HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florida Keys

$106+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Florida Keys with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated July 31, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$106
(Mytrip)

Popular in

May

Cheapest in

August

Average price

$346
From Knoxville McGhee Tyson to Florida Keys
Search Deals
One-way flight from Knoxville McGhee Tyson to Florida Keys
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:10 amTYS - MIA
Nonstop2h 08mAmerican Airlines
Sat 9/209:35 pmMIA - TYS
Nonstop2h 15mAmerican Airlines
Deal found 7/29$159
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/316:14 pmTYS - MIA
1 stop6h 10mDelta
Sat 9/67:30 amMIA - TYS
1 stop5h 42mDelta
Deal found 7/30$193
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:34 pmTYS - EYW
1 stop13h 28mAllegiant Air
Mon 9/223:44 pmEYW - TYS
1 stop5h 15mAllegiant Air
Deal found 7/30$238
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:06 amTYS - EYW
1 stop6h 53mAmerican Airlines
Fri 8/297:40 pmEYW - TYS
1 stop4h 06mAmerican Airlines
Deal found 7/31$249
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/57:15 amTYS - MIA
1 stop9h 47mMultiple Airlines
Sun 9/148:04 pmMIA - TYS
1 stop15h 51mMultiple Airlines
Deal found 7/31$256
This Frontier deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/288:36 pmTYS - MIA
1 stop9h 54mFrontier
Sun 8/316:00 amMIA - TYS
1 stop13h 41mFrontier
Deal found 7/31$258
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/203:48 pmTYS - EYW
1 stop4h 18mDelta
Wed 10/296:17 pmEYW - TYS
1 stop4h 50mDelta
Deal found 7/30$274
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2411:00 amTYS - EYW
1 stop6h 01mMultiple Airlines
Fri 8/2910:02 amEYW - TYS
1 stop11h 09mMultiple Airlines
Deal found 7/31$275

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 9/13

6:10 am-8:18 am

Nonstop2h 08m

Miami

Sat 9/20

9:35 pm-11:50 pm

Nonstop2h 15m

$159

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sun 8/31

6:14 pm-12:24 am

1 stop6h 10m

Miami

Sat 9/6

7:30 am-1:12 pm

1 stop5h 42m

$193

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 1/3

3:56 pm-9:45 pm

1 stop5h 49m

Key West

Fri 1/9

5:41 pm-7:56 pm

Nonstop2h 15m

$217

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 8/23

5:06 am-11:59 am

1 stop6h 53m

Key West

Fri 8/29

7:40 pm-11:46 pm

1 stop4h 06m

$249

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 9/5

7:15 am-5:02 pm

1 stop9h 47m

Miami

Sun 9/14

8:04 pm-11:55 am

1 stop15h 51m

$256

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 8/28

8:36 pm-6:30 am

1 stop9h 54m

Miami

Mon 9/1

6:00 am-6:25 pm

1 stop12h 25m

$258

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/20

3:48 pm-8:06 pm

1 stop4h 18m

Key West

Wed 10/29

6:17 pm-11:07 pm

1 stop4h 50m

$274

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sun 8/24

11:00 am-5:01 pm

1 stop6h 01m

Key West

Fri 8/29

10:02 am-9:11 pm

1 stop11h 09m

$275

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/3

9:54 pm-9:02 am

1 stop11h 08m

$106

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 8/26

5:45 am-10:52 am

1 stop5h 07m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated July 31, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Frontier
5.9
Fair
3,239 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Florida Keys one-way?

    $106 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and Frontier, with prices starting from $119 and $129, respectively.

  • What are the cheapest flights from Knoxville to Florida Keys?

    Looking at all options, your cheapest flight can be booked for $100. While the most popular route (Knoxville McGhee Tyson - Miami) can be booked for $194 on average our data indicates $140 when flying from Knoxville to Florida Keys.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Orlando flights
Nashville to Fort Lauderdale flights
Nashville to Miami flights
Memphis to Miami flights
Memphis to Orlando flights
Nashville to Tampa flights
Chattanooga to Miami flights
Chattanooga to West Palm Beach flights
Nashville to Pensacola flights
Knoxville to Orlando Sanford Intl flights
Memphis to Fort Lauderdale flights
Memphis to Sarasota flights
Nashville to Panama City flights
Knoxville to Fort Lauderdale flights
Nashville to Key West flights
Knoxville to Miami flights
Chattanooga to Orlando flights
Blountville to Jacksonville flights
Knoxville to Orlando flights
Chattanooga to Tampa flights
Nashville to Jacksonville flights
Blountville to Orlando flights
Memphis to Tampa flights
Nashville to Fort Myers flights
Knoxville to Tampa flights
Memphis to Panama City flights
Nashville to West Palm Beach flights
Chattanooga to Fort Myers flights
Memphis to Pensacola flights
Chattanooga to Sarasota flights
Chattanooga to Orlando Sanford Intl flights
Nashville to St Petersburg flights
Nashville to Valparaiso flights
Chattanooga to Fort Lauderdale flights
Memphis to Orlando Sanford Intl flights
Knoxville to St Petersburg flights
Knoxville to Pensacola flights
Knoxville to Key West flights
Nashville to Tallahassee flights
Nashville to Sarasota flights
Chattanooga to Jacksonville flights
Knoxville to Melbourne flights
Memphis to Jacksonville flights
Memphis to Key West flights
Knoxville to Panama City flights
Knoxville to Valparaiso flights
Chattanooga to Panama City flights
Memphis to St Petersburg flights
Knoxville to West Palm Beach flights
Memphis to West Palm Beach flights

Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$150FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$253Average$439FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$453FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.