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$81+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated November 3, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$84
(Kiwi.com)

One-way from

$81
(Priceline)

Popular in

May

Cheapest in

February

Average price

$399
Provider with most accurate pricing for Knoxville McGhee Tyson-Miami flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Miami flights.
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From Knoxville McGhee Tyson to Florida Keys
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One-way flight from Knoxville McGhee Tyson to Florida Keys
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Highest demand for flights based on searches. 4% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:12 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Wed 11/2610:01 amEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 11/3$84
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:06 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Fri 11/212:05 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 11/1$87
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:04 amTYS - EYW
Nonstop2h 11mAllegiant Air
Mon 11/243:13 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 11/1$106
This FlightHub deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:32 amTYS - EYW
Nonstop2h 11mAllegiant Air
Wed 12/248:45 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 11/2$112
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:06 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Fri 11/212:05 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 11/1$122
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:23 pmTYS - MIA
1 stop25h 22mMultiple Airlines
Fri 12/127:35 amMIA - TYS
1 stop11h 39mMultiple Airlines
Deal found 11/1$162
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Sat 12/139:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Deal found 11/3$163
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:32 amTYS - EYW
Nonstop2h 11mAllegiant Air
Sun 12/213:24 pmEYW - TYS
1 stop6h 30mAllegiant Air
Deal found 11/1$195
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:06 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Sun 11/99:36 pmEYW - TYS
1 stop25h 38mAllegiant Air
Deal found 11/1$197
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - MIA
1 stop12h 27mMultiple Airlines
Fri 12/127:35 amMIA - TYS
1 stop11h 39mMultiple Airlines
Deal found 11/2$205
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Tue 12/169:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Deal found 11/3$230
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:00 amTYS - MIA
2 stops18h 46mMultiple Airlines
Mon 12/87:05 amMIA - TYS
1 stop12h 09mMultiple Airlines
Deal found 11/2$247

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 12/19

11:32 am-1:43 pm

Nonstop2h 11m

Key West

Wed 12/24

8:45 pm-11:00 pm

Nonstop2h 15m

$112

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 12/15

11:22 am-1:33 pm

Nonstop2h 11m

Key West

Fri 12/19

2:33 pm-4:48 pm

Nonstop2h 15m

$122

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 1/7

5:36 pm-7:52 pm

Nonstop2h 16m

Miami

Sat 1/10

9:34 pm-11:59 pm

Nonstop2h 25m

$179

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 1/23

11:00 am-3:02 pm

1 stop4h 02m

Key West

Mon 1/26

5:41 pm-7:56 pm

Nonstop2h 15m

$212

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 12/10

6:00 am-8:17 am

Nonstop2h 17m

Miami

Sat 12/13

7:07 am-1:05 pm

1 stop5h 58m

$218

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sun 2/22

9:00 am-2:19 pm

1 stop5h 19m

Key West

Fri 2/27

11:01 am-1:16 pm

Nonstop2h 15m

$221

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 1/5

12:58 pm-9:11 pm

1 stop8h 13m

Key West

Wed 1/7

4:06 pm-12:49 pm

1 stop20h 43m

$227

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 1/23

5:14 pm-10:22 pm

1 stop5h 08m

Miami

Sat 1/31

9:34 pm-11:59 pm

Nonstop2h 25m

$239

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 2/21

7:00 am-12:07 pm

1 stop5h 07m

Key West

Tue 2/24

6:28 pm-10:54 pm

1 stop4h 26m

$240

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 12/5

11:28 am-1:39 pm

Nonstop2h 11m

Key West

Tue 12/9

11:45 am-12:03 pm

2 stops24h 18m

$247

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 28 results
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Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, March is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $78). Flying from Knoxville to Florida Keys in December is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

When flying from Knoxville to Florida Keys, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 76% versus a flight in the evening.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated November 3, 2025.
Get a feel of what it's like to fly with Delta, American Airlines, and Allegiant Air from Knoxville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,036 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Florida Keys?

    Allegiant Air, American Airlines, and Delta can get you from Knoxville to Florida Keys in just under 2h 11m. Your travel time can differ by up to 2h 36m. There are 788 mi between Knoxville and Florida Keys. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Knoxville to Florida Keys?

    Looking at all options, your cheapest flight can be booked for $90. While the most popular route (Knoxville McGhee Tyson - Miami) can be booked for $190 on average, our data indicates $144 when flying from Knoxville to Florida Keys.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $78). Flying from Knoxville to Florida Keys in December is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Florida Keys

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Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$80Average$145FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$248Average$437FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$402FlexibilityNo cancel feeOn-timeN/A

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