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Durham

$75+ Cheap flights from Iowa to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Iowa to Durham

Cheapest flights from Iowa to Durham
Explore the most affordable flight options available from Iowa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Orbitz deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:42 pmOMA - RDU
1 stop20h 59mFrontier
Mon 1/56:00 amRDU - OMA
1 stop10h 40mFrontier
Deal found 12/16$246
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:55 amCID - RDU
1 stop5h 42mAmerican Airlines
Sat 12/278:48 pmRDU - CID
1 stop4h 10mAmerican Airlines
Deal found 12/14$294
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2011:09 amMLI - RDU
1 stop8h 19mAmerican Airlines
Sat 1/39:01 amRDU - MLI
1 stop6h 04mAmerican Airlines
Deal found 12/17$324
This Frontier deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:35 pmOMA - RDU
1 stop6h 38mFrontier
Mon 1/56:00 amRDU - OMA
1 stop10h 40mFrontier
Deal found 12/16$342
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/151:28 pmCID - RDU
1 stop7h 35mAmerican Airlines
Mon 12/226:00 amRDU - CID
1 stop4h 47mAmerican Airlines
Deal found 12/14$354
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:50 amMLI - RDU
1 stop5h 06mDelta
Fri 12/266:50 pmRDU - MLI
1 stop4h 40mDelta
Deal found 12/16$354
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMLI - RDU
2 stops8h 26mAmerican Airlines
Wed 1/73:39 pmRDU - MLI
1 stop6h 54mAmerican Airlines
Deal found 12/17$357
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:50 amCID - RDU
1 stop4h 47mDelta
Mon 12/222:06 pmRDU - CID
2 stops9h 48mDelta
Deal found 12/14$359
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amMLI - RDU
2 stops8h 26mAmerican Airlines
Fri 12/266:37 pmRDU - MLI
1 stop4h 31mAmerican Airlines
Deal found 12/16$366
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:21 pmMLI - RDU
1 stop5h 45mAmerican Airlines
Sat 1/101:59 pmRDU - MLI
2 stops9h 24mAmerican Airlines
Deal found 12/17$382
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:40 amCID - RDU
1 stop6h 37mAmerican Airlines
Sat 12/278:48 pmRDU - CID
1 stop4h 10mAmerican Airlines
Deal found 12/17$394
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amCID - RDU
2 stops6h 26mAmerican Airlines
Sun 12/288:17 pmRDU - CID
1 stop4h 41mAmerican Airlines
Deal found 12/17$400

Find flight deals from Iowa to Durham

Keep the following information in mind while searching for Iowa to Durham flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$181
(Frontier)

One-way from

$75
(Trip.com)

Popular in

December

Cheapest in

September

Average price

$427
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Iowa to Durham
Search Deals
One-way flight from Iowa to Durham
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Iowa to Durham that are best for you.

Fly from

Iowa

Fly to

Durham

Route

Depart

Return

Price

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Fri 1/2

4:35 pm-12:13 am

1 stop6h 38m

Raleigh-Durham

Mon 1/5

6:00 am-3:40 pm

1 stop10h 40m

$217

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Sat 1/24

2:55 pm-12:15 am

2 stops8h 20m

Raleigh-Durham

Sat 1/31

5:10 pm-10:45 pm

1 stop6h 35m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Tue 1/20

8:00 am-2:02 pm

1 stop5h 02m

Raleigh-Durham

Tue 1/27

10:00 am-2:25 pm

1 stop5h 25m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Sat 1/17

10:34 am-4:18 pm

1 stop4h 44m

Raleigh-Durham

Sat 1/24

6:00 am-11:36 am

1 stop6h 36m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Tue 1/20

10:30 am-3:57 pm

1 stop4h 27m

Raleigh-Durham

Wed 1/28

5:30 am-9:50 am

1 stop5h 20m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Sun 1/18

6:05 am-12:02 pm

1 stop4h 57m

Raleigh-Durham

Tue 1/27

11:00 am-4:47 pm

1 stop6h 47m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Sun 1/18

10:34 am-4:06 pm

1 stop4h 32m

Raleigh-Durham

Wed 1/28

1:13 pm-5:00 pm

1 stop4h 47m

$256

OmahaRaleigh

OMA - RDU

OMARDU

Omaha Eppley Airfield

Sun 1/18

10:34 am-4:06 pm

1 stop4h 32m

Raleigh-Durham

Sat 1/24

12:12 pm-6:39 pm

1 stop7h 27m

$256

MolineRaleigh

MLI - RDU

MLIRDU

Moline Quad-City

Sat 4/4

10:46 am-5:21 pm

1 stop5h 35m

Raleigh-Durham

Sat 4/11

10:15 am-2:09 pm

1 stop4h 54m

$269

MolineRaleigh

MLI - RDU

MLIRDU

Moline Quad-City

Sat 5/16

5:55 am-2:09 pm

1 stop7h 14m

Raleigh-Durham

Sat 5/23

4:50 pm-10:31 pm

1 stop6h 41m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 57 results
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Best time to book a flight from Iowa to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Durham

What is the cheapest month to book a flight from Iowa to Durham?

Currently, January is the cheapest month in which you can book a flight from Iowa to Durham (average of $146). Flying from Iowa to Durham in December is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to DU8?

Find hourly flight availability from Iowa to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s optimal to fly from Iowa to Durham in the evening. By choosing this option you can save up to 38% on the cost of your flight, compared to a flight in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Durham?

    A quick flight from Iowa to Durham can take about 5h 02m. Frontier provides one of the quickest options available for as low as $256. Airlines will cover a distance of 994 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Iowa to Durham?

    While some choose either Omaha Eppley Airfield - Raleigh-Durham or Moline Quad-City - Raleigh-Durham, Des Moines - Raleigh-Durham is the most popular route from Iowa to Durham.

  • Can I find deals for flights from Iowa to Durham that include hotel bookings?

    Yes. In addition to deals on Iowa to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Durham.

  • Can I find deals for business class flights from Iowa to Durham?

    Yes. Cheapflights offers flight deals from Iowa to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Durham?

    Currently, January is the cheapest month in which you can book a flight from Iowa to Durham (average of $146). Flying from Iowa to Durham in December is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Durham

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Durham

Discover the top 4 airlines that operate flights from Iowa to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$417FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$222Average$399FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$223Average$365FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$309FlexibilityNo cancel feeOn-timeN/A

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