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$441+ Cheap flights from Clearwater, FL to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
MCO — FLO
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Clearwater to Florence

Keep the following information in mind while searching for Clearwater to Florence flight deals. Data was last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$441
(American Airlines)
Provider with most accurate pricing for Tampa-Florence flight deals.
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Provider most trusted by Cheapflights users for Tampa-Florence flights.
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From Clearwater to Florence
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Find flight deals from Clearwater to Florence

Cheapest flights from Clearwater to Florence
Explore the most affordable flight options available from Clearwater to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:12 amTPA - FLO
1 stop3h 59mAmerican Airlines
Tue 6/95:09 amFLO - TPA
1 stop4h 13mAmerican Airlines
Deal found 1/6$441
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/101:06 pmTPA - FLO
1 stop4h 03mAmerican Airlines
Mon 1/125:36 pmFLO - TPA
1 stop3h 33mAmerican Airlines
Deal found 1/6$517
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/228:48 amTPA - FLO
2 stops8h 21mAmerican Airlines
Mon 1/266:15 amFLO - TPA
2 stops7h 01mAmerican Airlines
Deal found 1/6$528
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/211:00 amTPA - FLO
1 stop6h 09mAmerican Airlines
Wed 2/45:36 pmFLO - TPA
1 stop5h 48mAmerican Airlines
Deal found 1/5$748
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/256:05 pmTPA - FLO
1 stop4h 38mAmerican Airlines
Fri 1/305:36 pmFLO - TPA
1 stop5h 48mAmerican Airlines
Deal found 1/6$773

Cheapflights Fare Finder

 
Customize your flight search to find flights from Clearwater to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Clearwater to Florence that are best for you.

Fly from

Clearwater

Fly to

Florence

Route

Depart

Return

Price

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Mon 6/1

10:12 am-2:11 pm

1 stop3h 59m

Florence

Tue 6/9

5:09 am-9:22 am

1 stop4h 13m

$441

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 1/22

11:00 am-5:09 pm

1 stop6h 09m

Florence

Mon 1/26

5:36 pm-11:24 pm

1 stop5h 48m

$517

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Fri 1/23

1:06 pm-5:09 pm

1 stop4h 03m

Florence

Tue 1/27

6:15 am-12:16 pm

1 stop6h 01m

$517

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Mon 2/2

11:00 am-5:09 pm

1 stop6h 09m

Florence

Wed 2/4

5:36 pm-11:24 pm

1 stop5h 48m

$748

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 1/25

6:05 pm-10:43 pm

1 stop4h 38m

Florence

Fri 1/30

5:36 pm-11:24 pm

1 stop5h 48m

$773

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Best time to book a flight from Clearwater to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Clearwater with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Clearwater to Florence

What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

Currently, February is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $39). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Clearwater to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Clearwater?

    Florence (FLO) is the airport you will fly into if you book a flight from Clearwater to Florence. You should not have trouble finding flights to Florence from Clearwater; the airport handles an average of 0 inbound flights from Clearwater per day. You should also have plenty of airline options to choose from since 0 airlines have flights to the Florence airport from Clearwater. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Clearwater to Florence, South Carolina?

    Departing from Clearwater to Florence, South Carolina will take you 3h 59m. The distance from Clearwater to Florence, South Carolina is about 460 mi.

  • Can I find deals for flights from Clearwater to Florence that include hotel bookings?

    Yes. In addition to deals on Clearwater to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Clearwater to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Clearwater to Florence.

  • Can I find deals for business class flights from Clearwater to Florence?

    Yes. Cheapflights offers flight deals from Clearwater to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Clearwater to Florence, South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Clearwater to Florence, South Carolina (average of $39). Flying from Clearwater to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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