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Florida Keys

$116+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated junio 12, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$136
(Mytrip)

Popular in

May

Cheapest in

August

Average price

$395
From Knoxville McGhee Tyson to Florida Keys
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One-way flight from Knoxville McGhee Tyson to Florida Keys
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Highest demand for flights based on searches. 6% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/86:11 pmTYS - MIA
Nonstop2h 09mAmerican Airlines
mié. 10/293:30 pmMIA - TYS
Nonstop2h 10mAmerican Airlines
Deal found 6/10$159
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/96:14 pmTYS - MIA
1 stop6h 10mDelta
mar. 9/1610:20 amMIA - TYS
1 stop4h 45mDelta
Deal found 6/12$179
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/49:00 amTYS - MIA
1 stop10h 45mMultiple Airlines
lun. 9/810:40 amMIA - TYS
1 stop12h 34mMultiple Airlines
Deal found 6/10$193
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/1412:06 pmTYS - EYW
Nonstop2h 11mAllegiant Air
dom. 11/169:36 pmEYW - TYS
1 stop23h 01mAllegiant Air
Deal found 6/11$206
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/112:36 pmTYS - EYW
1 stop5h 13mDelta
lun. 7/147:00 amEYW - TYS
1 stop6h 51mDelta
Deal found 6/9$249
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/97:10 amTYS - EYW
2 stops28h 31mMultiple Airlines
mié. 7/163:55 pmEYW - TYS
1 stop5h 03mMultiple Airlines
Deal found 6/10$252
This Frontier deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/218:36 pmTYS - MIA
1 stop9h 54mFrontier
dom. 8/316:00 amMIA - TYS
1 stop13h 41mFrontier
Deal found 6/10$256
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/86:00 amTYS - EYW
1 stop4h 53mAmerican Airlines
sáb. 9/1311:25 amEYW - TYS
2 stops11h 38mAmerican Airlines
Deal found 6/12$271
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/109:55 amTYS - EYW
2 stops28h 05mUnited Airlines
lun. 7/146:45 pmEYW - TYS
2 stops20h 13mUnited Airlines
Deal found 6/11$386
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/97:00 amTYS - MIA
1 stop8h 14mUnited Airlines
mar. 8/191:25 pmMIA - TYS
2 stops10h 32mUnited Airlines
Deal found 6/12$392

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

mié. 10/8

6:11 pm-8:20 pm

Nonstop2h 09m

Miami

mié. 10/29

3:30 pm-5:40 pm

Nonstop2h 10m

$159

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

mar. 9/9

6:14 pm-12:24 am

1 stop6h 10m

Miami

mar. 9/16

10:20 am-3:05 pm

1 stop4h 45m

$179

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

jue. 9/4

9:00 am-7:45 pm

1 stop10h 45m

Miami

lun. 9/8

10:40 am-11:14 pm

1 stop12h 34m

$193

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

mié. 7/9

9:48 pm-8:04 am

1 stop10h 16m

Key West

mié. 7/16

3:55 pm-8:58 pm

1 stop5h 03m

$210

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

vie. 7/11

2:36 pm-7:49 pm

1 stop5h 13m

Key West

lun. 7/14

7:00 am-1:51 pm

1 stop6h 51m

$249

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

mié. 7/9

7:10 am-11:41 am

2 stops28h 31m

Key West

mié. 7/16

3:55 pm-8:58 pm

1 stop5h 03m

$252

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

jue. 8/21

8:36 pm-6:30 am

1 stop9h 54m

Miami

dom. 8/31

6:00 am-7:41 pm

1 stop13h 41m

$256

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

lun. 9/8

6:00 am-10:53 am

1 stop4h 53m

Key West

sáb. 9/13

11:25 am-11:03 pm

2 stops11h 38m

$271

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

jue. 7/10

9:55 am-2:00 pm

2 stops28h 05m

Key West

lun. 7/14

6:45 pm-2:58 pm

2 stops20h 13m

$386

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

sáb. 8/9

7:00 am-3:14 pm

1 stop8h 14m

Miami

mar. 8/19

1:25 pm-11:57 pm

2 stops10h 32m

$392

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 17 results
1
2

Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated junio 12, 2025.
Read through reviews of airlines operating flights from Knoxville to Florida Keys, such as Delta, United Airlines and Allegiant Air. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Frontier
5.9
Fair
3,295 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Florida Keys one-way?

    $189 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and Delta, with prices starting from $200 and $289, respectively.

  • What are the cheapest flights from Knoxville to Florida Keys?

    Looking at all options, your cheapest flight can be booked for $115. While the most popular route (Knoxville McGhee Tyson - Miami) can be booked for $189 on average our data indicates $136 when flying from Knoxville to Florida Keys.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$207FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$248Average$423FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$480FlexibilityNo cancel feeOn-timeN/A

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