For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $455 (Kiwi.com) |
One-way from | $272 (Kiwi.com) |
Popular in | October |
Cheapest in | January |
Average price | $869 |
Good round-trip deal | $591 or less |
Good one-way deal | $367 or less |
Fly from
Fly to
Route
Depart
Return
Price
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Sat 1/24
11:25 am-12:07 am
2 stops13h 42m
Houston George Bush Intcntl
Sun 1/25
9:44 pm-12:40 am
3 stops25h 56m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Wed 12/24
7:31 am-5:40 pm
1 stop11h 09m
Houston George Bush Intcntl
Thu 1/1
10:44 am-7:51 pm
1 stop8h 07m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Fri 12/19
7:50 pm-4:35 pm
1 stop21h 45m
Houston George Bush Intcntl
Sat 2/7
7:30 am-6:55 pm
1 stop10h 25m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Fri 12/19
3:50 pm-4:35 pm
1 stop25h 45m
Houston George Bush Intcntl
Sun 1/4
9:30 am-6:55 pm
1 stop8h 25m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Wed 12/3
3:50 pm-4:35 pm
1 stop25h 45m
Houston George Bush Intcntl
Sun 12/28
9:30 am-6:55 pm
1 stop8h 25m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 2/10
2:55 am-3:10 pm
2 stops13h 15m
Houston George Bush Intcntl
Sun 2/22
4:35 pm-10:30 am
1 stop16h 55m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Mon 12/22
7:50 pm-11:05 am
1 stop16h 15m
Houston George Bush Intcntl
Sat 1/3
4:35 pm-10:30 am
1 stop16h 55m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Sun 11/23
2:55 am-3:10 pm
2 stops13h 15m
Houston George Bush Intcntl
Sun 1/11
1:00 pm-8:50 am
2 stops18h 50m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Sat 12/6
2:55 am-4:35 pm
2 stops14h 40m
Houston George Bush Intcntl
Sun 12/28
10:44 am-10:30 am
2 stops22h 46m
Panama CityHouston
PTY - IAH
PTYIAH
Panama City Tocumen Intl
Tue 3/31
9:55 am-4:10 pm
2 stops30h 15m
Houston George Bush Intcntl
Tue 4/7
3:41 pm-10:10 am
3 stops18h 29m
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
The best time to book flights from Panama City to Houston George Bush Intcntl Airport is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Currently, January is the cheapest month in which you can book a flight from Panama City to Houston George Bush Intcntl Airport (average of $322). Flying from Panama City to Houston George Bush Intcntl Airport in April is currently the most expensive (average of $809). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from Panama City to Houston George Bush Intcntl Airport in the evening. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.
About 8% of weekly flights between Panama City and Houston have experienced delays in the past year, with the average delay time being 178 minutes.
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
Monday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 8% of flights being delayed.
Overall
Food
Crew
Boarding
Comfort
Entertainment
Reviews
Sebrena,Oct 2025
IAH - RSW
Overall
Food
Crew
Boarding
Comfort
Entertainment
Reviews
Sebrena,Oct 2025
IAH - RSW
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$781 | Average$968 | FlexibilityNo cancel fee | On-time69% |