How long is the flight from Santa Ana, California to Greenville?

A quick flight from Santa Ana, California to Greenville can take about 9h 17m. American Airlines provides one of the quickest options available for as low as $363. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

According to our current data, American Airlines ($324), Delta ($337), and United Airlines ($434) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the most popular airlines that fly from Santa Ana, California to Greenville?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Santa Ana, California to Greenville.

What is the cheapest time of day to fly from SNA to GSP?

When flying from Santa Ana, California to Greenville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santa Ana to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

Can I find deals for business class flights from Santa Ana to Greenville?

Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$231+ Flights from Santa Ana, CA to Greenville

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Cheap flight deals from Santa Ana to Greenville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$327 (Delta)
One-way from	$231 (Kiwi.com)
Popular in	December
Cheapest in	July
Average price	$491

Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.

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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.

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From Santa Ana J. Wayne/Orange Cnty to Greenville

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One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville

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Highest demand for flights based on searches. 9% potential increase in price ($53 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).

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Average for round-trip flights in January 2026

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Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

Wed 4/151:05 pmSNA - GSP

1 stop6h 41mDelta

Tue 4/281:05 pmGSP - SNA

1 stop9h 42mDelta

Deal found 1/5

$327

Tue 4/213:48 pmSNA - GSP

2 stops14h 14mDelta

Tue 4/285:40 amGSP - SNA

2 stops13h 36mDelta

Deal found 1/5

$338

Wed 2/119:01 amSNA - GSP

1 stop8h 44mAmerican Airlines

Sat 2/147:29 amGSP - SNA

1 stop9h 54mAmerican Airlines

Deal found 1/5

$344

Tue 2/311:42 amSNA - GSP

1 stop9h 17mAmerican Airlines

Fri 2/65:26 pmGSP - SNA

1 stop7h 35mAmerican Airlines

Deal found 1/6

$363

Tue 2/36:55 pmSNA - GSP

2 stops12h 45mSouthwest

Fri 2/610:45 amGSP - SNA

2 stops9h 40mSouthwest

Deal found 1/5

$384

Wed 4/151:05 pmSNA - GSP

1 stop6h 41mDelta

Fri 4/245:40 pmGSP - SNA

1 stop7h 31mDelta

Deal found 1/5

$387

Tue 4/213:48 pmSNA - GSP

2 stops14h 14mDelta

Sat 4/253:00 pmGSP - SNA

1 stop7h 47mDelta

Deal found 1/5

$392

Best flights from Santa Ana to Greenville
Discover carefully curated flight deals from Santa Ana to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 6, 2026.

Tue 2/311:42 amSNA - GSP

1 stop9h 17mAmerican Airlines

Fri 2/65:26 pmGSP - SNA

1 stop7h 35mAmerican Airlines

Deal found 1/6

$363

Wed 4/89:00 amSNA - GSP

2 stops9h 40mSouthwest

Wed 4/1512:50 pmGSP - SNA

2 stops9h 15mSouthwest

Deal found 1/5

$398

Sat 1/179:10 pmSNA - GSP

1 stop10h 58mUnited Airlines

Sun 1/185:34 pmGSP - SNA

1 stop7h 50mUnited Airlines

Deal found 1/3

$407

Tue 5/2611:55 amSNA - GSP

1 stop6h 30mDelta

Fri 5/296:45 amGSP - SNA

1 stop9h 47mDelta

Deal found 1/5

$447

Fri 5/2912:15 pmSNA - GSP

1 stop6h 45mDelta

Sat 5/306:45 amGSP - SNA

1 stop9h 47mDelta

Deal found 1/5

$447

Mon 5/259:20 pmSNA - GSP

1 stop9h 08mDelta

Sun 5/313:42 pmGSP - SNA

1 stop6h 54mDelta

Deal found 1/5

$447

Thu 5/2811:55 amSNA - GSP

1 stop6h 30mDelta

Tue 6/26:45 amGSP - SNA

1 stop9h 47mDelta

Deal found 1/5

$447

Tue 5/2611:55 amSNA - GSP

1 stop8h 45mDelta

Tue 6/26:45 amGSP - SNA

1 stop9h 47mDelta

Deal found 1/5

$447

Sun 5/242:29 pmSNA - GSP

1 stop6h 11mDelta

Sat 5/306:45 amGSP - SNA

1 stop9h 47mDelta

Deal found 1/5

$447

Last-minute flights from Santa Ana to Greenville
Discover last-minute flight deals from Santa Ana to Greenville. Data last updated January 6, 2026 and is based on user searches.

Sat 1/179:10 pmSNA - GSP

1 stop10h 58mUnited Airlines

Sun 1/185:34 pmGSP - SNA

1 stop7h 50mUnited Airlines

Deal found 1/5

$407

Tue 2/311:42 amSNA - GSP

1 stop9h 17mAmerican Airlines

Fri 2/65:26 pmGSP - SNA

1 stop7h 35mAmerican Airlines

Deal found 1/6

$363

Tue 2/36:55 pmSNA - GSP

2 stops12h 45mSouthwest

Fri 2/610:45 amGSP - SNA

2 stops9h 40mSouthwest

Deal found 1/5

$384

Tue 2/36:45 amSNA - GSP

1 stop7h 07mUnited Airlines

Fri 2/66:49 amGSP - SNA

1 stop7h 32mUnited Airlines

Deal found 1/5

$387

Tue 2/39:51 amSNA - GSP

2 stops9h 33mDelta

Fri 2/63:05 pmGSP - SNA

1 stop7h 59mDelta

Deal found 1/5

$392

Wed 2/119:01 amSNA - GSP

1 stop8h 44mAmerican Airlines

Sat 2/147:29 amGSP - SNA

1 stop9h 54mAmerican Airlines

Deal found 1/5

$344

Wed 2/119:30 amSNA - GSP

1 stop8h 26mAmerican Airlines

Sun 2/154:26 pmGSP - SNA

1 stop9h 21mAmerican Airlines

Deal found 1/5

$412

One-way flights from Santa Ana to Greenville
Search for one-way flight options from Santa Ana to Greenville. Find affordable one-way fares based on user searches. Data last updated January 6, 2026.

Sun 1/114:16 pmSNA - GSP

2 stops20h 43mMultiple Airlines

Deal found 1/4

$231

Mon 1/1910:53 amSNA - GSP

1 stop7h 03mAmerican Airlines

Deal found 1/5

$284

Sun 1/119:20 pmSNA - GSP

1 stop8h 59mDelta

Deal found 1/4

$444

Mon 1/129:51 amSNA - GSP

2 stops9h 33mDelta

Deal found 1/3

$449

Tue 1/135:03 pmSNA - GSP

2 stops13h 16mDelta

Deal found 1/3

$634

Mon 1/196:45 amSNA - GSP

3 stops23h 34mMultiple Airlines

Deal found 1/5

$853

Tue 1/1311:42 amSNA - GSP

1 stop9h 17mAmerican Airlines

Deal found 1/3

$969

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/3

11:42 am-11:59 pm

1 stop9h 17m

Greenville

Fri 2/6

5:26 pm-10:01 pm

1 stop7h 35m

$363

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

9:00 am-9:40 pm

2 stops9h 40m

Greenville

Wed 4/15

12:50 pm-7:05 pm

2 stops9h 15m

$398

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 1/17

9:10 pm-11:08 am

1 stop10h 58m

Greenville

Sun 1/18

5:34 pm-10:24 pm

1 stop7h 50m

$407

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 5/26

11:55 am-9:25 pm

1 stop6h 30m

Greenville

Fri 5/29

6:45 am-1:32 pm

1 stop9h 47m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 5/29

12:15 pm-10:00 pm

1 stop6h 45m

Greenville

Sat 5/30

6:45 am-1:32 pm

1 stop9h 47m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 5/25

9:20 pm-9:28 am

1 stop9h 08m

Greenville

Sun 5/31

3:42 pm-7:36 pm

1 stop6h 54m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 5/28

11:55 am-9:25 pm

1 stop6h 30m

Greenville

Tue 6/2

6:45 am-1:32 pm

1 stop9h 47m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 5/26

11:55 am-11:40 pm

1 stop8h 45m

Greenville

Tue 6/2

6:45 am-1:32 pm

1 stop9h 47m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 5/24

2:29 pm-11:40 pm

1 stop6h 11m

Greenville

Sat 5/30

6:45 am-1:32 pm

1 stop9h 47m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 1/11

4:16 pm-3:59 pm

2 stops20h 43m

$231

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/4

Showing 1-10 of 16 results

Compare providers for flights from Santa Ana to Greenville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in January.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $115). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Delta

7.9

Good

8,018 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

United Airlines

7.4

Good

9,132 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

American Airlines

7.2

Good

11,084 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

How long is the flight from Santa Ana, California to Greenville?
A quick flight from Santa Ana, California to Greenville can take about 9h 17m. American Airlines provides one of the quickest options available for as low as $363. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?
According to our current data, American Airlines ($324), Delta ($337), and United Airlines ($434) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?
Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santa Ana to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.
Can I find deals for business class flights from Santa Ana to Greenville?
Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santa Ana, California to Greenville?
Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $115). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Simpsonville

Duncan

Greer

Seneca

Anderson

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Top 3 airlines flying from Santa Ana to Greenville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$324	Average$451	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$337	Average$459	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$434	Average$559	FlexibilityNo cancel fee	On-time69%

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$231+ Cheap flights from Santa Ana, CA to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santa Ana to Greenville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santa Ana to Greenville

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to GreenvilleExplore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in January.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Reviews of airlines servicing Greenville

See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santa Ana, California to Greenville?

What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

How can I find direct flights from Santa Ana to Greenville?

Can I find deals for business class flights from Santa Ana to Greenville?

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Traveling to a place near Greenville?

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Alternative routes for Santa Ana to Greenville

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Santa Ana to Greenville

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Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.