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$303+ Cheap flights from Detroit Metropolitan Wayne County Airport to Florence, SC (DTW - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Detroit to Florence

Cheapest flights from Detroit to Florence
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1911:55 am
DTW
-
FLO
1 stop5h 55m
American Airlines
Tue 3/245:58 pm
FLO
-
DTW
1 stop3h 55m
American Airlines
Deal found 2/16$303
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1711:03 am
DTW
-
FLO
1 stop6h 18m
American Airlines
Tue 3/246:15 am
FLO
-
DTW
1 stop4h 02m
American Airlines
Deal found 2/16$319
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/171:06 pm
DTW
-
FLO
1 stop4h 15m
American Airlines
Sat 3/216:25 pm
FLO
-
DTW
1 stop6h 11m
American Airlines
Deal found 2/15$353
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:03 am
DTW
-
FLO
1 stop6h 18m
American Airlines
Sat 3/75:16 am
FLO
-
DTW
1 stop4h 09m
American Airlines
Deal found 2/16$355
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:11 am
DTW
-
FLO
2 stops6h 39m
American Airlines
Sat 3/145:16 am
FLO
-
DTW
2 stops9h 02m
American Airlines
Deal found 2/18$365
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1911:55 am
DTW
-
FLO
1 stop5h 55m
American Airlines
Sat 3/216:25 pm
FLO
-
DTW
1 stop6h 11m
American Airlines
Deal found 2/15$373

Find flight deals from Detroit to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$303
(American Airlines)
Provider with most accurate pricing for Detroit Metropolitan Wayne County-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Florence flights.
Search Deals
From Detroit Metropolitan Wayne County to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence that are best for you.

Fly from

Detroit

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 3/19

11:55 am-5:50 pm

1 stop5h 55m

Florence

Tue 3/24

5:58 pm-9:53 pm

1 stop3h 55m

$303

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/17

11:03 am-5:21 pm

1 stop6h 18m

Florence

Tue 3/24

6:15 am-10:17 am

1 stop4h 02m

$319

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/3

11:03 am-5:21 pm

1 stop6h 18m

Florence

Sat 3/7

5:16 am-9:25 am

1 stop4h 09m

$355

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 3/11

11:55 am-5:50 pm

1 stop5h 55m

Florence

Sat 3/14

6:25 pm-12:36 am

1 stop6h 11m

$355

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 3/4

11:03 am-5:21 pm

1 stop6h 18m

Florence

Sat 3/7

5:16 am-9:25 am

1 stop4h 09m

$355

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/15

9:43 am-11:52 pm

2 stops14h 09m

$319

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 3/12

5:45 am-5:50 pm

2 stops12h 05m

$342

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 3/25

5:45 am-11:57 pm

2 stops18h 12m

$366

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 3/11

5:45 am-11:57 pm

2 stops18h 12m

$369

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 3/13

5:45 am-5:50 pm

2 stops12h 05m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/15

Showing 1-10 of 12 results
1
2

Compare providers for flights from Detroit to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Florence

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina (average of $89). Flying from Detroit Metropolitan Wayne County Airport to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

    A quick flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina can take about 5h 55m. American Airlines provides one of the quickest options available for as low as $303. The distance between Detroit Metropolitan Wayne County Airport and Florence, South Carolina is about 589 mi.

  • Can I find deals for flights from Detroit to Florence that include hotel bookings?

    Yes. In addition to deals on Detroit to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Florence.

  • Can I find deals for business class flights from Detroit to Florence?

    Yes. Cheapflights offers flight deals from Detroit to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina (average of $89). Flying from Detroit Metropolitan Wayne County Airport to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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