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Florence

$427+ Cheap flights from Tampa to Florence, SC (TPA - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
TPA — FLO
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Cheap flight deals from Tampa to Florence

Cheapest flights from Tampa to Florence
Explore the most affordable flight options available from Tampa to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/243:25 pm
TPA
-
FLO
1 stop6h 35m
American Airlines
Sun 5/315:05 am
FLO
-
TPA
1 stop5h 58m
American Airlines
Deal found 4/26$471
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:00 am
TPA
-
FLO
1 stop6h 26m
American Airlines
Wed 1/65:35 pm
FLO
-
TPA
1 stop5h 49m
American Airlines
Deal found 4/25$521
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:40 pm
TPA
-
FLO
1 stop4h 35m
American Airlines
Tue 1/55:15 am
FLO
-
TPA
1 stop5h 30m
American Airlines
Deal found 4/25$537
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:50 pm
TPA
-
FLO
1 stop4h 57m
American Airlines
Sun 5/105:20 am
FLO
-
TPA
1 stop5h 29m
American Airlines
Deal found 4/28$542
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:40 pm
TPA
-
FLO
1 stop4h 35m
American Airlines
Fri 1/86:15 am
FLO
-
TPA
1 stop3h 55m
American Airlines
Deal found 4/25$561
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am
TPA
-
FLO
1 stop6h 26m
American Airlines
Thu 1/76:15 am
FLO
-
TPA
1 stop6h 01m
American Airlines
Deal found 4/25$585
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:00 am
TPA
-
FLO
1 stop6h 26m
American Airlines
Tue 1/55:15 am
FLO
-
TPA
1 stop4h 26m
American Airlines
Deal found 4/25$652

Find flight deals from Tampa to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Tampa (TPA) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$471
(American Airlines)

One-way from

$427
(American Airlines)
Provider with most accurate pricing for Tampa-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Tampa-Florence flights.
Search Deals
From Tampa to Florence
Search Deals
One-way flight from Tampa to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Tampa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Tampa to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 5/24

3:25 pm-10:00 pm

1 stop6h 35m

Florence

Sun 5/31

5:05 am-11:03 am

1 stop5h 58m

$471

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 5/9

4:50 pm-9:47 pm

1 stop4h 57m

Florence

Sun 5/10

5:20 am-10:49 am

1 stop5h 29m

$542

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 5/13

4:50 pm-9:47 pm

1 stop4h 57m

Florence

Sun 5/17

4:16 pm-9:58 pm

1 stop5h 42m

$542
Quickest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Mon 5/11

10:45 am-3:50 pm

1 stop5h 05m

Florence

Fri 5/15

5:20 am-9:55 am

1 stop4h 35m

$853
Cheapest one-way

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Mon 5/25

3:24 pm-10:00 pm

1 stop6h 36m

$427
Quickest one-way

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 5/24

3:25 pm-10:00 pm

1 stop6h 35m

$427

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Sorted by cheapest first

Compare providers for flights from Tampa to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Tampa to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Tampa-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Tampa-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Tampa-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Tampa-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Tampa-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Tampa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Tampa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Tampa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Tampa to Florence, South Carolina?

    Airlines like American Airlines fly from Tampa to Florence, South Carolina in about 6h 35m. The time it takes to get you to your destination can typically vary by up to . There are 460 mi between Tampa and Florence, South Carolina.

  • Can I find deals for flights from Tampa to Florence that include hotel bookings?

    Yes. In addition to deals on Tampa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Tampa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Tampa to Florence.

  • Can I find deals for business class flights from Tampa to Florence?

    Yes. Cheapflights offers flight deals from Tampa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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