What’s the top layover airport for flights from New Orleans to Des Moines?

St. Louis (STL) – chosen by Cheapflights users on 60% of 1-stop itineraries from New Orleans to Des Moines on Cheapflights.

What’s the fastest layover option from New Orleans to Des Moines?

Flights via St. Louis (STL) have the shortest average one-way travel time for 1-stop routes: 3h 57m.

What’s the cheapest layover airport for flights from New Orleans to Des Moines?

St. Louis (STL) is the most affordable 1-stop option, with an average round-trip price of $312.

Which airport typically offers the quickest layover for flights from New Orleans to Des Moines?

Flights via St. Louis (STL) offer the fastest connection on this route, with an average layover time of 1h 13m.

How long is the flight from New Orleans to Des Moines?

American Airlines and Delta can get you from New Orleans to Des Moines in just under 5h 44m. Your travel time can differ by up to 1h 08m. Airlines will cover a distance of 820 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from New Orleans to Des Moines round-trip?

Flying on American Airlines is currently your cheapest option to Des Moines, with prices starting at $244. Additional round-trip tickets that might be worth considering are offered by Delta and Southwest, with the lowest prices starting at $296 and $312, respectively. These flights start at 43% lower than the current average price 3 months from now.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular airlines that fly from New Orleans to Des Moines?

Consider American Airlines, Southwest or Delta when booking your flight. These represent the most popular airlines when flying from New Orleans to Des Moines.

Most accurate provider : When it comes to deals on New Orleans-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on New Orleans-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from New Orleans-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on New Orleans-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for New Orleans-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from New Orleans to Des Moines that include hotel bookings?

Yes. In addition to deals on New Orleans to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from New Orleans to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from New Orleans to Des Moines.

Can I find deals for business class flights from New Orleans to Des Moines?

Yes. Cheapflights offers flight deals from New Orleans to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$129+ Flights from New Orleans to Des Moines

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Cheap flight deals from New Orleans to Des Moines

Cheapest flights from New Orleans to Des Moines
Explore the most affordable flight options available from New Orleans to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Sun 12/215:59 pmMSY - DSM

1 stop27h 10mMultiple Airlines

Mon 1/58:00 amDSM - MSY

2 stops32h 10mMultiple Airlines

Deal found 12/10

$256

Sat 12/206:40 amMSY - DSM

1 stop26h 16mMultiple Airlines

Mon 12/224:03 pmDSM - MSY

2 stops40h 44mMultiple Airlines

Deal found 12/10

$451

Thu 12/255:30 pmMSY - DSM

1 stop6h 05mAmerican Airlines

Mon 12/295:39 pmDSM - MSY

1 stop6h 47mAmerican Airlines

Deal found 12/10

$480

Mon 12/295:07 pmMSY - DSM

1 stop5h 23mUnited Airlines

Fri 1/28:00 amDSM - MSY

1 stop5h 28mUnited Airlines

Deal found 12/9

$507

Sun 12/217:55 pmMSY - DSM

1 stop4h 10mSouthwest

Mon 1/55:45 amDSM - MSY

1 stop5h 00mSouthwest

Deal found 12/10

$587

Sun 12/217:00 amMSY - DSM

2 stops8h 24mAmerican Airlines

Mon 1/53:27 pmDSM - MSY

2 stops8h 32mAmerican Airlines

Deal found 12/10

$597

Sat 12/205:05 amMSY - DSM

1 stop9h 37mMultiple Airlines

Sun 12/287:30 pmDSM - MSY

1 stop13h 17mMultiple Airlines

Deal found 12/10

$616

Best flights from New Orleans to Des Moines
Discover carefully curated flight deals from New Orleans to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Sun 12/215:59 pmMSY - DSM

1 stop27h 10mMultiple Airlines

Mon 1/58:00 amDSM - MSY

2 stops32h 10mMultiple Airlines

Deal found 12/10

$256

Thu 1/16:53 pmMSY - DSM

1 stop5h 44mAmerican Airlines

Thu 1/85:51 pmDSM - MSY

1 stop5h 08mAmerican Airlines

Deal found 12/11

$287

Sat 1/243:37 pmMSY - DSM

1 stop6h 52mDelta

Mon 1/265:16 pmDSM - MSY

1 stop6h 09mDelta

Deal found 12/10

$305

Fri 1/233:59 pmMSY - DSM

2 stops7h 45mUnited Airlines

Mon 1/263:04 pmDSM - MSY

1 stop6h 47mUnited Airlines

Deal found 12/10

$351

Fri 1/232:25 pmMSY - DSM

2 stops6h 45mSouthwest

Mon 1/263:20 pmDSM - MSY

2 stops6h 45mSouthwest

Deal found 12/10

$366

Fri 1/2311:10 amMSY - DSM

1 stop27h 34mMultiple Airlines

Mon 1/2611:09 amDSM - MSY

2 stops21h 12mMultiple Airlines

Deal found 12/10

$320

Fri 1/235:23 amMSY - DSM

1 stop5h 18mDelta

Mon 1/2610:59 amDSM - MSY

1 stop4h 26mDelta

Deal found 12/10

$346

Thu 1/16:03 pmMSY - DSM

1 stop5h 55mUnited Airlines

Thu 1/88:00 amDSM - MSY

2 stops8h 37mUnited Airlines

Deal found 12/11

$362

Sat 1/246:23 amMSY - DSM

2 stops10h 01mAmerican Airlines

Mon 1/2611:42 amDSM - MSY

2 stops9h 25mAmerican Airlines

Deal found 12/10

$385

Thu 12/255:30 pmMSY - DSM

1 stop6h 05mAmerican Airlines

Mon 12/295:39 pmDSM - MSY

1 stop6h 47mAmerican Airlines

Deal found 12/10

$480

Last-minute flights from New Orleans to Des Moines
Discover last-minute flight deals from New Orleans to Des Moines. Data last updated December 12, 2025 and is based on user searches.

Sat 12/206:40 amMSY - DSM

1 stop26h 16mMultiple Airlines

Mon 12/224:03 pmDSM - MSY

2 stops40h 44mMultiple Airlines

Deal found 12/10

$451

Sun 12/215:59 pmMSY - DSM

1 stop27h 10mMultiple Airlines

Mon 1/58:00 amDSM - MSY

2 stops32h 10mMultiple Airlines

Deal found 12/10

$256

Thu 1/16:53 pmMSY - DSM

1 stop5h 44mAmerican Airlines

Thu 1/85:51 pmDSM - MSY

1 stop5h 08mAmerican Airlines

Deal found 12/11

$287

Thu 1/16:03 pmMSY - DSM

1 stop5h 55mUnited Airlines

Thu 1/88:00 amDSM - MSY

2 stops8h 37mUnited Airlines

Deal found 12/11

$362

Fri 1/2311:10 amMSY - DSM

1 stop27h 34mMultiple Airlines

Mon 1/2611:09 amDSM - MSY

2 stops21h 12mMultiple Airlines

Deal found 12/10

$320

Fri 1/235:23 amMSY - DSM

1 stop5h 18mDelta

Mon 1/2610:59 amDSM - MSY

1 stop4h 26mDelta

Deal found 12/10

$346

Fri 1/233:59 pmMSY - DSM

2 stops7h 45mUnited Airlines

Mon 1/263:04 pmDSM - MSY

1 stop6h 47mUnited Airlines

Deal found 12/10

$351

Fri 1/232:25 pmMSY - DSM

2 stops6h 45mSouthwest

Mon 1/263:20 pmDSM - MSY

2 stops6h 45mSouthwest

Deal found 12/10

$366

Sat 1/243:37 pmMSY - DSM

1 stop6h 52mDelta

Mon 1/265:16 pmDSM - MSY

1 stop6h 09mDelta

Deal found 12/10

$305

Sat 1/247:00 amMSY - DSM

1 stop10h 08mMultiple Airlines

Mon 1/2611:09 amDSM - MSY

2 stops21h 12mMultiple Airlines

Deal found 12/10

$356

Sat 1/246:23 amMSY - DSM

2 stops10h 01mAmerican Airlines

Mon 1/2611:42 amDSM - MSY

2 stops9h 25mAmerican Airlines

Deal found 12/10

$385

One-way flights from New Orleans to Des Moines
Search for one-way flight options from New Orleans to Des Moines. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Tue 2/108:57 pmMSY - DSM

2 stops41h 22mMultiple Airlines

Deal found 12/11

$129

Tue 2/105:23 amMSY - DSM

1 stop5h 18mDelta

Deal found 12/11

$133

Fri 2/133:45 pmMSY - DSM

1 stop6h 45mAllegiant Air

Deal found 12/11

$150

Fri 2/137:27 pmMSY - DSM

2 stops42h 52mMultiple Airlines

Deal found 12/11

$191

Mon 1/196:25 amMSY - DSM

1 stop7h 15mSouthwest

Deal found 12/11

$214

Mon 1/198:36 pmMSY - DSM

3 stops44h 48mMultiple Airlines

Deal found 12/11

$216

Find flight deals from New Orleans to Des Moines

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$256 (Kiwi.com)
One-way from	$129 (Kiwi.com)
Popular in	April
Cheapest in	October
Average price	$396

Provider with most accurate pricing for New Orleans Louis Armstrong-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Des Moines flights.

Search Deals

From New Orleans Louis Armstrong to Des Moines

Search Deals

One-way flight from New Orleans Louis Armstrong to Des Moines

Search Deals

Highest demand for flights based on searches. 22% potential increase in price ($127 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from New Orleans to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Sun 12/21

5:59 pm-9:09 pm

1 stop27h 10m

Des Moines

Mon 1/5

8:00 am-4:10 pm

2 stops32h 10m

$256

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Thu 1/1

6:53 pm-12:37 am

1 stop5h 44m

Des Moines

Thu 1/8

5:51 pm-10:59 pm

1 stop5h 08m

$287

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Sat 1/24

3:37 pm-10:29 pm

1 stop6h 52m

Des Moines

Mon 1/26

5:16 pm-11:25 pm

1 stop6h 09m

$305

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Fri 1/23

11:10 am-2:44 pm

1 stop27h 34m

Des Moines

Mon 1/26

11:09 am-8:21 am

2 stops21h 12m

$320

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Fri 1/23

5:23 am-10:41 am

1 stop5h 18m

Des Moines

Mon 1/26

10:59 am-3:25 pm

1 stop4h 26m

$346

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Fri 1/23

3:59 pm-11:44 pm

2 stops7h 45m

Des Moines

Mon 1/26

3:04 pm-9:51 pm

1 stop6h 47m

$351

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Thu 1/1

6:03 pm-11:58 pm

1 stop5h 55m

Des Moines

Thu 1/8

8:00 am-4:37 pm

2 stops8h 37m

$362

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Fri 1/23

2:25 pm-9:10 pm

2 stops6h 45m

Des Moines

Mon 1/26

3:20 pm-10:05 pm

2 stops6h 45m

$366

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Sat 1/24

6:23 am-4:24 pm

2 stops10h 01m

Des Moines

Mon 1/26

11:42 am-9:07 pm

2 stops9h 25m

$385

New OrleansDes Moines

MSY - DSM

MSYDSM

New Orleans Louis Armstrong

Thu 12/25

5:30 pm-11:35 pm

1 stop6h 05m

Des Moines

Mon 12/29

5:39 pm-12:26 am

1 stop6h 47m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 17 results

Compare providers for flights from New Orleans to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from New Orleans to Des Moines in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on New Orleans-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on New Orleans-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from New Orleans-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on New Orleans-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for New Orleans-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from New Orleans to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from New Orleans with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from New Orleans to Des Moines

Prices

What is the cheapest month to book a flight from New Orleans to Des Moines?

Currently, August is the cheapest month in which you can book a flight from New Orleans to Des Moines (average of $143). Flying from New Orleans to Des Moines in December is currently the most expensive (average of $352). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MSY to DSM?

When flying from New Orleans to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 51% versus a flight in the afternoon.

Reviews of airlines servicing Des Moines

Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from New Orleans to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,253 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,253 reviews

Southwest

7.9

Good

4,253 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,008 reviews

Southwest

7.9

Good

4,253 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,050 reviews

Southwest

7.9

Good

4,253 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How long is the flight from New Orleans to Des Moines?
American Airlines and Delta can get you from New Orleans to Des Moines in just under 5h 44m. Your travel time can differ by up to 1h 08m. Airlines will cover a distance of 820 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from New Orleans to Des Moines round-trip?
Flying on American Airlines is currently your cheapest option to Des Moines, with prices starting at $244. Additional round-trip tickets that might be worth considering are offered by Delta and Southwest, with the lowest prices starting at $296 and $312, respectively. These flights start at 43% lower than the current average price 3 months from now.
Can I find deals for flights from New Orleans to Des Moines that include hotel bookings?
Yes. In addition to deals on New Orleans to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from New Orleans to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from New Orleans to Des Moines.
Can I find deals for business class flights from New Orleans to Des Moines?
Yes. Cheapflights offers flight deals from New Orleans to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from New Orleans to Des Moines?
Currently, August is the cheapest month in which you can book a flight from New Orleans to Des Moines (average of $143). Flying from New Orleans to Des Moines in December is currently the most expensive (average of $352). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Altoona

Johnston

Boone

Ames

Clive

West Des Moines

Ankeny

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Other flights to Des Moines

Top 3 airlines flying from New Orleans to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$244	Average$366	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$296	Average$431	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$312	Average$356	FlexibilityNo cancel fee	On-time63%

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$129+ Cheap flights from New Orleans to Des Moines (MSY - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from New Orleans to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from New Orleans to Des Moines

Cheapest flights from New Orleans to Des MoinesExplore the most affordable flight options available from New Orleans to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from New Orleans to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from New Orleans to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from New Orleans to Des Moines that are best for you.

Compare providers for flights from New Orleans to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from New Orleans to Des Moines in December.

Best time to book a flight from New Orleans to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from New Orleans with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from New Orleans to Des Moines

What is the cheapest month to book a flight from New Orleans to Des Moines?

What is the cheapest time of day to fly from MSY to DSM?

What’s the top layover airport for flights from New Orleans to Des Moines?

What’s the cheapest layover airport for flights from New Orleans to Des Moines?

What’s the fastest layover option from New Orleans to Des Moines?

Which airport typically offers the quickest layover for flights from New Orleans to Des Moines?

Reviews of airlines servicing Des Moines

Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from New Orleans to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from New Orleans to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from New Orleans to Des Moines?

What are the cheapest airlines flying from New Orleans to Des Moines round-trip?

Can I find deals for flights from New Orleans to Des Moines that include hotel bookings?

How can I find direct flights from New Orleans to Des Moines?

Can I find deals for business class flights from New Orleans to Des Moines?

What is the cheapest month to book a flight from New Orleans to Des Moines?

Traveling to a place near Des Moines?

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Alternative routes for New Orleans to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from New Orleans to Des Moines

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Cheapest flights from New Orleans to Des Moines
Explore the most affordable flight options available from New Orleans to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.