HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$382+ Cheap flights from Clearwater, FL to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
MCO — FLO
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Clearwater to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Clearwater to Florence

Cheapest flights from Clearwater to Florence
Explore the most affordable flight options available from Clearwater to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:45 am
TPA
-
FLO
1 stop5h 05m
American Airlines
Sat 4/115:20 am
FLO
-
TPA
1 stop5h 29m
American Airlines
Deal found 3/7$451
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:49 pm
TPA
-
FLO
1 stop6h 19m
American Airlines
Sat 3/285:16 am
FLO
-
TPA
1 stop4h 37m
American Airlines
Deal found 3/9$487
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:50 pm
TPA
-
FLO
1 stop4h 57m
American Airlines
Sun 4/125:20 am
FLO
-
TPA
1 stop5h 29m
American Airlines
Deal found 3/10$495
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/18:20 am
TPA
-
FLO
1 stop5h 51m
American Airlines
Sat 8/811:15 am
FLO
-
TPA
1 stop5h 37m
American Airlines
Deal found 3/6$507
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:50 pm
TPA
-
FLO
1 stop4h 57m
American Airlines
Wed 4/225:20 am
FLO
-
TPA
1 stop4h 35m
American Airlines
Deal found 3/8$522
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:30 pm
TPA
-
FLO
1 stop6h 27m
American Airlines
Wed 4/84:16 pm
FLO
-
TPA
1 stop3h 57m
American Airlines
Deal found 3/8$526
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:50 pm
TPA
-
FLO
1 stop4h 57m
American Airlines
Sat 4/254:16 pm
FLO
-
TPA
2 stops7h 34m
American Airlines
Deal found 3/8$527
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:30 pm
TPA
-
FLO
1 stop6h 27m
American Airlines
Tue 4/74:02 pm
FLO
-
TPA
2 stops7h 48m
American Airlines
Deal found 3/8$531

Find flight deals from Clearwater to Florence

Keep the following information in mind while searching for Clearwater to Florence flight deals. Data was last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$451
(American Airlines)

One-way from

$382
(American Airlines)
Provider with most accurate pricing for Tampa-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Tampa-Florence flights.
Search Deals
From Clearwater to Florence
Search Deals
One-way flight from Clearwater to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Clearwater to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Clearwater to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 4/9

10:45 am-3:50 pm

1 stop5h 05m

Florence

Sat 4/11

5:20 am-10:49 am

1 stop5h 29m

$451

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Tue 3/24

4:49 pm-11:08 pm

1 stop6h 19m

Florence

Sat 3/28

5:16 am-9:53 am

1 stop4h 37m

$487

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

6:00 am-2:11 pm

2 stops8h 11m

Florence

Sat 8/8

2:34 pm-11:59 pm

2 stops9h 25m

$517

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Fri 7/31

10:12 am-2:11 pm

1 stop3h 59m

Florence

Sat 8/8

2:34 pm-11:59 pm

2 stops9h 25m

$537

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 8/2

10:12 am-2:11 pm

1 stop3h 59m

Florence

Sat 8/8

11:15 am-4:52 pm

1 stop5h 37m

$552

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

8:20 am-2:11 pm

1 stop5h 51m

Florence

Sun 8/9

5:14 am-11:14 am

1 stop6h 00m

$552
Quickest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

4:50 pm-9:47 pm

1 stop4h 57m

Florence

Fri 4/24

5:20 am-9:55 am

1 stop4h 35m

$557

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/4

5:30 pm-11:57 pm

1 stop6h 27m

Florence

Wed 4/8

5:20 am-4:09 pm

2 stops10h 49m

$566
Cheapest one-way
Quickest one-way

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 3/18

11:53 am-5:50 pm

1 stop5h 57m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Sorted by cheapest first

Best time to book a flight from Clearwater to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Clearwater with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Clearwater to Florence

What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

Currently, September is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $49). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Clearwater to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Clearwater?

    Florence (FLO) is the airport you will fly into if you book a flight from Clearwater to Florence. You should not have trouble finding flights to Florence from Clearwater; the airport handles an average of 0 inbound flights from Clearwater per day. You should also have plenty of airline options to choose from since 0 airlines have flights to the Florence airport from Clearwater. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Clearwater to Florence, South Carolina?

    Departing from Clearwater to Florence, South Carolina will take you 5h 05m. The distance from Clearwater to Florence, South Carolina is about 460 mi.

  • Can I find deals for flights from Clearwater to Florence that include hotel bookings?

    Yes. In addition to deals on Clearwater to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Clearwater to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Clearwater to Florence.

  • Can I find deals for business class flights from Clearwater to Florence?

    Yes. Cheapflights offers flight deals from Clearwater to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $49). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Clearwater to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Charlotte flights
Tampa to Charlotte flights
Orlando to Charlotte flights
Miami to Charlotte flights
West Palm Beach to Charlotte flights
Fort Lauderdale to Charleston flights
Tampa to Charleston flights
Fort Myers to Charlotte flights
Miami to Charleston flights
Jacksonville to Charlotte flights
Tampa to Savannah flights
Sarasota to Charlotte flights
Fort Lauderdale to Myrtle Beach flights
Orlando to Charleston flights
Tampa to Myrtle Beach flights
Pensacola to Charlotte flights
Tampa to Greenville flights
Orlando to Myrtle Beach flights
Miami to Savannah flights
West Palm Beach to Savannah flights
Fort Lauderdale to Savannah flights
Orlando to Savannah flights
Fort Lauderdale to Greenville flights
Sarasota to Charleston flights
Tampa to Columbia flights
Fort Myers to Greenville flights
West Palm Beach to Charleston flights
Fort Myers to Savannah flights
Pensacola to Charleston flights
Orlando to Columbia flights
Miami to Greenville flights
Miami to Myrtle Beach flights
West Palm Beach to Myrtle Beach flights
Pensacola to Savannah flights
West Palm Beach to Greenville flights
Orlando to Greenville flights
Miami to Columbia flights
Fort Myers to Myrtle Beach flights
Fort Myers to Charleston flights
West Palm Beach to Columbia flights
Fort Lauderdale to Augusta flights
Gainesville to Charlotte flights
Jacksonville to Myrtle Beach flights
Key West to Charlotte flights
Fort Lauderdale to Columbia flights
Daytona Beach to Charlotte flights
West Palm Beach to Augusta flights
Sarasota to Myrtle Beach flights
Miami to Augusta flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights