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Des Moines

$156+ Cheap flights from Memphis to Des Moines (MEM - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
MEM — DSM
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Memphis to Des Moines

Cheapest flights from Memphis to Des Moines
Explore the most affordable flight options available from Memphis to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:05 am
MEM
-
DSM
1 stop6h 40m
Southwest
Mon 4/204:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Deal found 3/23$303
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:15 am
MEM
-
DSM
1 stop6h 10m
Southwest
Sun 4/194:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Deal found 3/21$309
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:50 am
MEM
-
DSM
1 stop4h 35m
United Airlines
Fri 4/176:20 am
DSM
-
MEM
1 stop4h 34m
United Airlines
Deal found 3/18$329
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:05 am
MEM
-
DSM
1 stop6h 40m
Southwest
Sun 5/104:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Deal found 3/23$332
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:40 am
MEM
-
DSM
1 stop5h 46m
American Airlines
Fri 4/1711:09 am
DSM
-
MEM
2 stops8h 38m
American Airlines
Deal found 3/18$334
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:45 am
MEM
-
DSM
1 stop4h 26m
United Airlines
Fri 8/216:50 pm
DSM
-
MEM
1 stop4h 56m
United Airlines
Deal found 3/20$347
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:20 am
MEM
-
DSM
1 stop4h 23m
Delta
Sat 6/206:03 pm
DSM
-
MEM
1 stop4h 18m
Delta
Deal found 3/23$367

Find flight deals from Memphis to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Memphis (MEM) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$303
(Southwest)

One-way from

$156
(Delta)

Popular in

March

Cheapest in

September

Average price

$562
Provider with most accurate pricing for Memphis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Memphis-Des Moines flights.
Search Deals
From Memphis to Des Moines
Search Deals
One-way flight from Memphis to Des Moines
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Memphis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Memphis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 8/22

5:45 am-10:11 am

1 stop4h 26m

Des Moines

Sat 8/22

6:50 pm-11:46 pm

1 stop4h 56m

$347

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 8/21

5:45 am-10:11 am

1 stop4h 26m

Des Moines

Fri 8/21

6:50 pm-11:46 pm

1 stop4h 56m

$347

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 4/16

12:20 pm-11:05 pm

2 stops10h 45m

Des Moines

Mon 4/20

4:20 pm-11:25 pm

1 stop7h 05m

$350

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 4/15

6:00 am-2:05 pm

2 stops8h 05m

Des Moines

Sun 4/19

6:40 am-7:30 pm

2 stops12h 50m

$375

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 4/23

5:05 am-11:45 am

1 stop6h 40m

Des Moines

Sun 4/26

5:20 am-3:20 pm

2 stops10h 00m

$384
Quickest round-trip

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 4/2

6:07 am-10:09 am

1 stop4h 02m

Des Moines

Mon 4/6

5:20 pm-10:14 pm

1 stop4h 54m

$447

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 4/7

3:11 pm-10:38 pm

1 stop7h 27m

Des Moines

Sat 4/11

6:15 am-11:24 am

1 stop5h 09m

$447

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 4/3

4:25 pm-11:15 pm

1 stop6h 50m

Des Moines

Mon 4/6

4:20 pm-11:20 pm

1 stop7h 00m

$447

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 4/2

2:55 pm-11:15 pm

2 stops8h 20m

Des Moines

Sat 4/4

5:20 am-12:45 pm

1 stop7h 25m

$458

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 4/7

7:30 am-12:29 pm

1 stop4h 59m

Des Moines

Sat 4/11

9:00 am-2:24 pm

1 stop5h 24m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/23

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Memphis to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Memphis to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Memphis-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Memphis-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Memphis-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Memphis-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Memphis-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Memphis to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Memphis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 23, 2026.
Peruse reviews from past customers who have flown with American Airlines from Memphis to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,488 reviews

Crew

7.9

Overall

7.1

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,488 reviews
American Airlines
7.1
Good
11,488 reviews

Crew

7.9

Overall

7.1

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Memphis to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Memphis to Des Moines?

    Airlines like United Airlines and Southwest fly from Memphis to Des Moines in about 4h 26m. The time it takes to get you to your destination can typically vary by up to 6h 19m. There are 491 mi between Memphis and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Memphis to Des Moines round-trip?

    Currently priced at $241, American Airlines will fly you from Memphis to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. This flight start at 36% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Memphis to Des Moines one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $98. United Airlines flights start at $125 while deals on American Airlines start at $153 one-way.

  • Can I find deals for flights from Memphis to Des Moines that include hotel bookings?

    Yes. In addition to deals on Memphis to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Memphis to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Memphis to Des Moines.

  • Can I find deals for business class flights from Memphis to Des Moines?

    Yes. Cheapflights offers flight deals from Memphis to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

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Top airline flying from Memphis to Des Moines

Discover the top airline that operate flights from Memphis to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$241Average$326FlexibilityNo cancel feeOn-time71%

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