, California to Greenville in January is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Santa Ana to Greenville

Discover the top 3 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$324Average$455FlexibilityNo cancel feeOn-time71%
DeltaCheapest$337Average$459FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$434Average$559FlexibilityNo cancel feeOn-time69%

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