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Durham

$71+ Cheap flights from Iowa to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
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Cheap flight deals from Iowa to Durham

Cheapest flights from Iowa to Durham
Explore the most affordable flight options available from Iowa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:59 pm
OMA
-
RDU
1 stop9h 11m
Frontier
Mon 3/96:00 am
RDU
-
OMA
1 stop5h 34m
Frontier
Deal found 2/2$173
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:07 pm
CID
-
RDU
1 stop16h 44m
Frontier
Sun 3/17:38 pm
RDU
-
CID
1 stop24h 34m
Frontier
Deal found 2/2$220
This Expedia deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
-
RDU
1 stop20h 27m
Frontier
Mon 3/910:38 pm
RDU
-
DSM
1 stop12h 27m
Frontier
Deal found 2/4$248
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:04 pm
OMA
-
RDU
1 stop7h 11m
Frontier
Mon 5/46:00 am
RDU
-
OMA
1 stop10h 09m
Frontier
Deal found 2/3$255
This Travelocity deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:14 pm
OMA
-
RDU
1 stop4h 57m
Frontier
Mon 2/96:10 am
RDU
-
OMA
1 stop12h 09m
Frontier
Deal found 2/2$256
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:33 am
CID
-
RDU
1 stop4h 55m
Delta
Sat 3/76:53 pm
RDU
-
CID
1 stop4h 50m
Delta
Deal found 2/2$260
This Trip.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:17 pm
DSM
-
RDU
1 stop19h 59m
Frontier
Sun 2/157:38 pm
RDU
-
DSM
1 stop23h 54m
Frontier
Deal found 2/4$268
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:19 pm
CID
-
RDU
1 stop6h 30m
Delta
Sun 3/16:00 am
RDU
-
CID
1 stop6h 38m
Delta
Deal found 2/2$269
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:20 am
MLI
-
RDU
1 stop4h 22m
United Airlines
Sun 3/226:00 am
RDU
-
MLI
1 stop5h 09m
United Airlines
Deal found 2/3$269
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:00 am
CID
-
RDU
2 stops7h 17m
American Airlines
Sat 3/71:13 pm
RDU
-
CID
2 stops6h 29m
American Airlines
Deal found 2/3$270
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:21 pm
DSM
-
RDU
2 stops25h 59m
Frontier
Tue 3/246:43 pm
RDU
-
DSM
1 stop25h 33m
Frontier
Deal found 2/4$273
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:00 am
CID
-
RDU
2 stops6h 23m
American Airlines
Sun 3/15:00 am
RDU
-
CID
1 stop5h 18m
American Airlines
Deal found 2/2$274

Find flight deals from Iowa to Durham

Keep the following information in mind while searching for Iowa to Durham flight deals. Data was last updated February 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$173
(Priceline)

One-way from

$71
(Trip.com)

Popular in

January

Cheapest in

September

Average price

$386
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Iowa to Durham
Search Deals
One-way flight from Iowa to Durham
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Iowa to Durham that are best for you.

Fly from

Iowa

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 3/6

8:21 pm-5:48 pm

1 stop20h 27m

Raleigh-Durham

Mon 3/9

10:38 pm-10:05 am

1 stop12h 27m

$248

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Tue 3/3

2:41 pm-8:56 pm

1 stop5h 15m

Raleigh-Durham

Tue 3/10

5:15 pm-10:45 pm

1 stop6h 30m

$260

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Wed 3/4

5:00 am-11:06 am

1 stop5h 06m

Raleigh-Durham

Sat 3/7

5:00 am-9:18 am

1 stop5h 18m

$260

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Wed 3/4

5:33 am-4:32 pm

2 stops9h 59m

Raleigh-Durham

Sat 3/7

6:53 pm-10:43 pm

1 stop4h 50m

$265

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Tue 3/3

1:15 pm-8:58 pm

2 stops6h 43m

Raleigh-Durham

Tue 3/10

10:26 am-3:14 pm

1 stop5h 48m

$265

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Fri 2/27

4:19 pm-11:49 pm

1 stop6h 30m

Raleigh-Durham

Sun 3/1

6:00 am-11:38 am

1 stop6h 38m

$269

MolineRaleigh

MLI - RDU

MLIRDU

Moline Quad-City

Tue 3/24

6:30 am-1:42 pm

1 stop6h 12m

Raleigh-Durham

Tue 3/31

5:20 pm-9:07 pm

1 stop4h 47m

$269

MolineRaleigh

MLI - RDU

MLIRDU

Moline Quad-City

Thu 7/9

5:00 pm-12:26 am

1 stop6h 26m

Raleigh-Durham

Sun 7/12

6:35 am-10:26 am

1 stop4h 51m

$269

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Thu 2/19

8:00 am-1:44 pm

1 stop4h 44m

Raleigh-Durham

Tue 2/24

9:20 am-4:51 pm

2 stops8h 31m

$270

Cedar RapidsRaleigh

CID - RDU

CIDRDU

Cedar Rapids

Thu 2/26

5:00 am-12:23 pm

2 stops6h 23m

Raleigh-Durham

Sun 3/1

5:00 am-9:18 am

1 stop5h 18m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Durham

What is the cheapest month to book a flight from Iowa to Durham?

Currently, August is the cheapest month in which you can book a flight from Iowa to Durham (average of $184). Flying from Iowa to Durham in December is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Durham?

    A quick flight from Iowa to Durham can take about 5h 06m. Frontier provides one of the quickest options available for as low as $260. Airlines will cover a distance of 808 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to Durham one-way?

    The cheapest airlines for a one-way flight from Iowa to Durham are American Airlines ($99), United Airlines ($134), and Southwest ($135).

  • What are the most popular routes from Iowa to Durham?

    While some choose either Des Moines - Raleigh-Durham or Cedar Rapids - Raleigh-Durham, Omaha Eppley Airfield - Raleigh-Durham is the most popular route from Iowa to Durham.

  • Can I find deals for flights from Iowa to Durham that include hotel bookings?

    Yes. In addition to deals on Iowa to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Durham.

  • Can I find deals for business class flights from Iowa to Durham?

    Yes. Cheapflights offers flight deals from Iowa to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Durham?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Durham (average of $184). Flying from Iowa to Durham in December is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Durham

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Durham

Discover the top 4 airlines that operate flights from Iowa to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$386FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$216Average$397FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$223Average$368FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$358FlexibilityNo cancel feeOn-timeN/A

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