HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$431+ Cheap flights from Clearwater, FL to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
MCO — FLO
Mar 25 — Apr 11
Wed 3/25
Wed 4/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Clearwater to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Clearwater to Florence

Cheapest flights from Clearwater to Florence
Explore the most affordable flight options available from Clearwater to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.

This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:40 am
TPA
-
FLO
1 stop5h 10m
American Airlines
Sun 4/194:16 pm
FLO
-
TPA
1 stop3h 57m
American Airlines
Deal found 2/21$431
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:30 am
TPA
-
FLO
1 stop5h 40m
American Airlines
Sat 6/275:09 am
FLO
-
TPA
2 stops11h 15m
American Airlines
Deal found 2/23$504
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/611:53 am
TPA
-
FLO
1 stop5h 57m
American Airlines
Tue 3/105:58 pm
FLO
-
TPA
1 stop5h 47m
American Airlines
Deal found 2/19$537
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/244:50 pm
TPA
-
FLO
1 stop6h 18m
American Airlines
Thu 2/266:20 pm
FLO
-
TPA
1 stop6h 08m
American Airlines
Deal found 2/21$768
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/91:51 pm
TPA
-
FLO
1 stop3h 59m
American Airlines
Fri 3/135:16 am
FLO
-
TPA
1 stop4h 37m
American Airlines
Deal found 2/21$793

Find flight deals from Clearwater to Florence

Keep the following information in mind while searching for Clearwater to Florence flight deals. Data was last updated February 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$431
(American Airlines)
Provider with most accurate pricing for Tampa-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Tampa-Florence flights.
Search Deals
From Clearwater to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Clearwater to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Clearwater to Florence that are best for you.

Fly from

Clearwater

Fly to

Florence

Route

Depart

Return

Price

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Fri 6/19

10:13 am-2:10 pm

1 stop3h 57m

Florence

Sat 6/27

5:09 am-9:22 am

1 stop4h 13m

$431

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

10:40 am-3:50 pm

1 stop5h 10m

Florence

Sun 4/19

4:16 pm-8:13 pm

1 stop3h 57m

$431

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Fri 3/6

11:53 am-5:50 pm

1 stop5h 57m

Florence

Tue 3/10

5:58 pm-11:45 pm

1 stop5h 47m

$537

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Mon 3/9

7:00 am-5:50 pm

2 stops10h 50m

Florence

Fri 3/13

5:16 am-9:53 am

1 stop4h 37m

$798

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/23

Best time to book a flight from Clearwater to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Clearwater with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Clearwater to Florence

What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $45). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Clearwater to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Clearwater?

    Florence (FLO) is the airport you will fly into if you book a flight from Clearwater to Florence. You should not have trouble finding flights to Florence from Clearwater; the airport handles an average of 0 inbound flights from Clearwater per day. You should also have plenty of airline options to choose from since 0 airlines have flights to the Florence airport from Clearwater. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Clearwater to Florence, South Carolina?

    Departing from Clearwater to Florence, South Carolina will take you 3h 57m. The distance from Clearwater to Florence, South Carolina is about 460 mi.

  • Can I find deals for flights from Clearwater to Florence that include hotel bookings?

    Yes. In addition to deals on Clearwater to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Clearwater to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Clearwater to Florence.

  • Can I find deals for business class flights from Clearwater to Florence?

    Yes. Cheapflights offers flight deals from Clearwater to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $45). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Clearwater to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Charlotte flights
Fort Lauderdale to Charlotte flights
Miami to Charlotte flights
Tampa to Charlotte flights
West Palm Beach to Charlotte flights
Tampa to Charleston flights
Jacksonville to Charlotte flights
Fort Lauderdale to Charleston flights
Fort Myers to Charlotte flights
Miami to Charleston flights
Tampa to Savannah flights
Sarasota to Charlotte flights
Fort Lauderdale to Myrtle Beach flights
Orlando to Charleston flights
Tampa to Myrtle Beach flights
West Palm Beach to Greenville flights
Daytona Beach to Charlotte flights
Pensacola to Charlotte flights
Tampa to Columbia flights
Miami to Savannah flights
Orlando to Myrtle Beach flights
Sarasota to Charleston flights
West Palm Beach to Savannah flights
Fort Myers to Myrtle Beach flights
West Palm Beach to Charleston flights
Miami to Myrtle Beach flights
Fort Myers to Savannah flights
Pensacola to Savannah flights
Orlando to Columbia flights
Fort Lauderdale to Savannah flights
Pensacola to Charleston flights
Pensacola to Myrtle Beach flights
Key West to Charlotte flights
Sarasota to Myrtle Beach flights
Miami to Columbia flights
Orlando to Greenville flights
Orlando to Savannah flights
Sarasota to Columbia flights
Tampa to Greenville flights
Fort Lauderdale to Hilton Head Island flights
Miami to Greenville flights
Fort Lauderdale to Greenville flights
West Palm Beach to Columbia flights
Jacksonville to Myrtle Beach flights
Tallahassee to Charlotte flights
Fort Lauderdale to Columbia flights
Orlando to Augusta flights
West Palm Beach to Myrtle Beach flights
Melbourne to Charlotte flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights