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Florida Keys

$95+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated September 16, 2025.

Round-trip from

$95
(Kiwi.com)

Popular in

May

Cheapest in

July

Average price

$395
From Knoxville McGhee Tyson to Florida Keys
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:55 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Fri 10/243:39 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/14$95
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1312:55 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Mon 10/209:50 amEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/15$118
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1511:22 amTYS - EYW
Nonstop2h 11mAllegiant Air
Fri 12/192:33 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/14$134
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1312:55 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Fri 10/179:02 amEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/15$145
This FlightHub deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:32 amTYS - EYW
Nonstop2h 11mAllegiant Air
Wed 12/248:45 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/16$147
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Thu 11/69:40 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Deal found 9/14$163
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Wed 11/52:21 pmMIA - TYS
Nonstop2h 16mAmerican Airlines
Deal found 9/14$164
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - MIA
1 stop10h 02mFrontier
Sun 10/196:00 amMIA - TYS
1 stop13h 32mFrontier
Deal found 9/14$182
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:44 amTYS - MIA
1 stop3h 51mDelta
Wed 10/226:00 amMIA - TYS
1 stop4h 45mDelta
Deal found 9/15$183
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Sat 12/132:14 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Deal found 9/14$198
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/29:25 pmTYS - EYW
1 stop9h 57mAllegiant Air
Mon 10/69:50 amEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 9/15$203
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - MIA
2 stops14h 54mFrontier
Thu 11/66:00 amMIA - TYS
1 stop12h 22mFrontier
Deal found 9/15$210

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 12/15

11:22 am-1:33 pm

Nonstop2h 11m

Key West

Fri 12/19

2:33 pm-4:48 pm

Nonstop2h 15m

$134

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 10/29

3:48 pm-8:51 pm

1 stop5h 03m

Miami

Wed 11/5

10:40 am-2:51 pm

1 stop4h 11m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 10/21

11:44 am-6:25 pm

1 stop6h 41m

Miami

Tue 10/28

10:40 am-4:31 pm

1 stop5h 51m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 10/28

5:44 am-9:35 am

1 stop3h 51m

Miami

Thu 11/6

8:11 am-2:51 pm

1 stop6h 40m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 10/15

5:44 am-9:35 am

1 stop3h 51m

Miami

Wed 10/22

6:00 am-10:45 am

1 stop4h 45m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 11/8

4:56 pm-7:08 pm

Nonstop2h 12m

Miami

Tue 11/11

2:21 pm-4:37 pm

Nonstop2h 16m

$198

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Thu 10/2

9:25 pm-7:22 am

1 stop9h 57m

Key West

Mon 10/6

9:50 am-12:05 pm

Nonstop2h 15m

$203

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 12/6

5:03 pm-7:20 pm

Nonstop2h 17m

Miami

Sat 12/13

7:10 pm-11:57 pm

1 stop4h 47m

$208

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/3

9:54 pm-9:02 am

1 stop11h 08m

Key West

Mon 10/6

9:50 am-12:05 pm

Nonstop2h 15m

$218

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/13

12:55 pm-3:06 pm

Nonstop2h 11m

Key West

Mon 10/20

9:57 am-11:16 pm

2 stops13h 19m

$222

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 32 results
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Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated September 16, 2025.
Get a feel of what it's like to fly with Delta, American Airlines, and Allegiant Air from Knoxville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Florida Keys?

    Allegiant Air and Delta can get you from Knoxville to Florida Keys in just under 2h 11m. Your travel time can differ by up to 2h 52m. There are 788 mi between Knoxville and Florida Keys. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Knoxville to Florida Keys?

    Looking at all options, your cheapest flight can be booked for $94. While the most popular route (Knoxville McGhee Tyson - Miami) can be booked for $183 on average, our data indicates $146 when flying from Knoxville to Florida Keys.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$145FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$248Average$439FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$412FlexibilityNo cancel feeOn-timeN/A

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