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$378+ Cheap flights from Detroit Metropolitan Wayne County Airport to Florence, SC (DTW - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
out 17 — out 241
sex 10/17
sex 10/24
1 adult, Economy
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Cheap flight deals from Detroit to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated setembro 17, 2025.

Round-trip from

$378
(American Airlines)
From Detroit Metropolitan Wayne County to Florence
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Find flight deals from Detroit to Florence

Cheapest flights from Detroit to Florence
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 10/141:02 pmDTW - FLO
2 stops10h 11mAmerican Airlines
ter 10/216:14 amFLO - DTW
2 stops10h 14mAmerican Airlines
Deal found 9/16$378
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 10/412:42 pmDTW - FLO
2 stops10h 34mAmerican Airlines
ter 10/73:19 pmFLO - DTW
2 stops17h 58mAmerican Airlines
Deal found 9/14$508
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 9/246:51 pmDTW - FLO
1 stop4h 25mAmerican Airlines
dom 9/284:57 pmFLO - DTW
1 stop5h 32mAmerican Airlines
Deal found 9/15$535
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 9/2510:13 amDTW - FLO
1 stop6h 19mAmerican Airlines
seg 9/295:37 pmFLO - DTW
1 stop4h 05mAmerican Airlines
Deal found 9/15$559

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 17, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence that are best for you.

Fly from

Detroit

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

ter 10/14

1:02 pm-11:13 pm

2 stops10h 11m

Florence

ter 10/21

6:14 am-4:28 pm

2 stops10h 14m

$378

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

sáb 10/4

12:42 pm-11:16 pm

2 stops10h 34m

Florence

ter 10/7

3:19 pm-9:17 am

2 stops17h 58m

$508

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

qua 9/24

11:30 am-5:12 pm

1 stop5h 42m

Florence

seg 9/29

5:37 pm-9:42 pm

1 stop4h 05m

$535

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Detroit to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Florence

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina (average of $366). Flying from Detroit Metropolitan Wayne County Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

    A quick flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina can take about 10h 11m. American Airlines provides one of the quickest options available for as low as $378. The distance between Detroit Metropolitan Wayne County Airport and Florence, South Carolina is about 589 mi.

  • Can I find deals for flights from Detroit to Florence that include hotel bookings?

    Yes. In addition to deals on Detroit to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Florence.

  • Can I find deals for business class flights from Detroit to Florence?

    Yes. Cheapflights offers flight deals from Detroit to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina (average of $366). Flying from Detroit Metropolitan Wayne County Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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