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Des Moines

$126+ Cheap flights from Memphis to Des Moines (MEM - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
MEM — DSM
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Memphis to Des Moines

Cheapest flights from Memphis to Des Moines
Explore the most affordable flight options available from Memphis to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:09 amMEM - DSM
1 stop5h 45mAmerican Airlines
Sun 1/46:52 pmDSM - MEM
1 stop6h 52mAmerican Airlines
Deal found 12/16$318
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amMEM - DSM
1 stop8h 21mAmerican Airlines
Sun 12/286:52 pmDSM - MEM
1 stop5h 07mAmerican Airlines
Deal found 12/16$393
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:12 amMEM - DSM
1 stop5h 35mAmerican Airlines
Sat 1/36:57 pmDSM - MEM
1 stop5h 02mAmerican Airlines
Deal found 12/16$502
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:30 pmMEM - DSM
1 stop4h 50mSouthwest
Sat 1/35:40 amDSM - MEM
2 stops13h 15mSouthwest
Deal found 12/16$528
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:17 pmMEM - DSM
1 stop26h 09mMultiple Airlines
Mon 12/224:03 pmDSM - MEM
1 stop27h 59mMultiple Airlines
Deal found 12/16$532
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:04 amMEM - DSM
1 stop5h 44mAmerican Airlines
Sat 12/206:35 pmDSM - MEM
1 stop5h 22mAmerican Airlines
Deal found 12/17$537
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2012:25 pmMEM - DSM
2 stops11h 30mSouthwest
Mon 12/226:35 amDSM - MEM
2 stops12h 55mSouthwest
Deal found 12/16$619

Find flight deals from Memphis to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Memphis (MEM) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(Delta)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

May

Average price

$422
Provider with most accurate pricing for Memphis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Memphis-Des Moines flights.
Search Deals
From Memphis to Des Moines
Search Deals
One-way flight from Memphis to Des Moines
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Memphis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Memphis to Des Moines that are best for you.

Fly from

Memphis

Fly to

Des Moines

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/7

5:50 am-10:19 am

1 stop4h 29m

Des Moines

Sat 2/14

5:24 am-11:01 am

1 stop5h 37m

$240

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/7

8:37 am-4:24 pm

2 stops7h 47m

Des Moines

Sat 2/14

5:56 pm-11:09 pm

1 stop5h 13m

$245

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 1/14

5:50 am-10:19 am

1 stop4h 29m

Des Moines

Wed 1/14

4:21 pm-10:40 pm

1 stop6h 19m

$251

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 3/25

7:30 am-2:22 pm

1 stop6h 52m

Des Moines

Sun 3/29

3:15 pm-9:51 pm

1 stop6h 36m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 1/23

4:15 pm-11:44 pm

1 stop7h 29m

Des Moines

Sun 1/25

8:10 am-1:49 pm

1 stop5h 39m

$327

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 1/23

5:50 am-10:19 am

1 stop4h 29m

Des Moines

Sun 1/25

6:54 am-11:43 am

1 stop4h 49m

$327

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 1/23

6:35 am-4:24 pm

2 stops9h 49m

Des Moines

Sun 1/25

7:00 am-5:08 pm

2 stops10h 08m

$337

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 1/1

7:04 am-12:54 pm

1 stop5h 50m

Des Moines

Mon 1/5

3:27 pm-11:56 pm

2 stops8h 29m

$353

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 3/25

5:30 am-1:15 pm

2 stops7h 45m

Des Moines

Sun 3/29

6:45 am-2:10 pm

1 stop7h 25m

$362

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 12/31

5:00 am-12:54 pm

2 stops7h 54m

Des Moines

Sun 1/4

6:52 pm-1:44 am

1 stop6h 52m

$378

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 13 results
1
2

Compare providers for flights from Memphis to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Memphis to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Memphis-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Memphis-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Memphis-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Memphis-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Memphis-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Memphis to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Memphis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Memphis to Des Moines

What is the cheapest time of day to fly from MEM to DSM?

Find hourly flight availability from Memphis to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from Memphis to Des Moines in the evening. If you’re flexible enough to do this you can expect to save up to 51% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 18, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Memphis to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Memphis to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Memphis to Des Moines?

    Airlines like Delta, American Airlines, and United Airlines fly from Memphis to Des Moines in about 4h 29m. The time it takes to get you to your destination can typically vary by up to 3h 18m. There are 491 mi between Memphis and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Memphis to Des Moines round-trip?

    Currently priced at $201, Delta will fly you from Memphis to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $241. These flights start at 44% lower than the current average price 3 months from now.

  • Can I find deals for flights from Memphis to Des Moines that include hotel bookings?

    Yes. In addition to deals on Memphis to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Memphis to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Memphis to Des Moines.

  • Can I find deals for business class flights from Memphis to Des Moines?

    Yes. Cheapflights offers flight deals from Memphis to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 2 airlines flying from Memphis to Des Moines

Discover the top 2 airlines that operate flights from Memphis to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$201Average$406FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$241Average$357FlexibilityNo cancel feeOn-time71%

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