Florida Keys

$74+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Mar 5 — Mar 121
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Florida Keys with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Mon 3/911:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 2/2$97
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Fri 4/2411:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 2/2$115
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Fri 2/2011:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 2/1$118
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Mon 3/2311:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 1/31$147
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:00 am
TYS
-
EYW
Nonstop2h 11m
Multiple Airlines
Mon 3/91:06 pm
EYW
-
TYS
1 stop23h 03m
Multiple Airlines
Deal found 2/2$156
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:00 am
TYS
-
EYW
Nonstop2h 11m
Multiple Airlines
Mon 2/239:49 am
EYW
-
TYS
1 stop13h 49m
Multiple Airlines
Deal found 2/1$162
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Mon 3/211:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 2/2$168
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Fri 5/811:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Deal found 1/31$169
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:00 am
TYS
-
MIA
Nonstop2h 12m
American Airlines
Tue 3/319:43 pm
MIA
-
TYS
Nonstop2h 16m
American Airlines
Deal found 2/1$189
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:02 am
TYS
-
MIA
1 stop6h 09m
Delta
Tue 5/127:00 am
MIA
-
TYS
1 stop6h 07m
Delta
Deal found 2/1$199
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:53 pm
TYS
-
MIA
1 stop28h 04m
Multiple Airlines
Sun 3/85:05 am
MIA
-
TYS
2 stops39h 55m
Multiple Airlines
Deal found 2/1$206
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:35 am
TYS
-
MIA
1 stop5h 01m
Delta
Wed 3/48:15 am
MIA
-
TYS
1 stop5h 36m
Delta
Deal found 2/1$209

Find flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$97
(Kiwi.com)

One-way from

$74
(Priceline)

Popular in

May

Cheapest in

February

Average price

$336
Provider with most accurate pricing for Knoxville McGhee Tyson-Miami flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Miami flights.
From Knoxville McGhee Tyson to Florida Keys
One-way flight from Knoxville McGhee Tyson to Florida Keys
Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Average for round-trip flights in February 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 3/2

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 3/9

11:01 am-1:16 pm

Nonstop2h 15m

$97

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 3/2

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 3/9

9:49 am-11:32 pm

1 stop13h 43m

$157

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 2/27

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 3/2

11:01 am-1:16 pm

Nonstop2h 15m

$168

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 2/13

7:22 pm-11:03 am

1 stop15h 41m

Key West

Fri 2/20

11:01 am-1:16 pm

Nonstop2h 15m

$185

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 3/4

5:35 am-12:23 pm

1 stop6h 48m

Miami

Wed 3/11

7:05 am-11:17 am

1 stop4h 12m

$214

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 3/17

7:50 am-2:25 pm

1 stop6h 35m

Miami

Wed 4/1

6:10 am-5:40 pm

2 stops11h 30m

$214

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 4/3

7:55 am-10:06 am

Nonstop2h 11m

Key West

Wed 4/8

11:51 am-12:24 pm

1 stop24h 33m

$220

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sun 3/1

7:00 am-9:09 am

1 stop26h 09m

Key West

Sun 3/8

9:46 am-9:50 pm

1 stop12h 04m

$226

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Mon 4/13

12:15 pm-10:00 pm

1 stop9h 45m

Miami

Wed 4/15

7:00 am-5:10 pm

1 stop10h 10m

$228

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Mon 4/13

12:15 pm-10:00 pm

1 stop9h 45m

Miami

Sat 4/18

6:15 am-6:30 pm

2 stops12h 15m

$233

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 31 results
1
2
3
4

Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, March is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $78). Flying from Knoxville to Florida Keys in April is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated February 3, 2026.
Get a feel of what it's like to fly with Delta, American Airlines, and Allegiant Air from Knoxville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How popular is this Knoxville to Florida Keys flight route?

  • How long is the flight from Knoxville to Florida Keys?

    Allegiant Air, Delta, and Southwest can get you from Knoxville to Florida Keys in just under 2h 11m. Your travel time can differ by up to 4h 37m. There are 788 mi between Knoxville and Florida Keys. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Florida Keys one-way?

    $60 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $89 and $145, respectively.

  • What are the cheapest flights from Knoxville to Florida Keys?

    Looking at all options, your cheapest flight can be booked for $88. While the most popular route (Knoxville McGhee Tyson - Miami) can be booked for $209 on average, our data indicates $165 when flying from Knoxville to Florida Keys.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $78). Flying from Knoxville to Florida Keys in April is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$82Average$150FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$250Average$425FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$395FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.