How long is the flight from Santa Ana, California to Greenville?

A quick flight from Santa Ana, California to Greenville can take about 8h 59m. Delta provides one of the quickest options available for as low as $396. The distance from Santa Ana, California to Greenville is about 2025 mi.

What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

According to our current data, American Airlines ($336), Delta ($337), and United Airlines ($426) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 31% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the most popular airlines that fly from Santa Ana, California to Greenville?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Santa Ana, California to Greenville.

Most accurate provider : When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santa Ana to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

Can I find deals for business class flights from Santa Ana to Greenville?

Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$165+ Flights from Santa Ana, CA to Greenville

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1. Tell us where you want to go

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Cheap flight deals from Santa Ana to Greenville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$353 (Mytrip)
One-way from	$165 (Kiwi.com)
Popular in	December
Cheapest in	July
Average price	$497

Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.

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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.

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From Santa Ana J. Wayne/Orange Cnty to Greenville

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One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($69 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).

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Average for round-trip flights in November 2025

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Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

Thu 12/411:39 amSNA - GSP

3 stops23h 31mMultiple Airlines

Mon 12/83:00 pmGSP - SNA

2 stops10h 23mMultiple Airlines

Deal found 11/19

$353

Thu 12/1111:46 amSNA - GSP

1 stop6h 56mDelta

Sun 12/146:45 amGSP - SNA

1 stop7h 50mDelta

Deal found 11/20

$456

Thu 12/1812:42 pmSNA - GSP

1 stop8h 10mAmerican Airlines

Thu 12/256:00 amGSP - SNA

1 stop8h 52mAmerican Airlines

Deal found 11/20

$504

Fri 12/267:35 pmSNA - GSP

2 stops10h 01mAmerican Airlines

Fri 1/25:00 amGSP - SNA

2 stops9h 56mAmerican Airlines

Deal found 11/18

$559

Thu 12/49:20 pmSNA - GSP

1 stop8h 42mDelta

Mon 12/85:17 pmGSP - SNA

1 stop8h 13mDelta

Deal found 11/19

$567

Best flights from Santa Ana to Greenville
Discover carefully curated flight deals from Santa Ana to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 21, 2025.

Thu 1/89:20 pmSNA - GSP

1 stop8h 59mDelta

Mon 1/128:22 amGSP - SNA

2 stops13h 03mDelta

Deal found 11/19

$396

Thu 1/89:45 amSNA - GSP

2 stops8h 11mAmerican Airlines

Mon 1/1212:09 pmGSP - SNA

2 stops9h 32mAmerican Airlines

Deal found 11/18

$503

Fri 12/1911:11 amSNA - GSP

3 stops30h 40mMultiple Airlines

Mon 12/228:43 pmGSP - SNA

3 stops28h 44mMultiple Airlines

Deal found 11/20

$504

Sun 3/229:10 pmSNA - GSP

2 stops11h 35mSouthwest

Sat 3/2812:35 pmGSP - SNA

2 stops12h 10mSouthwest

Deal found 11/20

$513

Thu 12/1111:46 amSNA - GSP

1 stop6h 56mDelta

Sun 12/146:45 amGSP - SNA

1 stop7h 50mDelta

Deal found 11/20

$456

Mon 3/29:20 pmSNA - GSP

1 stop9h 01mDelta

Sat 3/215:45 amGSP - SNA

2 stops9h 42mDelta

Deal found 11/19

$521

Thu 12/49:20 pmSNA - GSP

1 stop8h 42mDelta

Mon 12/85:17 pmGSP - SNA

1 stop8h 13mDelta

Deal found 11/19

$567

Last-minute flights from Santa Ana to Greenville
Discover last-minute flight deals from Santa Ana to Greenville. Data last updated November 21, 2025 and is based on user searches.

Thu 12/411:39 amSNA - GSP

3 stops23h 31mMultiple Airlines

Mon 12/83:00 pmGSP - SNA

2 stops10h 23mMultiple Airlines

Deal found 11/19

$353

Thu 12/49:20 pmSNA - GSP

1 stop8h 42mDelta

Mon 12/85:17 pmGSP - SNA

1 stop8h 13mDelta

Deal found 11/19

$567

Thu 12/1111:46 amSNA - GSP

1 stop6h 56mDelta

Sun 12/146:45 amGSP - SNA

1 stop7h 50mDelta

Deal found 11/20

$456

Thu 12/1812:42 pmSNA - GSP

1 stop8h 10mAmerican Airlines

Thu 12/256:00 amGSP - SNA

1 stop8h 52mAmerican Airlines

Deal found 11/20

$504

Fri 12/267:35 pmSNA - GSP

2 stops10h 01mAmerican Airlines

Fri 1/25:00 amGSP - SNA

2 stops9h 56mAmerican Airlines

Deal found 11/18

$559

One-way flights from Santa Ana to Greenville
Search for one-way flight options from Santa Ana to Greenville. Find affordable one-way fares based on user searches. Data last updated November 21, 2025.

Thu 12/1811:11 amSNA - GSP

2 stops29h 12mMultiple Airlines

Deal found 11/20

$165

Thu 11/2712:45 pmSNA - GSP

1 stop8h 00mDelta

Deal found 11/19

$180

Thu 12/1812:42 pmSNA - GSP

1 stop8h 10mAmerican Airlines

Deal found 11/20

$197

Thu 11/276:45 amSNA - GSP

3 stops25h 06mMultiple Airlines

Deal found 11/19

$230

Thu 2/56:45 amSNA - GSP

1 stop8h 54mDelta

Deal found 11/19

$329

Mon 12/19:30 amSNA - GSP

1 stop6h 57mAmerican Airlines

Deal found 11/19

$444

Mon 12/226:45 amSNA - GSP

2 stops14h 11mUnited Airlines

Deal found 11/19

$445

Mon 12/2212:05 pmSNA - GSP

1 stop6h 46mDelta

Deal found 11/20

$450

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 1/8

9:20 pm-9:19 am

1 stop8h 59m

Greenville

Mon 1/12

8:22 am-6:25 pm

2 stops13h 03m

$396

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 12/11

11:46 am-9:42 pm

1 stop6h 56m

Greenville

Sun 12/14

6:45 am-11:35 am

1 stop7h 50m

$456

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 1/8

9:45 am-8:56 pm

2 stops8h 11m

Greenville

Mon 1/12

12:09 pm-6:41 pm

2 stops9h 32m

$503

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 12/19

11:11 am-8:51 pm

3 stops30h 40m

Greenville

Mon 12/22

8:43 pm-10:27 pm

3 stops28h 44m

$504

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 3/22

9:10 pm-11:45 am

2 stops11h 35m

Greenville

Sat 3/28

12:35 pm-9:45 pm

2 stops12h 10m

$513

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 3/2

9:20 pm-9:21 am

1 stop9h 01m

Greenville

Sat 3/21

5:45 am-12:27 pm

2 stops9h 42m

$521

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 12/4

9:20 pm-9:02 am

1 stop8h 42m

Greenville

Mon 12/8

5:17 pm-10:30 pm

1 stop8h 13m

$567

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 12/18

11:11 am-7:23 pm

2 stops29h 12m

$165

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 11/27

12:45 pm-11:45 pm

1 stop8h 00m

$180

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 12/18

12:42 pm-11:52 pm

1 stop8h 10m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 14 results

Compare providers for flights from Santa Ana to Greenville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in November is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to GSP?

When flying from Santa Ana, California to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 4% versus a flight in the evening.

Reviews of airlines servicing Greenville

See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,002 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Delta

7.9

Good

8,002 reviews

Delta

7.9

Good

8,002 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

United Airlines

7.4

Good

9,029 reviews

Delta

7.9

Good

8,002 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

American Airlines

7.2

Good

11,047 reviews

Delta

7.9

Good

8,002 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

How long is the flight from Santa Ana, California to Greenville?
A quick flight from Santa Ana, California to Greenville can take about 8h 59m. Delta provides one of the quickest options available for as low as $396. The distance from Santa Ana, California to Greenville is about 2025 mi.
What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?
According to our current data, American Airlines ($336), Delta ($337), and United Airlines ($426) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 31% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?
Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santa Ana to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.
Can I find deals for business class flights from Santa Ana to Greenville?
Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santa Ana, California to Greenville?
Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in November is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Simpsonville

Duncan

Greer

Seneca

Anderson

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Top 3 airlines flying from Santa Ana to Greenville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$336	Average$452	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$337	Average$460	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$426	Average$626	FlexibilityNo cancel fee	On-time69%

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$165+ Cheap flights from Santa Ana, CA to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santa Ana to Greenville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santa Ana to Greenville

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to GreenvilleExplore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in November.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

What is the cheapest time of day to fly from SNA to GSP?

Reviews of airlines servicing Greenville

See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santa Ana, California to Greenville?

What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

How can I find direct flights from Santa Ana to Greenville?

Can I find deals for business class flights from Santa Ana to Greenville?

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Traveling to a place near Greenville?

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Alternative routes for Santa Ana to Greenville

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Santa Ana to Greenville

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Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.